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1. 发明申请

WO2004093759A8 THERMAL THERAPY SLEEVE 审中-公开
标题翻译：热疗法套管
公开(公告)号：WO2004093759A8
公开(公告)日：2004-12-16
申请号：PCT/US2004004065
申请日：2004-02-11
申请人： KIMBERLY CLARK CO , AGARWAL NAVEEN , FISH JEFFREY E , WEART ILONA F , WILLIS JEFFREY M
发明人： AGARWAL NAVEEN , FISH JEFFREY E , WEART ILONA F , WILLIS JEFFREY M
IPC分类号： A61F7/00 , A61F7/02 , A61F7/03
CPC分类号： A61F7/03 , A61F7/106 , A61F2007/0098 , A61F2007/023 , A61F2007/0276 , A61F2007/0292
摘要： A flexible thermal therapy sleeve (50) is disclosed. The sleeve includes a first layer (52) including a first phase change material (56) having a transition temperature of from about -10°C to about 40°C, and a second layer (58) including a second phase change material having a transition temperature of from about 35°C to about 65°C. The first layer is joined to the second layer to form at least a partial enclosure having an opening through which a thermoactive material may be inserted and removed.
摘要翻译：公开了一种柔性热疗套（50）。所述套筒包括第一层（52）和第二层（58），所述第一层包括具有约-10℃至约40℃的转变温度的第一相变材料（56），所述第二层包括第二相变材料，所述第二相变材料具有从约35℃至约65℃的转变温度。第一层连接到第二层以形成至少一个具有开口的部分外壳，热活性材料可通过该开口插入和移除。

2. 发明申请

WO2009047663A2 SYSTEM FOR PROVIDING A METHOD FOR APPLYING A SKIN SEALANT HAVING A PHASE CHANGE VISUAL INDICATING COMPONENT 审中-公开
标题翻译：提供具有相变视觉指示组件的皮肤密封剂的方法的系统
公开(公告)号：WO2009047663A2
公开(公告)日：2009-04-16
申请号：PCT/IB2008053779
申请日：2008-09-17
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
IPC分类号： A61M35/00
CPC分类号： A61M35/003 , A61B2017/00495
摘要： A system for providing a method of sealing skin with a film forming polymer is provided. The system includes providing an at least two part applicator containing a sealant composition in one or more frangible containers, providing instructions for using the applicator associated therewith, where the method including moving at least one of said applicator parts from a first position to a second position and applying said sealant to skin. The composition has film former, a plasticizer and 3000 to 10000 ppm of a dye that changes color when is undergoes a phase change. The color change is visible to a human eye under normal light conditions. changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.
摘要翻译：提供了一种用于提供用成膜聚合物密封皮肤的方法的系统。该系统包括在一个或多个易碎容器中提供含有密封剂组合物的至少两个部分施用器，其提供使用与其相关联的施用器的指导，其中所述方法包括将所述施用器部件中的至少一个从第一位置移动到第二位置并将所述密封剂施加到皮肤上。该组合物具有成膜剂，增塑剂和3000至10000ppm的染料，当发生相变时颜色变化。在正常光照条件下，人眼可见颜色变化。可以使用改变的染料来表示组合物已经干燥。染料根据相变而变色，即成膜剂的干燥。染料可以直接添加到组合物中，并入施用器上的海绵中，组合物通过其分配和施加，单独施用或从单独的储存器同时施用。可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。

3. 发明申请

WO2010070588A3 PLASTICIZER FOR THERMOPLASTIC POLYMER MATERIALS 审中-公开
标题翻译：用于热塑性聚合物材料的增塑剂
公开(公告)号：WO2010070588A3
公开(公告)日：2010-10-28
申请号：PCT/IB2009055771
申请日：2009-12-15
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
发明人： MACDONALD JOHN GAVIN , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
IPC分类号： C08L67/04 , C08J5/00 , C08K5/15
CPC分类号： C08K5/0016 , A61L15/42 , A61L29/141 , A61L31/141 , C08K5/0033 , C08K5/1545 , C08L67/04
摘要： A thermoplastic polymeric composition having a xanthene or xanthenes-based compound as a plasticizer, a method to modify the thermoplastic polymeric materials to increase their relative plasticity while maintaining good strength or "toughness" characteristics, and various articles of manufacture that can be made using the polymer composition are described.
摘要翻译：一种热塑性聚合物组合物，其具有基于x吨或x吨基的化合物作为增塑剂，改性热塑性聚合物材料以增加其相对可塑性同时保持良好强度或“韧性”特性的方法，以及可使用描述了聚合物组合物。

4. 发明申请

WO2011077281A3 SKIN PREPARATION THAT IMMOBILIZES BACTERIA 审中-公开
标题翻译：皮肤准备，可以固定细菌
公开(公告)号：WO2011077281A3
公开(公告)日：2011-11-17
申请号：PCT/IB2010055330
申请日：2010-11-22
申请人： KIMBERLY CLARK CO , SCHORR PHILLIP A , HOFFMAN DOUGLAS R , WEART ILONA F , YANG KAIYUAN
发明人： SCHORR PHILLIP A , HOFFMAN DOUGLAS R , WEART ILONA F , YANG KAIYUAN
IPC分类号： A61B19/08 , A61F13/02 , A61L15/20 , A61L15/42 , A61L31/14
CPC分类号： A61K31/00 , A61K31/05 , A61K31/14 , A61K31/155 , A61K33/00 , A61K33/18 , A61K47/32 , A61L26/0014 , A61L26/0066 , C08L33/12
摘要： Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. This two step process is time consuming, as each layer must dry before the next one is applied. A skin preparation is provided that immobilizes at least 95 percent of bacteria on the skin and is essentially free of cyanoacrylate. The skin preparation has a fugitive solvent and may also have antimicrobial compounds like iodophors, biguanides, phenols, quaternary amines, antibiotics and metals. This skin preparation may be used without an additional skin sealant or incise applied over it prior to surgery.
摘要翻译：通常将皮肤密封剂施用于皮肤制备物上以密封皮肤并在手术切口之前将任何残留的细菌保持在适当的位置。这种密封胶通常在手术后留在皮肤上。这两个步骤过程非常耗时，因为在应用下一个层之前，每层必须干燥。提供了一种皮肤制剂，其将至少95％的细菌固定在皮肤上并且基本上不含氰基丙烯酸酯。该皮肤制剂具有挥发性溶剂，并且还可以具有抗微生物化合物，如碘伏，双胍，酚，季胺，抗生素和金属。这种皮肤准备可以在手术前使用，而不需要额外的皮肤密封剂或切口。

5. 发明申请

WO2010001291A3 SEALANT APPLICATOR AND METHOD 审中-公开
标题翻译：密封剂涂布器和方法
公开(公告)号：WO2010001291A3
公开(公告)日：2010-04-08
申请号：PCT/IB2009052652
申请日：2009-06-20
申请人： KIMBERLY CLARK CO , BREWER JOHN , CESA JOSEPH A , HOUDE AJAY Y , WEART ILONA F
发明人： BREWER JOHN , CESA JOSEPH A , HOUDE AJAY Y , WEART ILONA F
IPC分类号： A45D34/04 , A45D34/00 , A61K8/37
CPC分类号： A61M35/003 , A61B17/00491 , A61B2017/00495
摘要： An applicator and associated method for applying a microbial sealant system and methods for controlling the polymerization of a microbial sealant, the applicator having a housing; a first reservoir element associated with the housing, the first reservoir element containing a polymerization control liquid; a first applicator element adapted to apply a substantially uniform layer polymerization control liquid to the skin; and a second reservoir element integrated with the housing and containing a liquid composed of cyanoacrylate pre-polymers that having polymerization characteristics influenced by the polymerization control liquid, the second reservoir being in fluid communication with a second applicator element adapted to apply a substantially uniform layer of the cyanoacrylate pre-polymers over the layer of polymerization control liquid.
摘要翻译：一种用于施用微生物密封剂系统的施用器和相关方法以及用于控制微生物密封剂聚合的方法，所述施用器具有壳体; 与所述壳体相关联的第一储存器元件，所述第一储存器元件包含聚合控制液体; 第一涂敷器元件，其适于将基本上均匀的层聚合控制液体施加至皮肤; 以及第二储存器元件，与壳体集成并且容纳由氰基丙烯酸酯预聚物组成的液体，所述液体具有受聚合控制液体影响的聚合特性，第二储存器与第二涂敷器元件流体连通，所述第二涂敷器元件适于将基本均匀的在聚合控制液体层上的氰基丙烯酸酯预聚物。

6. 发明申请

WO2009060327A3 COVERAGE INDICATING TECHNOLOGY FOR SKIN SEALANTS USING TANNATES 审中-公开
标题翻译：使用TANNATES的皮肤密封剂的覆盖技术指标
公开(公告)号：WO2009060327A3
公开(公告)日：2009-09-24
申请号：PCT/IB2008054072
申请日：2008-10-03
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
IPC分类号： A61L24/04 , G01N31/22
CPC分类号： A61K33/18 , A61K9/0014 , A61K47/26 , A61K47/44
摘要： A composition having various color changing tannates may be used to indicate that the composition has dried. The tannates change color in contact with an acid. The composition may be, for example, a skin prep, skin sealant, food product, paint or other building material or other product that undergoes a phase change. The tannate may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of tannate in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure.
摘要翻译：具有各种变色丹宁酸的组合物可用于表示组合物已干燥。丹宁酸改变与酸接触的颜色。组合物可以是例如皮肤制剂，皮肤密封剂，食品，油漆或其他建筑材料或经历相变的其它产品。丹宁酸可以直接添加到组合物中，并入施用组合物中的海绵中，组合物通过其分配和施用，单独施用或从单独的储存器同时施用。可以调整组合物中的单宁酸盐的量，以向使用者提供视觉提示和施用范围。

7. 发明申请

WO2010070524A3 XANTHENE-BASED PLASTICIZER OF RESINS AND POLYMERS 审中-公开
标题翻译：基于XANTHENE的树脂和聚合物增塑剂
公开(公告)号：WO2010070524A3
公开(公告)日：2010-09-30
申请号：PCT/IB2009055562
申请日：2009-12-08
申请人： KIMBERLY CLARK CO , MACDONALD JOHN G , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
发明人： MACDONALD JOHN G , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
IPC分类号： C08K5/151 , C08K5/1575 , C08L33/20
CPC分类号： A61K9/0014 , A61K47/32 , C08K5/0016 , C08K5/1545
摘要： A composition of matter for increasing the relative flexibility and plasticity of crystalline or semi-crystalline resins and polymers is described. In particular, the compositions include xanthene or anthene-based molecular structures that can increase the plastic properties of curable resins or thermosetting polymers when incorporated into the polymer material. Certain uses for such a polymeric composition are also provided.
摘要翻译：描述了用于增加结晶或半结晶树脂和聚合物的相对柔性和可塑性的物质组合物。特别地，组合物包括呫吨或基于铕的分子结构，其可以在掺入聚合物材料时增加可固化树脂或热固性聚合物的塑性。还提供了这种聚合物组合物的某些用途。

8. 发明申请

WO2009047655A3 PHASE CHANGE VISUAL INDICATING COMPOSITION 审中-公开
标题翻译：相变视觉指示组合物
公开(公告)号：WO2009047655A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008052825
申请日：2008-07-14
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
IPC分类号： A61K8/00 , A61K49/00 , C12Q1/04
CPC分类号： A61K33/18 , A61L26/0061 , A61L26/0066 , A61L26/0071 , A61L2300/202 , A61L2300/404 , A61L2300/442
摘要： A skin sealant composition of a film former and a plasticizer and having various color changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.
摘要翻译：可以使用成膜剂和增塑剂并具有各种变色染料的皮肤密封剂组合物来表示组合物已经干燥。染料根据相变而变色，即成膜剂的干燥。染料可以直接添加到组合物中，并入施用器上的海绵中，组合物通过其分配和施加，单独施用或从单独的储存器同时施用。可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。

9. 发明公开

EP2358814A4 PLASTICIZER FOR THERMOPLASTIC POLYMER MATERIALS 有权
标题翻译：增塑剂用于热塑性高分子材料
公开(公告)号：EP2358814A4
公开(公告)日：2014-10-08
申请号：EP09833046
申请日：2009-12-15
申请人： KIMBERLY CLARK CO
发明人： MACDONALD JOHN GAVIN , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
IPC分类号： C08K5/00 , A61L15/42 , A61L29/14 , C08J5/00 , C08K5/1545 , C08L67/04
CPC分类号： C08K5/0016 , A61L15/42 , A61L29/141 , A61L31/141 , C08K5/0033 , C08K5/1545 , C08L67/04
摘要： A thermoplastic polymeric composition having a xanthene or xanthenes-based compound as a plasticizer, a method to modify the thermoplastic polymeric materials to increase their relative plasticity while maintaining good strength or "toughness" characteristics, and various articles of manufacture that can be made using the polymer composition are described.

10. 发明公开

EP1513542A4 ANTI-CANCER AND WOUND HEALING COMPOUNDS 审中-公开
标题翻译：抗癌和伤口愈合化合物
公开(公告)号：EP1513542A4
公开(公告)日：2009-07-15
申请号：EP02759399
申请日：2002-08-15
申请人： KIMBERLY CLARK CO
发明人： QUIRK STEPHEN , WEART ILONA F
IPC分类号： A61K38/00 , A61K38/55 , A61P17/00 , C07K14/00 , C07K14/50 , C07K14/81 , C12N9/99 , A61K38/03 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/16
CPC分类号： C07K14/8146 , A61K38/00
摘要： The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.

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