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    • 10. 发明授权
    • Treatment of rumen acidosis with α-amylase inhibitors
    • 用α-淀粉酶抑制剂治疗瘤胃酸中毒
    • US07271158B2
    • 2007-09-18
    • US10774139
    • 2004-02-06
    • Bernard Joseph BanksMark Andrew HaxellGraham LunnMichael Stephen PaceyLee Richard Roberts
    • Bernard Joseph BanksMark Andrew HaxellGraham LunnMichael Stephen PaceyLee Richard Roberts
    • A01N43/04A61K31/715C07H1/00
    • A61K31/715A23K10/12A23K20/163A23K50/10A61K31/7016A61K31/702
    • The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase to a ruminant; a formulation suitable for the treatment of acidosis in an animal which comprises an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial α-amylase and/or α-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial α-amylase and/or α-glucosidase; a compound of the formula I: or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial α-amylase and/or α-glucosidase useful for the treatment of acidosis in a ruminant.
    • 本文描述的发明涉及:在制备用于治疗酸中毒的组合物中使用细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂; 一种治疗瘤胃酸中毒的方法,包括向反刍动物施用有效量的有效的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂; 适用于治疗动物中的酸中毒的制剂,其包含与适当的赋形剂,稀释剂或载体混合的有效抑制细菌α-淀粉酶和/或α-葡萄糖苷酶的方法,所述适合的赋形剂,稀释剂或载体相对于预期给药途径和标准药物 /兽医/农业实践; 用于鉴定用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的合适抑制剂的筛选方法; 一种改善反刍动物奶质量和/或量的方法,其包括用有效量的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂处理反刍动物; 式I化合物或兽医学上可接受的盐,溶剂合物(包括水合物)或其前药; 并且制备用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂的方法。