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1. 发明申请

WO2004055887A3 MANIPULATION OF MICROMETER-SIZED ELECTRONIC OBJECTS WITH LIQUID DROPLETS 审中-公开
标题翻译：用液滴法处理微电子电子对象
公开(公告)号：WO2004055887A3
公开(公告)日：2005-05-06
申请号：PCT/IB0305273
申请日：2003-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , DUINEVELD PAULUS C , PRINS MENNO W J , DECRE MICHEL M J
发明人： DUINEVELD PAULUS C , PRINS MENNO W J , DECRE MICHEL M J
IPC分类号： H01L21/68 , H01L21/98
CPC分类号： H01L25/50 , H01L21/6835 , H01L24/24 , H01L24/82 , H01L24/95 , H01L2224/24051 , H01L2224/24225 , H01L2224/24226 , H01L2224/24998 , H01L2224/76155 , H01L2224/82007 , H01L2224/82102 , H01L2224/95102 , H01L2224/95144 , H01L2224/95145 , H01L2224/95146 , H01L2924/01033 , H01L2924/01057 , H01L2924/01061 , H01L2924/10253 , H01L2924/12041 , H01L2924/00
摘要： A system for manipulating a small object (3) comprising a substrate to receive the small object (3), a liquid droplet (4), which carries the small object (3) on the substrate, and a pre-treated surface structure of the substrate in the vicinity (1,2) of the placement position (1) of the small object (3). The small objects (3) like silicon dies in the range from 100 down to 1 micrometer are fine-placed by an evaporating droplet (4). The dies will serve as active electronic elements in large-area displays and other applications.
摘要翻译：一种用于操纵小物体（3）的系统，其包括用于接纳小物体（3）的基板，在基板上承载小物体（3）的液滴（4），以及基板上的预处理表面结构基板在小物体（3）的放置位置（1）的附近（1,2）处。小型物体（3）像硅片一样在100到1微米的范围内被蒸发的微滴（4）精细放置。模具将作为大面积显示器和其他应用中的有源电子元件。

2. 发明申请

WO2006134546A3 ACCURATE MAGNETIC BIOSENSOR 审中-公开
标题翻译：精密生物传感器
公开(公告)号：WO2006134546A3
公开(公告)日：2007-03-08
申请号：PCT/IB2006051866
申请日：2006-06-12
申请人： KONINKL PHILIPS ELECTRONICS NV , PRINS MENNO W J , IMMINK ALBERT H J
发明人： PRINS MENNO W J , IMMINK ALBERT H J
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745 , G01N33/54366
摘要： The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.
摘要翻译：本发明提供了一种用于确定流体中含有至少一种可极化的极化磁性标签的流体中的至少一种靶的浓度的方法，装置和系统，所述感测表面包括至少一种结合所述感测装置还包括至少一个磁性传感器元件，所述感测装置还包括用于时间分辨的区分装置，所述区别装置用于特别附着于所述磁性标签的磁性标签结合位点与非特异性连接的标记。根据本发明的方法和装置可以应用于生物分子诊断。

3. 发明申请

WO2007129275A2 RAPID MAGNETIC BIOSENSOR 审中-公开
标题翻译：快速生物传感器
公开(公告)号：WO2007129275A2
公开(公告)日：2007-11-15
申请号：PCT/IB2007051698
申请日：2007-05-07
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER WIJK THEA , PRINS MENNO W J , SCHROEDERS RICHARD J M
发明人： VAN DER WIJK THEA , PRINS MENNO W J , SCHROEDERS RICHARD J M
IPC分类号： G01R33/12
CPC分类号： G01R33/02 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01R33/0213 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles are removed.
摘要翻译：本发明涉及方法和（生物）传感器系统。这里，施加磁场以便将磁性颗粒横向移动到具有分析物特异性探针的传感器表面上。本发明的方法允许将磁性颗粒特异性结合到传感器表面，同时除去特异性和未结合的颗粒。

4. 发明申请

WO2004087322A3 FLUID PARTITIONING IN MULTIPLE MICROCHANNELS 审中-公开
标题翻译：流体分散在多个微通道
公开(公告)号：WO2004087322A3
公开(公告)日：2004-11-25
申请号：PCT/IB2004050345
申请日：2004-03-26
申请人： KONINKL PHILIPS ELECTRONICS NV , PRINS MENNO W J
发明人： PRINS MENNO W J
IPC分类号： B01L3/00 , G01N1/18 , G01N30/16 , G01N30/60 , G01N35/08 , G01N35/10
CPC分类号： B01L3/502738 , B01L3/5025 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2300/0861 , B01L2400/0487 , B01L2400/0633 , G01N1/18 , G01N30/16 , G01N30/6095 , G01N2035/1032 , G01N30/466
摘要： A device (3) and method to generate independent fluid samples (51) for multichannel analysis, preferably in diagnostic cartridges, are disclosed according to the invention. A fluidic device (3), preferably a microfluidic device, has a plurality of fluid channels (35). Fluids are transported in the fluid channels. A cross-over channel (32) has a fluid inlet (33) and a fluid outlet (34). In use of said device (3), a method is performed. According to the method, the sample channels are filled with sample fluid up to a threshold (39). A flush fluid (gas or inert liquid) is then flushed through the sample-filled cross-over channel, replacing the sample fluid with flush fluid. Subsequently the cross-over channels' inlet and outlet are closed and the sample fluid is pushed further into the channel arrays (30, 31). Alternatively, an appropriate pressure is applied to the fluid in order to push the fluid into said sample channels. The method steps are repeated in an appropriate way if it is desired to obtain multiple (in time and/or space) independent sample plugs in the microchannels. Thus a series of longitudinally spaced independent sample fluid segments separated from each other by flush segments is created in each microchannel.
摘要翻译：根据本发明公开了一种用于生成用于多通道分析的独立流体样品（51）的装置（3）和方法，优选地在诊断盒中。流体装置（3），优选微流体装置，具有多个流体通道（35）。流体在流体通道中运输。交叉通道（32）具有流体入口（33）和流体出口（34）。在使用所述装置（3）时，执行一种方法。根据该方法，样品通道用样品流体填充至阈值（39）。然后冲洗流体（气体或惰性液体）冲洗通过样品填充的交叉通道，用冲洗液替代样品流体。随后，交叉通道的入口和出口关闭，样品流体被进一步推入通道阵列（30,31）。或者，对流体施加适当的压力，以将流体推入所述样品通道。如果希望在微通道中获得多个（在时间和/或空间中）独立的样本插头，则以适当的方式重复该方法步骤。因此，在每个微通道中产生一系列纵向间隔开的独立样品流体段，其通过齐平段彼此分离。

5. 发明申请

WO2007054850A2 DEVICE FOR TESTING A FLUID 审中-公开
标题翻译：用于测试流体的装置
公开(公告)号：WO2007054850A2
公开(公告)日：2007-05-18
申请号：PCT/IB2006054001
申请日：2006-10-30
申请人： KONINKL PHILIPS ELECTRONICS NV , WEEKAMP JOHANNES W , PRINS MENNO W J , IMMINK ALBERT H J
发明人： WEEKAMP JOHANNES W , PRINS MENNO W J , IMMINK ALBERT H J
IPC分类号： G01N33/487 , A61B10/00 , B01L3/00
CPC分类号： B01L3/5029 , A61B10/0051 , A61B2010/0009 , B01L3/502715 , B01L2200/027 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/065
摘要： A device (1) for testing a fluid comprises an elongated carrier (3); two foam members (5a, 5b) for absorbing the fluid, which are arranged at an end (4) of the carrier (3); a positioning member (6) comprising a sleeve (7) which is slidably arranged on the carrier (3); and a diagnostic device (2), which is arranged in the positioning member (6), and which comprises a sensor die (40) adapted to detecting at least one property of the fluid and means for supplying the fluid to a sensitive surface of the sensor die (40). After the fluid has been supplied to the foam members (5 a, 5b), the positioning member (6) is moved towards the end (4) of the carrier (3) where the foam members (5a, 5b) are located. When the diagnostic device (2) comes into contact with one of the foam members (5a, 5b), the fluid is squeezed from the foam member (5a) and supplied to the sensitive surface of the sensor die (40), through the fluid supplying means of the diagnostic device (2).
摘要翻译：用于测试流体的装置（1）包括细长载体（3）; 用于吸收流体的两个泡沫构件（5a，5b），布置在载体（3）的端部（4）处; 定位构件（6），其包括可滑动地布置在所述载体（3）上的套筒（7）; 以及诊断装置（2），其布置在所述定位构件（6）中，并且包括适于检测所述流体的至少一种性质的传感器模具（40）和用于将所述流体供应到所述流体的敏感表面的装置传感器模具（40）。在流体被供应到泡沫构件（5a，5b）之后，定位构件（6）朝着泡沫构件（5a，5b）所在的载体（3）的端部（4）移动。当诊断装置（2）与泡沫构件（5a，5b）中的一个接触时，流体从泡沫构件（5a）被挤压并通过流体供应到传感器模具（40）的敏感表面诊断装置（2）的供给装置。

6. 发明申请

WO2005010542A3 ON-CHIP MAGNETIC PARTICLE SENSOR WITH IMPROVED SNR 审中-公开
标题翻译：具有改进SNR的片上磁性粒子传感器
公开(公告)号：WO2005010542A3
公开(公告)日：2005-04-21
申请号：PCT/IB2004051297
申请日：2004-07-27
申请人： KONINKL PHILIPS ELECTRONICS NV , KAHLMAN JOSEPHUS A H M , PRINS MENNO W J
发明人： KAHLMAN JOSEPHUS A H M , PRINS MENNO W J
IPC分类号： G01N15/06 , G01N33/543 , G01N35/00 , G01R33/12
CPC分类号： G01R33/1269 , G01N15/0656 , G01N27/745 , G01N33/54326 , G01N35/0098 , G01N2035/00158 , G01R33/12
摘要： A device and method is disclosed for the detection or determination of the presence of magnetic particles (15), such as for example, but not limited to, magnetic tianoparticles. In particular it relates to an integrated or on-chip magnetic sensor element (11) for the detection of magnetic particles. The device and method of the present invention o er high signal-to-noise ratio and low power consumption and do not require an external magnetic field. They may be used for magnetic detection of binding of biological molecules on a micro-array or biochip.
摘要翻译：公开了用于检测或确定磁性颗粒（15）的存在的装置和方法，例如但不限于磁性天然颗粒。特别地，其涉及用于检测磁性颗粒的集成或片上磁传感器元件（11）。本发明的装置和方法具有高信噪比和低功耗，并且不需要外部磁场。它们可用于磁性检测微阵列或生物芯片上生物分子的结合。

7. 发明申请

WO2009013668A3 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：WO2009013668A3
公开(公告)日：2010-07-15
申请号：PCT/IB2008052844
申请日：2008-07-16
申请人： KONINKL PHILIPS ELECTRONICS NV , IMMINK ALBERT H J , DE THEIJE FEMKE K , PRINS MENNO W J , DITTMER WENDY U , NIEUWENHUIS JEROEN H
发明人： IMMINK ALBERT H J , DE THEIJE FEMKE K , PRINS MENNO W J , DITTMER WENDY U , NIEUWENHUIS JEROEN H
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

8. 发明申请

WO2009083814A3 MICROELECTRONIC SENSOR DEVICE FOR THE DETECTION OF TARGET PARTICLES 审中-公开
标题翻译：用于检测目标颗粒的微电子传感器装置
公开(公告)号：WO2009083814A3
公开(公告)日：2009-10-15
申请号：PCT/IB2008054541
申请日：2008-10-31
申请人： KONINKL PHILIPS ELECTRONICS NV , BRULS DOMINIQUE M , SCHLEIPEN JOHANNES J H B , KAHLMAN JOSEPHUS A H M , PRINS MENNO W J
发明人： BRULS DOMINIQUE M , SCHLEIPEN JOHANNES J H B , KAHLMAN JOSEPHUS A H M , PRINS MENNO W J
IPC分类号： G01N21/17 , G01N21/55 , G01N33/543
CPC分类号： G01N21/1717 , G01N21/552 , G01N21/648 , G01N2021/1721 , G01N2021/1727 , G01N2201/0691
摘要： The invention relates to a microelectronic sensor device for the examination of target particles (1) that are bound to binding sites (3) at the binding surface (12) of a carrier (11). In a preferred embodiment, an input light beam (Ll) is transmitted into the carrier (11), where a frustrated total internal reflection (FTIR) takes place at the binding surface (12). The amount of light in a resulting output light beam (L2) is detected by a light detector (31) and provides information about the presence of target particles at the binding surface. Moreover, an actuation unit (50) induces movements of the bound target particles (1) by an interaction with a magnetic field (B) or an electric field, particularly with a given modulation frequency (COIn), such that by a demodulation of the detector signal (S) effects of the target particles can be distinguished from background.
摘要翻译：本发明涉及一种用于检查在载体（11）的结合表面（12）处结合到结合位点（3）的靶颗粒（1）的微电子传感器装置。在优选实施例中，输入光束（L1）被传输到载体（11）中，其中在结合表面（12）处发生挫败的全内反射（FTIR）。通过光检测器（31）检测所得到的输出光束（L2）中的光量，并提供关于在结合表面处存在目标颗粒的信息。此外，致动单元（50）通过与磁场（B）或电场的相互作用（特别是给定的调制频率（COIn））的相互作用来诱导结合的目标颗粒（1）的运动，使得通过解调目标颗粒的检测器信号（S）效应可以与背景区分开。

9. 发明申请

WO2007004142A3 PACKED SEMICONDUCTOR SENSOR CHIP FOR USE IN LIQUIDS 审中-公开
标题翻译：包装半导体传感器芯片用于液体
公开(公告)号：WO2007004142A3
公开(公告)日：2007-03-22
申请号：PCT/IB2006052160
申请日：2006-06-28
申请人： KONINKL PHILIPS ELECTRONICS NV , WEEKAMP JOHANNES W , PRINS MENNO W J
发明人： WEEKAMP JOHANNES W , PRINS MENNO W J
IPC分类号： G01N33/487
CPC分类号： G01N27/745 , H01L24/18 , H01L2924/15747 , H01L2924/00
摘要： The present invention provides a packed semiconductor sensor chip (10) in which the sensing circuit (17) is positioned at substantially the same level or above the level of the packaging (13) . Because of this, when the sensor is immersed in a fluid, in particular in a liquid, for the detection of an analyte in the fluid, substantially the total top surface of the semiconductor sensor chip will be in contact with the fluid and thus detection results can be optimised.
摘要翻译：本发明提供了一种封装半导体传感器芯片（10），其中感测电路（17）位于与包装（13）的水平基本相同的水平面上。因此，当传感器浸入液体中，特别是在液体中时，为了检测流体中的分析物，基本上半导体传感器芯片的总上表面将与流体接触，从而检测结果可以优化。

10. 发明申请

WO2009125339A2 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 审中-公开
标题翻译：小样本容量光学检测的载体
公开(公告)号：WO2009125339A2
公开(公告)日：2009-10-15
申请号：PCT/IB2009051454
申请日：2009-04-07
申请人： KONINKL PHILIPS ELECTRONICS NV , SCHLEIPEN JOHANNES J H B , EVERS TOON H , NIEUWENHUIS JEROEN H , DITTMER WENDY U , BRULS DOMINIQUE M , PRINS MENNO W J , NEIJZEN JACOBUS H M , BOURQUIN YANNYK P J
发明人： SCHLEIPEN JOHANNES J H B , EVERS TOON H , NIEUWENHUIS JEROEN H , DITTMER WENDY U , BRULS DOMINIQUE M , PRINS MENNO W J , NEIJZEN JACOBUS H M , BOURQUIN YANNYK P J
IPC分类号： G01N21/25 , G01N21/41
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (Ll) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及用于在样本室（2）中的样本（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻样品室（2）中并且用于从源自样品室（2）的光中收集输出光束（L2）的光学结构（50）来自输入光束。优选地，光学结构（50）包括载体（11）的表面（12）中的凹槽，其中输入光束以短距离穿过样本传输。光学结构（50）也可以用于润湿检测。

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