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1. 发明申请

WO2007115115A2 TARGETED MR IMAGING AGENTS 审中-公开
标题翻译：目标成像剂
公开(公告)号：WO2007115115A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065533
申请日：2007-03-29
申请人： KEREOS INC , LANZA GREGORY M , WICKLINE SAMUEL A , KIEFER GARRY E , ATHEY PHILLIP S
发明人： LANZA GREGORY M , WICKLINE SAMUEL A , KIEFER GARRY E , ATHEY PHILLIP S
IPC分类号： G06Q40/00
CPC分类号： A61K49/1812 , A61K49/085 , A61K49/10 , A61K49/106 , C07D257/02
摘要： MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.
摘要翻译：使用顺磁性药剂和化学交换饱和转移（paraCEST）并与靶向颗粒递送载体相结合的MRI造影剂提供足够浓度的对比剂造影剂以获得目标组织或器官的有用图像。此外，可以用预饱和射频脉冲打开或关闭图像对比度，避免了获得预注射和后注射图像的必要性。

2. 发明申请

WO2009151788A3 UNIVERSAL ANCHOR PEPTIDE FOR NANOPARTICLES 审中-公开
标题翻译：通用锚固剂用于纳米颗粒
公开(公告)号：WO2009151788A3
公开(公告)日：2010-06-24
申请号：PCT/US2009041000
申请日：2009-04-17
申请人： UNIV WASHINGTON , WICKLINE SAMUEL A , PAN HUA , SOMAN NEELESH R , LANZA GREGORY M , SCHLESINGER PAUL H
发明人： WICKLINE SAMUEL A , PAN HUA , SOMAN NEELESH R , LANZA GREGORY M , SCHLESINGER PAUL H
IPC分类号： A61K38/00 , A61K9/127
CPC分类号： A61K9/5123 , A61K49/1806
摘要： The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.
摘要翻译：本发明提供了能够稳定地插入脂质膜中的基本上非裂解性的非细胞毒性锚定肽。特别地，本发明提供包含稳定插入的锚定肽的纳米颗粒，其可以缀合到各种不同的货物配合物。

3. 发明申请

WO2007100715A2 CELL LABELING WITH PERFLUOROCARBON NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY 审中-公开
标题翻译：用于磁共振成像和光谱的全氟碳纳米管的细胞标记
公开(公告)号：WO2007100715A2
公开(公告)日：2007-09-07
申请号：PCT/US2007004823
申请日：2007-02-23
申请人： UNIV WASHINGTON , WICKLINE SAMUEL A , LANZA GREGORY M
发明人： WICKLINE SAMUEL A , LANZA GREGORY M
CPC分类号： A61K49/1896 , B82Y5/00
摘要： Methods of obtaining cells internally labeled with perfluorocarbon nanoparticles suitable for magnetic resonance imaging and spectroscopy are disclosed. Also disclosed are methods for obtaining magnetic resonance imaging data from labeled cells under clinically relevant scan times and field strengths. Finally, the application further discloses methods of specifically detecting and distinguishing magnetic resonance imaging and spectroscopy data from two distinct sets of cells labeled with distinct types of perfluorocarbon nanoparticles.
摘要翻译：公开了获得内部标记有适用于磁共振成像和光谱学的全氟化碳纳米颗粒的细胞的方法。还公开了用于在临床相关扫描时间和场强下从标记细胞获得磁共振成像数据的方法。最后，本申请还公开了用不同类型的全氟化碳纳米颗粒标记的两组不同组的细胞特异性检测和区分磁共振成像和光谱数据的方法。

4. 发明申请

WO2006096499A3 MR CORONARY ANGIOGRAPHY WITH A FLUORINATED NANOPARTICLE CONTRAST AGENT AT 1.5 T 审中-公开
标题翻译：与1.5T的氟化纳米对比剂的冠状动脉造影
公开(公告)号：WO2006096499A3
公开(公告)日：2007-04-05
申请号：PCT/US2006007579
申请日：2006-03-03
申请人： UNIV WASHINGTON , WICKLINE SAMUEL A , LANZA GREGORY M
发明人： WICKLINE SAMUEL A , LANZA GREGORY M
IPC分类号： A61K51/12
CPC分类号： B82Y5/00 , A61K49/1806
摘要： Disclosed herein is a medical imaging technique that uses a fluorinated nanoparticle contrast agent for imaging of an interior portion of a body. The fluorinated nanoparticles preferably comprise nontargeted intravascular fluorocarbon or perfluorocarbon nanoparticles. The interior body portion may be a patient's vasculature, and the medical imaging is preferably noninvasive MR angiography, which may encompass (either for 2D imaging or 3D imaging) MR coronary angiography, MR carotid angiography, MR peripheral angiography, MR cerebral angiography, MR arterial angiography, and MR venous angiography. Coils tuned to match to the 19 F signal can be used, or dual tuned coils for 19 F and 1 H imaging can be used. Clinical field strengths (e.g.. 1.5T) and clinical doses may be used while still providing effective images.
摘要翻译：本文公开了一种医疗成像技术，其使用氟化纳米颗粒造影剂来成像身体的内部部分。氟化纳米颗粒优选包含非靶向的血管内碳氟化合物或全氟化碳纳米颗粒。内部主体部分可以是患者的脉管系统，并且医学成像优选为非侵入性MR血管造影术，其可以包括（用于2D成像或3D成像）MR冠状动脉造影，MR颈动脉血管造影术，MR外周血管造影术，MR脑血管造影术，MR动脉血管造影和MR静脉血管造影。可以使用调谐到与^{19F信号相匹配的线圈，或者可以使用用于<20> F和<1> H / H成像的双调谐线圈。可以使用临床场强（例如1.5T）和临床剂量，同时仍然提供有效图像。}

5. 发明申请

WO2004067483A3 CHELATING AGENTS WITH LIPOPHILIC CARRIERS 审中-公开
标题翻译：用脂质载体螯合剂
公开(公告)号：WO2004067483A3
公开(公告)日：2004-11-25
申请号：PCT/US2004002257
申请日：2004-01-26
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A
发明人： LANZA GREGORY M , WICKLINE SAMUEL A
IPC分类号： A61K49/18 , C07F9/10 , A61K51/00
CPC分类号： C07F9/10 , A61K49/103 , A61K49/1806
摘要： Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
摘要翻译：可用于与纳米粒子或微粒乳剂结合以获得磁共振图像的化合物允许控制信号的弛豫性并容易与粒状组分相结合。

6. 发明申请

WO2005086639A3 IMPROVED EFFICACY AND SAFETY OF TARGETED PARTICULATE AGENTS WITH DECOY SYSTEMS 审中-公开
标题翻译：改进的针对吸引系统的颗粒剂的有效性和安全性
公开(公告)号：WO2005086639A3
公开(公告)日：2005-11-24
申请号：PCT/US2005004858
申请日：2005-02-10
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A
发明人： LANZA GREGORY M , WICKLINE SAMUEL A
IPC分类号： A61K9/127 , A61K9/14 , A61K9/51 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12
CPC分类号： A61K9/1075 , A61K9/127 , A61K49/0002 , A61K51/1234 , A61K51/1244 , B82Y5/00
摘要： A decoy inactive carrier composition is administered simultaneously with a targeted composition containing vehicles for delivering a desired agent to a biological target. This simultaneous administration enhances the delivery of the targeted composition to the desired location in a subject.
摘要翻译：将诱饵非活性载体组合物与含有载体的靶向组合物同时施用以将期望的试剂递送至生物学靶标。这种同时给药增强了靶向组合物向受试者所需位置的递送。

7. 发明申请

WO2005051305A3 ENHANCED DRUG DELIVERY 审中-公开
标题翻译：增强药物递送
公开(公告)号：WO2005051305A3
公开(公告)日：2005-08-04
申请号：PCT/US2004039095
申请日：2004-11-19
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A
发明人： LANZA GREGORY M , WICKLINE SAMUEL A
IPC分类号： A61K20060101 , A61K9/00 , A61K9/127 , A61K9/51 , A61K41/00 , A61K47/48 , A61K49/00
CPC分类号： A61K9/0009 , A61K9/1075 , A61K41/0047 , A61K47/6909 , A61K51/0408 , A61K51/1227
摘要： The invention is directed to methods for the delivery of a therapeutic agent using lipid-encapsulated particles containing the therapeutic agent and ultrasound energy. For example, it particularly relates to the use of ultrasound with a lipid-encapsulated emulsion comprising an oil where the emulsion is coupled a targeting ligand and comprises a therapeutic agent.
摘要翻译：本发明涉及使用含有治疗剂和超声能量的脂质包封颗粒递送治疗剂的方法。例如，它特别涉及超声与包含油的脂质包封的乳液的使用，其中乳液与靶向配体偶联并且包含治疗剂。

8. 发明申请

WO02060524A2 ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS 审中-公开
标题翻译：增强超声波检测与温度相关对比剂
公开(公告)号：WO02060524A2
公开(公告)日：2002-08-08
申请号：PCT/US0202631
申请日：2002-01-30
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S
发明人： LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S
IPC分类号： G01R33/28 , A61B5/055 , A61B8/00 , A61K9/133 , A61K49/00 , A61K49/04 , A61K49/22 , A61K51/00 , A61N
CPC分类号： A61K49/223 , A61K49/226 , Y10S514/937 , Y10S514/938
摘要： Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.
摘要翻译：公开了基于与超声目标结合的温度依赖性造影剂的改变温度和超声反射率的用于增强超声检测的方法和装置。所述方法和装置可用于单独增强成像或与药物递送联合使用，具有治疗方法如热疗或冷冻治疗或其它成像方式。

9. 发明申请

WO2007127958A2 DETECTION AND IMAGING OF TARGET TISSUE 审中-公开
标题翻译：靶组织的检测与成像
公开(公告)号：WO2007127958A2
公开(公告)日：2007-11-08
申请号：PCT/US2007067701
申请日：2007-04-27
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A
发明人： LANZA GREGORY M , WICKLINE SAMUEL A
IPC分类号： A61K49/10
CPC分类号： A61K49/1809 , A61K49/0041 , A61K49/0082 , A61K49/0093 , A61K51/122
摘要： Methods for high resolution imaging of a suspected target tissue are encompassed by the invention. Such methods include administering low resolution and high resolution contrast agents specific to targeted cells or tissues. The contrast agents are allowed to bind to the target cells or accumulate in a target tissue. A low resolution imaging technique is used to localize an accumulation of the low resolution contrast agent in a target tissue. A high resolution image of the target tissue is then obtained to localize an accumulation of the higher resolution contrast agent, allowing the generation of a higher resolution image than that obtained by the use of the low resolution contrast agent alone. These methods may utilize nanoparticles optionally in an emulsion as a contrast agent.
摘要翻译：本发明涵盖用于疑似目标组织的高分辨率成像的方法。这些方法包括施用对靶细胞或组织特异的低分辨率和高分辨率造影剂。允许造影剂结合靶细胞或积聚在靶组织中。低分辨率成像技术用于定位低分辨率造影剂在目标组织中的积聚。然后获得目标组织的高分辨率图像以定位较高分辨率造影剂的积聚，从而允许产生比单独使用低分辨率造影剂所获得的图像更高分辨率的图像。这些方法可以将乳剂任选地用于乳剂中作为造影剂。

10. 发明申请

WO02060524A9 ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS 审中-公开
标题翻译：增强超声波检测与温度相关对比剂
公开(公告)号：WO02060524A9
公开(公告)日：2004-01-08
申请号：PCT/US0202631
申请日：2002-01-30
申请人： BARNES JEWISH HOSPITAL , LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S
发明人： LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S
IPC分类号： G01R33/28 , A61B5/055 , A61B8/00 , A61K9/133 , A61K49/00 , A61K49/04 , A61K49/22 , A61K51/00 , A61B5/05 , A61B5/06 , A61K9/107 , A61K9/127 , A61K9/14
CPC分类号： A61K49/223 , A61K49/226 , Y10S514/937 , Y10S514/938
摘要： Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.
摘要翻译：公开了基于与超声目标结合的温度依赖性造影剂的改变温度和超声反射率的用于增强超声检测的方法和装置。所述方法和装置可用于单独增强成像或与药物递送联合使用，具有治疗方法如热疗或冷冻治疗或其它成像方式。

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