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1. 发明授权

US4601746A Substituted sulfonylurea, processes for the production of these compounds, as well as compositions containing the same and having herbicidal and plant growth regulating activity 失效
标题翻译：取代的磺酰脲，这些化合物的生产方法，以及含有这些化合物的组合物，并具有除草和植物生长调节活性
公开(公告)号：US4601746A
公开(公告)日：1986-07-22
申请号：US623134
申请日：1984-06-18
申请人： Jurgen Westermann , Gerhard Boroschewski , Ulrich Eder , Friedrich Arndt , Hansjorg Krahmer , Clemens Kotter
发明人： Jurgen Westermann , Gerhard Boroschewski , Ulrich Eder , Friedrich Arndt , Hansjorg Krahmer , Clemens Kotter
IPC分类号： C07D249/16 , A01N47/36 , A01P13/00 , C07C311/58 , C07D239/42 , C07D239/47 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/42 , C07D251/46 , C07D251/52 , C07D521/00 , C07D239/46
CPC分类号： C07C311/65 , A01N47/36 , C07D521/00
摘要： New substituted sulfonyl urea are disclosed of the general formula ##STR1## in which R.sub.1 is chlorine, --COOR.sub.5, --S(O).sub.n --R.sub.6 or ##STR2## R.sub.2 is ##STR3## or --CH.sub.2 --C.tbd.C--R.sub.11, R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,R.sub.4 is hydrogen C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino, or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,Z is --CH.dbd. or --N.dbd.,R.sub.5 is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkyl, phenyl, substituted phenyl, benzene or substituted benzene,R.sub.6 is C.sub.1 -C.sub.6 -alkyl or phenyl,R.sub.7 is C.sub.1 -C.sub.4 -alkyl,R.sub.8 is C.sub.1 -C.sub.4 -alkyl,R.sub.7 and R.sub.8 are independently C.sub.3 -C.sub.8 -cycloalkyl, morpholinyl, pyrrolidinyl, piperidyl or piperazinyl,R.sub.9 is hydrogen, chlorine, fluorine, or C.sub.1 -C.sub.3 -alkyl,R.sub.10 is hydrogen, chlorine, fluorine, trifluoromethyl or C.sub.1 -C.sub.3 -alkyl,R.sub.11 is hydrogen, chlorine, fluorine, cyano, C.sub.1 -C.sub.4 -alkyl or phenyl,X is oxygen or sulfur, andn is 0, 1 or 2, as well as processes for the preparation of these compounds and compositions having herbicidal and plant growth regulating effectiveness.
摘要翻译：公开了通式为I，其中R 1为氯，-COOR 5，-S（O）n -R 6或R 2为“或”-CH 2 -C 3 CON C-R 11“的新取代的磺酰脲， R 3是氢，C 1 -C 4 - 烷基，C 1 -C 4 - 烷硫基，卤素，卤素-C 1 -C 4烷基，卤素-C 1 -C 4 - 烷氧基，二-C 1 -C 3 - 烷基 - 氨基，C 1 -C 3烷基 - 氨基或C 1 -C 3 - 烷氧基-C 1 -C 3 - 烷氧基，R 4是C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 烷硫基，卤素，卤素-C 1 -C 4烷基，卤素-C 1 -C 4 - 烷氧基，二-C 1 -C 3 - 烷基 - 氨基，C 1 -C 3 - 烷基 - 氨基或C 1 -C 3 - 烷氧基-C 1 -C 3 - 烷氧基，Z是-CH =或-N =，R 5是C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 1 -C 3 - 烷氧基-C 1 -C 3 - 烷基，苯基，取代的苯基，苯或取代的苯，R 6是C 1 -C 6烷基或苯基，R 7是C 1 -C 4烷基，R 8是 C 1 -C 4 - 烷基，R 7和R 8独立地是C 3 -C 8 - 环烷基，吗啉基，吡咯烷基，哌啶基或哌嗪基，R 9是氢，氯，氟或C 1 -C 3烷基，R 10是氢，氯，氟，三氟甲基或 C 1 -C 3 - 烷基，R 11是氢，氯，氟，氰基，C 1 -C 4 - 烷基或苯基，X是氧或硫，n是0,1或2，以及制备具有除草和植物生长调节效力的这些化合物和组合物的方法。

2. 发明授权

US4591650A Hexanor-brassinolid-22-ethers 失效
标题翻译：己糖 - 油菜素合物-22-醚
公开(公告)号：US4591650A
公开(公告)日：1986-05-27
申请号：US579856
申请日：1984-02-13
申请人： Ulrich Kerb , Ulrich Eder , Hansjorg Krahmer
发明人： Ulrich Kerb , Ulrich Eder , Hansjorg Krahmer
IPC分类号： A01N43/22 , C07D313/06 , C07J9/00 , C07J31/00 , C07J73/00 , C07D313/10
CPC分类号： C07J73/003 , A01N43/22 , C07J31/006 , C07J9/00
摘要： New hexanor-brassinolid-22-ethers are disclosed, of the formula ##STR1## wherein Z is the group ##STR2## OR.sub.2 and OR.sub.3 are oriented cis 2.alpha., 3.alpha. or 2.beta., 3.beta., R.sub.2 and R.sub.3 are the same or different and are each hydrogen formyl, C.sub.2 -C.sub.7 -alkyl-CO--, C.sub.2 -C.sub.7 -alkoxy-C.sub.1 -C.sub.3 -alkyl-CO-- or aryl-CO--, and R.sub.23 is straight-chain or branched C.sub.1 -C.sub.7 -alkyl or C.sub.1 -C.sub.7 -alkoxy-C.sub.1 -C.sub.3 -alkyl. Also disclosed are processes for the production of these compounds as well as compositions containing the same having growth-regulatory activity for plants.
摘要翻译：公开了具有下式的新的六 - 油菜素合物-22-醚：其中Z是基团OR2，OR3定向为顺式2α，3α或2β，3β，R2和R3是相同的或不同的，各自为甲酰基，C 2 -C 7 - 烷基-CO - ，C 2 -C 7 - 烷氧基-C 1 -C 3 - 烷基-CO-或芳基-CO-，R 23为直链或支链C 1 -C 7 - 烷基或C 1 -C 7 - 烷氧基-C 1 -C 3 - 烷基。还公开了用于生产这些化合物的方法以及含有对植物具有生长调节活性的组合物。

3. 发明授权

US4826852A Novel ergolinyl compounds nitrogen-substituted in the 8-position, useful for treating dopamine deficiency 失效
标题翻译：在8-位氮取代的新型麦角酰基化合物，可用于治疗多巴胺缺乏症
公开(公告)号：US4826852A
公开(公告)日：1989-05-02
申请号：US878762
申请日：1986-06-26
申请人： Gregor Haffer , Gerhard Sauer , Helmut Wachtel , Herbert Schneider , Ulrich Eder
发明人： Gregor Haffer , Gerhard Sauer , Helmut Wachtel , Herbert Schneider , Ulrich Eder
IPC分类号： A61K31/48 , A61P9/12 , A61P25/00 , A61P25/18 , A61P25/28 , A61P43/00 , C07D457/04 , C07D457/06 , C07D457/12 , A61K31/44 , A61K31/54 , C07D417/14
CPC分类号： C07D457/04 , C07D457/06 , C07D457/12
摘要： Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) ##STR1## and physiologically compatible salts thereof, wherein (a) R.sup.1 is hydrogen, the 8-substituent can be in the .alpha.- or .beta.-position and ##STR2## represents a single or a double bond, R.sup.2 is hydrogen, C.sub.1-4 -alkyl or C.sub.1-7 -acyl,R.sup.3 is hydrogen, chlorine or bromine, andR.sup.4 is C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; or(b) R.sup.1 is ##STR3## and the 8-substituent can be in the .alpha.- or .beta.-position, ##STR4## represents a single or double bond, R.sup.2, R.sup.3 are as defined above,R.sup.4, is C.sub.1.varies.6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; andR.sup.5 is hydrogen, C.sub.-10 -alkyl, C.sub.3-10 -alkenyl, or C.sub.3-10 -alkynyl, andR.sup.6 is C.sub.1-10 -alkyl, C.sub.3-10 -alkenyl, C.sub.3-10 -alkynyl, or aryl, orR.sup.5 and R.sup.6 together with the connecting N-atom form a 5- to 10-membered heterocyclic ring, preferably 5- or 6-membered, which optionally can contain further heteroatoms.
摘要翻译：在8-位上被氮取代且具有式（I）的化合物和其生理上相容的盐，其中（a）R 1是氢，所述8-取代基可以是α-或β- - 位和表示单键或双键，R 2为氢，C 1-4 - 烷基或C 1-7 - 酰基，R 3为氢，氯或溴，且R 4为C 1-6 - 烷基，C 3-6 环烷基-C 1-3 - 烷基，C 3-6 - 烯基或C 3-6 - 炔基; 或（b）R 1是，并且8-取代基可以是α-或β-位，表示单键或双键，R2，R3如上所定义，R4是C1，烷基，C 3-6 - 环烷基-C 1-3 - 烷基，C 3-6 - 烯基或C 3-6 - 炔基; 和R 5是氢，C 1-10烷基，C 3-10 - 烯基或C 3-10 - 炔基，R 6是C 1-10烷基，C 3-10 - 烯基，C 3-10 - 炔基或芳基或R 5 和R6连同连接的N-原子形成5-至10-元杂环，优选5-或6-元，其任选地可含有其它杂原子。

4. 发明授权

US4024166A Process for the preparation of 13.beta.-alkyl-4-gonene-3,17-diones 失效
标题翻译：制备13 {62-烷基-4-锑烯-3,17-二酮的方法
公开(公告)号：US4024166A
公开(公告)日：1977-05-17
申请号：US621384
申请日：1975-10-10
申请人： Gerhard Sauer , Ulrich Eder , Gregor Haffer , Gunter Neef , Rudolf Wiechert
发明人： Gerhard Sauer , Ulrich Eder , Gregor Haffer , Gunter Neef , Rudolf Wiechert
IPC分类号： B01J23/00 , C07B61/00 , C07C317/14 , C07D317/26 , C07D317/72 , C07J1/00
CPC分类号： C07C317/00 , C07D317/26 , C07D317/72 , C07J1/0059
摘要： Novel process for the preparation of 13.beta.-alkyl-4-gonene-3,17-diones of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, consists of REACTING A 7A.beta.-ALKYL,5,6,7,7A-TETRAHYDROINDANE-1,5-DIONE WITH FORMALDEHYDE AND AN ARYLSULFINIC ACID OR AN ADDUCT OF FORMALDEHYDE AND ARYLSULFINIC ACID TO PRODUCE A TETRAHYDROINDANE DERIVATIVE;Hydrogenating the tetrahydroindane derivative with hydrogen in the presence of a palladium-, platinum-, or rhodium-containing hydrogenation catalyst to produce a perhydroindane derivative;Condensing the perhydroindane derivative in the presence of a proton-accepting agent with a 7,7-alkylenedioxy-3-oxooctanoic acid ester;Treating the product obtained with a strong aqueous base and then heating the product in an inert solvent to produce a 4,5-secosteroid;Hydrogenating the 4,5-secosteroid in the presence of a palladium-, platinum-, rhodium-, or nickel-containing hydrogenation catalyst; andHydrolyzing and cyclizing the hydrogenated 4,5-secosteroid by treatment with a strong acid.
摘要翻译：用于制备式“IMAGE”的13β-烷基-4-单宁-3,17-二酮的新方法，其中R 1是甲基或乙基，由反应A7Aβ-烷基，5,6,7,7a- 四氢呋喃-1,5-二酮与甲醛和氨基磺酸或甲醛和芳香酸的添加以生产四氢衍生物衍生物; 在含有氢氧化钯，或含氢氧化铑的氢化催化剂存在下氢化四氢呋喃衍生物生成四氢呋喃衍生物; 在具有7,7-亚甲基氧化亚硝酸酯酸酯的接受原料的情况下，冷凝该衍生物衍生物; 处理用强碱性基质获得的产品，然后加入产品中的产品用于生产4,5代谢物; 在含有钯，铑，铑，或含镍的氢化催化剂存在下氢化4,5-二氧化硫; 并通过用强酸处理氢化和循环氢化的4,5代谢物。

5. 发明授权

US4012420A 9,10-Secoestrane derivatives and their production 失效
标题翻译： 9,10-Secoestrane衍生物及其生产
公开(公告)号：US4012420A
公开(公告)日：1977-03-15
申请号：US570072
申请日：1975-04-21
申请人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
发明人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
IPC分类号： C07C49/84 , C07C69/01 , C07C401/00 , C07D317/46 , C07D319/08
CPC分类号： C07D317/46 , C07C49/84 , C07C69/01
摘要： 9,10-Secoestranes, useful as intermediates in the total synthesis of steroids, of the formula ##STR1## WHEREIN N IS 1 OR 2, R.sub.1 is lower alkyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkoxy or acyloxy, X is free or ketalized carbonyl or free, esterified or etherified hydroxymethylene, and Y is carbonyl or dialkoxymethylene are produced by condensing, in the presence of a basic catalyst, ##STR2## WHEREIN X, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4 have the values given above, and Z is Cl, Br or I, to produce a 9,10-secoestrane of the above formula wherein Y is a free carbonyl group, which can then, if desired, be ketalized to a corresponding compound wherein Y is dialkoxymethylene or like ketal group.
摘要翻译： 9,10-Secoestranes，用作类固醇总合成中的中间体，式为“IMAGE”，其中N为1或2，R 1为低级烷基，R 2，R 3和R 4为氢，烷氧基或酰氧基，X为游离或缩酮化的羰基或游离的，酯化的或醚化的羟基亚甲基，Y是羰基或二烷氧基亚甲基，是在碱性催化剂存在下，通过在上述给定的值下，并且Z是Cl，Br或I，以产生上式的9,10-隔离子，其中Y是游离羰基，如果需要，其可以被缩醛化成相应的化合物，其中Y是二烷氧基亚甲基或类似的缩酮基。

6. 发明授权

US4072716A Bicycloalkane derivatives 失效
标题翻译：双环烷烃衍生物
公开(公告)号：US4072716A
公开(公告)日：1978-02-07
申请号：US754000
申请日：1976-12-27
申请人： Gerhard Sauer , Helmut Hauser , Gregor Haffer , Juergen Ruppert , Ulrich Eder , Rudolf Wiechert
发明人： Gerhard Sauer , Helmut Hauser , Gregor Haffer , Juergen Ruppert , Ulrich Eder , Rudolf Wiechert
IPC分类号： C07D317/30 , C07D317/46 , C07C49/54
CPC分类号： C07D317/46 , C07D317/30
摘要： Bicycloalkane derivatives of the formula ##STR1## WHEREIN N IS 1 OR 2, R.sub.1 is lower alkyl, X is carbonyl or free or etherified hydroxymethylene, and Y is --S--R.sub.2, --SO.sub.m --R.sub.2, or ##STR2## wherein m is 1 or 2, R.sub.2 is alkyl, R.sub.3 is hydrogen or lower alkyl, R.sub.4 is aliphatic acyl and Z is nitro, lower alkanoyl, lower alkylsulfinyl, or lower alkylsulfonyl are useful intermediates in the total synthesis of steroids. The compounds are prepared by reacting a corresponding compound lacking the CH.sub.2 Y substituent with formaldehyde and a mercaptan or a sulfinic acid, followed if desired by oxidation and optional salt condensation.
摘要翻译：式中，R 1为低级烷基，X为羰基或游离的或醚化的羟基亚甲基，Y为-S-R 2，-SO m-R 2或其中m为1的双环烷烃衍生物或2，R2是烷基，R3是氢或低级烷基，R4是脂族酰基，Z是硝基，低级烷酰基，低级烷基亚磺酰基或低级烷基磺酰基是在类固醇的总合成中的有用的中间体。通过使相应的缺少CH 2 Y取代基的化合物与甲醛和硫醇或亚磺酸反应来制备化合物，随后如果需要，通过氧化和任选的盐缩合。

7. 发明授权

US4066674A Process for the preparation of 1,3-oxygenated 8.alpha.-estratrienes and novel intermediates obtained therefrom 失效
标题翻译：制备1,3-氧化的8'-离子的方法及其获得的新型中间体
公开(公告)号：US4066674A
公开(公告)日：1978-01-03
申请号：US741497
申请日：1976-11-12
申请人： Ulrich Eder , Gerhard Sauer , Gregor Haffer , Guenter Neef , Rudolf Wiechert
发明人： Ulrich Eder , Gerhard Sauer , Gregor Haffer , Guenter Neef , Rudolf Wiechert
IPC分类号： C07C59/52 , C07J1/00 , C07J15/00
CPC分类号： C07C59/52 , C07J1/0074 , C07J15/00
摘要： Novel 1,3-dialkoxy 8.alpha.-estratriene compounds of the formula ##STR1## WHEREIN R.sub.1 is alkyl of 1-18 carbon atoms, R.sub.2 is alkyl of 1-5 carbon atoms and Ac is alkanoyl of 1-8 carbon atoms, are obtained by a three-step synthesis from a tetrahydroindane-5-one compound.

8. 发明授权

US4001302A 9,10-Secoestrane derivatives and their production 失效
标题翻译： 9,10- SECOESTRANE衍生物及其生产
公开(公告)号：US4001302A
公开(公告)日：1977-01-04
申请号：US570091
申请日：1975-04-21
申请人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
发明人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
IPC分类号： C07C49/84 , C07C69/01 , C07C401/00 , C07D317/46 , C07C69/02
CPC分类号： C07D317/46 , C07C49/753 , C07C49/84 , C07C2102/24
摘要： 9,10-Secoestranes, useful as intermediates in the total synthesis of steroids, of the formula ##STR1## WHEREIN N IS 1 OR 2, R.sub.1 is lower alkyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkoxy or acyloxy, X is free or ketalized carbonyl or free, esterified or etherified hydroxymethylene, and Y is carbonyl or dialkoxymethylene are produced by condensing, in the presence of a basic catalyst, ##STR2## WHEREIN X, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4 have the values given above, and Z is Cl, Br or I, to produce a 9,10-secoestrane of the above formula wherein Y is a free carbonyl group, which can then, if desired, be ketalized to a corresponding compound wherein Y is dialkoxymethylene or like ketal group.

9. 发明授权

US3965124A 6,9-Oxido-9,10-secoestrane derivatives and method of synthesis 失效
标题翻译： 6,9-氧化-9,10-过氧化物衍生物和合成方法
公开(公告)号：US3965124A
公开(公告)日：1976-06-22
申请号：US587986
申请日：1975-06-18
申请人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
发明人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
IPC分类号： C07C43/168 , C07C43/20 , C07C49/84 , C07D307/77 , C07J1/00 , C07J51/00 , C07D307/79 , C07D307/80
CPC分类号： C07D307/77 , C07C43/168 , C07C43/20 , C07C49/84 , C07J1/00 , C07J51/00
摘要： 6,9-Oxido-9,10-seco-1,3,5(10),6,8,14-estrahexaenes, useful as intermediates in the total synthesis of steroids, of the formula ##SPC1##Wherein n is 1 or 2, R.sub.1 is lower-alkyl, R.sub.2, R.sub.3 and R.sub.4 are H, alkoxy or acyloxy, X is a free or ketalized keto or free, esterified or etherified hydroxymethylene, are produced by the cyclization, with an acid catalyst, of a 9,10-secoestrane of the formula ##SPC2##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the values given above and Q is carbonyl or dialkoxymethylene. Hydrogenation produces the corresponding 6,9-oxido-9,10-seco-1,3,5(10)-estratrienes and 9-oxy-9,10-seco-1,3,5(10)-estratrienes.
摘要翻译： 6,9-氧代-9,10-断-1,3,5（10），6,8,14-异己烯，其用作全合成类固醇的中间体，式为WHEREIN N IS 1 OR 2，R1 是低级烷基，R2，R3和R4是H，烷氧基或酰氧基，X是游离的或缩酮化的酮基或游离的，酯化的或醚化的羟基亚甲基，是通过用酸催化剂，9,10-隔离子式中R1，R2，R3，R4，X和n具有上面给出的值，Q是羰基或二烷氧基亚甲基。氢化产生相应的6,9-氧化-9,10-断-1,3,5（10） - 三亚甲基和9-氧基-9,10-断-1,3,5（10） - 三亚甲基。

10. 发明授权

US3962280A Process for preparing benzopyran derivatives 失效
标题翻译：制备苯并吡喃衍生物的方法
公开(公告)号：US3962280A
公开(公告)日：1976-06-08
申请号：US367509
申请日：1973-06-06
申请人： Ulrich Eder , Gerhard Sauer , Gregor Haffer , Jurgen Ruppert , Rudolf Wiechert
发明人： Ulrich Eder , Gerhard Sauer , Gregor Haffer , Jurgen Ruppert , Rudolf Wiechert
IPC分类号： C07D311/78 , B01J27/00 , B01J31/00 , C07B61/00 , C07D311/92 , C07D311/94 , C07D317/44
CPC分类号： C07D317/44 , C07D311/94
摘要： Novel benzopyran derivatives of the formula ##SPC1##Wherein R.sub.1 and R.sub.3 each are lower alkyl; n is the integer 1 or 2; --A--B-- is >CH--CH.sub.2 -- or >CH=CH--; X is a free, esterified or etherified hydroxy group; and Y is H or X and Y collectively are =O; and W is --(CH.sub.2).sub.3 --Z--R.sub.4,--(ch.sub.2).sub.3 --coor.sub.6 or --(CH.sub.2).sub.3 CN, wherein V is halogen, Z is a ketalized carbonyl group R.sub.4 and R.sub.5 each are lower alkyl and R.sub.6 is alkyl, aryl or aralkyl, are valuable intermediates in the synthesis of steroids.

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