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1. 发明申请

US20070172460A1 Random peptide library displayed on aav vectors 审中-公开
标题翻译：随机肽库显示在aav载体上
公开(公告)号：US20070172460A1
公开(公告)日：2007-07-26
申请号：US10550374
申请日：2004-03-19
申请人： Jurgen Kleinschmidt , Oliver Muller , Martin Trepel , Felix Kaul , Christoph Leder
发明人： Jurgen Kleinschmidt , Oliver Muller , Martin Trepel , Felix Kaul , Christoph Leder
IPC分类号： A61K48/00 , C40B30/06 , C40B40/02 , C40B40/10 , C07K14/47
CPC分类号： C40B40/02 , A61K48/00 , C07K2319/33 , C12N15/1037 , C12N15/86 , C12N2750/14143 , C12N2799/025 , C12N2810/40
摘要： Described is a method of producing a repertoire of random peptides on the surface of AAV particles wherein said random peptides are expressed as a fusion with an AAV capsid protein of an AAV particle which displays at its surface said random polypeptides. Also described is a peptide library obtainable by said method as well as a method of selecting a gene therapy vector specific for a desired cell type comprising the steps of (a) infecting the desired cell type with a peptide library of the invention and (b) harvesting AAV library particles from the supernatant and/or cell lysates. Finally, AAV vectors obtained by said method are described which are useful for gene therapy, e.g., AAV vectors targeting primary human coronary artery endothelial cells which are suitable for the treatment of diseases associated with a dysfunction of said cells.
摘要翻译：描述了在AAV颗粒的表面上产生随机肽的所有组成成分的方法，其中所述随机肽表达为与其表面上显示所述随机多肽的AAV颗粒的AAV衣壳蛋白的融合。还描述了可通过所述方法获得的肽文库以及选择对所需细胞类型特异性的基因治疗载体的方法，包括以下步骤：（a）用本发明的肽文库感染所需细胞类型，和（b）从上清液和/或细胞裂解物中收获AAV文库颗粒。最后，描述了通过所述方法获得的AAV载体，其可用于基因治疗，例如靶向原代人冠状动脉内皮细胞的AAV载体，其适于治疗与所述细胞的功能障碍相关的疾病。

2. 发明申请

US20070036757A1 Aav vector for gene therapy 失效
标题翻译：用于基因治疗的Aav载体
公开(公告)号：US20070036757A1
公开(公告)日：2007-02-15
申请号：US10560268
申请日：2004-06-09
申请人： Jurgen Kleinschmidt , Oliver Muller
发明人： Jurgen Kleinschmidt , Oliver Muller
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143 , C12N2750/14145 , C12N2810/60
摘要： Described are recombinant AAV vectors characterized in that they carry capsid protein modification(s) resulting in a reduced or eliminated heparin binding function. The AAV vectors of the present invention are particularly suitable for gene therapy by systemic application, since (a) transduction of the liver is eliminated or at least drastically reduced and (b) the transduction efficiency of non-hepatic tissues is increased.
摘要翻译：描述了重组AAV载体，其特征在于它们携带衣壳蛋白修饰，导致肝素结合功能的降低或消除。本发明的AAV载体特别适用于通过全身应用的基因治疗，因为（a）肝脏的转导被消除或至少大大降低，（b）非肝组织的转导效率增加。

3. 发明授权

US6134886A Exhaust manifold 有权
标题翻译：排气歧管
公开(公告)号：US6134886A
公开(公告)日：2000-10-24
申请号：US168503
申请日：1998-10-08
申请人： Johannes Bussmann , Andreas Fritz , Jurgen Kleinschmidt
发明人： Johannes Bussmann , Andreas Fritz , Jurgen Kleinschmidt
IPC分类号： F01N13/10 , F01N13/18 , F01N7/10
CPC分类号： F01N13/10 , F01N13/1883 , F01N2260/10 , F01N2470/24
摘要： 05267372An exhaust manifold includes a curved end portion and at least two T-shaped portions connected to the curved portion through sliding fits, wherein the end portion and the T-shaped portions each are provided with a flange connection and a pipe connection, and wherein each T-shaped portion has a sliding fit connection piece. Each sliding fit connection piece is shaped by internal high pressure shaping at the outer radius of a curved section of the T-shaped portion.
摘要翻译：排气歧管包括弯曲端部和通过滑动配合连接到弯曲部分的至少两个T形部分，其中端部部分和T形部分各自设置有凸缘连接和管连接，并且其中每个T形部分具有滑动配合连接件。每个滑动配合连接件通过在T形部分的弯曲部分的外半径处的内部高压成形而成形。

4. 发明授权

US5761236A Laser for generating narrow-band radiation 失效
标题翻译：用于产生窄带辐射的激光
公开(公告)号：US5761236A
公开(公告)日：1998-06-02
申请号：US687793
申请日：1996-07-18
申请人： Jurgen Kleinschmidt , Peter Heist
发明人： Jurgen Kleinschmidt , Peter Heist
IPC分类号： H01S3/134 , H01S3/08 , H01S3/137 , H01S3/225
CPC分类号： H01S3/08004 , H01S3/137 , H01S3/225
摘要： A laser, especially an excimer laser, is designed to generate narrow-band radiation and comprises a laser resonator, including two reflecting elements (12, 14) between which there is disposed a laser active medium (10), and further comprises a group of several refractive dispersive elements (32, 34) arranged in the laser beam path and each deflecting, incident light at an angle (.gamma..sub.a, .gamma..sub.b) which is specific of the wavelength of the incident light. It is provided to reduce variations of the emission wavelength which are temperature responsive and time dependent during burst operation by giving at least one of the refractive dispersive elements (32) a refractive index which increases as the temperature goes up and at least one of these elements (34) a refractive index which drops as the temperature rises.
摘要翻译：激光器，特别是准分子激光器被设计成产生窄带辐射并且包括激光谐振器，包括两个反射元件（12,14），在该激光谐振器之间设置有激光活性介质（10），并且还包括一组布置在激光束路径中的几个折射色散元件（32,34），并且每个偏转的入射光以入射光的波长特有的角度（γa，γb）偏转。提供了通过使折射色散元件（32）中的至少一个折射率随着温度升高而增加的这些元件中的至少一个来减少在脉冲串操作期间温度响应和时间依赖性的发射波长的变化，（34）当温度升高时降低的折射率。

5. 发明授权

US6160831A Wavelength calibration tool for narrow band excimer lasers 失效
标题翻译：窄带准分子激光器的波长校准工具
公开(公告)号：US6160831A
公开(公告)日：2000-12-12
申请号：US271020
申请日：1999-03-17
申请人： Jurgen Kleinschmidt , Hans-Stephan Albrecht , Peter Heist
发明人： Jurgen Kleinschmidt , Hans-Stephan Albrecht , Peter Heist
IPC分类号： H01S3/225 , G01J9/00 , H01S3/00 , H01S3/137 , H01S3/22
CPC分类号： G01J9/00
摘要： An excimer laser system having a precisely calibratable absolute emission wavelength is provided wherein at least one source of reference light is used. The reference light may be a laser such as a HeNe laser or a cathode lamp such as a hollow Pt, As, C, or Fe cathode lamp. The reference light and the excimer laser beam are directed along substantially the same optical path. The beams are broadened and recollimated by beam expanding optics. The broadened beams impinge upon a dispersive element, preferably an echelle grating, and various orders for each incident wavelength are dispersed. The beams are refocused onto a position sensitive detector such as a CCD camera. Different orders of one or more lines of known wavelength of the reference light and a line from the excimer laser emission are also incident at the detector simultaneously. An absolute wavelength calibration of the excimer laser emission is precisely determinable based on a position of said excimer laser emission relative to positions of the one or more lines of the reference light at the detector. The grating constant of the preferred grating and the detector are such that calibration of the central wavelength of the narrowed excimer laser emission is performable when the central wavelength is anywhere within the broadband emission spectrum of the excimer laser. A processor calculates the absolute wavelength of the excimer laser emission. Embodiments are provided for refractive optic, catadioptric, and reflective imaging systems.
摘要翻译：提供具有精确可校准的绝对发射波长的准分子激光系统，其中使用至少一个参考光源。参考光可以是诸如HeNe激光器的激光器或诸如中空Pt，As，C或Fe阴极灯的阴极灯。参考光和准分子激光束沿着基本上相同的光路被引导。光束通过光束扩展光学器件变宽和重新准直。扩大的光束撞击在色散元件上，优选地是一个电子琴格栅，并且各个入射波长的各种顺序被分散。光束被重新聚焦到诸如CCD相机的位置敏感检测器上。参考光的已知波长的一条或多条线和来自准分子激光发射的线的不同阶数也同时入射到检测器。准分子激光发射的绝对波长校准可以基于所述准分子激光发射相对于检测器上参考光的一行或多行的位置的位置来精确地确定。优选光栅和检测器的光栅常数使得当中心波长在准分子激光器的宽带发射光谱内的任何位置时，可以对变窄的准分子激光器发射的中心波长进行校准。处理器计算准分子激光器发射的绝对波长。为折射光学，反射折射和反射成像系统提供实施例。

6. 发明授权

US6160832A Method and apparatus for wavelength calibration 失效
公开(公告)号：US6160832A
公开(公告)日：2000-12-12
申请号：US416344
申请日：1999-10-12
申请人： Jurgen Kleinschmidt , Uwe Stamm , Klaus Vogler , Peter Lokai
发明人： Jurgen Kleinschmidt , Uwe Stamm , Klaus Vogler , Peter Lokai
IPC分类号： H01S3/139 , H01S3/225 , H01S3/22
CPC分类号： H01S3/1392 , H01S3/225
摘要： A wavelength calibration system determines an absolute wavelength of a narrowed spectral emission band of an excimer or molecular laser system. The system includes a module including an element which optically interacts with a component of an output beam of the laser within the tunable range of the laser system around the narrowed band. An inter-level resonance is detected by monitoring changes in voltage within the module, or photo-absorption is detected by photodetecting equipment. The absolute wavelength of the narrowed band is precisely determinable when the optical transitions occur and are detected. When the system specifically includes an ArF-excimer laser chamber, the module is preferably a galvatron containing an element that photo-absorbs around 193 nm and the element is preferably a gas or vapor selected from the group consisting of arsenic, carbon, oxygen, iron, gaseous hydrocarbons, halogenized hydrocarbons, carbon-contaminated inert gases, germanium and platinum vapor. When the system specifically includes F.sub.2 -laser chamber, the module is preferably a galvatron containing an element that photo-absorbs around 157 nm and the element is preferably a gas or vapor selected from the group consisting of selenium, bromine and silicon. The module is alternatively a purge chamber configurable for purging with a photo-absorbing gas.

7. 发明授权

US6018971A Apparatus for hydraulically shaping hollow bodies of metal 有权
标题翻译：用于液压成型中空体金属的装置
公开(公告)号：US6018971A
公开(公告)日：2000-02-01
申请号：US263583
申请日：1999-03-06
申请人： Jurgen Kleinschmidt
发明人： Jurgen Kleinschmidt
IPC分类号： B21D26/02 , B21D26/025 , B21D26/039 , B30B15/00 , B30B15/04 , B30B15/06
CPC分类号： B21D26/025 , B21D26/039
摘要： An apparatus for hydraulically shaping hollow bodies of metal using a shaping tool arranged in a press frame includes a shaping tool arranged in a press frame, wherein the shaping tool has a lower part mounted so as to be displaceable vertically guided between an open position and a closed position and a movably supported upper part, wherein the lower part can be locked in the closed position by a locking member and the upper part can be pressed hydraulically against the lower part.
摘要翻译：使用布置在压机框架中的成形工具来液压成形中空体的装置包括：设置在压框中的成形工具，其中成形工具具有安装成可以在打开位置和打开位置之间垂直地引导的下部关闭位置和可移动地支撑的上部，其中下部可以通过锁定构件锁定在关闭位置，并且上部可以液压地压靠在下部。

8. 发明授权

US5857718A Arrangement for connecting a metal pipe to a receiving sleeve 失效
标题翻译：用于将金属管连接到接收套筒的布置
公开(公告)号：US5857718A
公开(公告)日：1999-01-12
申请号：US737397
申请日：1996-11-08
申请人： Jurgen Kleinschmidt
发明人： Jurgen Kleinschmidt
IPC分类号： F16L37/14 , F16L37/12
CPC分类号： F16L37/144
摘要： An arrangement for tightly connecting a metal pipe to a receiving sleeve includes a plug-in sleeve of metal fastened on the metal pipe, wherein the plug-in sleeve has radial projections engaging in two diametrically oppositely located grooves of the receiving sleeve, wherein the grooves terminate at the end face of the receiving sleeve. A U-shaped clamp is inserted in tangential slots of the receiving sleeve and the plug-in sleeve for coupling the sleeves to each other detachably but rigidly against pulling and pushing forces. The plug-in sleeve has a cylindrical fixing portion, a cylindrical coupling portion with greater inner and outer diameter than the fixing portion, and a conically-shaped transition portion integrally connecting the transition portion and the coupling portion. The radial projections are substantially axially oriented tongues cut out of the coupling portion and extending at an angle relative to the coupling portion.
摘要翻译： PCT No.PCT / DE96 / 00811 Sec。 371日期：1996年11月8日 102（e）1996年11月8日PCT PCT 1996年5月10日PCT公布。公开号WO96 / 35901 日期：1996年11月14日金属管与接收套筒的紧密连接的装置包括紧固在金属管上的金属插入式套筒，其中插入式套管具有接合在接收器的两个直径相对定位的凹槽中的径向突起套筒，其中凹槽终止在接收套筒的端面。 U形夹具插入接收套筒和插入式套筒的切槽中，用于将套筒彼此可拆卸地连接，但是刚性地抵抗拉力和推力。插入式套筒具有圆柱形固定部分，具有比固定部分更大的内径和外径的圆柱形联接部分和一体地连接过渡部分和联接部分的圆锥形过渡部分。径向突起是从联接部分切出并且相对于联接部分以一定角度延伸的大致轴向取向的舌片。

9. 发明授权

US5559816A Narrow-band laser apparatus 失效
标题翻译：窄带激光装置
公开(公告)号：US5559816A
公开(公告)日：1996-09-24
申请号：US453609
申请日：1995-05-30
申请人： Dirk Basting , Jurgen Kleinschmidt
发明人： Dirk Basting , Jurgen Kleinschmidt
IPC分类号： G03F7/20 , H01S3/08 , H01S3/098 , H01S3/106 , H01S3/225 , H01S3/10
CPC分类号： H01S3/08036 , G03F7/70025 , G03F7/70566 , G03F7/70575 , H01S3/1066 , H01S3/08009 , H01S3/225
摘要： A narrow-band laser apparatus comprises an optical resonator including first and second reflectors for reflecting radiation, a laser medium for amplifying radiation in said resonator and an etalon for selecting a given wavelength component from said radiation. A polarizing beam splitter is provided for linearly polarizing said radiation and also for acting as an output coupler. In order to obtain very narrow bandwidth radiation of high intensity, a Faraday rotator is provided for rotating the plane of polarization while maintaining the linear polarization thereby allowing a second wavelength selection element (such as a grating) to be efficiently employed to further narrow the output of the laser.
摘要翻译：窄带激光装置包括光谐振器，其包括用于反射辐射的第一和第二反射器，用于放大所述谐振器中的辐射的激光介质和用于从所述辐射中选择给定波长分量的标准具。提供偏振分束器用于使所述辐射线性偏振并且还用作输出耦合器。为了获得高强度的非常窄的带宽辐射，提供了用于旋转极化平面的法拉第旋转器，同时保持线性偏振，从而允许有效地使用第二波长选择元件（例如光栅）来进一步缩小输出的激光。

10. 发明授权

US5559815A Pulsed laser 失效
标题翻译：脉冲激光
公开(公告)号：US5559815A
公开(公告)日：1996-09-24
申请号：US438168
申请日：1995-05-09
申请人： Vadim Berger , Jurgen Kleinschmidt , Uwe Stamm , Wolfgang Zschoke
发明人： Vadim Berger , Jurgen Kleinschmidt , Uwe Stamm , Wolfgang Zschoke
IPC分类号： H01S3/094 , H01S3/102 , H01S3/10
CPC分类号： H01S3/1022 , H01S2301/02 , H01S2301/08 , H01S3/094
摘要： A pulsed laser comprises an oscillator (10), a laser medium (14), a wavelength selective member (12) for tuning the wavelength of a beam pulse (18) emitted by the oscillator, and means for pulsed excitation of the laser medium (14). The laser medium (14) is excited at least twice at consecutive times to generate a single beam pulse (18).
摘要翻译：脉冲激光器包括振荡器（10），激光介质（14），用于调谐由振荡器发射的束脉冲（18）的波长的波长选择部件（12），以及激光介质的脉冲激励装置 14）。激光介质（14）在连续时间被激励至少两次，以产生单光束脉冲（18）。

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