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    • 1. 发明申请
    • AUTOMATIC DRUG ADMINISTRATION WITH REDUCED POWER CONSUMPTION
    • 具有降低功耗的自动药物管理
    • WO2008117214A1
    • 2008-10-02
    • PCT/IB2008/051065
    • 2008-03-20
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.KRIJNSEN, Hendrika, C.IORDANOV, Ventzeslav, P.JANNER, Anna, M.VAN BRUGGEN, Michel, P., B.
    • KRIJNSEN, Hendrika, C.IORDANOV, Ventzeslav, P.JANNER, Anna, M.VAN BRUGGEN, Michel, P., B.
    • A61M5/172A61M5/142
    • A61M5/1723A61M5/142A61M2205/8212A61M2230/63G06F19/00
    • It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) may be realized as a closed- loop system for monitoring and treatment of various diseases such as hemophilia A and Parkinson.
    • 描述了适于在与患者的状态相关的轮廓中注入至少一种药物的药物递送系统(100)。 该系统包括传感器(110),专用电子设备(140)和用于监视患者活动并维持对药物释放特征的控制的软件。 系统(100)的控制单元(120)适于将系统(100)的至少一个组件(110,120,150)临时设置为空闲模式(265)。 这将特别导致系统(100)所需的功率的降低。 所描述的系统(100)能够通过监测患者的个体活动状态来对患者进行个性化治疗,并将该信息与适当的递送概况相关联地传递给药物递送。 系统(100)可以设置有存储器,以便存储活动数据的时间依赖性。 这种时间依赖可以由医生使用来监测,支持和适应患者的治疗。 系统(100)可以实现为用于监测和治疗诸如血友病A和帕金森病等各种疾病的闭环系统。
    • 3. 发明申请
    • A DRUG DELIVERY SYSTEM WITH THERMOSWITCHABLE MEMBRANES
    • 具有热稳定膜的药物递送系统
    • WO2008012725A3
    • 2008-04-03
    • PCT/IB2007052809
    • 2007-07-13
    • KONINKL PHILIPS ELECTRONICS NVVAN BRUGGEN MICHEL P BKRIJNSEN HENDRIKA CIORDANOV VENTZESLAV PJANNER ANNA-MARIA
    • VAN BRUGGEN MICHEL P BKRIJNSEN HENDRIKA CIORDANOV VENTZESLAV PJANNER ANNA-MARIA
    • A61K9/00A61M31/00A61M35/00
    • A61M37/00A61M2037/0007
    • The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion. The present invention also provides a method for modulating the release of molecules, using such a device.
    • 本发明提供了用于分子控制释放的装置。 该装置特别适用于向患者控制释放治疗药物。 该装置包括具有用于从壳体释放分子的开口的壳体。 壳体还包括用于容纳分子的储库,特别是治疗药物。 储存器布置在壳体中以允许分子通过开口释放。 该装置还包括至少一个可热转换膜和至少一个用于至少部分地加热膜的加热元件。 该装置被配置为使用加热元件通过加热膜来调节开口处分子的释放。 可选地,所述装置还包括用于从所述装置提供所述分子的加压释放的压力元件。 以这种方式,药物可以以脉动方式递送给患者。 本发明还提供了使用这种装置调节分子释放的方法。
    • 9. 发明申请
    • HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE
    • 用于检测环境状态的基于HYDROGEL的设备
    • WO2008122926A1
    • 2008-10-16
    • PCT/IB2008/051224
    • 2008-04-02
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.IORDANOV, Ventzeslav, P.KRIJNSEN, Hendrika, C.VAN BRUGGEN, Michel, P., B.JANNER, Anna-MariaKURT, Ralph
    • IORDANOV, Ventzeslav, P.KRIJNSEN, Hendrika, C.VAN BRUGGEN, Michel, P., B.JANNER, Anna-MariaKURT, Ralph
    • A61B5/00
    • A61B5/1459A61B5/0008A61B5/0031A61B5/4839
    • The invention relates to a transducer device (100,200,300,400) for detecting an environmental state or a change in the environmental state, in particular for detecting an environmental state within a biological material. The transducer device (100,200,300,400) comprises a channel (2,22,51) comprising a fluid, a hydrogel material (1,21,51), which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel (2,22,51) such that the volume of the channel (2,22,51) changes when the volume of the hydrogel material (1,21,51) changes. The transducer device (100,200,300,400) further comprises a sensor (11,12,25,35), which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel (2,22,51). By applying the transducer device (100,200,300,400) according to the invention within a bodily lumen, an accurate monitoring of physiological parameters, for which the hydrogel material (1,21,51) is sensitive, within the bodily lumen is possible. It is also possible to apply the transducer device (100,200,300,400) outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.
    • 本发明涉及用于检测环境状态或环境状态变化的换能器装置(100,200,300,400),特别是用于检测生物材料内的环境状态。 所述换能器装置(100,200,300,400)包括包含流体的通道(2,22,51),水凝胶材料(1,21,51),其适于在与环境材料接触时改变其体积,和/或 检测环境变化,并且其机械耦合到通道(2,22,51),使得当水凝胶材料(1,21,51)的体积变化时,通道(2,22,51)的体积改变 。 换能器装置(100,200,300,400)还包括传感器(11,12,25,35),其适于在检测到由通道的体积变化引起的流体的物理特性的变化时产生信号( 2,22,51)。 通过将根据本发明的换能器装置(100,200,300,400)应用于体腔内,可以精确地监测身体内水凝胶材料(1,21,51)敏感的生理参数。 也可以将换能器装置(100,200,300,400)应用于体腔外,例如监测患者体外的血液。