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1. 发明申请

WO2010115008A1 OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES, SYSTEMS, AND METHODS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM AND/OR MEASURING OCULAR TEAR FILM LAYER THICKNESS (ES) 审中-公开
标题翻译：用于成像，处理和/或显示眼睛薄膜和/或测量眼部膜片厚度（ES）的OCULAR SURFACE INTERFEROMETRY（OSI）装置，系统和方法
公开(公告)号：WO2010115008A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029645
申请日：2010-04-01
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
发明人： KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
IPC分类号： A01N57/26
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image.
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。

2. 发明申请

WO2004103478A1 OPHTHALMIC DRUG DELIVERY SYSTEM 审中-公开
标题翻译： OPHTHALMIC药物递送系统
公开(公告)号：WO2004103478A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/016181
申请日：2004-05-20
申请人： COLLINS, James, F. , CHINNOCK, Randal, B. , MELANSON, Jeffrey , HOWARD, Joseph
发明人： COLLINS, James, F. , CHINNOCK, Randal, B. , MELANSON, Jeffrey , HOWARD, Joseph
IPC分类号： A62C13/62
CPC分类号： B05B17/0646 , A61F9/0008 , A61M11/005 , A61M11/041 , A61M11/042 , A61M11/065 , A61M2205/59 , A61M2210/0612 , B05B17/0623 , B05B17/0676
摘要： A fluid atomizer is disclosed. The fluid atomizer comprises a body having a proximal end and a distal end. A removable reservoir containing a fluid disposed therein is connected to the body. A discharge plate is disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough. An ultrasonic oscillator is disposed in the body for transmitting the fluid from the reservoir to the discharge plate and through the plurality of openings, wherein transmission of the fluid through the plurality of openings atomizes the fluid.
摘要翻译：公开了一种流体雾化器。流体雾化器包括具有近端和远端的主体。包含设置在其中的流体的可移除的储存器连接到主体。放电板设置在远端，其中放电板包括从其延伸穿过的多个开口。超声波振荡器设置在主体中，用于将流体从储存器传送到排放板并通过多个开口，其中通过多个开口的流体的传输使流体雾化。

3. 发明申请

WO2003007796A3 METHODS AND DEVICES FOR TISSUE RECONFIGURATION 审中-公开
公开(公告)号：WO2003007796A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/022842
申请日：2002-07-18
申请人： NDO SURGICAL, INC. , LAUFER, Michael D. , CERIER, Jeffrey, C. , CRUZ, Amos , O'KEEFE, Jonathan , ANDREWS, Richard , CHUTTANI, Ram , PIUCCI, Vincent, A. , BARENBOYM, Michael , MARSHALL, Neal, H. , CHINNOCK, Randal, B.
发明人： LAUFER, Michael D. , CERIER, Jeffrey, C. , CRUZ, Amos , O'KEEFE, Jonathan , ANDREWS, Richard , CHUTTANI, Ram , PIUCCI, Vincent, A. , BARENBOYM, Michael , MARSHALL, Neal, H. , CHINNOCK, Randal, B.
IPC分类号： A61B17/08
摘要： A method includes advancing an apparatus (10) including an elongated member (12) transorally into the stomach. The apparatus (10) includes a distal end effector (15) having first and second members (16) configured to engage tissue. The first and second members (16) are movable relatively toward one another generally in a first plane. The method includes moving the distal end effector relative to the elongated member (12) in the first plane such that the distal end effector is retroflexed out of alignment with the elongated member (16) to position the first and second members (16) for engagement with the tissue. At least one of the first and second members (16) carries a fixation device (22) for fixing engaged portions of tissue together.

4. 发明申请

WO2003007796A2 METHODS AND DEVICES FOR TISSUE RECONFIGURATION 审中-公开
标题翻译：用于组织重建的方法和装置
公开(公告)号：WO2003007796A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/022842
申请日：2002-07-18
申请人： NDO SURGICAL, INC. , LAUFER, Michael D. , CERIER, Jeffrey, C. , CRUZ, Amos , O'KEEFE, Jonathan , ANDREWS, Richard , CHUTTANI, Ram , PIUCCI, Vincent, A. , BARENBOYM, Michael , MARSHALL, Neal, H. , CHINNOCK, Randal, B.
发明人： LAUFER, Michael D. , CERIER, Jeffrey, C. , CRUZ, Amos , O'KEEFE, Jonathan , ANDREWS, Richard , CHUTTANI, Ram , PIUCCI, Vincent, A. , BARENBOYM, Michael , MARSHALL, Neal, H. , CHINNOCK, Randal, B.
IPC分类号： A61B
CPC分类号： A61B17/0482 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0467 , A61B17/0485 , A61B17/0643 , A61B17/068 , A61B17/285 , A61B17/29 , A61B2017/00349 , A61B2017/00827 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/061 , A61B2017/2905 , A61B2017/2915 , A61B2017/2916 , A61B2017/2917 , A61B2017/3488 , A61M25/0133
摘要： A method includes advancing an apparatus (10) including an elongated member (12) transorally into the stomach. The apparatus (10) includes a distal end effector (15) having first and second members (16) configured to engage tissue. The first and second members (16) are movable relatively toward one another generally in a first plane. The method includes moving the distal end effector relative to the elongated member (12) in the first plane such that the distal end effector is retroflexed out of alignment with the elongated member (16) to position the first and second members (16) for engagement with the tissue. At least one of the first and second members (16) carries a fixation device (22) for fixing engaged portions of tissue together.
摘要翻译：一种方法包括将包括细长构件（12）的装置（10）经由胃内推进。该装置（10）包括具有构造成接合组织的第一和第二构件（16）的远端执行器（15）。第一和第二构件（16）通常在第一平面中可相对于彼此移动。该方法包括在第一平面中使远端执行器相对于细长构件（12）移动，使得远端执行器被反转而不与细长构件（16）对准，以定位第一和第二构件（16）用于接合与组织。第一和第二构件（16）中的至少一个承载用于将组织的接合部分固定在一起的固定装置（22）。

5. 发明申请

WO2011047214A2 PORTABLE RETINAL CAMERA AND IMAGE ACQUISITION METHOD 审中-公开
标题翻译：便携式视频相机和图像采集方法
公开(公告)号：WO2011047214A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052761
申请日：2010-10-14
申请人： OPTIMUM TECHNOLOGIES, INC. , CHINNOCK, Randal, B. , BARGOOT, Fredrick, G. , GRUBNER, George , JULIAN, Jason, P. , LATTA, Sarah , WEBER, William
发明人： CHINNOCK, Randal, B. , BARGOOT, Fredrick, G. , GRUBNER, George , JULIAN, Jason, P. , LATTA, Sarah , WEBER, William
IPC分类号： A61B3/12
CPC分类号： A61B3/14 , A61B3/0091
摘要： A camera for capturing an image of an object, for example an eye. The camera has at least two light sources and an image-sensing system having two image sensors. A multiple branch optical system transmits outgoing light from the light sources to the object, and transmits incoming light from the object to the image-sensing system. The multiple branch optical system includes an autofocusing element such as a variable power optical element that varies the focus of the incoming light. There is also an image display. There is a controller that controls the operation of the light sources, controls acquisition of images by the image-sensing system, and controls the display of images on the image display. The controller activates an autofocus light source and uses the resulting captured image to automatically adjust the image exposure parameters. The controller automatically adjusts the autofocusing element to improve the image focus, and then activates the second light source and acquires one or more images of the object while the second light source is activated.
摘要翻译：
用于捕捉物体（例如眼睛）图像的相机。相机至少有两个光源和一个具有两个图像传感器的图像传感系统。多分支光学系统将来自光源的出射光传输到物体，并将来自物体的入射光传输到图像传感系统。多分支光学系统包括自动聚焦元件，例如改变入射光的焦点的可变功率光学元件。还有一个图像显示。有一个控制器控制光源的操作，控制图像传感系统获取图像，并控制图像显示器上的图像显示。控制器激活自动对焦光源，并使用拍摄的图像自动调整图像曝光参数。控制器自动调整自动对焦元件以改善图像焦点，然后激活第二光源并在第二光源激活时获取对象的一个或多个图像。

6. 发明申请

WO2009117727A1 LIGHT-GUIDED TRANSLUMINAL CATHETER 审中-公开
标题翻译：轻型透明导管
公开(公告)号：WO2009117727A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037927
申请日：2009-03-23
申请人： IMAM, Farhad, B. , CHILDREN'S MEDICAL CENTER CORPORATION , CHINNOCK, Randal, B. , GRUBNER, George , KLEBANOV, Leo
发明人： IMAM, Farhad, B. , CHINNOCK, Randal, B. , GRUBNER, George , KLEBANOV, Leo
IPC分类号： A61B5/00
CPC分类号： A61B19/54 , A61B18/24 , A61B90/39 , A61B2090/306 , A61B2090/3945
摘要： Generally, the present invention is directed to a light-guided catheter for direct visualization of placement through the skin. An embodiment of the invention includes a method for transcutaneous viewing and guiding of intracorporeal catheters into a body that comprises inserting a catheter into the body having at least one lumen and internally illuminating the catheter with light capable of propagating through the blood and tissue to an external viewer outside of the body. The illumination may be point source, continuous, single or multi wavelength. A method of treatment of blood conditions is also disclosed using direct placement of a photo treatment source in the blood stream.
摘要翻译：通常，本发明涉及用于直接观察通过皮肤放置的光引导导管。本发明的一个实施例包括一种用于体内观察和引导体内导管进入体内的方法，该方法包括将导管插入到具有至少一个内腔的体内，并用能够通过血液和组织传播的外部照射导管的外部观众身体外。照明可以是点源，连续，单波长或多波长。还公开了一种治疗血液病症的方法，其使用将光处理源直接放置在血流中。

7. 发明申请

WO2005115223A2 SPECULUM 审中-公开
标题翻译：窥器
公开(公告)号：WO2005115223A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/018360
申请日：2005-05-25
申请人： INNOVATIVE GYNECOLOGICAL SOLUTIONS, INC. , RICHARDS, Charlotte, J. , ROSS, Richard , JORGE, JoAnn , GLEASON, Francis, G., Jr. , CHINNOCK, Randal, B. , FORNI, Ronald , LANGER, John, W. , WALSH, John , ANDERSON, Brian , DOUCETTE, Kenneth, J., Jr.
发明人： RICHARDS, Charlotte, J. , ROSS, Richard , JORGE, JoAnn , GLEASON, Francis, G., Jr. , CHINNOCK, Randal, B. , FORNI, Ronald , LANGER, John, W. , WALSH, John , ANDERSON, Brian , DOUCETTE, Kenneth, J., Jr.
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B1/00105 , A61B1/0676 , A61B1/303
摘要： A speculum for use with a body opening, such as a vagina, rectum or surgical wound, may have an insertion portion with an arcuately-shaped wall and a slot that extends along a length of the wall. An end face of the wall at the distal end of the insertion portion may be arranged at a non-perpendicular angle to the longitudinal axis of the insertion portion. A flange portion joined at a proximal end of the insertion portion may have a continuous band that extends radially outwardly from the wall and includes a notch that communicates with the slot. A handle portion may have a gripping surface extending proximally at a bottom side of the flange portion with an arcuate shape that is approximately concentric with the wall of the insertion portion. A top side of the flange portion may be free of the handle portion.
摘要翻译：用于身体开口的窥器（1），例如阴道，直肠或外科伤口，可以具有插入部分（2），其具有弓形壁和沿着壁的长度延伸的狭槽（6）。插入部分的远端处的壁的端面（5）可以布置成与插入部分的纵向轴线成非垂直的角度。在插入部分的近端处接合的凸缘部分（3）可以具有从壁径向向外延伸的连续带，并且包括与槽连通的凹口。手柄部分可以具有在凸缘部分的底侧处向近侧延伸的夹持表面，其具有与插入部分的壁大致同心的弓形形状。凸缘部分的顶侧可以没有手柄部分。

8. 发明申请

WO2013163367A1 APPARATUSES AND METHODS OF OCULAR SURFACE INTERFEROMETRY (OSI) EMPLOYING POLARIZATION AND SUBTRACTION FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 审中-公开
标题翻译：用于成像，处理和/或显示眼睛电影的极化表面干涉（OSI）的装置和方法进行偏振和分离
公开(公告)号：WO2013163367A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038116
申请日：2013-04-25
申请人： TEARSCIENCE, INC.
发明人： KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Stephen, M.
IPC分类号： A61B3/14
CPC分类号： A61B3/101 , G01B7/06 , G01B11/0675
摘要： Apparatuses and methods employing ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film are disclosed. The apparatuses and methods can be employed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image.
摘要翻译：公开了使用用于成像，处理和/或显示眼泪膜的偏振和减影的眼表面干涉测量（OSI）的装置和方法。该装置和方法可用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。测量的TFLT可用于诊断干眼综合征（DES）。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。

9. 发明授权

EP2413699B1 OCULAR SURFACE INTERFEROMETRY (OSI) APPARATUS FOR IMAGING AN OCULAR TEAR FILM 有权转让
公开(公告)号：EP2413699B1
公开(公告)日：2019-11-20
申请号：EP10759411.1
申请日：2010-04-01
申请人： Tearscience, Inc.
发明人： KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
IPC分类号： A61B3/00 , G01B11/06

10. 发明公开

EP2413699A1 OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES, SYSTEMS, AND METHODS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM AND/OR MEASURING OCULAR TEAR FILM LAYER THICKNESS (ES) 有权转让
标题翻译： OSI装置，系统和用于图像处理和/或显示眼睛FILMS TEARS的方法和/或用于测量眼睛的眼泪流层的厚度（S）
公开(公告)号：EP2413699A1
公开(公告)日：2012-02-08
申请号：EP10759411.1
申请日：2010-04-01
申请人： Tearscience, Inc.
发明人： KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
IPC分类号： A01N57/26
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). A measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image.

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