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1. 发明申请

WO2007113724A3 MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
标题翻译：磁传感器作为温度传感器
公开(公告)号：WO2007113724A3
公开(公告)日：2008-02-21
申请号：PCT/IB2007051030
申请日：2007-03-23
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN H , JANSEN THEODORUS P H G , VEEN JEROEN , KAHLMAN JOSEPHUS A H M , IMMINK ALBERT H J
发明人： NIEUWENHUIS JEROEN H , JANSEN THEODORUS P H G , VEEN JEROEN , KAHLMAN JOSEPHUS A H M , IMMINK ALBERT H J
IPC分类号： G01N15/06 , G01N33/543 , G01N35/00 , G01R33/09 , G01R33/12
CPC分类号： G01R33/09 , B82Y25/00 , G01R33/007 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (I adj ) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (I sense ) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f 1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (I adj ) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f 1 ) is different from the first frequency (f 1 }). The invention also relates to a corresponding method.
摘要翻译：描述了用于定性或定量检测调制磁场的磁场特性的检测系统（100,150）。调制磁场可以例如。来自相邻的电流（I SUB）或磁性颗粒。检测系统（100,150）包括至少一个磁阻传感器元件（102），电流控制器（104），用于提供流经磁传感器元件（102）的感测电流（I ）和控制装置（108）。控制装置（108）适于以至少一个磁阻传感器的温度相关参数的第一频率f 1导出。此外，控制装置（108）还适于导出相邻电流（I SUB）或磁性颗粒的定性或定量特性，同时考虑导出的温度相关参数。该第二频率（f 1> 1）不同于第一频率（f 1 N 1）。本发明还涉及相应的方法。

2. 发明申请

WO2009027935A3 BIOCHEMICAL SENSOR CARTRIDGE 审中-公开
标题翻译：生化传感器盒
公开(公告)号：WO2009027935A3
公开(公告)日：2009-06-25
申请号：PCT/IB2008053453
申请日：2008-08-27
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN H , PELSSERS EDUARD G M , REIJNDORP JOCHEM , IMMINK ALBERT H J , MATTERS MARCO , MEUFFELS MARIA E H G
发明人： NIEUWENHUIS JEROEN H , PELSSERS EDUARD G M , REIJNDORP JOCHEM , IMMINK ALBERT H J , MATTERS MARCO , MEUFFELS MARIA E H G
IPC分类号： A61B10/00 , B01L3/00
CPC分类号： A61B10/0051 , A61B2010/0003 , B01L3/5023 , B01L3/5029 , B01L2300/022 , B01L2300/023 , B01L2300/0627
摘要： The invention relates to a (bio-)chemical sensor cartridge (100) for the examination of samples like blood or saliva, which comprises a sample collection element (e.g. a swab (120)), a sensor element (130) for sensing a parameter of interest, a sample transportation mechanism (110) for transferring the sample from the sample collection element (120) to the sensor element (130), and a connector (140) for linking the device to an external reader. The sample transportation mechanism (110) may particularly comprise a reservoir (111) with a buffer liquid that can be transferred via the sample collection element (120) to the sensor element (130). Moreover, the cartridge preferably consists of two parts (101, 102) that can reversibly be connected.
摘要翻译：本发明涉及用于检查诸如血液或唾液的样品的（生物）化学传感器盒（100），其包括样品收集元件（例如拭子（120）），用于感测参数的传感器元件（130）感兴趣的样品传送机构（110），用于将样品从样品收集元件（120）传送到传感器元件（130）;以及连接器（140），用于将该装置连接到外部读取器。样品输送机构（110）可以特别地包括具有可以经由样品收集元件（120）传递到传感器元件（130）的缓冲液的储存器（111）。此外，该盒优选地由可逆地连接的两个部分（101,102）组成。

3. 发明申请

WO2009013658A2 MICROFLUIDIC METHODS AND SYSTEMS FOR USE IN DETECTING ANALYTES 审中-公开
标题翻译：用于检测分析的微流体方法和系统
公开(公告)号：WO2009013658A2
公开(公告)日：2009-01-29
申请号：PCT/IB2008052803
申请日：2008-07-11
申请人： KONINKL PHILIPS ELECTRONICS NV , VERHOECKX GODEFRIDUS J , VAN DAMME HENDRIK S , NIEUWENHUIS JEROEN H , SHULEPOV SERGEI , WEEKAMP JOHANNES W , SIJBERS MARA J J , BRANS HAROLD J A , DE THEIJE FEMKE K , IMMINK ALBERT H J
发明人： VERHOECKX GODEFRIDUS J , VAN DAMME HENDRIK S , NIEUWENHUIS JEROEN H , SHULEPOV SERGEI , WEEKAMP JOHANNES W , SIJBERS MARA J J , BRANS HAROLD J A , DE THEIJE FEMKE K , IMMINK ALBERT H J
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/161 , B01L2400/0406 , B01L2400/0487 , Y10T29/49826
摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.
摘要翻译：描述了用于检测流体样本（106）中的分析物的微流体反应器装置（100）。反应器装置设有试剂提供装置，使得试剂可在组装反应器装置后引入。后者可以通过将溶液或分散体形式的试剂引入并通过除去液体（即通过干燥）将其固定在保持装置（118）上来进行，即通过干燥将包含试剂的保持装置固定在检测器室。在引入试剂之前，已经存在的反应器装置的组件（例如样品入口）可以通过润湿亲水技术亲水化。本发明涉及制造技术以及所得产品。本发明还涉及用于特定应用的具有特定试剂的反应器装置的官能化。后者可以在主反应器布置部件的制造和组装之后良好地执行。

4. 发明申请

WO2009013668A3 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：WO2009013668A3
公开(公告)日：2010-07-15
申请号：PCT/IB2008052844
申请日：2008-07-16
申请人： KONINKL PHILIPS ELECTRONICS NV , IMMINK ALBERT H J , DE THEIJE FEMKE K , PRINS MENNO W J , DITTMER WENDY U , NIEUWENHUIS JEROEN H
发明人： IMMINK ALBERT H J , DE THEIJE FEMKE K , PRINS MENNO W J , DITTMER WENDY U , NIEUWENHUIS JEROEN H
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

5. 发明申请

WO2009027935A2 BIOCHEMICAL SENSOR CARTRIDGE 审中-公开
公开(公告)号：WO2009027935A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008053453
申请日：2008-08-27
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN H , PELSSERS EDUARD G M , REIJNDORP JOCHEM , IMMINK ALBERT H J , MATTERS MARCO , MEUFFELS MARIA E H G
发明人： NIEUWENHUIS JEROEN H , PELSSERS EDUARD G M , REIJNDORP JOCHEM , IMMINK ALBERT H J , MATTERS MARCO , MEUFFELS MARIA E H G
IPC分类号： A61B10/00 , B01L3/00
CPC分类号： A61B10/0051 , A61B2010/0003 , B01L3/5023 , B01L3/5029 , B01L2300/022 , B01L2300/023 , B01L2300/0627
摘要： The invention relates to a (bio-)chemical sensor cartridge (100) for the examination of samples like blood or saliva, which comprises a sample collection element (e.g. a swab (120)), a sensor element (130) for sensing a parameter of interest, a sample transportation mechanism (110) for transferring the sample from the sample collection element (120) to the sensor element (130), and a connector (140) for linking the device to an external reader. The sample transportation mechanism (110) may particularly comprise a reservoir (111) with a buffer liquid that can be transferred via the sample collection element (120) to the sensor element (130). Moreover, the cartridge preferably consists of two parts (101, 102) that can reversibly be connected.

6. 发明申请

WO2009027935A8 BIOCHEMICAL SENSOR CARTRIDGE 审中-公开
公开(公告)号：WO2009027935A8
公开(公告)日：2009-12-30
申请号：PCT/IB2008053453
申请日：2008-08-27
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN H , PELSSERS EDUARD G M , REIJNDORP JOCHEM , IMMINK ALBERT H J , MATTERS MARCO , MEUFFELS MARIA E H G
发明人： NIEUWENHUIS JEROEN H , PELSSERS EDUARD G M , REIJNDORP JOCHEM , IMMINK ALBERT H J , MATTERS MARCO , MEUFFELS MARIA E H G
IPC分类号： A61B10/00 , B01L3/00
CPC分类号： A61B10/0051 , A61B2010/0003 , B01L3/5023 , B01L3/5029 , B01L2300/022 , B01L2300/023 , B01L2300/0627
摘要： The invention relates to a (bio-)chemical sensor cartridge (100) for the examination of samples like blood or saliva, which comprises a sample collection element (e.g. a swab (120)), a sensor element (130) for sensing a parameter of interest, a sample transportation mechanism (110) for transferring the sample from the sample collection element (120) to the sensor element (130), and a connector (140) for linking the device to an external reader. The sample transportation mechanism (110) may particularly comprise a reservoir (111) with a buffer liquid that can be transferred via the sample collection element (120) to the sensor element (130). Moreover, the cartridge preferably consists of two parts (101, 102) that can reversibly be connected.

7. 发明申请

WO2009001280A3 A METHOD FOR THE PRODUCTION OF A MICROELECTRONIC SENSOR DEVICE 审中-公开
标题翻译：一种用于生产微电子传感器装置的方法
公开(公告)号：WO2009001280A3
公开(公告)日：2009-04-09
申请号：PCT/IB2008052472
申请日：2008-06-23
申请人： KONINKL PHILIPS ELECTRONICS NV , WEEKAMP JOHANNES W , IMMINK ALBERT H J , NIEUWENHUIS JEROEN H
发明人： WEEKAMP JOHANNES W , IMMINK ALBERT H J , NIEUWENHUIS JEROEN H
IPC分类号： H01L21/68 , B01L3/00 , G01N27/26 , G01N33/48 , H01L21/56 , H01L21/60 , H01L23/13 , H01L23/29 , H01L23/31
CPC分类号： H01L21/6835 , B01L3/5027 , H01L21/568 , H01L24/45 , H01L24/48 , H01L24/82 , H01L24/85 , H01L2224/451 , H01L2224/48091 , H01L2224/85 , H01L2924/00014 , H01L2924/09701 , H01L2924/14 , H01L2924/15153 , H01L2924/15165 , H01L2924/00 , H01L2224/05599
摘要： The invention relates to a microelectronic sensor device and to a method for the production of such a device comprising the following steps: placing an IC chip (10) in an insertion hole (21) of an interconnect carrier (20), wherein a sensitive side (12) of the chip contacts a removable layer (30) that is attached to the bottom side (22) of the carrier (20); filling the insertion hole (21) with an underfill material (40) and removing the removable layer (30); electrically connecting (via wire bonding or any other method) bond-pads (11) on the chip (10); placing a structured element (50) with fluidic channels (51) on ridges (52) that are disposed on the bottom side of the interconnect carrier (20) and/or the chip (10); encapsulating the bondwires (14) in an insulating material (60).
摘要翻译：本发明涉及一种微电子传感器装置和一种用于制造这种装置的方法，包括以下步骤：将IC芯片（10）放置在互连载体（20）的插入孔（21）中，其中敏感侧所述芯片（12）与所述载体（20）的底侧（22）相连接的可拆卸层（30）。用底部填充材料（40）填充插入孔（21）并移除可移除层（30）; 在芯片（10）上电连接（通过引线接合或任何其它方法）接合焊盘（11）; 将具有流体通道（51）的结构化元件（50）放置在设置在互连托架（20）和/或芯片（10）的底侧上的脊（52）上; 将所述接合线（14）封装在绝缘材料（60）中。

8. 发明申请

WO2009087519A3 WETTING DETECTION AND REMOVAL 审中-公开
标题翻译：湿度检测和去除
公开(公告)号：WO2009087519A3
公开(公告)日：2009-11-26
申请号：PCT/IB2008055405
申请日：2008-12-18
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN H
发明人： NIEUWENHUIS JEROEN H
IPC分类号： F25D21/02 , G01J5/58 , G01N21/35
CPC分类号： G01N21/15 , G01J5/02 , G01J5/026 , G01J5/60 , G01N21/3554 , G01N21/552 , G01N2021/158 , G01N2021/3595
摘要： An optical biosensor device for detecting the wetting of a sensor surface and/or means for removing wetting of an entrance and/or exit window of the light detection path comprising an infrared (IR) light source for emitting IR light having a first wavelength with a high absorption coefficient for a predetermined liquid.
摘要翻译：一种用于检测传感器表面的润湿的光学生物传感器装置和/或用于去除光检测路径的入口和/或出射窗口的润湿的装置，包括用于发射具有第一波长的IR光的红外（IR）光源，对于预定液体的高吸收系数。

9. 发明申请

WO2009125339A2 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 审中-公开
标题翻译：小样本容量光学检测的载体
公开(公告)号：WO2009125339A2
公开(公告)日：2009-10-15
申请号：PCT/IB2009051454
申请日：2009-04-07
申请人： KONINKL PHILIPS ELECTRONICS NV , SCHLEIPEN JOHANNES J H B , EVERS TOON H , NIEUWENHUIS JEROEN H , DITTMER WENDY U , BRULS DOMINIQUE M , PRINS MENNO W J , NEIJZEN JACOBUS H M , BOURQUIN YANNYK P J
发明人： SCHLEIPEN JOHANNES J H B , EVERS TOON H , NIEUWENHUIS JEROEN H , DITTMER WENDY U , BRULS DOMINIQUE M , PRINS MENNO W J , NEIJZEN JACOBUS H M , BOURQUIN YANNYK P J
IPC分类号： G01N21/25 , G01N21/41
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (Ll) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及用于在样本室（2）中的样本（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻样品室（2）中并且用于从源自样品室（2）的光中收集输出光束（L2）的光学结构（50）来自输入光束。优选地，光学结构（50）包括载体（11）的表面（12）中的凹槽，其中输入光束以短距离穿过样本传输。光学结构（50）也可以用于润湿检测。

10. 发明申请

WO2009040712A3 MICROELECTRONIC SENSOR DEVICE WITH AN ARRAY OF DETECTION CELLS 审中-公开
标题翻译：具有检测电极阵列的微电子传感器装置
公开(公告)号：WO2009040712A3
公开(公告)日：2010-06-17
申请号：PCT/IB2008053813
申请日：2008-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN LANKVELT PETRUS J W , NIEUWENHUIS JEROEN H , VAN ZON HANS
发明人： VAN LANKVELT PETRUS J W , NIEUWENHUIS JEROEN H , VAN ZON HANS
IPC分类号： G01N15/06 , G01N15/10 , G01N33/543 , G01R33/12
CPC分类号： G01N27/745 , G01N15/0656 , G01N33/54326 , G01N33/54333 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a microelectronic sensor device with a matrix array of rows (R4, R5) and columns (Cl, C2) of detection cells (10), wherein each detection cell comprises an activation element (30) for transferring target particles (e.g. magnetic beads) into an activated state and a sensor element (20) for detecting activated target particles. According to a preferred embodiment, the activation elements (20) of each row of the matrix as well as the sensor elements (20) of each column of the matrix are connected in series. By activating one row and reading out one column, each detection cell (10) can thus individually be addressed with a limited number of column- and row-address circuits.
摘要翻译：本发明涉及具有检测单元（10）的行（R4，R5）和列（C1，C2）的矩阵阵列的微电子传感器装置，其中每个检测单元包括用于转移目标颗粒的活化元件（例如，磁珠）转换为激活状态，以及用于检测激活的靶颗粒的传感器元件（20）。根据优选实施例，矩阵的每行的激活元件（20）以及矩阵的每列的传感器元件（20）串联连接。通过激活一行并读出一列，每个检测单元（10）因此可以用有限数量的列和行地址电路单独寻址。

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