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1. 发明申请

WO2009039145A1 POLYURETHANE POLYMER SYSTEMS 审中-公开
标题翻译：聚氨酯聚合物体系
公开(公告)号：WO2009039145A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/076614
申请日：2008-09-17
申请人： DOW GLOBAL TECHNOLOGIES INC. , WORLEY, William, G. , SHAH, Harshad, M. , ATHEY, Phillip, S. , BRUCHERTSEIFER, Christian , MUELLER, Gerhard
发明人： WORLEY, William, G. , SHAH, Harshad, M. , ATHEY, Phillip, S. , BRUCHERTSEIFER, Christian , MUELLER, Gerhard
IPC分类号： C08G18/69 , C08G18/48 , C08G18/50 , C08G18/10
CPC分类号： C09D175/04 , C08G18/10 , C08G18/12 , C08G18/4808 , C08G18/4825 , C08G18/4841 , C08G18/5021 , C08G18/69 , C08G18/7664 , C08G2150/90 , C08G18/6685 , C08G18/6674 , C08G18/66 , C08G18/6594
摘要： The present invention is to the preparation and application of isocyanate based polymers, particularly polyurethane and polyurea elastomeric polymers. By incorporating polybutadiene with a polyether polyol in a polyurethane system, the produced elastomer have improved chemical resistance as compared to conventional polyurethane elastomers. For polyurea elastomer, the incorporation of high functional polyols or crosslinkers with polybutadiene gives elastomer with improved chemical resistance as compared to conventional polyurea elastomers.
摘要翻译：本发明涉及异氰酸酯基聚合物，特别是聚氨酯和聚脲弹性体聚合物的制备和应用。通过在聚氨酯体系中加入聚丁二烯与聚醚多元醇，与常规聚氨酯弹性体相比，所生产的弹性体具有改善的耐化学性。对于聚脲弹性体，与常规聚脲弹性体相比，高官能多元醇或交联剂与聚丁二烯的结合产生具有改善的耐化学性的弹性体。

2. 发明申请

WO2005049096A2 CHELANTS WITH ENHANCED BLOOD RETENTION 审中-公开
标题翻译：具有增强血液保留的化痰
公开(公告)号：WO2005049096A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/037769
申请日：2004-11-12
申请人： DOW GLOBAL TECHNOLOGIES INC. , ATHEY, Phillip, S. , KIEFER, Garry, E. , SIMON, Jaime , FRANK, R. Keith , ADAIR, Christopher , GULYAS, Gyongyi
发明人： ATHEY, Phillip, S. , KIEFER, Garry, E. , SIMON, Jaime , FRANK, R. Keith , ADAIR, Christopher , GULYAS, Gyongyi
IPC分类号： A61K51/06
CPC分类号： A61K51/065 , A61K49/085 , A61K49/126 , A61K49/14 , A61K51/0497 , A61K51/088
摘要： The present invention is a pharmaceutical composition that exhibits enhanced IP blood retention, the composition comprising: a biotargeting molecule; and a chelating agent conjugated to the biotargeting molecule; wherein the composition exhibits a half-life in the bloodstream of from 15 minutes to 24 hours. The present invention is also directed to the use of functionalized chelants to modify the pharmacokinetics of radiopharmaceuticals. Compared with non-functionalized chelants, chelants functionalized with bulky and/or lipophilic groups can slow down the renal clearance and enhance the blood retention of metals complexed therewith. This enhanced blood retention leads to increased uptake of metal in target tissue.
摘要翻译：本发明是一种具有增强的IP血液保留性的药物组合物，该组合物包含：生物靶向分子; 和与生物靶向分子缀合的螯合剂; 其中所述组合物在血液中的半衰期为15分钟至24小时。本发明还涉及功能化螯合剂用于改变放射性药物的药代动力学的用途。与非官能化螯合剂相比，用大体积和/或亲脂基团官能化的螯合剂可以减慢肾清除率并增强与其结合的金属的血液保持性。这种增强的血液保留导致靶组织中金属的摄取增加。

3. 发明申请

WO2013102097A3 CYCLIC AMINE COMPOUNDS, COMPOSITIONS, AND POLYURETHANE FOAMS MADE THEREFROM 审中-公开
标题翻译：循环胺化合物，组合物和聚氨酯纤维素
公开(公告)号：WO2013102097A3
公开(公告)日：2013-10-10
申请号：PCT/US2012072095
申请日：2012-12-28
申请人： DOW GLOBAL TECHNOLOGIES LLC , LATHAM DWIGHT D , ATHEY PHILLIP S , KING STEPHEN W
发明人： LATHAM DWIGHT D , ATHEY PHILLIP S , KING STEPHEN W
IPC分类号： C07D295/13 , C08G18/32
CPC分类号： C08G18/2081 , C07D295/13 , C08G18/14 , C08G18/18 , C08G18/2027 , C08G18/3218 , C08G18/4816 , C08G18/4829 , C08G18/4841 , C08G18/7657 , C08G18/7664 , C08G2101/00 , C08G2101/005 , C08G2101/0083 , C08J9/144 , C08J9/146 , C08J2375/08
摘要： The present invention describes cyclic amine compounds useful for catalysts for polyurethane form-forming compositions. The cyclic amine compounds of the invention provide distinct benefits for reaction compositions, methods, and polyurethane foams based on their desirable physical and catalytic properties.
摘要翻译：本发明描述了可用于聚氨酯形成组合物的催化剂的环胺化合物。基于其所需的物理和催化性质，本发明的环胺化合物为反应组合物，方法和聚氨酯泡沫提供了明显的益处。

4. 发明申请

WO2012154473A1 CURABLE COMPOSITION FOR USE AS LOST CIRCULATION MATERIAL 审中-公开
标题翻译：可固化组合物用作失效循环材料
公开(公告)号：WO2012154473A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036213
申请日：2012-05-03
申请人： DOW GLOBAL TECHNOLOGIES LLC , ATHEY, Phillip S. , OBI, Bernard E. , POINDEXTER, Michael K.
发明人： ATHEY, Phillip S. , OBI, Bernard E. , POINDEXTER, Michael K.
IPC分类号： C09K8/035 , C08G18/00 , C09K8/508
CPC分类号： C09K8/035 , C08G18/672 , C09D175/16 , C09K8/5086 , C08G18/48
摘要： The present invention relates to compositions and methods for reducing or preventing the loss of drilling fluids and other well servicing fluids into a subterranean formation during drilling or construction of boreholes in said formation. Specifically, this invention comprises a curable composition capable of free radical polymerization for creating lost circulation material in-situ. The curable composition comprises an organic compound capable of free radical (co)polymerization represented by the formula (I) : wherein x is an integer from 1 to 8; Fp comprises one or more moiety comprising a free radical polymerizable group; L is an organic moiety comprising a (substituted) aromatic or (substituted) aliphatic group comprising one or more O, N, S, or combinations thereof; and Q comprises a substituted or unsubstituted mono- or polyvalent organic radical comprising one or one or more moiety selected from alkyl, alkylene, alkenyl, cycloalkyl, cycloalkylene, aryl, aralkyl, alkaryl, poly(oxyalkylene), poly(carboalkoxyalkylene), a substituted heterocyclic radical, or an unsubstituted heterocyclic radical.
摘要翻译：本发明涉及用于减少或防止在所述地层钻孔或构造井眼期间钻井液和其它维修良好的流体进入地下地层的组合物和方法。具体地说，本发明包括一种可自由基聚合的可固化组合物，用于原位产生流失物质。可固化组合物包含能够由式（I）表示的自由基（共）聚合的有机化合物：其中x是1至8的整数; Fp包含一个或多个包含自由基可聚合基团的部分; L是包含（取代的）芳族或（取代的）脂族基团的有机部分，其包含一个或多个O，N，S或其组合; 和Q包括取代或未取代的单价或多价有机基团，其包含一个或一个或多个选自烷基，亚烷基，烯基，环烷基，亚环烷基，芳基，芳烷基，烷芳基，聚（氧亚烷基），聚（碳烷氧基亚烷基）杂环基或未取代的杂环基。

5. 发明申请

WO2007115115A2 TARGETED MR IMAGING AGENTS 审中-公开
标题翻译：目标成像剂
公开(公告)号：WO2007115115A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065533
申请日：2007-03-29
申请人： KEREOS INC , LANZA GREGORY M , WICKLINE SAMUEL A , KIEFER GARRY E , ATHEY PHILLIP S
发明人： LANZA GREGORY M , WICKLINE SAMUEL A , KIEFER GARRY E , ATHEY PHILLIP S
IPC分类号： G06Q40/00
CPC分类号： A61K49/1812 , A61K49/085 , A61K49/10 , A61K49/106 , C07D257/02
摘要： MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.
摘要翻译：使用顺磁性药剂和化学交换饱和转移（paraCEST）并与靶向颗粒递送载体相结合的MRI造影剂提供足够浓度的对比剂造影剂以获得目标组织或器官的有用图像。此外，可以用预饱和射频脉冲打开或关闭图像对比度，避免了获得预注射和后注射图像的必要性。

6. 发明申请

WO2005049096A3 PROTEIN AND POLYMER CONJUGATES AS CHELANTS WITH ENHANCED BLOOD RETENTION 审中-公开
标题翻译：蛋白质和聚合物作为具有增强血液保持力的药物
公开(公告)号：WO2005049096A3
公开(公告)日：2005-12-29
申请号：PCT/US2004037769
申请日：2004-11-12
申请人： DOW GLOBAL TECHNOLOGIES INC , ATHEY PHILLIP S , KIEFER GARRY E , SIMON JAIME , FRANK R KEITH , ADAIR CHRISTOPHER , GULYAS GYONGYI
发明人： ATHEY PHILLIP S , KIEFER GARRY E , SIMON JAIME , FRANK R KEITH , ADAIR CHRISTOPHER , GULYAS GYONGYI
IPC分类号： A61K49/08 , A61K49/14 , A61K51/04 , A61K51/06 , A61K51/08
CPC分类号： A61K51/065 , A61K49/085 , A61K49/126 , A61K49/14 , A61K51/0497 , A61K51/088
摘要： The present invention is a pharmaceutical composition that exhibits enhanced IP blood retention, the composition comprising: a biotargeting molecule; and a chelating agent conjugated to the biotargeting molecule; wherein the composition exhibits a half-life in the bloodstream of from 15 minutes to 24 hours. The present invention is also directed to the use of functionalized chelants to modify the pharmacokinetics of radiopharmaceuticals. Compared with non-functionalized chelants, chelants functionalized with bulky and/or lipophilic groups can slow down the renal clearance and enhance the blood retention of metals complexed therewith. This enhanced blood retention leads to increased uptake of metal in target tissue.
摘要翻译：本发明是一种具有增强的IP血液保留性的药物组合物，该组合物包含：生物靶向分子; 和与生物靶向分子缀合的螯合剂; 其中所述组合物在血液中的半衰期为15分钟至24小时。本发明还涉及功能化螯合剂用于改变放射性药物的药代动力学的用途。与非官能化螯合剂相比，用大体积和/或亲脂基团官能化的螯合剂可以减慢肾清除率并增强与其结合的金属的血液保持性。这种增强的血液保留导致靶组织中金属的摄取增加。

7. 发明申请

WO2013102097A2 CYCLIC AMINE COMPOUNDS, COMPOSITIONS, AND POLYURETHANE FOAMS MADE THEREFROM 审中-公开
标题翻译：环胺类化合物，组合物和由此制备的聚氨酯泡沫
公开(公告)号：WO2013102097A2
公开(公告)日：2013-07-04
申请号：PCT/US2012/072095
申请日：2012-12-28
申请人： DOW GLOBAL TECHNOLOGIES LLC , LATHAM, Dwight D. , ATHEY, Phillip S. , KING, Stephen W.
发明人： LATHAM, Dwight D. , ATHEY, Phillip S. , KING, Stephen W.
IPC分类号： C07D295/13 , C08G18/32
CPC分类号： C08G18/2081 , C07D295/13 , C08G18/14 , C08G18/18 , C08G18/2027 , C08G18/3218 , C08G18/4816 , C08G18/4829 , C08G18/4841 , C08G18/7657 , C08G18/7664 , C08G2101/00 , C08G2101/005 , C08G2101/0083 , C08J9/144 , C08J9/146 , C08J2375/08
摘要： The present invention describes cyclic amine compounds useful for catalysts for polyurethane form-forming compositions. The cyclic amine compounds of the invention provide distinct benefits for reaction compositions, methods, and polyurethane foams based on their desirable physical and catalytic properties.
摘要翻译：本发明描述了用于形成聚氨酯形式的组合物的催化剂的环胺化合物。基于它们所需的物理和催化性质，本发明的环胺化合物为反应组合物，方法和聚氨酯泡沫提供了明显的益处。

8. 发明申请

WO2013028292A1 CYCLIC CARBONATE MONOMERS AND POLYMERS PREPARED THEREFROM 审中-公开
标题翻译：循环碳酸单体和制备的聚合物
公开(公告)号：WO2013028292A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/047329
申请日：2012-07-19
申请人： DOW GLOBAL TECHNOLOGIES LLC , MARKS, Maurice J. , BULICK, Allen S. , ATHEY, Phillip S. , LATHAM, Dwight D.
发明人： MARKS, Maurice J. , BULICK, Allen S. , ATHEY, Phillip S. , LATHAM, Dwight D.
IPC分类号： C08G59/24 , C07D317/40
CPC分类号： C07D317/36 , C07D317/40 , C08G71/04
摘要： A cyclic carbonate monomer including the reaction product of (a) a divinylarene dioxide, and (b) carbon dioxide; a process for making the cyclic carbonate monomer; and a polymer such as a poly(hydroxyurethane) composition made therefrom. The poly(hydroxyurethane) composition made from the above cyclic carbonate monomer forms a reactive intermediate that can be used for making, for example, a poly(hydroxyurethane) foam product.
摘要翻译：包含（a）二乙烯基芳烃二氧化物和（b）二氧化碳的反应产物的环状碳酸酯单体; 制备环状碳酸酯单体的方法; 和由其制成的聚（羟基氨基甲酸酯）组合物的聚合物。由上述环状碳酸酯单体制成的聚（羟基氨基甲酸酯）组合物形成可用于制备例如聚（羟基氨基甲酸酯）泡沫产品的反应性中间体。

9. 发明申请

WO2013003061A1 IMPROVED PROCESS FOR MAKING LOW VISCOSITY, FAST CURING SILANE TERMINATED POLYMERS 审中-公开
标题翻译：用于制造低粘度的改进方法，快速固化硅烷终止聚合物
公开(公告)号：WO2013003061A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/042444
申请日：2012-06-14
申请人： DOW GLOBAL TECHNOLOGIES LLC , VYAKARANAM, Kamesh R. , ZHANG, Ling , MINNIKANTI, Venkat S. , DUGGAL, Rajat , KOONCE, William A. , SINGH, Amarnath , ATHEY, Phillip S.
发明人： VYAKARANAM, Kamesh R. , ZHANG, Ling , MINNIKANTI, Venkat S. , DUGGAL, Rajat , KOONCE, William A. , SINGH, Amarnath , ATHEY, Phillip S.
IPC分类号： C08G18/10 , C08G18/28 , C08G18/71 , C08G18/76
CPC分类号： C08G18/10 , C08G18/289 , C08G18/718 , C08G18/7621 , C08G2190/00 , C08G18/4825 , C08G18/4829
摘要： Methods of producing a composition comprising a crosslinkable silane-terminated polymer having at least one crosslinkable silyl group in each molecule are provided. The method may comprise providing a polymer having at least one unsaturated group and at least one alcohol hydroxyl group in each molecule and having a number average molecular weight between about 100 and about 5,000, adding to the polymer a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out a hydrosilylation reaction to form a composition comprising hydrosilylated polymers, wherein the hydrosilylation reaction has a hydrosilylation efficiency greater than 50% as determined by 1 H-NMR, capping the hydrosilylated polymers by adding the hydrosilylated polymer to at least one isocyanate at an index of between about 100 and about 250, and reacting the isocyanate capped hydrosilylated polymer with a polyol having a nominal functionality of at least 2 to form the composition comprising a crosslinkable silane-terminated polymer.
摘要翻译：提供了包含在每个分子中具有至少一个交联性甲硅烷基的可交联硅烷封端的聚合物的组合物的方法。该方法可以包括提供在每个分子中具有至少一个不饱和基团和至少一个醇羟基并且数均分子量在约100至约5,000之间的聚合物，向聚合物中加入具有氢 - 硅键的化合物和每个分子中的可交联甲硅烷基和氢化硅烷化催化剂，由此进行氢化硅烷化反应以形成包含氢化硅烷化聚合物的组合物，其中氢化硅烷化反应的氢化硅烷化效率大于50％，如通过1 H-NMR确定的，氢化硅烷化聚合物由将氢化硅烷化聚合物以约100至约250的指数加入到至少一种异氰酸酯中，并使异氰酸酯封端的硅烷化聚合物与标称官能度至少为2的多元醇反应，以形成包含可交联硅烷封端的聚合物的组合物。

10. 发明申请

WO2009039130A1 PREPOLYMERS AND POLYMERS FOR ELASTOMERS 审中-公开
标题翻译：弹性体的制备物和聚合物
公开(公告)号：WO2009039130A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/076585
申请日：2008-09-17
申请人： DOW GLOBAL TECHNOLOGIES INC. , ATHEY, Phillip, S. , BAE, Woo-Sung
发明人： ATHEY, Phillip, S. , BAE, Woo-Sung
IPC分类号： C08G18/12 , C08G18/36 , C08G18/42 , C08G18/50 , C08G18/69
CPC分类号： C08G18/36 , C08G18/12 , C08G18/4288 , C08G18/5021 , C08G18/69 , C08G18/324 , C08G18/50 , C08G18/6685
摘要： The present invention is to the preparation and application of isocyanate based polymers, particularly polyurea elastomeric polymers. By incorporating polybutadiene with a natural oil based polyol in a thermoplastic system, particularly in the formation of a prepolymer the produced elastomer display good chemical resistance. Such prepolymers are an isocyanate terminate prepolymer wherein the polyol composition for the production of the prepolymer comprises a polybutadiene polyol and a natural oil based polyol.
摘要翻译：本发明涉及异氰酸酯基聚合物，特别是聚脲弹性体聚合物的制备和应用。通过将聚丁二烯与天然油基多元醇结合在热塑性体系中，特别是在预聚物的形成中，所制备的弹性体显示出良好的耐化学性。这种预聚物是异氰酸酯端基预聚物，其中用于制备预聚物的多元醇组合物包含聚丁二烯多元醇和天然油基多元醇。

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