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1. 发明授权

US5942639A Process for the preparation of alkylphosphocholines and the production thereof in pure form 失效
公开(公告)号：US5942639A
公开(公告)日：1999-08-24
申请号：US938331
申请日：1997-09-25
申请人： Jurgen Engel , Bernd Kutscher , Wolfgang Schumacher , Ulf Niemeyer , Alfred Olbrich , Gerhard Nssner
发明人： Jurgen Engel , Bernd Kutscher , Wolfgang Schumacher , Ulf Niemeyer , Alfred Olbrich , Gerhard Nssner
IPC分类号： C07F9/02 , C07F9/09 , C07F9/10
CPC分类号： C07F9/091 , C07F9/025
摘要： A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

2. 发明授权

US6028209A Process for the preparation of alkylphosphocholines and the production thereof in pure form 有权
标题翻译：制备烷基磷酰胆碱的方法及其纯形式的制备
公开(公告)号：US6028209A
公开(公告)日：2000-02-22
申请号：US296260
申请日：1999-04-22
申请人： Jurgen Engel , Bernd Kutscher , Wolfgang Schumacher , Ulf Niemeyer , Alfred Olbrich , Gerhard Nossner
发明人： Jurgen Engel , Bernd Kutscher , Wolfgang Schumacher , Ulf Niemeyer , Alfred Olbrich , Gerhard Nossner
IPC分类号： C07F9/02 , C07F9/09 , C07F9/10
CPC分类号： C07F9/091 , C07F9/025
摘要： A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.
摘要翻译：通过在惰性溶剂中或在不存在碱性物质的情况下在惰性溶剂中或不存在溶剂的情况下使正链烷醇与C 3 -C 18烷基链与磷酰氯反应制备C14-C18-烷基磷酰胆碱的方法随后在惰性溶剂中与胆碱盐在碱性物质存在下反应生成磷酸二酯，然后水解和分离烷基磷酸胆碱，以及任选地使用混合床离子交换剂进行纯化或连续使用酸性离子交换剂和碱性离子交换剂。

3. 发明授权

US5985834A Nova- and decapeptides in the preparation of a drug for the treatment of aids 失效
标题翻译： Nova-和十肽在制备用于治疗辅助剂的药物中的用途
公开(公告)号：US5985834A
公开(公告)日：1999-11-16
申请号：US569111
申请日：1995-12-18
申请人： Jurgen Engel , Bernhard Kutscher , Michael Bernd , Ulf Niemeyer
发明人： Jurgen Engel , Bernhard Kutscher , Michael Bernd , Ulf Niemeyer
IPC分类号： A61K38/00 , A61K38/02 , A61K38/09 , A61K38/10 , A61P31/12 , A61P31/18 , C07K7/06 , C07K7/23
CPC分类号： A61K38/09 , A61K38/105 , C07K7/23 , Y10S514/80 , Y10S930/13
摘要： Described are LHRH-antagonistic and bombesin-antagonistic nona- and decapeptides suitable for use in the preparation of a drug for the treatment of AIDS and ARC as well as for use in the preparation of an immunostimulation drug.
摘要翻译： PCT No.PCT / EP94 / 01037 371 1995年12月18日第 102（e）日期1995年12月18日PCT 1994年4月2日PCT PCT。出版物WO95 / 00168 日期1995年1月5日描述了适用于制备用于治疗AIDS和ARC以及用于制备免疫刺激药物的药物的LHRH拮抗剂和铃蟾肽拮抗性非 - 和十肽。

4. 发明授权

US4716242A Salts of oxazaphosphorine derivatives 失效
标题翻译：恶唑烷衍生物的盐
公开(公告)号：US4716242A
公开(公告)日：1987-12-29
申请号：US704465
申请日：1985-02-22
申请人： Jurgen Engel , Axel Kleemann , Ulf Niemeyer , Peter Hilgard , Joerg Pohl
发明人： Jurgen Engel , Axel Kleemann , Ulf Niemeyer , Peter Hilgard , Joerg Pohl
IPC分类号： C07F9/24 , A61K31/675 , A61P35/00 , A61P35/02 , C07F9/22 , C07F9/6584 , C07F9/40
CPC分类号： C07F9/65846
摘要： There are provided new antitumor salts of oxazaphosphorine derivatives of the formula ##STR1## where R.sub.1, R.sub.2, and R.sub.3 are the same or different and represent hydrogen, methyl, ethyl, 2-chloroethyl, or 2-methanesulfonyloxyethyl and wherein at least two of these residues are 2-chloroethyl and/or 2-methanesulfonyl-oxyethyl and A is the group --S--alk--SO.sub.3 H or --N(OH)--CONH--alk--CO.sub.2 H and alk represents a C.sub.2 -C.sub.6 -alkylene residue optionally containing a mercapto group, whereby alk also can be --CH.sub.2 -- in case there is a carboxy group attached to the alk group, with homocysteinethiolactone or .alpha.-amino-.epsilon.-caprolactam or a basic compound of the formula: ##STR2## wherein R.sub.4 is a hydroxy group, an amino group or a C.sub.1 -C.sub.6 -alkoxy group, R.sub.5 is hydrogen or a difluoromethyl group, R.sub.6 is hydrogen, an indolyl-(3)-methyl residue, imidazolyl-(4)-methyl residue, a C.sub.1 -C.sub.10 -alkyl group or a C.sub.1 -C.sub.10 -alkyl group which is substituted by a hydroxy group, a C.sub.1 -C.sub.6 -alkoxy group, a mercapto group, a C.sub.1 -C.sub.6 -alkylmercapto group, a phenyl group, a hydroxy phenyl group, an amino-C.sub.1 -C.sub.6 -alkylmercapto group, an amino-C.sub.1 -C.sub.6 -alkoxy group, an amino group, an aminocarbonyl group, a ureido group (H.sub.2 NCONH--), a guanidino group or a C.sub.1 -C.sub.6 -alkoxycarbonyl group, or wherein R.sub.6 together with the structured portion >CR.sub.5 (NR.sub.7 R.sub.8) forms the proline residue, the 4-hydroxy-proline residue or the 2-oxo-3-amino-3-difluoromethyl-piperidine and the residues R.sub.7 and R.sub.8 represent hydrogen or C.sub.1 -C.sub.6 -alkyl residues.
摘要翻译：提供了新的式（ⅩⅧ）的恶唑烷磷衍生物的抗肿瘤盐，其中R 1，R 2和R 3相同或不同，代表氢，甲基，乙基，2-氯乙基或2-甲磺酰氧基乙基，其中这些残基是2-氯乙基和/或2-甲磺酰氧基乙基，A是-S-烷基-SO 3 H或-N（OH）-CONH-烷基-CO 2 H，烷基代表任选含有巯基的C 2 -C 6亚烷基其中烷基也可以是-CH 2 - ，如果存在与烷基连接的羧基，具有同半胱氨酸硫内酯或α-氨基 - ε-己内酰胺或下式的碱性化合物：其中R 4是羟基基团，氨基或C1-C6-烷氧基，R5是氢或二氟甲基，R6是氢，吲哚基 - （3） - 甲基残基，咪唑基 - （4） - 甲基残基，C1-C10- 烷基或被羟基，C1-C6-烷氧基，巯基，C1-C6烷基巯基取代的C1-C10-烷基基团，苯基，羟基苯基，氨基-C 1 -C 6烷基巯基，氨基-C 1 -C 6烷氧基，氨基，氨基羰基，脲基（H 2 NCONH-），胍基或C 1 -C 6烷氧基羰基，或其中R 6与结构部分> CR 5（NR 7 R 8）一起形成脯氨酸残基，4-羟基 - 脯氨酸残基或2-氧代-3-氨基-3-二氟甲基 - 哌啶和残基R7和R8表示氢或C1-C6烷基残基。

5. 发明授权

US4929607A oxazaphosphorin-4-thio alkanesulphonic acids, neutral salts thereof and method to treat cancer diseases and to produce immunosuppression 失效
标题翻译：恶唑磷脂-4-硫烷基磺酸，其中性盐和治疗癌症疾病和产生免疫抑制的方法
公开(公告)号：US4929607A
公开(公告)日：1990-05-29
申请号：US149954
申请日：1988-02-02
申请人： Gerhard Scheffler , Ulf Niemeyer , Norbert Brock , Jorg Pohl
发明人： Gerhard Scheffler , Ulf Niemeyer , Norbert Brock , Jorg Pohl
IPC分类号： C07F9/24 , A61K31/675 , A61P35/00 , C07F9/6584
CPC分类号： C07F9/65846
摘要： This invention relates to new oxzaphosphorin-4-thio-alkanesulphonic acids and to the neutral salts thereof corresponding to the general formula I ##STR1## and to methods to use such compounds to treat cancer diseases and to produce immunosuppression in humans and animals.

6. 发明授权

US06690312B1 Method and circuit for regulating the signal level fed to an analog/digital converter 有权
标题翻译：用于调节馈送到模拟/数字转换器的信号电平的方法和电路
公开(公告)号：US06690312B1
公开(公告)日：2004-02-10
申请号：US09959231
申请日：2001-12-11
申请人： Andreas Falkenberg , Ulf Niemeyer , Christoph Rohe
发明人： Andreas Falkenberg , Ulf Niemeyer , Christoph Rohe
IPC分类号： H03M166
CPC分类号： H03M1/185
摘要： For regulating the signal level fed to an analog/digital converter, the rate of change at which the output signal of the analog/digital converter changes over time, in particular the rate of change of an output bit of the analog/digital converter, is measured and compared with a setpoint value, in order to set the signal level fed to the analog/digital converter based on the comparison.
摘要翻译：为了调节馈送到模拟/数字转换器的信号电平，模拟/数字转换器的输出信号随时间变化的变化率，特别是模拟/数字转换器的输出位的变化率是测量并与设定值进行比较，以便基于比较设置馈送到模拟/数字转换器的信号电平。

7. 发明授权

US4623742A Oxazaphosphorin-4-thio-alkanesulphonic acids, and neutral salts thereof 失效
标题翻译：氧氮杂磷素-4-硫代烷基磺酸及其中性盐
公开(公告)号：US4623742A
公开(公告)日：1986-11-18
申请号：US683374
申请日：1984-12-19
申请人： Gerhard Scheffler , Ulf Niemeyer , Norbert Brock , Jorg Pohl
发明人： Gerhard Scheffler , Ulf Niemeyer , Norbert Brock , Jorg Pohl
IPC分类号： C07F9/24 , A61K31/675 , A61P35/00 , C07F9/6584 , C07F9/21
CPC分类号： C07F9/65846
摘要： This invention relates to new oxazaphosphorin-4-thio-alkanesulphonic acids and to the neutral salts thereof corresponding to the general formula I ##STR1## and to methods to use such compounds to control cancer diseases and to produce immunosuppression in humans and animals.
摘要翻译：本发明涉及新的恶唑磷蛋白-4-硫代烷基磺酸及其对应于通式Ⅰ“IMAGE”的中性盐，以及使用这些化合物来控制癌症疾病并在人和动物中产生免疫抑制的方法。

8. 发明授权

US4618692A 4-carbamoyloxy-oxazaphosphorins 失效
标题翻译： 4-氨基甲酰氧基 - 恶唑磷
公开(公告)号：US4618692A
公开(公告)日：1986-10-21
申请号：US579570
申请日：1984-02-13
申请人： Gerhard Scheffler , Ulf Niemeyer , Norbert Brock , Jorg Pohl
发明人： Gerhard Scheffler , Ulf Niemeyer , Norbert Brock , Jorg Pohl
IPC分类号： C07F9/6584 , C07F9/24 , C07F9/65
CPC分类号： C07F9/65846
摘要： The present invention relates to new 4-carbamoyloxy-oxazaphosphorins of the general Formula I ##STR1## as well as to a method for the treatment of malign tumor diseases in humans using such compounds as active agent.
摘要翻译：本发明涉及通式Ⅰ“IMAGE”I的新的4-氨基甲酰氧基 - 恶唑磷酸，以及使用这些化合物作为活性剂治疗人类恶性肿瘤疾病的方法。

9. 发明授权

US4997822A Heterocyclic compounds having a 2-(2-(N,N-bis(2-chloroethyl)-diamidophosphoryloxy) ethyl) radical 失效
标题翻译：具有2-（2-（N，N-双（2-氯乙基） - 二酰氨基磷酰氧基）乙基）基团的杂环化合物
公开(公告)号：US4997822A
公开(公告)日：1991-03-05
申请号：US16915
申请日：1987-02-20
申请人： Hans-Jurgen Hohorst , Ludmilla Bielicki , Georg Voelcker , Ulf Niemeyer
发明人： Hans-Jurgen Hohorst , Ludmilla Bielicki , Georg Voelcker , Ulf Niemeyer
IPC分类号： A61K38/00 , C07F9/6506 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/6539 , C07F9/6544 , C07K5/06
CPC分类号： C07K5/06191 , C07F9/65062 , C07F9/65122 , C07F9/653 , C07F9/6533 , C07F9/6539 , C07F9/6544 , A61K38/00
摘要： There are disclosed compounds of the formula ##STR1## The compounds have antitumour and AIDS treatment activity.
摘要翻译：公开了下式的化合物。该化合物具有抗肿瘤和AIDS治疗活性。

10. 发明授权

US07054351B1 Method for memory access control in rake receivers with early late tracking in telecommunication systems 失效
标题翻译：在电信系统中早期跟踪的耙式接收机中的存储器访问控制方法
公开(公告)号：US07054351B1
公开(公告)日：2006-05-30
申请号：US09830624
申请日：1999-10-27
申请人： Reinhold Braam , Ulf Niemeyer , Oskar Skuk , Andreas Falkenberg , Christoph Rohe
发明人： Reinhold Braam , Ulf Niemeyer , Oskar Skuk , Andreas Falkenberg , Christoph Rohe
IPC分类号： H04B1/69
CPC分类号： H04B1/7085 , H04B1/7117 , H04B1/712
摘要： In order to control memory accesses in RAKE receivers having early-late tracking in telecommunications systems with wire-free telecommunication between mobile and/or stationary transmitters/receivers, in particular in third-generation mobile radio systems, such that the number of memory accesses is less than with previous known methods, data which is received in the RAKE receiver and is read by an early finger in the early-late tracking is buffer-stored and is passed on one read cycle later to a late finger for reading by the same in the early-late tracking.
摘要翻译：为了控制具有在移动和/或固定发射机/接收机之间的有线电信的电信系统中具有早期跟踪的RAKE接收机中的存储器访问，特别是在第三代移动无线电系统中，使得存储器访问的数量为与先前已知的方法相比，在RAKE接收机中接收的并且在早期跟踪中由早期手指读取的数据被缓冲存储，并且在一个读取周期之后被传递到后期的手指以便读取它们早期跟踪。

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