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1. 发明授权

US10208031B2 Photocrosslinkable materials comprising alicyclic group 有权
公开(公告)号：US10208031B2
公开(公告)日：2019-02-19
申请号：US12596706
申请日：2008-04-10
申请人： Jean-Francois Eckert , Guy Marck , Oliver Muller
发明人： Jean-Francois Eckert , Guy Marck , Oliver Muller
IPC分类号： C08G69/08 , C07D471/04 , C07C69/75 , C07C69/757 , C07C219/32 , C07C229/60 , C08F220/36 , C08G73/10 , G02F1/1337
摘要： A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.

2. 发明申请

US20070172460A1 Random peptide library displayed on aav vectors 审中-公开
标题翻译：随机肽库显示在aav载体上
公开(公告)号：US20070172460A1
公开(公告)日：2007-07-26
申请号：US10550374
申请日：2004-03-19
申请人： Jurgen Kleinschmidt , Oliver Muller , Martin Trepel , Felix Kaul , Christoph Leder
发明人： Jurgen Kleinschmidt , Oliver Muller , Martin Trepel , Felix Kaul , Christoph Leder
IPC分类号： A61K48/00 , C40B30/06 , C40B40/02 , C40B40/10 , C07K14/47
CPC分类号： C40B40/02 , A61K48/00 , C07K2319/33 , C12N15/1037 , C12N15/86 , C12N2750/14143 , C12N2799/025 , C12N2810/40
摘要： Described is a method of producing a repertoire of random peptides on the surface of AAV particles wherein said random peptides are expressed as a fusion with an AAV capsid protein of an AAV particle which displays at its surface said random polypeptides. Also described is a peptide library obtainable by said method as well as a method of selecting a gene therapy vector specific for a desired cell type comprising the steps of (a) infecting the desired cell type with a peptide library of the invention and (b) harvesting AAV library particles from the supernatant and/or cell lysates. Finally, AAV vectors obtained by said method are described which are useful for gene therapy, e.g., AAV vectors targeting primary human coronary artery endothelial cells which are suitable for the treatment of diseases associated with a dysfunction of said cells.
摘要翻译：描述了在AAV颗粒的表面上产生随机肽的所有组成成分的方法，其中所述随机肽表达为与其表面上显示所述随机多肽的AAV颗粒的AAV衣壳蛋白的融合。还描述了可通过所述方法获得的肽文库以及选择对所需细胞类型特异性的基因治疗载体的方法，包括以下步骤：（a）用本发明的肽文库感染所需细胞类型，和（b）从上清液和/或细胞裂解物中收获AAV文库颗粒。最后，描述了通过所述方法获得的AAV载体，其可用于基因治疗，例如靶向原代人冠状动脉内皮细胞的AAV载体，其适于治疗与所述细胞的功能障碍相关的疾病。

3. 发明申请

US20090045638A1 METHOD OF MAKING A BUMPER STRUCTURE OF A MOTOR VEHICLE, AND BUMPER STRUCTURE 审中-公开
标题翻译：制造电动车辆的缓冲结构的方法和缓冲结构
公开(公告)号：US20090045638A1
公开(公告)日：2009-02-19
申请号：US12191636
申请日：2008-08-14
申请人： CHRISTIAN HANDING , Oliver Muller , Ludger Gehringhoff
发明人： CHRISTIAN HANDING , Oliver Muller , Ludger Gehringhoff
IPC分类号： B60R19/04 , B21D53/88
CPC分类号： B60R19/18 , B60R2019/1826 , Y10T29/49622
摘要： In a method of making a bumper structure of a motor vehicle, a blank of quenched and tempered steel is formed into a U-shaped bumper beam having a middle part and attachment parts which adjoin the middle part on opposite ends and define crash boxes. The middle part of the bumper beam is hardened either during or after the blank is formed into the bumper beam.
摘要翻译：在制造机动车辆的保险杠结构的方法中，淬火和回火钢的坯料形成为具有中间部分的U形保险杠梁和在相对端上与中间部分相邻并且限定碰撞箱的附接部分。在坯料形成保险杠梁之间或之后，保险杠梁的中部被硬化。

4. 发明申请

US20070036757A1 Aav vector for gene therapy 失效
标题翻译：用于基因治疗的Aav载体
公开(公告)号：US20070036757A1
公开(公告)日：2007-02-15
申请号：US10560268
申请日：2004-06-09
申请人： Jurgen Kleinschmidt , Oliver Muller
发明人： Jurgen Kleinschmidt , Oliver Muller
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143 , C12N2750/14145 , C12N2810/60
摘要： Described are recombinant AAV vectors characterized in that they carry capsid protein modification(s) resulting in a reduced or eliminated heparin binding function. The AAV vectors of the present invention are particularly suitable for gene therapy by systemic application, since (a) transduction of the liver is eliminated or at least drastically reduced and (b) the transduction efficiency of non-hepatic tissues is increased.
摘要翻译：描述了重组AAV载体，其特征在于它们携带衣壳蛋白修饰，导致肝素结合功能的降低或消除。本发明的AAV载体特别适用于通过全身应用的基因治疗，因为（a）肝脏的转导被消除或至少大大降低，（b）非肝组织的转导效率增加。

5. 发明申请

US20050095134A1 METHODS AND APPARATUS FOR COOLING GAS TURBINE ROTOR BLADES 有权
标题翻译：用于冷却气体涡轮转子叶片的方法和装置
公开(公告)号：US20050095134A1
公开(公告)日：2005-05-05
申请号：US10699056
申请日：2003-10-31
申请人： Xiuzhang Zhang , Oliver Muller , Tahar Bouktir
发明人： Xiuzhang Zhang , Oliver Muller , Tahar Bouktir
IPC分类号： F01D5/18 , F01D5/14 , F01D5/30 , F02C7/16 , B63H1/16
CPC分类号： F01D5/147 , F01D5/22 , F05D2240/81
摘要： A turbine blade is provided. The turbine blade includes a blade platform having an airfoil portion and a root portion extending therefrom, an undercut formed in a first side of the platform and a purge slot formed in a second side of the platform.
摘要翻译：提供涡轮叶片。涡轮机叶片包括具有翼型部分和从其延伸的根部的叶片平台，形成在平台的第一侧中的底切和形成在平台的第二侧中的吹扫槽。

6. 发明申请

US20100048849A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP 审中-公开
标题翻译：包含ALICYCLIC集团的可透光材料
公开(公告)号：US20100048849A1
公开(公告)日：2010-02-25
申请号：US12596706
申请日：2008-04-10
申请人： Jean-Francois Eckert , Guy Marck , Oliver Muller
发明人： Jean-Francois Eckert , Guy Marck , Oliver Muller
IPC分类号： C08G69/08 , C07C229/42 , C07C229/44
CPC分类号： C07D471/04 , C07C69/75 , C07C69/757 , C07C219/32 , C07C229/60 , C07C2601/14 , C08F220/36 , C08G73/10 , G02F1/133723 , G02F1/133753 , G02F1/133788
摘要： A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.
摘要翻译：提出式（I）的二胺化合物以及基于这种化合物的聚合物，共聚物，聚酰胺酸，聚酰胺酸酯或聚酰亚胺。

7. 发明申请

US20090316252A1 Fluidic Multi Color Display 有权
标题翻译：流体多色显示
公开(公告)号：US20090316252A1
公开(公告)日：2009-12-24
申请号：US12427029
申请日：2009-04-21
申请人： Oliver Muller-Marc , Dieter Jerosch
发明人： Oliver Muller-Marc , Dieter Jerosch
IPC分类号： G02B26/02
CPC分类号： G02B26/004 , G09F9/377 , G09F13/24
摘要： The apparatus claimed by the invention uses as the display medium colors in the form of colored fluids which are transported by means of transport in a system of compartments within a fluidic chain, whereby they are visible from the direction of an observer only through a single one these compartments (image compartment). Depending on the position of the individual colored fluids, a different color impression is received by the observer. The invention thereby teaches the presence of a fluidic chain in a subpixel and the combination of a plurality of these subpixels in a pixel. The display claimed by the invention consists of a plurality of pixels. With the use of eight colors in connection with an optically created color mixing effect, a color space can be displayed which is sufficient at least for the display of the information typically used on advertising signs.
摘要翻译：本发明所要求保护的设备用作显色介质的颜色，其色彩流体的形式通过运输在流体链条内的隔间系统中运输，从而从观察者的方向只能通过单个的一个这些隔间（图像室）。根据各种彩色液体的位置，观察者收到不同的颜色印象。因此，本发明教导了子像素中的流体链的存在以及像素中的多个这些子像素的组合。本发明要求保护的显示器由多个像素构成。通过使用与光学创建的混色效果相结合的八种颜色，可以显示至少足以显示通常用于广告标志的信息的颜色空间。

8. 发明申请

US20080266204A1 Method, Device and System for Creating Images, Text and Information that are Visible Under Incident Light 审中-公开
标题翻译：用于创建在入射光下可见的图像，文本和信息的方法，设备和系统
公开(公告)号：US20080266204A1
公开(公告)日：2008-10-30
申请号：US11793421
申请日：2005-12-20
申请人： Frank Bartels , Nader Mark Isam Tahhan , Dieter Jerosch , Oliver Muller-Marc
发明人： Frank Bartels , Nader Mark Isam Tahhan , Dieter Jerosch , Oliver Muller-Marc
IPC分类号： G09G5/00
CPC分类号： G09G3/00 , G09F9/00 , G09F9/37 , G09F13/00
摘要： System (1) is provided for the creation of images, texts and information that are visible under incident light. The system (1) includes: at least one display (10); and one control unit (11) for the control of the display (10). The control unit (11) is connected with a display (10), and/or at least one sensor (13), and/or at least one second remote control unit (12) via at least one interface (110).
摘要翻译：系统（1）被提供用于创建在入射光下可见的图像，文本和信息。系统（1）包括：至少一个显示器（10）; 以及用于控制显示器（10）的一个控制单元（11）。控制单元（11）经由至少一个接口（110）与显示器（10）和/或至少一个传感器（13）和/或至少一个第二遥控单元（12）连接。

9. 发明申请

US20080069968A1 Photocrosslinkable Materials 有权
标题翻译：光交联材料
公开(公告)号：US20080069968A1
公开(公告)日：2008-03-20
申请号：US11665351
申请日：2005-10-05
申请人： Zoubair Cherkaoui , Thomas Bachels , Guy Marck , Oliver Muller , Andreas Schuster , Hubert Seiberle
发明人： Zoubair Cherkaoui , Thomas Bachels , Guy Marck , Oliver Muller , Andreas Schuster , Hubert Seiberle
IPC分类号： C07C229/52 , B05D3/06 , C08F24/00
CPC分类号： G02F1/133723 , C07C219/32 , C07C229/60 , C07C2601/14 , C08G73/10 , C08G73/1078 , G02F1/133788 , Y10T428/1023 , Y10T428/1027
摘要： A diamine compound is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound. The compound is represented by one of the general formulae (Ia) and (Ib). It could be shown that such structures, in particular for a specific choice of the residue B, provide, if e.g. used as orientation layers, a photostable, vertically aligning material with an improved VHR.
摘要翻译：提出了二胺化合物以及基于这种化合物的聚合物，共聚物，聚酰胺酸，聚酰胺酸酯或聚酰亚胺。化合物由通式（Ia）和（Ib）之一表示。可以表明，这样的结构，特别是残留物B的具体选择，如果例如用作取向层，具有改进的VHR的可光稳定的垂直取向材料。

10. 发明授权

US06446478B1 Two-stage hemming machine with movable dies 失效
标题翻译：两级折边机带活动模具
公开(公告)号：US06446478B1
公开(公告)日：2002-09-10
申请号：US09627655
申请日：2000-07-28
申请人： Colin Oliver Muller
发明人： Colin Oliver Muller
IPC分类号： B21D3902
CPC分类号： B21D39/021
摘要： A two-stage hemming machine has a centrally located press station with an anvil extendable along a vertical axis, and a loading station and an unloading station located on opposite sides of the press station. Separate first and second dies slide on horizontal tracks mounted above the press, the first die movable therealong between the loading station and the press station, and the second die movable between the unloading station and the press station. The dies shuttle back and forth, in unison, between the press station during a production cycle wherein a component to be hemmed is loaded into the first die in the loading station, is carried into the press station along with the first die where the first stage of the hemming operation occurs, and remains on the anvil as the anvil is lowered. The first die then returns to the loading station as the second die moves into the press station. The anvil is extended again to perform a second stage of the hemming operation, the anvil is retracted, the component remaining in contact with the second die, and the second die moves to the unloading station where the component is removed from the press. Spring actuated arms hold the component in connection with the first die as the first die moves to the press station, and a power actuated retaining arm holds the component in connection with the second die as the second die moves to the unloading station.
摘要翻译：两级折边机具有中心位置的压力站，其具有沿垂直轴线延伸的砧座，以及位于压力站对面的装载站和卸载站。分离的第一和第二模具在安装在压机上方的水平轨道上滑动，第一模具可在装载站和压力站之间移动，第二模具可在卸载站和压力站之间移动。模具在制造循环期间在冲压站之间来回穿梭，其中待卷绕的部件被装载到装载站中的第一模具中，与第一模具一起被携带到压力机中，其中第一级的折边操作发生，并且随着砧座的降低而保持在砧座上。当第二个模具移动到压力站时，第一个模具然后返回到装载站。砧座再次延伸以执行折边操作的第二阶段，砧座缩回，部件保持与第二模具接触，并且第二模具移动到卸载站，其中部件从压机移除。当第一模具移动到压力站时，弹簧致动的臂保持与第一模具连接的部件，并且当第二模具移动到卸载站时，动力驱动的保持臂将部件与第二模具连接。

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