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1. 发明申请

US20080188478A1 Compounds Useful In Therapy 审中-公开
标题翻译：化合物可用于治疗
公开(公告)号：US20080188478A1
公开(公告)日：2008-08-07
申请号：US11912592
申请日：2006-04-18
申请人： Justin Stephen Bryans , Mark Edward Bunnage , Patrick Stephen Johnson , Helen Janet Mason , Lee Richard Roberts , Thomas Ryckmans , Alan Stobie , Toby James Underwood
发明人： Justin Stephen Bryans , Mark Edward Bunnage , Patrick Stephen Johnson , Helen Janet Mason , Lee Richard Roberts , Thomas Ryckmans , Alan Stobie , Toby James Underwood
IPC分类号： A61K31/454 , C07D401/04 , C07D471/04 , A61K31/5025 , A61P25/00 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents a group selected from H, CF3, and C1-6 alkyl (optionally substituted by C1-6 alkyloxy or triazolyl); R2 represents halo; Ring A represents a 5- or 6-membered heterocyclic ring containing at least one N atom (the ring being optionally bridged with two or more carbon atoms); R3 represents a 5- or 6-membered heterocyclic ring containing at least one atom selected from N, O or S, the heterocyclic ring being optionally substituted by one or more groups selected from C1-6 alkyl oxo or NH2, the heterocyclic ring being further optionally fused to a 5- or 6-membered aryl or heterocyclic ring containing at least one atom selected from N, O or S, the fused aryl or heterocyclic ring being substituted by one or more halo atoms; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhea.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：R 1表示选自H，CF 3 N和C 1-6的基团，（任选被C 1-6烷氧基或三唑基取代）; R 2表示卤素; 环A表示含有至少一个N原子（该环任选地与两个或多个碳原子桥连）的5-或6-元杂环; R 3表示含有至少一个选自N，O或S的原子的5元或6元杂环，杂环任选被一个或多个选自C 1〜 -6个烷基氧基或NH 2，杂环进一步任选地与含有至少一个选自N，O或S的原子的5-或6-元芳基或杂环稠合稠合的芳基或杂环被一个或多个卤素原子取代; 可用于治疗指示V1a拮抗剂的疾病，特别是痛经。

2. 发明授权

US07745630B2 Triazolyl piperidine arginine vasopressin receptor modulators 失效
标题翻译：三唑基哌啶精氨酸加压素受体调节剂
公开(公告)号：US07745630B2
公开(公告)日：2010-06-29
申请号：US11009768
申请日：2004-12-10
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： A61K31/454 , C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D249/08 , C07D249/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Z, O, A, V, Y and Y′ are as defined herein; are useful for treating dysmenorreah.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：Z，O，A，V，Y和Y'如本文所定义; 对治疗dysmenorreah有用。

3. 发明授权

US08093400B2 Compounds useful in therapy 失效
标题翻译：化合物可用于治疗
公开(公告)号：US08093400B2
公开(公告)日：2012-01-10
申请号：US12777522
申请日：2010-05-11
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： C07D249/12 , C07D249/08 , C07D249/04 , A61K31/4196 , A61K31/4192
CPC分类号： C07D401/04 , C07D249/08 , C07D249/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的衍生物，其中变量Z，Q，环A，V，X，Y和Y'如本文所定义，以及包含这些化合物的药物组合物。式（I）化合物和包含它们的药物组合物可用于治疗指示V1a拮抗剂，特别是痛经的病症。

4. 发明申请

US20100317652A1 Compounds Useful In Therapy 失效
标题翻译：化合物可用于治疗
公开(公告)号：US20100317652A1
公开(公告)日：2010-12-16
申请号：US12777522
申请日：2010-05-11
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： A61K31/454 , C07D413/14 , C07D401/14 , C07D403/04 , C07D413/04 , A61K31/5377 , A61K31/506 , A61K31/4545 , A61K31/551 , A61K31/496 , A61P9/10 , A61P9/00 , A61P9/12 , A61P9/04 , A61P29/00 , A61P15/00 , A61P15/06
CPC分类号： C07D401/04 , C07D249/08 , C07D249/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的衍生物，其中变量Z，Q，环A，V，X，Y和Y'如本文所定义，以及包含这些化合物的药物组合物。式（I）化合物和包含它们的药物组合物可用于治疗指示V1a拮抗剂，特别是痛经的病症。

5. 发明申请

US20080234252A1 Compounds Useful in Therapy 审中-公开
标题翻译：化合物可用于治疗
公开(公告)号：US20080234252A1
公开(公告)日：2008-09-25
申请号：US11914688
申请日：2006-05-08
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： A61K31/55 , C07D249/08 , A61K31/4196 , C07D471/02 , C07D487/02 , A61P15/00 , A61K31/519 , A61K31/437 , C07D221/20 , C07D223/16
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D403/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D498/04
摘要： Compounds of formula (I), or a pharmaceutically acceptable salt, solvate, ester or amide thereof, wherein R1 represents [CH2]n—R2. R2 represents H, C1-6 alkyloxy or Het; n represents a number selected from 0 to 6; Het represents an unsaturated heterocycle of 5 or 6 atoms containing one or more heteroatoms selected from O, N, and S; R3 represents halo; Ring A represents a 4 to 7 membered, saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from O, N, and S; Ring B represents a saturated, partially saturated, or unsaturated heterocycle of from 3 to 8 atoms containing one or more heteroatoms selected from O, N, and S, or Ring B represents a saturated or unsaturated carbocyclic ring of from 3 to 8 atoms; Ring B is optionally fused to an aryl ring and is optionally substituted with one or more groups independently selected from R4; Ring A and Ring B share at least one atom; R4 represents oxo, [CH2]m—R5 or CH—R6R7; R5 represents H, OH, C1-6 alkyloxy, COOH, or CONR8R9; m represents a number selected from 0 or 1; and R6, R7, R8 and R9 independently represent H or C1-6 alkyl; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂合物，酯或酰胺，其中R 1表示[CH 2 N] -R <2> 。 R 2表示H，C 1-6烷氧基或Het; n表示选自0〜6的数; Het表示含有一个或多个选自O，N和S的杂原子的5或6个原子的不饱和杂环; R 3表示卤素; 环A表示含有一个或多个选自O，N和S的杂原子的4至7元饱和的，部分饱和的或不饱和的杂环; 环B表示含有一个或多个选自O，N和S的杂原子的3至8个原子的饱和，部分饱和或不饱和杂环，或环B表示3至8个原子的饱和或不饱和碳环; 环B任选地与芳环稠合并且任选地被一个或多个独立地选自R 4的基团取代; 环A和环B共享至少一个原子; R 4表示氧代，[CH 2 CH 2] m -R 5或CH-R 6， 7＆lt; 7＆gt;; R 5表示H，OH，C 1-6烷氧基，COOH或CONR 8 R 9; m表示选自0或1的数字; 且R 6，R 7，R 8和R 9独立地表示H或C 1〜 6烷基; 可用于治疗指示V1a拮抗剂的疾病，特别是痛经。

6. 发明申请

US20140017239A1 IGE CH3 Peptide Vaccine 审中-公开
标题翻译： IGE CH3肽疫苗
公开(公告)号：US20140017239A1
公开(公告)日：2014-01-16
申请号：US13904432
申请日：2013-05-29
申请人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号： A61K47/48 , A61K39/395
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

7. 发明申请

US20120294848A1 IGE CH3 Peptide Vaccine 有权
标题翻译： IGE CH3肽疫苗
公开(公告)号：US20120294848A1
公开(公告)日：2012-11-22
申请号：US13564103
申请日：2012-08-01
申请人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号： C07K17/00 , A61K39/395 , A61P37/02 , C07K16/00
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

8. 发明申请

US20110196011A1 SUBSTITUTED ARYLPYRAZOLES 有权
标题翻译：取代的芳基
公开(公告)号：US20110196011A1
公开(公告)日：2011-08-11
申请号：US13089423
申请日：2011-04-19
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/415 , C07D231/38 , A61P33/00 , A01N43/56 , A01P7/00
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
摘要翻译：本发明涉及包含式I化合物的组合产品，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 9如本文所述，以及本文所述的一种或多种其它生物活性化合物， - 寄生虫剂。

9. 发明授权

US09216229B2 IgE CH3 peptide vaccine 有权
标题翻译： IgE CH3肽疫苗
公开(公告)号：US09216229B2
公开(公告)日：2015-12-22
申请号：US13904432
申请日：2013-05-29
申请人： Alan Daniel Brown , Brian Robert Champion , Clare Lees , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人： Alan Daniel Brown , Brian Robert Champion , Clare Lees , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号： A61K38/04 , A61K47/48 , A61K39/00 , A61K39/395
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

10. 发明申请

US20140230133A1 PROTECTIVE INSERT FOR AN ITEM OF HEADWEAR 审中-公开
标题翻译：头盔保护插件
公开(公告)号：US20140230133A1
公开(公告)日：2014-08-21
申请号：US14347589
申请日：2012-10-09
申请人： Lee Richard Roberts
发明人： Lee Richard Roberts
IPC分类号： A42B3/12
CPC分类号： A42B3/12 , A42B1/08
摘要： A protective insert for an item of golfing headwear with integral rigid peak. The protective insert is configured to protect a user's head from injury caused by a golf ball.
摘要翻译：高尔夫球头保护插件，具有整体刚性高度。保护插入物被配置为保护使用者的头部不受高尔夫球引起的伤害。

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