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1. 发明申请

WO2012046191A3 IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS 审中-公开
标题翻译：生物医学标记之间的多模式关联的鉴定
公开(公告)号：WO2012046191A3
公开(公告)日：2012-06-07
申请号：PCT/IB2011054366
申请日：2011-10-04
申请人： KONINKL PHILIPS ELECTRONICS NV , COLD SPRING HARBOR LAB , BANERJEE NILANJANA , JANEVSKI ANGEL , KAMALAKARAN SITHARTHAN , VARADAN VINAY , DIMITROVA NEVENKA , LUCITO ROBERT
发明人： BANERJEE NILANJANA , JANEVSKI ANGEL , KAMALAKARAN SITHARTHAN , VARADAN VINAY , DIMITROVA NEVENKA , LUCITO ROBERT
IPC分类号： G06F19/12
CPC分类号： G06F19/20 , G06F19/12 , G06F19/18
摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.
摘要翻译：本发明涉及一种用于识别生物医学标记之间的多模式关联的方法，其允许确定网络节点和/或高排名网络成员或其组合，指示具有医疗状况的诊断，预后或预测值，特别是卵巢癌。本发明进一步涉及与受试者对癌症疗法的响应性的高度可能性相关联的生物医学标记物或生物医学标记物组，其中所述生物医学标记物或生物医学标记物组包括至少1种， 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17，8,19,20或所有选自PKMYT1，SKIL，RAB8A，HIRIP3， CTNNB1，NGFR，ZCCHC11，LSP1，CD200，PAX8，CYBRD1，HOXC11，TCEAL1，FZD10，FZD1，BBS4，IRS2，TLX3，TSPAN2，TXN和CFLAR。此外，提供了用于检测，诊断，分级，监测或预测医疗状况或用于检测，诊断，监测或预测受试者针对所述医疗状况，特别是卵巢癌的疗法的响应性的测定，作为以及用于分类包括医疗决策支持系统的对象的相应方法。

2. 发明申请

WO2012168810A2 CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE 审中-公开
标题翻译：组合标志的交叉模式应用
公开(公告)号：WO2012168810A2
公开(公告)日：2012-12-13
申请号：PCT/IB2012052551
申请日：2012-05-22
申请人： KONINKL PHILIPS ELECTRONICS NV , JANEVSKI ANGEL , KAMALAKARAN SITHARTHAN , BANERJEE NILANJANA , VARADAN VINAY , DIMITROVA NEVENKA , SURYANARAYANAN SANKARARAMAN
发明人： JANEVSKI ANGEL , KAMALAKARAN SITHARTHAN , BANERJEE NILANJANA , VARADAN VINAY , DIMITROVA NEVENKA , SURYANARAYANAN SANKARARAMAN
IPC分类号： G06F19/18
CPC分类号： G06F19/18
摘要： The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.
摘要翻译：本发明涉及一种适应表型复合特征的方法。该方法包括以下步骤：提供具有至少两种不同数据类型的表型的复合特征，其分别由测量样本的两种不同方式产生。由于表型的一部分签名的适应，所得到的适应表型签名可以用作从通过第三测量方式测量的数据导出的签名评估工具的输入。

3. 发明申请

WO2012093363A3 INTEGRATED ACCESS TO AND INTERATION WITH MULTIPLICITY OF CLINICA DATA ANALYTIC MODULES 审中-公开
标题翻译：综合访问和与临床数据分析模块的多重性相关联
公开(公告)号：WO2012093363A3
公开(公告)日：2013-04-18
申请号：PCT/IB2012050041
申请日：2012-01-04
申请人： KONINKL PHILIPS ELECTRONICS NV , JANEVSKI ANGEL , KAMALAKARAN SITHARTHAN , REICHELT CHRISTIAN , BANERJEE NILANJANA , VARADAN VINAY , DIMITROVA NEVENKA
发明人： JANEVSKI ANGEL , KAMALAKARAN SITHARTHAN , REICHELT CHRISTIAN , BANERJEE NILANJANA , VARADAN VINAY , DIMITROVA NEVENKA
IPC分类号： G06F19/00
CPC分类号： G06F19/3443 , G06F19/325 , G16H40/63 , G16H50/70
摘要： A state machine (22) stores a current state (30) comprising a clinical context defined by available patient-related information relating to a medical patient, and identifies one or more available analytical tools of a set of analytical tools (24) that are applicable to the current state. A graphical user interface module (16) receives a user selection of an available analytical tool. The state machine loads patient-related information (40) to the user-selected available analytical tool (24sel) and invokes the user-selected available analytical tool to operate on the loaded patient-related information to generate additional patient-related information relating to the medical patient and/or graphical patient-related content relating to the medical patient. The state machine transitions from the current state (30) to a next state (30') and/or invokes the graphical user interface module to display the graphical patient related content.
摘要翻译：状态机（22）存储当前状态（30），其包括由与医疗患者有关的可用患者相关信息定义的临床上下文，并且识别可应用的一组分析工具（24）中的一个或多个可用分析工具到目前状态。图形用户界面模块（16）接收可用分析工具的用户选择。状态机将患者相关信息（40）加载到用户选择的可用分析工具（24sel），并且调用用户选择的可用分析工具对所加载的患者相关信息进行操作，以生成与患者相关的附加信息与患者有关的医疗病人和/或图形患者相关内容。状态机从当前状态（30）转换到下一状态（30'）和/或调用图形用户界面模块以显示图形的患者相关内容。

4. 发明申请

WO2011128820A2 METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS 审中-公开
标题翻译：乳腺癌分析方法
公开(公告)号：WO2011128820A2
公开(公告)日：2011-10-20
申请号：PCT/IB2011051517
申请日：2011-04-08
申请人： KONINKL PHILIPS ELECTRONICS NV , DIMITROVA NEVENKA , KAPAETTU SATYAMOORTHY , GORTHI APARNA , KABEKKODU SHAMA PRASADA , CHAKRABARTY SANJIBAN , KESWARPU PAYAL , BANERJEE NILANJANA , JANEVSKI ANGEL , HEBBAR PRASHANTHA
发明人： DIMITROVA NEVENKA , KAPAETTU SATYAMOORTHY , GORTHI APARNA , KABEKKODU SHAMA PRASADA , CHAKRABARTY SANJIBAN , KESWARPU PAYAL , BANERJEE NILANJANA , JANEVSKI ANGEL , HEBBAR PRASHANTHA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.
摘要翻译：本发明涉及用于辅助乳腺癌疾病分类的方法，阵列和计算机程序。特别地，本发明涉及通过确定根据SEQ ID NO：1-111的一个或多个序列的甲基化状态来分类乳腺癌病症。考虑到一种或多种蛋白质的表达水平，可以进一步加强分类。

5. 发明申请

WO2011128820A3 METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS 审中-公开
标题翻译：乳腺癌分析方法
公开(公告)号：WO2011128820A3
公开(公告)日：2012-03-01
申请号：PCT/IB2011051517
申请日：2011-04-08
申请人： KONINKL PHILIPS ELECTRONICS NV , DIMITROVA NEVENKA , KAPAETTU SATYAMOORTHY , GORTHI APARNA , KABEKKODU SHAMA PRASADA , CHAKRABARTY SANJIBAN , KESWARPU PAYAL , BANERJEE NILANJANA , JANEVSKI ANGEL , HEBBAR PRASHANTHA
发明人： DIMITROVA NEVENKA , KAPAETTU SATYAMOORTHY , GORTHI APARNA , KABEKKODU SHAMA PRASADA , CHAKRABARTY SANJIBAN , KESWARPU PAYAL , BANERJEE NILANJANA , JANEVSKI ANGEL , HEBBAR PRASHANTHA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.
摘要翻译：本发明涉及用于辅助乳腺癌疾病分类的方法，阵列和计算机程序。特别地，本发明涉及通过确定根据SEQ ID NO：1-111的一个或多个序列的甲基化状态来分类乳腺癌病症。考虑到一种或多种蛋白质的表达水平，可以进一步加强分类。

6. 发明申请

WO2010131162A2 DEVICE AND METHOD FOR COMPARING MOLECULAR SIGNATURES 审中-公开
标题翻译：用于比较分子信号的装置和方法
公开(公告)号：WO2010131162A2
公开(公告)日：2010-11-18
申请号：PCT/IB2010051969
申请日：2010-05-05
申请人： KONINKL PHILIPS ELECTRONICS NV , ALSAFADI YASSER H , BANERJEE NILANJANA , VARADAN VINAY VV , JANEVSKI ANGEL J
发明人： ALSAFADI YASSER H , BANERJEE NILANJANA , VARADAN VINAY VV , JANEVSKI ANGEL J
IPC分类号： G06F19/18
CPC分类号： G06F19/18 , G06Q50/22
摘要： A method (10) for clinical decision support by comparison of multiple molecular signatures of biological data is provided. The method comprises comparing at least two of said molecular signatures are different kinds of molecular signatures. Furthermore, a device (70), a system (100), and a computer program product (200) and a use for clinical decision support, performing the steps according to the method (10) is provided.
摘要翻译：提供了一种用于通过比较生物数据的多个分子特征的临床决定支持的方法（10）。所述方法包括比较所述分子特征中的至少两个是不同种类的分子标记。此外，提供了根据方法（10）的设备（70），系统（100）和计算机程序产品（200）和用于临床决策支持的用途，执行步骤。

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