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1. 发明申请

WO2008039220A1 MEIBOMIAN GLAND IMAGING 审中-公开
公开(公告)号：WO2008039220A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/000505
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , GRENON, Stephen, M. , WILLS, Timothy, R. , GRAVELY, Benjamin, T. , KORB, Donald, R.
发明人： GRENON, Stephen, M. , WILLS, Timothy, R. , GRAVELY, Benjamin, T. , KORB, Donald, R.
IPC分类号： A61B3/14
CPC分类号： A61B3/10 , A61B5/0066 , A61B5/0073 , A61B5/411 , A61B5/4261
摘要： A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland (20) in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland (20). This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：一种评估人眼干眼症的方法，其中由于眼睑中睑板腺（20）的阻塞的存在，减少或停止天然存在于眼睛的分泌物的流动，包括对眼睑施加压力，模拟施加的压力眨眼期间并同时对腺体进行成像以诊断睑板腺的状况（20）。该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

2. 发明申请

WO2008024100A2 METHOD AND APPARATUS FOR TREATING GLAND DYSFUNCTION 审中-公开
标题翻译：治疗腺体功能障碍的方法和装置
公开(公告)号：WO2008024100A2
公开(公告)日：2008-02-28
申请号：PCT/US2006/032544
申请日：2006-08-21
申请人： KOLIS SCIENTIFIC, INC. , KORB, Donald, R. , WILLIS, Timothy, R. , GRAVELY, Benjamin, T. , GRENON, Stephen, M.
发明人： KORB, Donald, R. , WILLIS, Timothy, R. , GRAVELY, Benjamin, T. , GRENON, Stephen, M.
IPC分类号： A61F7/12
CPC分类号： A61F7/007 , A61F7/02 , A61F2007/0004 , A61N7/00
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动，此后清除阻塞物。

3. 发明申请

WO2008085162A1 TREATMENT OF MEIBOMIAN GLANDS 审中-公开
标题翻译：治疗墨西哥湾
公开(公告)号：WO2008085162A1
公开(公告)日：2008-07-17
申请号：PCT/US2007/000525
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , KORB, Donald, R. , WILLIS, Timothy, R. , GRENON, Stephen, M.
发明人： KORB, Donald, R. , WILLIS, Timothy, R. , GRENON, Stephen, M.
IPC分类号： A61F7/00 , A61B19/00
CPC分类号： A61F7/02 , A61F2007/0004
摘要： In one embodiment consistent with the present invention a method of treating mammalian meibomian glands (10) involves clearing the glands by applying a regulated heat (104) to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands (108), wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) (112) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在与本发明一致的一个实施方案中，治疗哺乳动物睑板腺的方法（10）涉及通过对含有睑板腺的眼睑施加调节热（104）至足以融化睑板腺中的阻塞物的温度来清除腺体在流体或悬浮（熔化）状态下的障碍物并将热量保持足以熔化障碍物的时间。然后可以对腺体进行机械处理以从腺体（108）表达流体，其中治疗在时间段期间或在时间段之后进行，但是阻塞物保持在流体状态。然后使用药物（局部或全身）（112）对腺体进行的后续药理学治疗可以用于帮助保持来自腺体的适当的脂质流动。该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

4. 发明申请

WO2008042002A1 METHOD AND APPARATUS FOR DIAGNOSING MEIBOMIAN GLAND DYSFUNCTION 审中-公开
标题翻译：用于诊断MEIBOMIAN GLAND DYSFUNCTION的方法和装置
公开(公告)号：WO2008042002A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/000495
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , KORB, Donald, R. , GRAVELY, Benjamin, T. , JANS, John, M. , GAUSMANN, Keith, H.
发明人： KORB, Donald, R. , GRAVELY, Benjamin, T. , JANS, John, M. , GAUSMANN, Keith, H.
IPC分类号： A61B3/16
CPC分类号： A61B3/101
摘要： An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland disease is provided The apparatus compπses a handle, and a probe tip mounted for movement relative to said handle such that when the probe tip is placed against the eyelid and compressive force is applied, movement of the handle a preselected distance replicates the force required for natural expression of secretion from the meibomian gland An indicator means selected from the group consisting of auditory, visual and tactile signals is provided and when activated alerts the clinician that the required force has been reached According to the method of the present invention a probe tip is located in contacting relation with the eyelid, the probe tip being connected to a handle (105) When pressure is exerted on the eyelid by pressing it against the eyelid, a preselected pressure is exerted thereon
摘要翻译：提供了一种用于测试睑板腺疾病的人类眼皮中睑板腺的装置。该装置包括手柄和安装成相对于所述手柄移动的探针尖端，使得当探针针头靠着眼睑放置并施加压缩力时手柄的移动预选距离复制了睑板腺分泌物的自然表达所需的力量提供了从听觉，视觉和触觉信号组成的组中选择的指示器，并且当激活时向临床医生警告所需的力已经被达到根据本发明的方法，探针尖端与眼睑呈接触关系，探针尖端连接到手柄（105）当通过将眼压压在眼睑上而施加压力时，预选的压力为施加于其上

5. 发明申请

WO2008039221A1 MELTING MEIBOMIAN GLAND OBSTRUCTIONS 审中-公开
标题翻译：熔化MEIBOMIAN GLAND阻塞
公开(公告)号：WO2008039221A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/000508
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , GRENON, Stephen, M. , FOSHEE, David , KORB, Donald, R. , WILLIS, Timothy, R. , BARRIER, Omer, Jack
发明人： GRENON, Stephen, M. , FOSHEE, David , KORB, Donald, R. , WILLIS, Timothy, R. , BARRIER, Omer, Jack
IPC分类号： A61F7/00
CPC分类号： A61F7/007 , A61F2007/0004
摘要： Consistent with certain embodiments, an apparatus provides regulated heat to at least one of a patient's eyelids, using a heater unit (38) having a heating element (42) that produces heat that is transferred to the patient's eyelid when an electrical signal is applied thereto. A temperature regulator applies an electrical signal to the heating elements (42) in order to achieve heating of the heating elements (42) to a specified temperature range. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：根据某些实施例，一种装置使用具有加热元件（42）的加热器单元（38）向患者的眼睑中的至少一个提供调节的热量，所述加热器单元产生当向其施加电信号时传递到患者眼皮的热量。温度调节器将电信号施加到加热元件（42），以实现加热元件（42）的加热到指定的温度范围。该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

6. 发明申请

WO2008027069A1 METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION EMPLOYING FLUID 审中-公开
标题翻译：用于处理使用流体的MEIBOMIAN GLAND DYSFUNCTION的方法和装置
公开(公告)号：WO2008027069A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/000493
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , GRENON, Stephen, M. , ROE, Steven , KORB, Donald, R. , PAUL, Lyle
发明人： GRENON, Stephen, M. , ROE, Steven , KORB, Donald, R. , PAUL, Lyle
IPC分类号： B08B3/10
CPC分类号： A61F9/00 , A61B17/3203 , A61B18/04 , A61B2018/046 , A61F9/00772 , A61F2007/0004 , A61F2007/0059
摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice (O). The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is applied to the exterior surface of the eyelid, proximate to the gland channel orifice (O), a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed.
摘要翻译：根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物流出腺体通道孔口（O）。本发明包括选择能够输送加热介质射流的装置。该装置被定位成使得当喷射器施加到眼睑的外表面时，靠近腺体通道孔口（O），加热介质射流被施加到靠近腺体通道孔的眼睑外表面约2psi至约30psi的压力。维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分堵塞被去除。

7. 发明申请

WO2010115008A1 OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES, SYSTEMS, AND METHODS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM AND/OR MEASURING OCULAR TEAR FILM LAYER THICKNESS (ES) 审中-公开
标题翻译：用于成像，处理和/或显示眼睛薄膜和/或测量眼部膜片厚度（ES）的OCULAR SURFACE INTERFEROMETRY（OSI）装置，系统和方法
公开(公告)号：WO2010115008A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029645
申请日：2010-04-01
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
发明人： KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
IPC分类号： A01N57/26
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image.
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。

8. 发明申请

WO2008156883A3 TEAR FILM MEASUREMENT 审中-公开
公开(公告)号：WO2008156883A3
公开(公告)日：2008-12-24
申请号：PCT/US2008/057578
申请日：2008-03-20
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , GRAVELY, Benjamin, T.
发明人： KORB, Donald, R. , GRAVELY, Benjamin, T.
IPC分类号： A61B3/10
摘要： Apparatus for measuring the relative thickness of the lipid layer of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking An illuminator directs light to the lipid layer of an eye The illuminator is a broad spectrum source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable The collector produces output representative of the specularly reflected light for further analysis, such as projection on to a high resolution monitor or computer analysis The patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the eye.

9. 发明申请

WO2013003594A2 METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY 审中-公开
标题翻译：使用无线电频率处理MEIBOMIAN GLAND DYSFUNCTION的方法和系统
公开(公告)号：WO2013003594A2
公开(公告)日：2013-01-03
申请号：PCT/US2012/044650
申请日：2012-06-28
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , BACICH, Steven
发明人： KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , BACICH, Steven
IPC分类号： A61F7/00 , A61N1/39
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.
摘要翻译：公开了治疗睑板腺功能障碍的方法。该方法包括将RF能量引导到睑板腺的内部部分，以施加的RF能量选择性地靶向睑板腺导管内的阻塞物，以熔化，松开或软化阻塞物，并且将来自管道的阻塞物睑板腺还公开了一种治疗睑板腺功能障碍的装置。该装置包括至少一个RF电极，其被配置为将RF能量引导到位于眼睛的眼睑中的睑板腺的内部部分，所述至少一个RF电极还被配置为选择性地将睑板腺的管道内的阻塞物对准，应用的射频能量来融化，松动或软化障碍物。该装置还包括至少一个构造成从睑板腺的管道表达梗阻的表达器。

10. 发明申请

WO2008089327A1 METHODS, SYSTEMS, AND APPARATUSES FOR HEAT TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 审中-公开
标题翻译：用于治疗脑血管功能障碍的热处理方法，系统和装置
公开(公告)号：WO2008089327A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/051309
申请日：2008-01-17
申请人： KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , JANS, John, Martin , HUTCHINSON, Jordan, W. , GAUSMANN, Keith
发明人： KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , JANS, John, Martin , HUTCHINSON, Jordan, W. , GAUSMANN, Keith
IPC分类号： A61M35/00
CPC分类号： A61F7/02 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0086
摘要： Apparatuses, systems, and methods of treating meibomian gland dysfunction. Heat is applied to the patient's eyelid or surrounding tissue to apply heat to the patient's meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the patient's eyelid or surrounding tissue to improve conductive heat transfer and reduce blood flow in the tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reached desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的装置，系统和方法。对患者的眼睑或周围组织施加热量以对患者的睑板腺施加热量。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者的眼睑或周围组织以改善传导性热传递并减少导致对流热损失的组织中的血液流动。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。达到升高的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到所需温度水平的时间量和/或有助于减轻治疗期间患者的不适。

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