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1. 发明申请

WO2006079965A3 SYSTEM AND METHOD FOR THE GUIDANCE OF A CATHETER IN ELECTROPHYSIOLOGIC INTERVENTIONS 审中-公开
标题翻译：用于指导电生理干预中导管的系统和方法
公开(公告)号：WO2006079965A3
公开(公告)日：2006-10-12
申请号：PCT/IB2006050239
申请日：2006-01-23
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , WEESE JUERGEN , MOLLUS SABINE , ECK KAI , BREDNO JOERG
发明人： WEESE JUERGEN , MOLLUS SABINE , ECK KAI , BREDNO JOERG
IPC分类号： A61B6/12 , A61B5/044 , A61B5/05
CPC分类号： A61B5/042 , A61B6/12 , A61B6/4441 , A61B6/487 , A61B6/503 , A61B6/5288
摘要： The invention relates to a system and a method for the guidance of a catheter (20) with an electrode (21) in an electrophysiological procedure. A sequence of images (I1, ... Ik, ...) of the catheter (20) and of a resting reference catheter (30) is generated with an X-ray device (10) and stored together with the associated electrographic recordings from the electrodes (21, 31). A reference image (Ik) may then be selected from said sequence that corresponds to a desired electrographic pattern (Ek). In a next step, the positions (T, R) of the catheters (20, 30) are localized on the reference image (Ik), wherein the position (R) of the reference catheter (30) can be identified with the position of this catheter (30) on an actual image (I). Thus it is possible to determine on the actual image also a target position (T') for the catheter (20) that corresponds to the position (T) of this catheter (20) on the reference image (Ik). Said target position (T) may finally be indicated on a monitor (60) to assist the guidance of the catheter (20) to a desired location.
摘要翻译：本发明涉及用于在电生理学过程中引导具有电极（21）的导管（20）的系统和方法。利用X射线装置（10）产生导管（20）和静止参考导管（30）的一系列图像（I 1，...，I k，...），并将其与相关联的电子照相记录来自电极（21,31）。然后可以从对应于期望的电子照相图案（Ek）的所述序列中选择参考图像（Ik）。在下一个步骤中，导管（20,30）的位置（T，R）位于参考图像（Ik）上，其中参考导管（30）的位置（R）可以用该导管（30）位于实际图像（I）上。因此，有可能在实际图像上还确定与参考图像（Ik）上的该导管（20）的位置（T）对应的导管（20）的目标位置（T'）。所述目标位置（T）最终可以在监视器（60）上指示以辅助将导管（20）引导至期望的位置。

2. 发明申请

WO2005101277A2 DATA SET VISUALIZATION 审中-公开
标题翻译：数据集可视化
公开(公告)号：WO2005101277A2
公开(公告)日：2005-10-27
申请号：PCT/IB2005051186
申请日：2005-04-11
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , GROTH ALEXANDRA , KIEFER GUNDOLF , LEHMANN HELKO , BREDNO JOERG , WEESE JUERGEN
发明人： ECK KAI , GROTH ALEXANDRA , KIEFER GUNDOLF , LEHMANN HELKO , BREDNO JOERG , WEESE JUERGEN
IPC分类号： A61B5/055 , A61B6/00 , A61B6/03 , A61B8/08 , A61B10/00 , A61B10/02 , A61B19/00 , G06F19/00
CPC分类号： G06F19/321 , A61B5/055 , A61B6/03 , A61B6/541 , A61B8/0833 , A61B8/0841 , A61B8/463 , A61B8/466 , A61B10/0233 , A61B90/36 , G16H50/50
摘要： In real-time three-dimensional imaging the choice of the visualization method and orientation is crucial for intervention success. The key question is what to ignore and what to show in real-time applications, where user control is not appropriate. The invention addresses this problem by visualizing an intervention (caused by a user) to an object of interest without the requirement of an interactive input by the user. Advantageously, according to an exemplary embodiment of the present invention, parameters for a visualization procedure are automatically chosen during data acquisition which may allow for an efficient tracking of the actual orientation and relative position of the structure with respect to the object of interest.
摘要翻译：在实时三维成像中，可视化方法和方向的选择对于干预成功至关重要。关键的问题是什么要忽略，什么显示在实时应用程序，用户控制不合适。本发明通过将干预（由用户引起）视觉化为感兴趣的对象而不需要用户的交互式输入来解决该问题。有利地，根据本发明的示例性实施例，在数据获取期间自动选择用于可视化过程的参数，这可以有效地跟踪结构相对于感兴趣对象的实际取向和相对位置。

3. 发明申请

WO2005101277A8 DATA SET VISUALIZATION 审中-公开
标题翻译：数据集可视化
公开(公告)号：WO2005101277A8
公开(公告)日：2006-10-05
申请号：PCT/IB2005051186
申请日：2005-04-11
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , GROTH ALEXANDRA , KIEFER GUNDOLF , LEHMANN HELKO , BREDNO JOERG , WEESE JUERGEN
发明人： ECK KAI , GROTH ALEXANDRA , KIEFER GUNDOLF , LEHMANN HELKO , BREDNO JOERG , WEESE JUERGEN
IPC分类号： A61B5/055 , A61B6/00 , A61B6/03 , A61B8/08 , A61B10/00 , A61B10/02 , A61B19/00 , G06F19/00
CPC分类号： G06F19/321 , A61B5/055 , A61B6/03 , A61B6/541 , A61B8/0833 , A61B8/0841 , A61B8/463 , A61B8/466 , A61B10/0233 , A61B90/36 , G16H50/50
摘要： In real-time three-dimensional imaging the choice of the visualization method and orientation is crucial for intervention success. The key question is what to ignore and what to show in real-time applications, where user control is not appropriate. The invention addresses this problem by visualizing an intervention (caused by a user) to an object of interest without the requirement of an interactive input by the user. Advantageously, according to an exemplary embodiment of the present invention, parameters for a visualization procedure are automatically chosen during data acquisition which may allow for an efficient tracking of the actual orientation and relative position of the structure with respect to the object of interest.
摘要翻译：在实时三维成像中，可视化方法和方向的选择对于干预成功至关重要。关键的问题是什么要忽略，什么显示在实时应用程序，用户控制不合适。本发明通过将干预（由用户引起）视觉化为感兴趣的对象而不需要用户的交互式输入来解决该问题。有利地，根据本发明的示例性实施例，在数据获取期间自动选择用于可视化过程的参数，这可以有效地跟踪结构相对于感兴趣对象的实际取向和相对位置。

4. 发明申请

WO2005024729A8 DEVICE AND METHOD FOR DISPLAYING ULTRASOUND IMAGES OF A VESSEL 审中-公开
标题翻译：用于显示船舶超声波图像的装置和方法
公开(公告)号：WO2005024729A8
公开(公告)日：2006-06-01
申请号：PCT/IB2004051525
申请日：2004-08-23
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , MARTIN-LEUNG BARBARA , BREDNO JOERG , WEESE JUERGEN
发明人： ECK KAI , MARTIN-LEUNG BARBARA , BREDNO JOERG , WEESE JUERGEN
IPC分类号： A61B6/12 , A61B8/12
CPC分类号： A61B8/4416 , A61B6/12 , A61B6/5247 , A61B8/12
摘要： The invention relates to a device and a method for displaying a vessel (2) with the aid of intravascular ultrasound images (I). A sequence of intravascular ultrasound images (I(E,x)) is generated by means of a probe (5) and stored in a memory (10) in a manner indexed by the associated location (x) where they were generated and also the associated heartbeat phase (E) and/or breathing phase. During a subsequent medical intervention, those ultrasound images (I 1 , I 2 , I 3 ) which best correspond to the heartbeat phase of a current fluoroscopic image (A t ) or belong to the current stopping location of a catheter (13) can be selected from the memory (10) and displayed on a monitor (12).
摘要翻译：本发明涉及借助于血管内超声图像（I）显示血管（2）的装置和方法。通过探针（5）产生血管内超声图像序列（I（E，x）），并以由它们产生的相关位置（x）索引的方式存储在存储器（10）中，并且还相关的心跳期（E）和/或呼吸阶段。在随后的医疗干预期间，最好对应于电流的心跳相位的那些超声图像（I 1，I 2，I 3 3）可以从存储器（10）中选择属于导管（13）的当前停止位置的荧光透视图像（A SUB），并显示在监视器（12）上。

5. 发明申请

WO03083777A2 METHOD OF DETERMINING AN IMAGE FROM AN IMAGE SEQUENCE 审中-公开
标题翻译：从图像序列确定图像的方法
公开(公告)号：WO03083777A2
公开(公告)日：2003-10-09
申请号：PCT/IB0301183
申请日：2003-04-01
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , MOLLUS SABINE , STUKE INGO , ECK KAI , AACH TIL
发明人： MOLLUS SABINE , STUKE INGO , ECK KAI , AACH TIL
IPC分类号： A61B6/00 , A61B8/08 , G06T7/00 , G06T7/20
CPC分类号： A61B6/541 , G06T7/38 , G06T2207/30048
摘要： The invention relates to a method of determining a corresponding image of a moving object for a reference image from an image sequence which represents the motion as a sequence of states of motion. To this end, two motion signals, representing the development of the relevant motions, are examined for similarities. Using the similarity function thus obtained, that image in the image sequence can be determined which represents at least approximately the state of motion of the object which is represented in the reference image. Furthermore, the invention relates to a system which is suitable for carrying out the method as well as to a computer program and a computer program product enabling a data processing unit to carry out the method.
摘要翻译：本发明涉及一种从表示运动的图像序列确定参考图像的移动物体的相应图像的方法，该图像序列是运动状态序列。为此，审查了相关动议的两个运动信号，以表达相似的动议。使用如此获得的相似度函数，可以确定图像序列中的至少近似表示在参考图像中的对象的运动状态的图像。此外，本发明涉及一种适合于执行该方法的系统，以及一种能使数据处理单元执行该方法的计算机程序和计算机程序产品。

6. 发明申请

WO2004034329A3 ASSOCIATING STORED IMAGES WITH CURRENT IMAGES 审中-公开
标题翻译：与当前图像相关的存储图像
公开(公告)号：WO2004034329A3
公开(公告)日：2004-12-02
申请号：PCT/IB0304339
申请日：2003-10-02
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , GIJSBERS GEERT , MOLLUS SABINE
发明人： ECK KAI , GIJSBERS GEERT , MOLLUS SABINE
IPC分类号： A61B6/00 , A61B6/12 , G06T7/20
CPC分类号： A61B6/481 , A61B5/7289 , A61B6/12 , A61B6/504 , A61B6/541 , G06T7/0016 , G06T7/246
摘要： The invention relates to the association of a current (X-ray image) image of a body volume with one of several stored previous images, the ECG and the respiratory cycle being determined each time together with the images. Using this data, that one of the previous images is chosen which is closest to the current image in respect of cardiac rhythm and respiratory cycle. The resultant association yields a very high accuracy enabling superposed reproduction of the current image and the associated previous image.
摘要翻译：本发明涉及身体体积的当前（X射线图像）图像与几个存储的先前图像之一的关联，ECG和呼吸周期每次与图像一起确定。使用该数据，选择与心律和呼吸周期相关的当前图像最接近的先前图像之一。所得到的关联产生非常高的精度，使得能够叠加当前图像和相关联的先前图像的再现。

7. 发明申请

WO2005111932A8 INFORMATION ENHANCED IMAGE GUIDED INTERVENTIONS 审中-公开
标题翻译：信息增强图像指导干预
公开(公告)号：WO2005111932A8
公开(公告)日：2006-12-14
申请号：PCT/IB2005051497
申请日：2005-05-09
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , BREDNO JOERG
发明人： ECK KAI , BREDNO JOERG
IPC分类号： G06T5/00 , A61B5/055 , A61B6/00 , A61B6/03 , A61B8/08 , G06T7/00
CPC分类号： A61B6/504 , A61B6/032 , A61B6/4085 , A61B6/5247 , A61B6/541 , A61B8/0833 , A61B8/0841 , A61B8/5238 , G06T7/38 , G06T2207/30004
摘要： Linking of interventional and real time ultrasonic information with nonereal time anatomical information of, for example, a vessel or a tumor vascularization provided by x-ray rotational angiography requires high computational performance. According to an aspect of the present invention, an ultrasonic reference image is calibrated with respect to a high quality image acquired by a different imaging system. Then, during operational intervention, a registration or calibration of a data set acquired during the intervention is performed with respect to the reference image and not (as in state of the art devices) to the high quality image. Advantageously, this may allow for a fast fusion of the high quality image with the real time images and therefore allow for an improved tracking of operational interventions performed on a patient.
摘要翻译：介入和实时超声信息与例如由X射线旋转血管造影提供的血管或肿瘤血管形成的非时间解剖信息的连接需要高计算性能。根据本发明的一个方面，相对于由不同成像系统获取的高质量图像校准超声参考图像。然后，在操作干预期间，相对于参考图像执行在干预期间获取的数据集的注册或校准，而不是（如现有技术装置的状态）到高质量图像。有利地，这可以允许高质量图像与实时图像的快速融合，并且因此允许对患者进行的操作干预的改进跟踪。

8. 发明申请

WO2005020147A8 DEVICE AND METHOD FOR COMBINING TWO IMAGES 审中-公开
标题翻译：用于组合两个图像的装置和方法
公开(公告)号：WO2005020147A8
公开(公告)日：2006-06-01
申请号：PCT/IB2004051446
申请日：2004-08-11
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , BREDNO JOERG , DESMEDT PAUL ANTON CYRIEL , RONGEN PETER MARIA JOHANNES , STEGEHUIS HERMAN , GIJSBERS GEERT
发明人： ECK KAI , BREDNO JOERG , DESMEDT PAUL ANTON CYRIEL , RONGEN PETER MARIA JOHANNES , STEGEHUIS HERMAN , GIJSBERS GEERT
IPC分类号： A61B6/00 , A61B6/12 , G06T3/00 , G06T7/00
CPC分类号： G06T3/4053 , A61B5/7289 , A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5235 , A61B6/5247 , G06T7/30 , G06T2207/10116 , G06T2207/30101
摘要： The invention relates to a device and to a method for combining two images, especially for superimposition of static vascular maps (B), which were taken at different phases of the cardiac cycle and/or the respiratory cycle and were archived in a memory (6), on a current image (A) of a catheter (2, 8) in the vascular system (9). In the method, a defined section of a map image (B) around the estimated actual position of the catheter is selected and is displayed superimposed on the current image (A) in an image (C) on a monitor (10). The map image (B) used for this is preferably selected by means of an electrocardiogram to match the particular cardiac cycle. The position of the catheter relative to the map image (B) can be estimated using a distance image (D).
摘要翻译：本发明涉及一种用于组合两个图像的装置和方法，特别是用于叠加在心脏周期和/或呼吸周期的不同阶段拍摄的静态血管图（B），并将其存档在存储器中），在血管系统（9）中的导管（2,8）的当前图像（A）上。在该方法中，选择围绕估计的导管的实际位置的地图图像（B）的限定部分，并且叠加在监视器（10）上的图像（C）中的当前图像（A）上。用于此的地图图像（B）优选地通过心电图来选择以匹配特定的心动周期。可以使用距离图像（D）来估计导管相对于地图图像（B）的位置。

9. 发明申请

WO2005111932A2 INFORMATION ENHANCED IMAGE GUIDED INTERVENTIONS 审中-公开
标题翻译：信息增强图像指导干预
公开(公告)号：WO2005111932A2
公开(公告)日：2005-11-24
申请号：PCT/IB2005051497
申请日：2005-05-09
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , ECK KAI , BREDNO JOERG
发明人： ECK KAI , BREDNO JOERG
IPC分类号： A61B5/055 , A61B6/00 , A61B6/03 , A61B8/08 , G06T5/00 , G06T7/00
CPC分类号： A61B6/504 , A61B6/032 , A61B6/4085 , A61B6/5247 , A61B6/541 , A61B8/0833 , A61B8/0841 , A61B8/5238 , G06T7/38 , G06T2207/30004
摘要： Linking of interventional and real time ultrasonic information with nonereal time anatomical information of, for example, a vessel or a tumor vascularization provided by x-ray rotational angiography requires high computational performance. According to an aspect of the present invention, an ultrasonic reference image is calibrated with respect to a high quality image acquired by a different imaging system. Then, during operational intervention, a registration or calibration of a data set acquired during the intervention is performed with respect to the reference image and not (as in state of the art devices) to the high quality image. Advantageously, this may allow for a fast fusion of the high quality image with the real time images and therefore allow for an improved tracking of operational interventions performed on a patient.
摘要翻译：介入和实时超声信息与例如由X射线旋转血管造影提供的血管或肿瘤血管形成的非时间解剖信息的连接需要高计算性能。根据本发明的一个方面，相对于由不同成像系统获取的高质量图像校准超声参考图像。然后，在操作干预期间，相对于参考图像执行在干预期间获取的数据集的注册或校准，而不是（如现有技术装置的状态）到高质量图像。有利地，这可以允许高质量图像与实时图像的快速融合，并且因此允许对患者进行的操作干预的改进跟踪。

10. 发明申请

WO2008001258A2 MODEL-BASED DETERMINATION OF THE CONTRACTION STATUS OF A PERIODICALLY CONTRACTING OBJECT 审中-公开
标题翻译：基于模型的周期性约束对象收缩状态的确定
公开(公告)号：WO2008001258A2
公开(公告)日：2008-01-03
申请号：PCT/IB2007052322
申请日：2007-06-18
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GROTH ALEXANDRA , ECK KAI
发明人： GROTH ALEXANDRA , ECK KAI
IPC分类号： G06T7/60 , A61B6/12 , G06T7/00
CPC分类号： G06T7/0012 , A61B5/042 , A61B5/7289 , A61B6/12 , A61B6/503 , A61B6/5217 , G06T7/62 , G06T2207/30048
摘要： It is described a model-based estimation of the current contraction status (S) of a periodically contracting object such as a beating heart. Thereby, a characteristic feature that is directly related to the contraction status (S) is extracted from a current image (340) and subsequently compared to a model that gives the contraction status (S) of the heart in dependence on the characteristic feature. Thereby, an appropriate patient- individual model may be obtained e.g. from an ECG gated pre-interventional data set. A potential characteristic feature is the distance between two arbitrary reference catheters (341a, 341b, 342a, 342b) that are usually in a fix known standard position during a whole electrophysiological intervention. The knowledge about the current contraction status may be used to combine the current image with other images depicting the object in the same contraction status. Thereby, image elements, which depend on the contraction status and which are not viewable in the current image, may be made visible by overlaying different images depicting the object in one and the same contraction status.
摘要翻译：它描述了对周期性收缩对象（例如跳动心脏）的当前收缩状态（S）的基于模型的估计。由此，从当前图像（340）中提取与收缩状态（S）直接相关的特征特征，并随后将其与根据特征特征给出心脏的收缩状态（S）的模型进行比较。由此，可以获得适当的患者个体模型，例如，来自心电门控的预干预数据集。潜在的特征是两个任意参考导管（341a，341b，342a，342b）之间的距离，这两个参考导管在整个电生理干预期间通常处于固定的已知标准位置。关于当前收缩状态的知识可用于将当前图像与描绘处于相同收缩状态的对象的其他图像组合。由此，可以通过将描绘对象的不同图像叠加在同一收缩状态中而使得取决于收缩状态并且在当前图像中不可见的图像元素变得可见。

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