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1. 发明申请

WO1991014359A1 PROCESS FOR PRODUCING TUBER 审中-公开
标题翻译：生产管子的方法
公开(公告)号：WO1991014359A1
公开(公告)日：1991-10-03
申请号：PCT/JP1991000382
申请日：1991-03-25
申请人： KIRIN BEER KABUSHIKI KAISHA , ONISHI, Noboru , HAYASHIDA, Kunihiro , MAMIYA, Kanji
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A01H04/00
CPC分类号： A01H4/005
摘要： A process for producing tubers of a solanum readily in a large amount, wherein the stolon and foliage which have grown in a liquid phase under application of carbon dioxide in the light period of the foliage growth stage are exposed to a gas phase in the tuber formation stage to form tubers in a high yield, and the culture in the tuber formation stage is conducted while aerating the gas phase of a culture tank to form a large amount of tubers not only near the boundary of the culture medium but also in the gas phase apart from the medium. As a result, the efficiency of tuber formation and the quality of the tuber are improved.

2. 发明申请

WO1997037674A1 SUBSTANCE ORIGINATING IN GERMINATING SEEDS OF GRAMINEOUS PLANT AND CONTAINING PROTEINS AND INSOLUBLE DIETARY FIBERS AND USE THEREOF 审中-公开
标题翻译：植物种子和含有蛋白质和不溶性膳食纤维的种子中的物质及其用途
公开(公告)号：WO1997037674A1
公开(公告)日：1997-10-16
申请号：PCT/JP1997000671
申请日：1997-03-05
申请人： KIRIN BEER KABUSHIKI KAISHA , KANAUCHI, Osamu , AGATA, Kazue
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A61K35/78
CPC分类号： A61K36/899 , A23K20/147 , A23L33/185 , A23L33/21 , A61K36/88 , A61K36/8998 , Y10S514/867 , Y10S514/925
摘要： A substance separated from germinating seeds of a gramineous plant and containing proteins and insoluble dietary fibers; a medicinal composition containing as the active ingredient a substance separated from germinating seeds of a gramineous plant and containing proteins and insoluble dietary fibers; a food composition containing a substance separated from germinating seeds of a gramineous plant and containing proteins and insoluble dietary fibers; and the use of the above substance.
摘要翻译：与禾本科植物的发芽种子分离并含有蛋白质和不溶性膳食纤维的物质; 含有与禾本科植物的发芽种子分离并含有蛋白质和不溶性膳食纤维的物质作为活性成分的药物组合物; 含有与禾本科植物的发芽种子分离并含有蛋白质和不溶性膳食纤维的物质的食物组合物; 并使用上述物质。

3. 发明申请

WO1995032289A1 TRANSFORMANT LINE OF CANDIDA UTILIS YEAST AND EXPRESSION OF HETEROGENE THEREWITH 审中-公开
标题翻译：坎迪达酵母菌的转化体系及其异构体的表达
公开(公告)号：WO1995032289A1
公开(公告)日：1995-11-30
申请号：PCT/JP1995001005
申请日：1995-05-25
申请人： KIRIN BEER KABUSHIKI KAISHA , KONDO, Keiji , KAJIWARA, Susumu , MISAWA, Norihiko
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： C12N15/31
CPC分类号： C12N9/14 , C07K14/40 , C12N9/88 , C12N15/815
摘要： A reproducible transformant line of a Candida utilis yeast; a method of expressing a heterogene in the above line; a vector utilizable in the above line and method of expression; and a novel DNA group. The method of expressing a heterogene in a Candida utilis yeast comprises transforming Candida utilis with a vector containing a drug-resistant marker, a sequence homologous with that of a chromosomal (DNA) of a Candida utilis yeast and a heterogene, culturing the resultant transformant, and isolating the product of expression of the heterogene.
摘要翻译：产朊假丝酵母的可重现的转化体系; 在上述行中表达异质的方法; 上述可利用的载体和表达方法; 和一个新的DNA组。在产朊假丝酵母中表达异源的方法包括用含有药物抗性标记的载体转化产朊假丝酵母，与产朊假丝酵母和异源的染色体（DNA）同源的序列，培养所得的转化体，并分离异源基因的表达产物。

4. 发明申请

WO1995009010A1 ARTERIOSCLEROSIS REMEDY 审中-公开
标题翻译：麻醉药物补救
公开(公告)号：WO1995009010A1
公开(公告)日：1995-04-06
申请号：PCT/JP1994000320
申请日：1994-02-28
申请人： KIRIN BEER KABUSHIKI KAISHA , OSAKA PREFECTURAL GOVERNMENT
发明人： KIRIN BEER KABUSHIKI KAISHA , OSAKA PREFECTURAL GOVERNMENT , TAKAHASHI, Katsuhito , SHIBATA, Nobuhiko
IPC分类号： A61K48/00
CPC分类号： C07K14/47
摘要： An arteriosclerosis remedy containing a carponin gene as the active ingredient, which is useful because it can inhibit the thickening of the endangium. It is therefore efficacious for the treatment of arteriosclerosis and ischemic heart diseases which may be caused thereby, such as angina pectoris and myocardial infarction. In particular, it can remarkably effectively inhibit the occurrence of restenosis after percutaneous transluminal coronary angioplasty (PTCA).
摘要翻译：含有carponin基因作为活性成分的动脉硬化症药物，因为它可以抑制内膜的增厚是有用的。因此，对于可能由此引起的动脉硬化和缺血性心脏病的治疗，如心绞痛和心肌梗死是有效的。特别是可以显着有效地抑制经皮腔内冠状动脉成形术（PTCA）后再狭窄的发生。

5. 发明申请

WO1994002168A1 NOVEL MEDICINAL COMPOSITION 审中-公开
标题翻译：新型药物组合物
公开(公告)号：WO1994002168A1
公开(公告)日：1994-02-03
申请号：PCT/JP1993000984
申请日：1993-07-15
申请人： KIRIN BEER KABUSHIKI KAISHA
发明人： KIRIN BEER KABUSHIKI KAISHA , KOEZUKA, Yasuhiko , KABAYA, Koji , MOTOKI, Kazuhiro
IPC分类号： A61K37/20
CPC分类号： C07H15/10 , A61K31/70 , C07H15/04
摘要： A medicinal composition comprising at least one compound represented by general formula (A), specifically a myeloid cell growth promoter, a radiation damage protective and a thrombocytopenia remedy, wherein R represents ((alpha)), (R2 being H or OH, and X being an integer of 0 to 26) or -(CH2)7CH=CH(CH2)7CH3; R1 represents a substituent selected from the group consisting of -CH2(CH2)YCH3, -CH(OH)(CH2)YCH3, -CH(OH)(CH2)YCH(CH3)2 and -CH=CH(CH2)YCH3; and Y represents an integer of 5 to 17.
摘要翻译：一种药物组合物，其包含至少一种由通式（A）表示的化合物，特别是骨髓细胞生长促进剂，辐射损伤保护性和血小板减少症治疗，其中R表示（（α）），（R2为H或OH，X 为0〜26的整数）或 - （CH 2）7 CH = CH（CH 2）7 CH 3; R1表示选自-CH2（CH2）YCH3，-CH（OH）（CH2）YCH3，-CH（OH）（CH2）YCH（CH3）2和-CH = CH（CH2）YCH3的取代基; Y表示5〜17的整数。

6. 发明申请

WO1993005055A1 NOVEL SPHINGOGLYCOLIPID AND USE THEREOF 审中-公开
标题翻译：新型亲水性及其用途
公开(公告)号：WO1993005055A1
公开(公告)日：1993-03-18
申请号：PCT/JP1992000561
申请日：1992-04-28
申请人： KIRIN BEER KABUSHIKI KAISHA
发明人： KIRIN BEER KABUSHIKI KAISHA , HIGA, Tatsuo , AKIMOTO, Koji; , KOEZUKA, Yasuhiko; , SAKAI, Teruyuki; , MORITA, Masahiro; , NATORI, Takenori;
IPC分类号： C07H15/10
CPC分类号： C07H15/10 , C12P19/44
摘要： A novel sphingoglycolipid represented by general formula (A), wherein R represents -CH(R2)-(CH2)X-H or -(CH2)7CH=CH(CH2)7-CH3; R1 represents -CH(R2)-(CH2)Y-R3 or -CH=CH-(CH2)Y-CH3; R2 represents H or OH; R3 represents methyl, isopropyl or sec-butyl; X represents an integer of 0 to 26; and Y represents an integer of 5 to 17. An antineoplastic agent and an immunopotentiator containing at least one abovementioned compound as an active ingredient. A process for preparing a sphingoglycolipid by taking a specified sphingoglycolipid out of a sponge Agelas mauritianus.
摘要翻译：由通式（A）表示的新型鞘糖脂，其中R表示-CH（R 2） - （CH 2）x -H或 - （CH 2）7 CH = CH（CH 2）7 -CH 3; R1表示-CH（R2） - （CH2）Y-R3或-CH = CH-（CH2）Y-CH3; R2表示H或OH; R3表示甲基，异丙基或仲丁基; X表示0〜26的整数， Y表示5〜17的整数。含有至少一种上述化合物作为有效成分的抗肿瘤药和免疫增强剂。通过从海绵Agelas mauritianus中摄取特定的鞘糖脂来制备鞘糖脂的方法。

7. 发明申请

WO1990015811A1 SPICAMYCIN X AND ITS USE 审中-公开
标题翻译： SPICAMYCIN X及其用途
公开(公告)号：WO1990015811A1
公开(公告)日：1990-12-27
申请号：PCT/JP1990000781
申请日：1990-06-14
申请人： KIRIN BEER KABUSHIKI KAISHA , OTAKE, Noboru , KAWAI, Hiroyuki; , KAMISHOHARA, Masaru;
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： Spicamycin X represented by formula (I) and acid addition salts thereof have an anti-neoplastic activity. It is produced by, for example, culturing a microorganism to produce a spicamycin mixture, hydrolyzing the mixture to give a spicamycin aminonucleotide, and chemically modifiying the nucleotide.
摘要翻译：由式（I）表示的吐温霉素X及其酸加成盐具有抗肿瘤活性。它通过例如培养微生物以产生spicamycin混合物产生，水解该混合物以得到一个spicamycin氨基核苷酸，并化学修饰该核苷酸。

8. 发明申请

WO1990011679A1 ARTIFICIAL SEED SOWING MACHINE 审中-公开
标题翻译：人造种子机
公开(公告)号：WO1990011679A1
公开(公告)日：1990-10-18
申请号：PCT/JP1990000444
申请日：1990-03-31
申请人： KIRIN BEER KABUSHIKI KAISHA , SUZUKI, Akira , MATSUDA, Shoichi , KAWATA, Hironori , SAKAMOTO, Yuji , SUZUKI, Katsuhito
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A01C07/16
CPC分类号： A01C7/04
摘要： In an artificial seed sowing machine, a feed hopper (3) for supplying bulb- and capsule-like artificial seeds (C) to a dispersing plate (1) is provided and dispersing holes (1A) capable of storing a large number of artificial seeds (C) are bored equidistantly in the dispersing plate (1). A plurality of vallies (1B) are formed in parallel along the dispersing holes (1A) so as to form the rolling direction of the artificial seeds (C) and a sowing plate (2) is disposed below and in close contact with the dispersing plate (1). Furthermore, as many sowing holes (2A) as the number of dispersing holes (1A) and in comformity with the latter are formed in this sowing plate (2). A rocking device (4) for rocking the dispersing plate (1) and the sowing plate (2) by a predetermined angle and a sliding device (5) for sliding the dispersing plate (1) by a predetermined distance relative to the sowing plate (2) are disposed.

9. 发明申请

WO1987007477A1 MARGARINE WITH FERMENTATION TASTE 审中-公开
标题翻译：玛格丽特与发酵的味道
公开(公告)号：WO1987007477A1
公开(公告)日：1987-12-17
申请号：PCT/JP1986000295
申请日：1986-06-13
申请人： KIRIN BEER KABUSHIKI KAISHA , TANIMURA, Syuya , FUKAZAWA, Koichiro , ISHINO, Katsuhiko , ONODA, Daisaku
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A23D03/00
CPC分类号： A23D7/001
摘要： Margarine with a fermentation taste, which contains 0.3 to 5 wt % (in terms of milk solids) (based on the sum of the milk solids, water, and fatty component) of fermented butter milk. This margarine is hardly scorched when used in heat cooking and has a good fermentation taste.
摘要翻译：具有发酵味道的人造黄油，其含有0.3至5重量％（以乳固体计）（基于乳固体，水和脂肪组分的总和）的发酵奶油。当用于热烹饪时，这种人造黄油几乎不被烧焦并具有良好的发酵味道。

10. 发明申请

WO1997005246A1 DNA STRANDS ENCODING GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 审中-公开
标题翻译：编码甘油-3-磷酸酯酶的DNA结构
公开(公告)号：WO1997005246A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996001844
申请日：1996-07-03
申请人： KIRIN BEER KABUSHIKI KAISHA , FERRI, Stefano , TOGURI, Toshihiro
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： C12N15/00
CPC分类号： C12N9/1029 , C12N15/8247 , C12N15/8273
摘要： Techniques relating to DNA strands having a bioengineering productivity of glycerol-3-phosphate acyltransferase (ATase) which is useful in the conversion of a membrane lipid PG into one having improved cold resistance, more particularly, a chimeric gene wherein the central region (about 1/3; cleaved with Kpn I and Hind III) of glycerol-3-phosphate ATase cDNA originating in pumpkin has been replaced by the corresponding region of spinach ATase cDNA; a chimeric gene wherein the central region (about 1/6; cleaved with Hind III Sac I) of cDNA originating in pumpkin has been replaced by cDNA originating in spinach; or a chimeric gene wherein the 3'-terminal region (about 1/3; cleaved with Kpn I and Eco RI) of cDNA of ATase originating in spinach has been replaced by the corresponding region of cDNA of pumpkin ATase. Such chimeric genes can express a chimeric ATase having an enhanced substrate-specificity for unsaturated fatty acids. When this DNA strand is transduced into a low-temperature-sensitive plant and expressed therein, an increased cold resistance can be imparted to the plant compared with the case with the use of an ATase gene originating in a known cold-resistant plant.
摘要翻译：涉及具有甘油-3-磷酸酰基转移酶（ATase）的生物工程生产力的DNA链的技术，其可用于将膜脂质PG转化为具有改善的耐寒性的组合物，更具体地，涉及嵌合基因，其中中心区域（约1 / 3;用Kpn I和Hind III切割）源自南瓜的甘油-3-磷酸ATase cDNA已被相应的菠菜ATase cDNA区域取代; 一种嵌合基因，其中源自南瓜的cDNA的中心区域（约1/6;用Hind III Sac I切割）已经被源自菠菜的cDNA替代; 或其中源自菠菜的ATase的cDNA的3'末端区域（约1/3;用Kpn I和Eco RI切割）已经被南瓜ATase的cDNA的相应区域替代的嵌合基因。这样的嵌合基因可以表达对不饱和脂肪酸具有增强的底物特异性的嵌合ATase。当将该DNA链转导入低温敏感性植物并在其中表达时，与使用来自已知耐寒植物的ATase基因的情况相比，可以赋予植物更高的耐寒性。

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