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1. 发明专利

CA2632353C VACCINE ADJUVANTS COMPRISING MYCOBATERIUM 未知
公开(公告)号：CA2632353C
公开(公告)日：2018-02-20
申请号：CA2632353
申请日：2006-04-21
申请人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADAN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
发明人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADAN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
IPC分类号： C12N1/20 , A61K39/00
摘要： The invention relates. to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen (s) with pharmaceutical acceptable carrier and its uses. Mycobacterium w and or its constituents when administered with antigen (s) to mammal results in enhanced immunogenicity of antigen. The enhanced immunogenicity manifests as humoral responses as well as cell mediated immunity. The adjuvant effect is seen with variety of antigens in various mammals irrespective of their immune status at the time of administration of Mycobacterium w and antigen containing composition, e.g. immune naÊve or preimmunised status.

2. 发明申请

WO2006114680A8 VACCINE ADJUVANTS 审中-公开
公开(公告)号：WO2006114680A8
公开(公告)日：2008-08-14
申请号：PCT/IB2006000978
申请日：2006-04-21
申请人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADAN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
发明人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADAN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
IPC分类号： C12N1/20
CPC分类号： A61K39/39 , A61K2039/55594
摘要： The invention relates. to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen (s) with pharmaceutical acceptable carrier and its uses. Mycobacterium w and or its constituents when administered with antigen (s) to mammal results in enhanced immunogenicity of antigen. The enhanced immunogenicity manifests as humoral responses as well as cell mediated immunity. The adjuvant effect is seen with variety of antigens in various mammals irrespective of their immune status at the time of administration of Mycobacterium w and antigen containing composition, e.g. immune naÊve or preimmunised status.
摘要翻译：本发明涉及涉及含有抗原与药学上可接受的载体及其用途的新型佐剂分枝杆菌及其组分和含佐剂的组合物。当向哺乳动物施用抗原时，分枝杆菌和/或其成分导致抗原的增强的免疫原性。增强的免疫原性表现为体液应答以及细胞介导的免疫。在施用分枝杆菌和含抗原的组合物时，各种哺乳动物中的各种抗原可以观察到佐剂效果，而不管其免疫状态如何。免疫原或免疫前状态。

3. 发明专利

AU2006238906B2 Vaccine adjuvants 未知
公开(公告)号：AU2006238906B2
公开(公告)日：2013-04-11
申请号：AU2006238906
申请日：2006-04-21
申请人： DESAI NIRAV , GHOSH PRASANTA KUMAR , KHAMAR BAKULESH MAFATLAL , MODI INDRAVADN AMBALAL , MODI RAJIV INDRAVADAN
发明人： KHAMAR BAKULESH MAFATLAL , GHOSH PRASANTA KUMAR , MODI INDRAVADN AMBALAL , MODI RAJIV INDRAVADAN , DESAI NIRAV
IPC分类号： C12N1/20 , A61K39/00
摘要： The invention relates. to a novel adjuvant

4. 发明申请

WO2008114119A3 P38 INHIBITORS 审中-公开
标题翻译： P38抑制剂
公开(公告)号：WO2008114119A3
公开(公告)日：2009-12-23
申请号：PCT/IB2008000633
申请日：2008-03-18
申请人： CADILA PHARMACEUTICALS LTD , MODI INDRAVADAN AMBALAL , GHOSH PRASANTA KUMAR , BHARDWAJ DEVESH , DESAI NIRAV M , KHAMAR BAKULESH MAFATLAL
发明人： MODI INDRAVADAN AMBALAL , GHOSH PRASANTA KUMAR , BHARDWAJ DEVESH , DESAI NIRAV M , KHAMAR BAKULESH MAFATLAL
IPC分类号： A01N47/28 , A61K31/17
CPC分类号： A61K35/74
摘要： The invention relates to novel p38 MAPK inhibitor which involves Mycobacterium w and/or its constituents in pharmaceutically acceptable carriers and their uses. Mycobacterium w and/or its constituents when administered to mammal results in p38 inhibition The inhibition is found to last more than 28 days. It is also found to induce inhibition of TNF-alfa. it suppresses cytokines in a pattern identical to Glucocorticoids. In transforms cells it also induces apoptosis. P38 mediated conditions include inflammation, cell differentiation, cell proliferation, cell inhibition, cell cycle regulation, anti-inflammatory reactions, immune modulation, vascularization, response to external stimuli and angiogenesis. The use of Mycobacterium w (Mw) and / or constituents of Mycobacterium w for inhibition of p38 protein kinase i.e. (i) to induce apoptosis in transformed cells (ii) for inhibition of TNF-alfa (iii) for inhibition of cytokines.
摘要翻译：本发明涉及新颖的p38MAPK抑制剂，其涉及在药学上可接受的载体中的分枝杆菌和/或其成分及其用途。当对哺乳动物施用时，分枝杆菌w和/或其成分导致p38抑制。发现抑制持续超过28天。还发现诱导TNF-α的抑制。它以与糖皮质激素相似的模式抑制细胞因子。在转化细胞时，它也诱导细胞凋亡。 P38介导的病症包括炎症，细胞分化，细胞增殖，细胞抑制，细胞周期调节，抗炎反应，免疫调节，血管化，对外部刺激的反应和血管生成。使用分枝杆菌w（Mw）和/或组织分枝杆菌w来抑制p38蛋白激酶，即（i）诱导转化细胞凋亡（ii）抑制TNF-α（iii）抑制细胞因子。

5. 发明申请

WO2006114680A2 VACCINE ADJUVANTS 审中-公开
公开(公告)号：WO2006114680A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006000978
申请日：2006-04-21
申请人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADN AMBALAL CADILA , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
发明人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADN AMBALAL CADILA , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K2039/55594
摘要： The invention relates. to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen (s) with pharmaceutical acceptable carrier and its uses. Mycobacterium w and or its constituents when administered with antigen (s) to mammal results in enhanced immunogenicity of antigen. The enhanced immunogenicity manifests as humoral responses as well as cell mediated immunity. The adjuvant effect is seen with variety of antigens in various mammals irrespective of their immune status at the time of administration of Mycobacterium w and antigen containing composition, e.g. immune naÊve or preimmunised status.
摘要翻译：本发明涉及涉及含有抗原与药学上可接受的载体及其用途的新型佐剂分枝杆菌及其组分和含佐剂的组合物。当向哺乳动物施用抗原时，分枝杆菌和/或其成分导致抗原的增强的免疫原性。增强的免疫原性表现为体液应答以及细胞介导的免疫。在施用分枝杆菌和含抗原的组合物时，各种哺乳动物中的各种抗原可以观察到佐剂效果，而不管其免疫状态如何。免疫原或免疫前状态。

6. 发明专利

GB2442408A Vaccine adjuvants 未知
公开(公告)号：GB2442408A
公开(公告)日：2008-04-02
申请号：GB0801474
申请日：2006-04-21
申请人： CADILA PHARMACEUTICALS LTD , MODI INDRAVADAN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAI
发明人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADAN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAI
IPC分类号： A61K39/04 , A61K35/74 , A61K39/00 , A61K39/395 , A61P35/00 , A61P37/04
摘要： The invention relates. to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition which contains antigen (s) with pharmaceutical acceptable carrier and its uses. Mycobacterium w and or its constituents when administered with antigen (s) to mammal results in enhanced immunogenicity of antigen. The enhanced immunogenicity manifests as humoral responses as well as cell mediated immunity. The adjuvant effect is seen with variety of antigens in various mammals irrespective of their immune status at the time of administration of Mycobacterium w and antigen containing composition, e.g. immune na¬ve or preimmunised status.

7. 发明专利

GB2442408B Mycobacterium W as an adjuvant 未知
公开(公告)号：GB2442408B
公开(公告)日：2010-06-30
申请号：GB0801474
申请日：2006-04-21
申请人： CADILA PHARMACEUTICALS LTD , MODI INDRAVADN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
发明人： KHAMAR BAKULESH MAFATLAL , MODI INDRAVADN AMBALAL , MODI RAJIV INDRAVADAN , GHOSH PRASANTA KUMAR , DESAI NIRAV
IPC分类号： A61K39/04 , A61K35/74 , A61K39/00 , A61K39/395 , A61P35/00 , A61P37/04
摘要： The invention relates to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen(s) with pharmaceutical acceptable carrier and its uses. Mycobacterium w and or its constituents when administered with antigen(s) to mammal results in enhanced immunogenicity of antigen. The enhanced immunogenicity manifests as humoral responses as well as cell mediated immunity. The adjuvant effect is seen with variety of antigens in various mammals irrespective of their immune status at the time of administration of Mycobacterium w and antigen containing composition. e.g. immune naïve or preimmunized status.

8. 发明专利

CA2632353A1 VACCINE ADJUVANTS 未知
公开(公告)号：CA2632353A1
公开(公告)日：2006-11-02
申请号：CA2632353
申请日：2006-04-21
申请人： GHOSH PRASANTA , KHAMAR BAKULESH , MODI RAJIV INDRAVADAN , MODI INDRAVADN , DESAI NIRAV
发明人： GHOSH PRASANTA KUMAR , KHAMAR BAKULESH MAFATLAL , MODI RAJIV INDRAVADAN , MODI INDRAVADAN AMBALAL , DESAI NIRAV
IPC分类号： C12N1/20 , A61K39/00
摘要： The invention relates to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen(s) with pharmaceutical acceptable carrier and its uses. Mycobacterium w and or its constituents when administered with antigen(s) to mammal results in enhanced immunogenicity of antigen. The enhanced immunogenicity manifests as humoral responses as well as cell mediated immunity. The adjuvant effect is seen with variety of antigens in various mammals irrespective of their immune status at the time of administration of Mycobacterium w and antigen containing composition. e.g. immune naïve or preimmunized status.

9. 发明专利

JPH10330406A PRODUCTION OF POLYMERIC, HYDROPHILIC NANO-PARTICLE 失效
公开(公告)号：JPH10330406A
公开(公告)日：1998-12-15
申请号：JP13397197
申请日：1997-05-23
申请人： MAITRA AMARNATH , GHOSH PRASANTA KUMAR , DE TAPAS K , SAHOO SANJEEB KUMAR
发明人： MAITRA AMARNATH , GHOSH PRASANTA KUMAR , DE TAPAS K , SAHOO SANJEEB KUMAR
IPC分类号： A61K47/30 , A61K9/51 , B01J13/04 , B01J13/18 , C08F2/32 , C08F2/44 , C08F6/16 , C08F26/10 , C08L39/06
摘要： PROBLEM TO BE SOLVED: To provide a method for producing highly monodisperse, polymeric, hydrophilic nano-particles with or without a target molecule, having 100 mm or more in size and high in monodisperse capacity. SOLUTION: This method comprises steps of (1) dissolving a surfactant in oil to produce a reverse micelle, (2) adding an aqueous solution of a monomer or polymer formed beforehand, a crosslinking agent, an initiator, an additive and, as required, a target material to the reverse micelle obtained in the above step, (3) polymerizing the above mixture, (4) removing the solvent and drying the polymerization product to produce a dried polymer containing the dried nano-particles and surfactant, (5) dispersing the dried polymer in an aqueous buffer liquid, and (6) removing the surfactant and other toxic components from the above system.

10. 发明专利

IN191203B A process for preparation of pharmaceutical composition of paclitaxol entrapped into a polymeric micelles nanoparticles 未知
公开(公告)号：IN191203B
公开(公告)日：2003-10-04
申请号：IN263DE1999
申请日：1999-02-17
申请人： MAITRA AMARNATH PROF , SAHOO SANJEEV KUMAR DR , GHOSH PRASANTA KUMAR , DABUR RES FOUNDATION
发明人： MAITRA AMARNATH PROF , SAHOO SANJEEV KUMAR DR , GHOSH PRASANTA KUMAR
IPC分类号： A61K9/51 , A61K31/337 , A61K31/00
摘要： This invention relates to pharmaceutical formulations of paclitaxel, its derivatives or analogs entrapped into nanoparticles of co-polymeric micelles, a process for preparing the same and the use thereof.

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