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1. 发明专利

DE60041534D1 未知
公开(公告)号：DE60041534D1
公开(公告)日：2009-03-26
申请号：DE60041534
申请日：2000-03-20
申请人： KAEKONEN SANNA-MARIA , LOEVGREN TIMO , LUUKINEN HEIKKI , PETTERSSON KIM , VAEAENAENEN H KALERVO
发明人： KAEKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN KALERVO H
IPC分类号： G01N33/68
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

2. 发明专利

AT422672T 未知
公开(公告)号：AT422672T
公开(公告)日：2009-02-15
申请号：AT00914195
申请日：2000-03-20
申请人： KAEKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H KALERVO
发明人： KAEKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H
IPC分类号： G01N33/68
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

3. 发明专利

FI990693A0 未知
公开(公告)号：FI990693A0
公开(公告)日：1999-03-29
申请号：FI990693
申请日：1999-03-29
申请人： KAEKOENEN SANNA MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H KALERVO
发明人： KAEKOENEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H KALERVO
IPC分类号： G01N33/68
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

4. 发明专利

ES2320848T3 PROCEDIMIENTO PARA LA PREDICCION DE FRACTURAS OSEAS MEDIANTE MEDICIONES DE OSTEOCALCINA. 未知
公开(公告)号：ES2320848T3
公开(公告)日：2009-05-29
申请号：ES00914195
申请日：2000-03-20
申请人： KAKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOVGREN TIMO , VAANANEN H KALERVO
发明人： KAKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOVGREN TIMO , VAANANEN H KALERVO
IPC分类号： G01N33/68
摘要： Procedimiento para la evaluación de la fragilidad ósea y el riesgo de fractura, o la osteoporosis, en una persona, que comprende las etapas siguientes a) medir la concentración de osteocalcina gamma-carboxilada (COC) por medio de por lo menos un anticuerpo monoclonal o policlonal o fragmento del mismo que es específico para la osteocalcina gammacarboxilada y siendo un anticuerpo o fragmento cuya especificidad para la osteocalcina gamma-carboxilada depende de la presencia de iones Ca 2+ , disminuyendo dicha especificidad en presencia de dichos iones Ca 2+ ; y también la concentración de osteocalcina intacta (IOC) u osteocalcina total (TOC) en una muestra de suero o de plasma de dicha persona, b) comparar la razón determinada COC/IOC o COC/TOC, para dicha persona con la razón media COC/IOC o la razón media COC/TOC, determinadas a partir de mediciones en unas muestras de fluidos corporales similares de la población del mismo sexo y edad, y c) utilizar la razón determinada COC/IOC o COC/TOC que es inferior a la razón media COC/IOC o la razón media COC/TOC como indicación de osteoporosis, fragilidad ósea o aumento del riesgo de fractura ósea en dicha persona.

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