专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1166122A1 METHOD FOR PREDICTION OF BONE FRACTURES BY OSTEOCALCIN MEASUREMENTS 有权
标题翻译：一种用于预测骨折的概率估算骨钙测
公开(公告)号：EP1166122A1
公开(公告)日：2002-01-02
申请号：EP00914195.3
申请日：2000-03-20
申请人： Käkonen, Sanna-Maria , Luukinen, Heikki , Pettersson, Kim , Lövgren, Timo , Väänänen, H. Kalervo
发明人： Käkonen, Sanna-Maria , Luukinen, Heikki , Pettersson, Kim , Lövgren, Timo , Väänänen, H. Kalervo
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N2333/78 , G01N2800/108 , Y10S435/81
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

2. 发明公开

EP0892927A1 ONE-STEP ALL-IN-ONE DRY REAGENT IMMUNOASSAY 失效
标题翻译：一步一体式干试剂免疫试剂盒
公开(公告)号：EP0892927A1
公开(公告)日：1999-01-27
申请号：EP97906208.0
申请日：1997-03-07
申请人： Pettersson, Kim , Lövgren, Timo
发明人： Pettersson, Kim , Lövgren, Timo
IPC分类号： G01N33
CPC分类号： G01N33/54393 , G01N2333/4712 , G01N2333/9123 , Y10S435/81 , Y10S435/962 , Y10S435/969 , Y10S436/80 , Y10S436/809
摘要： The invention relates to a novel competitive or non-competitive immunoassay comprising the steps of: immobilizing an assay specific component on a solid phase in a reaction well; adding a labelled assay specific component; drying said components; adding the sample containing the marker to be analyzed; allowing the marker to react with the assay specific components; and detecting the signal from the label. Furthermore, the invention relates to a device useful in carrying out the novel assay.
摘要翻译：本发明涉及新颖的竞争性或非竞争性免疫测定法，其包括以下步骤：将测定特异性组分固定在反应孔中的固相上; 添加标记的测定特异性组分; 干燥所述组分; 加入含有待分析标记的样品; 使标记与测定特异性组分反应; 并检测来自标签的信号。此外，本发明涉及用于实施新型测定的装置。

3. 发明授权

EP1166122B1 METHOD FOR PREDICTION OF BONE FRACTURES BY OSTEOCALCIN MEASUREMENTS 有权
标题翻译：一种用于预测骨折的概率估算骨钙测
公开(公告)号：EP1166122B1
公开(公告)日：2009-02-11
申请号：EP00914195.3
申请日：2000-03-20
申请人： Käkonen, Sanna-Maria , Luukinen, Heikki , Pettersson, Kim , Lövgren, Timo , Väänänen, H. Kalervo
发明人： Käkonen, Sanna-Maria , Luukinen, Heikki , Pettersson, Kim , Lövgren, Timo , Väänänen, H. Kalervo
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N2333/78 , G01N2800/108 , Y10S435/81
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

4. 发明公开

EP1473567A1 Immunoassay for cardiac troponin I 有权转让
标题翻译： ImmunotestverfahrenfürHerz-Troponin I
公开(公告)号：EP1473567A1
公开(公告)日：2004-11-03
申请号：EP04076042.3
申请日：2004-04-01
申请人： Eriksson, Susann , Pettersson, Kim
发明人： Eriksson, Susann , Pettersson, Kim
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N2333/4712 , Y10S435/962 , Y10S435/967 , Y10S435/973 , Y10T436/25125
摘要： This invention relates to a method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, said method being based on a sandwich immunoassay employing at least two capture antibodies and at least one tracer antibody, wherein

a first capture antibody is directed to the N-terminal part of cTnI, to the C-terminal part of cTnI or to the part of the cTnI midfragment, which is slightly affected by the interfering factor, and a second capture antibody is directed to another of the aforementioned parts, and
a tracer antibody is directed to the N-terminal part of cTnI, to the C-terminal part of cTnI or to TnC, which is complexed with cTnI.
摘要翻译：本发明涉及一种用于检测和/或定量来自个体血液的样品中心肌肌钙蛋白I（cTnI）的方法，所述方法基于采用至少两种捕获抗体和至少一种示踪抗体的夹心免疫测定法，其中将第一捕获抗体引导至cTnI的N末端部分，cTnI的C端部分或受到干扰因子稍微影响的cTnI中间片段的部分，第二种捕获抗体针对另一种的上述部分，并且示踪抗体被引导至cTnI的N末端部分，cTnI的C端部分或与cTnI复合的TnC。

5. 发明专利

ES2320848T3 PROCEDIMIENTO PARA LA PREDICCION DE FRACTURAS OSEAS MEDIANTE MEDICIONES DE OSTEOCALCINA. 未知
公开(公告)号：ES2320848T3
公开(公告)日：2009-05-29
申请号：ES00914195
申请日：2000-03-20
申请人： KAKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOVGREN TIMO , VAANANEN H KALERVO
发明人： KAKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOVGREN TIMO , VAANANEN H KALERVO
IPC分类号： G01N33/68
摘要： Procedimiento para la evaluación de la fragilidad ósea y el riesgo de fractura, o la osteoporosis, en una persona, que comprende las etapas siguientes a) medir la concentración de osteocalcina gamma-carboxilada (COC) por medio de por lo menos un anticuerpo monoclonal o policlonal o fragmento del mismo que es específico para la osteocalcina gammacarboxilada y siendo un anticuerpo o fragmento cuya especificidad para la osteocalcina gamma-carboxilada depende de la presencia de iones Ca 2+ , disminuyendo dicha especificidad en presencia de dichos iones Ca 2+ ; y también la concentración de osteocalcina intacta (IOC) u osteocalcina total (TOC) en una muestra de suero o de plasma de dicha persona, b) comparar la razón determinada COC/IOC o COC/TOC, para dicha persona con la razón media COC/IOC o la razón media COC/TOC, determinadas a partir de mediciones en unas muestras de fluidos corporales similares de la población del mismo sexo y edad, y c) utilizar la razón determinada COC/IOC o COC/TOC que es inferior a la razón media COC/IOC o la razón media COC/TOC como indicación de osteoporosis, fragilidad ósea o aumento del riesgo de fractura ósea en dicha persona.

6. 发明专利

FI20030140A0 未知
公开(公告)号：FI20030140A0
公开(公告)日：2003-01-30
申请号：FI20030140
申请日：2003-01-30
申请人： HELLMAN JUKKA , KAEKOENEN SANNA-MARIA , LOEVGREN TIMO , IVASKA KAISA , VAEAENAENEN KALERVO , PETTERSSON KIM
发明人： IVASKA KAISA , HELLMAN JUKKA , KAEKOENEN SANNA-MARIA , LOEVGREN TIMO , VAEAENAENEN KALERVO , PETTERSSON KIM
IPC分类号： C12Q20060101 , C12Q

7. 发明专利

FI990693A0 未知
公开(公告)号：FI990693A0
公开(公告)日：1999-03-29
申请号：FI990693
申请日：1999-03-29
申请人： KAEKOENEN SANNA MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H KALERVO
发明人： KAEKOENEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H KALERVO
IPC分类号： G01N33/68
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

8. 发明专利

DE60041534D1 未知
公开(公告)号：DE60041534D1
公开(公告)日：2009-03-26
申请号：DE60041534
申请日：2000-03-20
申请人： KAEKONEN SANNA-MARIA , LOEVGREN TIMO , LUUKINEN HEIKKI , PETTERSSON KIM , VAEAENAENEN H KALERVO
发明人： KAEKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN KALERVO H
IPC分类号： G01N33/68
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

9. 发明专利

AT422672T 未知
公开(公告)号：AT422672T
公开(公告)日：2009-02-15
申请号：AT00914195
申请日：2000-03-20
申请人： KAEKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H KALERVO
发明人： KAEKONEN SANNA-MARIA , LUUKINEN HEIKKI , PETTERSSON KIM , LOEVGREN TIMO , VAEAENAENEN H
IPC分类号： G01N33/68
摘要： This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC/IOC or COC/TOC for said person, is compared to the mean ratio COC/IOC or COC/TOC, (mean ratio COC/IOC or mean ratio COC/TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC/TOC that is lower than the mean ratio COC/TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

10. 发明专利

FI973371A0 未知
公开(公告)号：FI973371A0
公开(公告)日：1997-08-15
申请号：FI973371
申请日：1997-08-15
申请人： HELLMAN JUKKA , KAEKOENEN SANNA MARIA , KARP MATTI , LOEVGREN TIMO , VAEAENAENEN H KALERVO , PETTERSSON KIM
发明人： HELLMAN JUKKA , KAEKOENEN SANNA-MARIA , KARP MATTI , LOEVGREN TIMO , VAEAENAENEN H KALERVO , PETTERSSON KIM
IPC分类号： G01N33/53 , C07K14/47 , C07K14/78 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/68 , C07K

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式