专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008117214A1 AUTOMATIC DRUG ADMINISTRATION WITH REDUCED POWER CONSUMPTION 审中-公开
标题翻译：具有降低功耗的自动药物管理
公开(公告)号：WO2008117214A1
公开(公告)日：2008-10-02
申请号：PCT/IB2008/051065
申请日：2008-03-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna, M. , VAN BRUGGEN, Michel, P., B.
发明人： KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna, M. , VAN BRUGGEN, Michel, P., B.
IPC分类号： A61M5/172 , A61M5/142
CPC分类号： A61M5/1723 , A61M5/142 , A61M2205/8212 , A61M2230/63 , G06F19/00
摘要： It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) may be realized as a closed- loop system for monitoring and treatment of various diseases such as hemophilia A and Parkinson.
摘要翻译：描述了适于在与患者的状态相关的轮廓中注入至少一种药物的药物递送系统（100）。该系统包括传感器（110），专用电子设备（140）和用于监视患者活动并维持对药物释放特征的控制的软件。系统（100）的控制单元（120）适于将系统（100）的至少一个组件（110,120,150）临时设置为空闲模式（265）。这将特别导致系统（100）所需的功率的降低。所描述的系统（100）能够通过监测患者的个体活动状态来对患者进行个性化治疗，并将该信息与适当的递送概况相关联地传递给药物递送。系统（100）可以设置有存储器，以便存储活动数据的时间依赖性。这种时间依赖可以由医生使用来监测，支持和适应患者的治疗。系统（100）可以实现为用于监测和治疗诸如血友病A和帕金森病等各种疾病的闭环系统。

2. 发明申请

WO2008044186A2 ENVIRONMENTAL STATE DETECTION WITH HYDROGEL BASED FULLY INTEGRATED TRANSDUCER DEVICE 审中-公开
标题翻译：基于氢化物的全集成传感器设备的环境状态检测
公开(公告)号：WO2008044186A2
公开(公告)日：2008-04-17
申请号：PCT/IB2007/054078
申请日：2007-10-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , JANNER, Anna-Maria
发明人： IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , JANNER, Anna-Maria
IPC分类号： G01N33/50
CPC分类号： G01N21/77 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/14539 , G01N2021/7723
摘要： It is described a hydrogel based transducer device for detecting an environmental state, in particular for detecting an environmental state within a biological material. The transducer device (300) comprises a base element (302), a radiation source (305), which is formed at the base element (302) and which is adapted to emit electromagnetic radiation (306), an optical element (325), which is arranged at the base element (302) and which is adapted to interact with the electromagnetic radiation (306). The transducer device (300) further comprises a radiation detector (350), which is adapted to receive the electromagnetic radiation (326) having interacted with the optical element (325), and a hydrogel material (340), which is mechanically coupled to the optical element (325) and which is adapted to change its volume when getting into contact with an environmental material of the transducer device (300) such that the spatial position of the optical element (325) is changed. The base element (302), the radiation source (305) and the radiation detector (350) are formed integrally from an electronic substrate material.
摘要翻译：描述了用于检测环境状态的基于水凝胶的换能器装置，特别是用于检测生物材料内的环境状态。换能器装置（300）包括基座元件（302），辐射源（305），其形成在基座元件（302）处并适于发射电磁辐射（306），光学元件（325）其布置在基座元件（302）处并且适于与电磁辐射（306）相互作用。换能器装置（300）还包括辐射检测器（350），其适于接收与光学元件（325）相互作用的电磁辐射（326），以及水凝胶材料（340），其被机械耦合到光学元件（325），并且适于在与所述换能器装置（300）的环境材料接触时改变其体积，使得所述光学元件（325）的空间位置改变。基底元件（302），辐射源（305）和辐射检测器（350）由电子基底材料一体地形成。

3. 发明申请

WO2008012725A3 A DRUG DELIVERY SYSTEM WITH THERMOSWITCHABLE MEMBRANES 审中-公开
标题翻译：具有热稳定膜的药物递送系统
公开(公告)号：WO2008012725A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007052809
申请日：2007-07-13
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN BRUGGEN MICHEL P B , KRIJNSEN HENDRIKA C , IORDANOV VENTZESLAV P , JANNER ANNA-MARIA
发明人： VAN BRUGGEN MICHEL P B , KRIJNSEN HENDRIKA C , IORDANOV VENTZESLAV P , JANNER ANNA-MARIA
IPC分类号： A61K9/00 , A61M31/00 , A61M35/00
CPC分类号： A61M37/00 , A61M2037/0007
摘要： The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion. The present invention also provides a method for modulating the release of molecules, using such a device.
摘要翻译：本发明提供了用于分子控制释放的装置。该装置特别适用于向患者控制释放治疗药物。该装置包括具有用于从壳体释放分子的开口的壳体。壳体还包括用于容纳分子的储库，特别是治疗药物。储存器布置在壳体中以允许分子通过开口释放。该装置还包括至少一个可热转换膜和至少一个用于至少部分地加热膜的加热元件。该装置被配置为使用加热元件通过加热膜来调节开口处分子的释放。可选地，所述装置还包括用于从所述装置提供所述分子的加压释放的压力元件。以这种方式，药物可以以脉动方式递送给患者。本发明还提供了使用这种装置调节分子释放的方法。

4. 发明申请

WO2006129246A2 LIGHT-SOURCE WITH FABRIC DIFFUSING LAYER 审中-公开
标题翻译：具有织物扩散层的光源
公开(公告)号：WO2006129246A2
公开(公告)日：2006-12-07
申请号：PCT/IB2006/051652
申请日：2006-05-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ASVADI, Sima , KRANS, Martijn , VAN BRUGGEN, Michel, P., B. , WILDERBEEK, Johannes, T., A. , DEN TOONDER, Jacob, M., J.
发明人： ASVADI, Sima , KRANS, Martijn , VAN BRUGGEN, Michel, P., B. , WILDERBEEK, Johannes, T., A. , DEN TOONDER, Jacob, M., J.
CPC分类号： G09F9/33 , G09F13/22 , G09F21/02 , G09F2021/023
摘要： A light-source comprising at least one lighting unit (101) being arranged on a substrate (102) and a diffusing element (103) being arranged to receive and diffuse light emitted by said at least one lighting unit (101) is provided. The diffusing element (103) comprises a layer of non-woven fabric having a lower density at a side facing the lighting unit and a higher density at a side opposite to the lighting unit to obtain good diffusing properties.
摘要翻译：提供一种光源，包括布置在基板（102）上的至少一个照明单元（101）和布置成用于接收和漫射由所述至少一个照明单元（101）发射的光的漫射元件（103）。扩散元件（103）包括在面向照明单元的一侧具有较低密度的一层无纺织物，并且在与照明单元相对的一侧具有更高的密度以获得良好的扩散性质。

5. 发明申请

WO2006129244A3 LIGHT-SOURCE WITH FABRIC DIFFUSING LAYER 审中-公开
公开(公告)号：WO2006129244A3
公开(公告)日：2006-12-07
申请号：PCT/IB2006/051649
申请日：2006-05-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ASVADI, Sima , KRANS, Martijn , VAN BRUGGEN, Michel, P., B. , WILDERBEEK, Johannes, T., A. , DEN TOONDER, Jacob, M., J.
发明人： ASVADI, Sima , KRANS, Martijn , VAN BRUGGEN, Michel, P., B. , WILDERBEEK, Johannes, T., A. , DEN TOONDER, Jacob, M., J.
IPC分类号： G09F13/22 , G09F9/33
摘要： A light-source comprising at least one lighting unit (101) being arranged on a substrate (102) and a diffusing element (103) being arranged to receive and diffuse light emitted by said at least one lighting unit (101) is provided. The diffusing element (103) comprises a layer of non-woven fabric having a lower density at a side facing the lighting unit and a higher density at a side opposite to the lighting unit to obtain good diffusing properties.

6. 发明申请

WO2005119798A3 LIGHT- EMITTING DIODE 审中-公开
标题翻译：发光二极管
公开(公告)号：WO2005119798A3
公开(公告)日：2006-03-16
申请号：PCT/IB2005051708
申请日：2005-05-25
申请人： KONINKL PHILIPS ELECTRONICS NV , WOLF RONALD M , VAN BRUGGEN MICHEL P B
发明人： WOLF RONALD M , VAN BRUGGEN MICHEL P B
IPC分类号： H01L33/16 , H01L33/32 , H01L33/00
CPC分类号： H01L33/16 , H01L33/32
摘要： Light-emitting diode (LED) comprising a translucent substrate of a-Al
摘要翻译：发光二极管（LED）包括a-Al的半透明衬底

7. 发明申请

WO2009144625A1 IMPLANTABLE DRUG DELIVERY DEVICE WITH DOSAGE CONTROL 审中-公开
标题翻译：具有剂量控制的可植入药物递送装置
公开(公告)号：WO2009144625A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052096
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , EVERAERTS, Fransciscus, J., L.
发明人： IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , EVERAERTS, Fransciscus, J., L.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/16881 , A61M2005/1726 , A61M2205/3507
摘要： An implantable drug delivery device (10, 30) is provided, comprising a reservoir(14) for storing reservoirfluid and a plurality of capsules (20), the capsules (20) comprising medicine, the outer surface of the capsules (20) being made of a water degradable materialthat does not dissolve in the reservoirfluid. The device (10, 30) further comprises an actuator (13) for initiating release of a capsule (20) of the pluralityofcapsules (20) from the 5 device (10, 30), a valve (17) for controlling the release of the capsule (20) and processing electronics (12) being arranged for controlling the actuator (13) and the valve (17).
摘要翻译：提供了可植入药物输送装置（10,30），其包括用于储存储存器流体的储存器（14）和多个胶囊（20），所述胶囊（20）包括药物，所述胶囊（20）的外表面被制成的水可降解材料，不溶于储液器。装置（10,30）还包括用于启动从5装置（10,30）释放多个胶囊（20）的胶囊（20）的致动器（13），用于控制所述多个胶囊（20）的释放的阀（17）胶囊（20）和处理电子器件（12）被布置用于控制致动器（13）和阀（17）。

8. 发明申请

WO2008155703A1 MRI RADIO FREQUENCY RECEIVER COMPRISING DIGITAL DOWN CONVERTER 审中-公开
标题翻译：包含数字下变频器的磁共振无线电频率接收机
公开(公告)号：WO2008155703A1
公开(公告)日：2008-12-24
申请号：PCT/IB2008/052355
申请日：2008-06-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SAES, Marc, P. , VAN DEN BRINK, Johan, S. , VAN LIERE, Filips , PENTERMAN, Roel , KURT, Ralph , PEETERS, Emiel , BROER, Dirk, J. , VAN BRUGGEN, Michel, P., B. , VAN ZON, Hans , FUDERER, Miha
发明人： SAES, Marc, P. , VAN DEN BRINK, Johan, S. , VAN LIERE, Filips , PENTERMAN, Roel , KURT, Ralph , PEETERS, Emiel , BROER, Dirk, J. , VAN BRUGGEN, Michel, P., B. , VAN ZON, Hans , FUDERER, Miha
IPC分类号： G01R33/341 , G01R33/3415 , G01R33/36
CPC分类号： G01R33/341 , G01R33/3415 , G01R33/3621 , G01R33/3692
摘要： The invention relates to a nuclear magnetic resonance imaging radio frequency- receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analogue signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analogue-digital converter (118; 226) to convert the analogue pre-amplif ied magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).
摘要翻译：本发明涉及一种核磁共振成像射频接收器（112; 216; 308; 404），所述接收器（112; 216; 308; 404）适于接收来自至少一个射频接收器线圈单元 106; 200; 202; 300; 400; 402），所述射频接收器（112; 216; 308; 404）包括：模拟数字转换器（118; 226），用于将所述模拟预放大磁共振信号转换成数字信号，用于数字下变频数字信号的装置（120; 230）和适于经由通信链路（例如无线，光或有线）发送经下变频的数字信号的第一通信接口（130; 252）。

9. 发明申请

WO2008122926A1 HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE 审中-公开
标题翻译：用于检测环境状态的基于HYDROGEL的设备
公开(公告)号：WO2008122926A1
公开(公告)日：2008-10-16
申请号：PCT/IB2008/051224
申请日：2008-04-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria , KURT, Ralph
发明人： IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria , KURT, Ralph
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0008 , A61B5/0031 , A61B5/4839
摘要： The invention relates to a transducer device (100,200,300,400) for detecting an environmental state or a change in the environmental state, in particular for detecting an environmental state within a biological material. The transducer device (100,200,300,400) comprises a channel (2,22,51) comprising a fluid, a hydrogel material (1,21,51), which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel (2,22,51) such that the volume of the channel (2,22,51) changes when the volume of the hydrogel material (1,21,51) changes. The transducer device (100,200,300,400) further comprises a sensor (11,12,25,35), which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel (2,22,51). By applying the transducer device (100,200,300,400) according to the invention within a bodily lumen, an accurate monitoring of physiological parameters, for which the hydrogel material (1,21,51) is sensitive, within the bodily lumen is possible. It is also possible to apply the transducer device (100,200,300,400) outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.
摘要翻译：本发明涉及用于检测环境状态或环境状态变化的换能器装置（100,200,300,400），特别是用于检测生物材料内的环境状态。所述换能器装置（100,200,300,400）包括包含流体的通道（2,22,51），水凝胶材料（1,21,51），其适于在与环境材料接触时改变其体积，和/或检测环境变化，并且其机械耦合到通道（2,22,51），使得当水凝胶材料（1,21,51）的体积变化时，通道（2,22,51）的体积改变。换能器装置（100,200,300,400）还包括传感器（11,12,25,35），其适于在检测到由通道的体积变化引起的流体的物理特性的变化时产生信号（ 2,22,51）。通过将根据本发明的换能器装置（100,200,300,400）应用于体腔内，可以精确地监测身体内水凝胶材料（1,21,51）敏感的生理参数。也可以将换能器装置（100,200,300,400）应用于体腔外，例如监测患者体外的血液。

10. 发明申请

WO2008099356A2 DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2008099356A2
公开(公告)日：2008-08-21
申请号：PCT/IB2008/050526
申请日：2008-02-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KRIJNSEN, Hendrika, C. , JANNER, Anna-maria , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B.
发明人： KRIJNSEN, Hendrika, C. , JANNER, Anna-maria , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B.
IPC分类号： A61M5/142
CPC分类号： A61M5/142 , A61M5/1723 , A61M2005/14208
摘要： The invention relates to a method and a device(10) for supplying a substance (e.g. a drug) to a physiological system(1) (e.g. a patient) during a predetermined time period (e.g. 24 hours). The amounts(u) of substance that have to be administered are determined in such a way that the predicted concentration of the substance, which is predicted with a pharmacokinetic model, matches a target concentration(c tar ) within the predetermined time period according to some optimization criterion. The optimization may particularly minimize the overall difference between target and predicted concentration during the time period. In a preferred embodiment, parameters of the pharmacokinetic model are individually adjusted to the associated patient.
摘要翻译：本发明涉及在预定时间段（例如24小时）内向物理系统（1）（例如患者）提供物质（例如药物）的方法和装置（10）。确定必须给药的物质的量（u），使得以药物动力学模型预测的物质的预测浓度与预定时间段内的目标浓度（c tar）相符合优化标准。优化可以特别地在时间段内最小化目标和预测浓度之间的总体差异。在优选的实施方案中，药代动力学模型的参数被单独调整到相关患者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式