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1. 发明授权

US07826042B2 Recognition chip for target substance, and detection method and device for the same 有权
标题翻译：目标物质识别芯片及其检测方法及装置
公开(公告)号：US07826042B2
公开(公告)日：2010-11-02
申请号：US10571906
申请日：2005-03-02
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihhiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihhiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/27 , G01N21/64
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

2. 发明授权

US08023109B2 Recognition chip for target substance, and detection method and device for the same 有权
标题翻译：目标物质识别芯片及其检测方法及装置
公开(公告)号：US08023109B2
公开(公告)日：2011-09-20
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/27 , G01N21/64
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

3. 发明申请

US20110019195A1 RECOGNITION CHIP FOR TARGET SUBSTANCE, AND DETECTION METHOD AND DEVICE FOR THE SAME 有权
标题翻译：目标物质的识别芯片及其相关的检测方法和装置
公开(公告)号：US20110019195A1
公开(公告)日：2011-01-27
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/59
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

4. 发明申请

US20090009756A1 Recognition Chip for Target Substance, and Detection Method and Device for the Same 有权
标题翻译：目标物质识别芯片及其检测方法及装置
公开(公告)号：US20090009756A1
公开(公告)日：2009-01-08
申请号：US10571906
申请日：2005-03-02
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/01
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

5. 发明授权

US07919263B2 Organic material-immobiling structure and method for production of the same, and peptide and DNA therefor 失效
标题翻译：有机材料固定结构及其生产方法，以及肽和DNA
公开(公告)号：US07919263B2
公开(公告)日：2011-04-05
申请号：US10548442
申请日：2004-08-18
申请人： Hidenori Shiotsuka , Takeshi Imamura , Tsuyoshi Nomoto , Miki Ogawa
发明人： Hidenori Shiotsuka , Takeshi Imamura , Tsuyoshi Nomoto , Miki Ogawa
IPC分类号： G01N31/00 , G01N33/53
CPC分类号： C07K17/14 , C07K7/08 , C07K17/08 , C12N11/14 , G01N33/54353 , G01N33/552
摘要： The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound to the organic material and containing an amino acid sequence capable of binding to silicon oxide, selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 and 2: Val-Ser-Pro-Met-Arg-Ser-Ala-Thr-Thr-His-Thr-Val; and Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val, and derivatives thereof.
摘要翻译：本发明提供一种使用新的固定装置的有机材料固定结构，其特征在于，基底表面的至少一部分由含有氧化硅的一种或多种构件组成，有机材料通过与有机材料结合并含有能够结合氧化硅的氨基酸序列的结合结构域，其选自SEQ ID NO：1和2的氨基酸序列：Val-Ser-Pro-Met-Arg-Ser -Ala-Thr-Thr-His-Thr-Val; 和Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val及其衍生物。

6. 发明申请

US20110136264A1 METHOD FOR DETECTING TARGET SUBSTANCE AND TARGET-SUBSTANCE DETECTION KIT 审中-公开
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：US20110136264A1
公开(公告)日：2011-06-09
申请号：US13030089
申请日：2011-02-17
申请人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
发明人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting part, and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ1ψ3>0 and ψ2=0, i) ψ1ψ2 0, and |ψ2|>|ψ3|, and iii) ψ1ψ2
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。样品溶液中的磁性标记的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系式i）至iv）中的任何一个：ψ1ψ3> 0和 ψ2= 0，i）ψ1ψ2<0和ψ3= 0，ii）ψ1ψ2<0，ψ2ψ3> 0和|ψ2|> |ψ3|，以及iii）ψ1ψ2<0和ψ2ψ3<0; iv）并且由磁性标签承载的目标物质被由检测部分承载的主要捕获体捕获，或者由被检测部分承载的主捕获体捕获的目标物质被由磁体承载的二次捕获体捕获标签。

7. 发明授权

US07920266B2 Detection element, detection apparatus for detecting target substance, method of detecting target substance and metal-containing member 有权
标题翻译：检测元件，用于检测目标物质的检测装置，检测目标物质的方法和含金属元件
公开(公告)号：US07920266B2
公开(公告)日：2011-04-05
申请号：US11941517
申请日：2007-11-16
申请人： Miki Ogawa , Takeshi Imamura
发明人： Miki Ogawa , Takeshi Imamura
IPC分类号： G01N21/00
CPC分类号： G01N21/554
摘要： There is provided a detection apparatus detecting target substance in a sample by utilizing plasmon resonance including a substrate and a plurality of metal-containing members arranged on the substrate, wherein the metal-containing members are shaped tubular and the metal-containing members are arranged on the substrate with a given orientation. By use hereof, a detection apparatus and a detection method enabling highly sensitive detection on target substance are provided.
摘要翻译：提供一种检测装置，通过利用包括基板和布置在基板上的多个含金属构件的等离子体共振来检测样品中的目标物质，其中含金属的构件是成形管状的，并且含金属构件布置在具有给定取向的基板。通过使用本发明，提供了能够对目标物质进行高灵敏度检测的检测装置和检测方法。

8. 发明申请

US20100216253A1 Organic Material-Immobiling Structure and Method for Production of the Same, and Peptide and DNA Therefor 失效
标题翻译：有机材料固定结构及其制备方法，以及肽及其DNA
公开(公告)号：US20100216253A1
公开(公告)日：2010-08-26
申请号：US10548442
申请日：2004-08-18
申请人： Hidenori Shiotsuka , Takeshi Imamura , Tsuyoshi Nomoto , Miki Ogawa
发明人： Hidenori Shiotsuka , Takeshi Imamura , Tsuyoshi Nomoto , Miki Ogawa
IPC分类号： G01N33/53 , C07K7/08 , C07H21/04 , C12N15/63 , G01N30/00
CPC分类号： C07K17/14 , C07K7/08 , C07K17/08 , C12N11/14 , G01N33/54353 , G01N33/552
摘要： The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound to the organic material and containing an amino acid sequence capable of binding to silicon oxide, selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 and 2: Val-Ser-Pro-Met-Arg-Ser-Ala-Thr-Thr-His-Thr-Val; and Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val, and derivatives thereof.
摘要翻译：本发明提供一种使用新的固定装置的有机材料固定结构，其特征在于，基底表面的至少一部分由含有氧化硅的一种或多种构件组成，有机材料通过与有机材料结合并含有能够结合氧化硅的氨基酸序列的结合结构域，其选自SEQ ID NO：1和2的氨基酸序列：Val-Ser-Pro-Met-Arg-Ser -Ala-Thr-Thr-His-Thr-Val; 和Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val及其衍生物。

9. 发明申请

US20080117423A1 DETECTION ELEMENT, DETECTION APPARATUS FOR DETECTING TARGET SUBSTANCE, METHOD OF DETECTING TARGET SUBSTANCE AND METAL-CONTAINING MEMBER 有权
标题翻译：检测元件，用于检测目标物质的检测装置，检测目标物质和含金属成分的方法
公开(公告)号：US20080117423A1
公开(公告)日：2008-05-22
申请号：US11941517
申请日：2007-11-16
申请人： Miki Ogawa , Takeshi Imamura
发明人： Miki Ogawa , Takeshi Imamura
IPC分类号： G01N21/55
CPC分类号： G01N21/554
摘要： There is provided a detection apparatus detecting target substance in a sample by utilizing plasmon resonance including a substrate and a plurality of metal-containing members arranged on the substrate, wherein the metal-containing members are shaped tubular and the metal-containing members are arranged on the substrate with a given orientation. By use hereof, a detection apparatus and a detection method enabling highly sensitive detection on target substance are provided.
摘要翻译：提供一种检测装置，通过利用包括基板和布置在基板上的多个含金属构件的等离子体共振来检测样品中的目标物质，其中含金属的构件是成形管状的，并且含金属构件布置在具有给定取向的基板。通过使用本发明，提供了能够对目标物质进行高灵敏度检测的检测装置和检测方法。

10. 发明申请

US20090000360A1 Method for Detecting Target Substance and Target-Substance Detection Kit 有权
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：US20090000360A1
公开(公告)日：2009-01-01
申请号：US12162789
申请日：2007-03-30
申请人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
发明人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N30/62 , G06K7/08
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting parts and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ1ψ3>0 and ψ2=0, i) ψ1ψ2 0, and |ψ2|>|ψ3|, and iii) ψ1ψ2
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。样品溶液中的磁性标记的表面电位psi1，检测部分的表面电位psi2和非检测部分的表面电位psi3满足以下关系式i）至iv）中的任何一个：<？in-line -formulae description =“In-line Formulas”end =“lead”？> psi1psi3> 0 and psi2 = 0，i）<？in-line-formula description =“In-line Formulas”end =“tail”？> ？in-line-formula description =“In-line Formulas”end =“lead”？> psi1psi2 <0 and psi3 = 0，ii）<？in-line-formula description =“In-line Formulas”end =“tail “？> <？in-line-formula description =”在线公式“end =”lead“？> psi1psi2 <0，psi2psi3> 0和| psi2 |> | psi3 |，以及iii） -formulae description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line formula”end =“lead”？> psi1psi2 <0 and psi2psi3 <0; iv）<？in-line-formula description =“In-line Formulas”end =“tail”？>，由磁性标签承载的目标物质由检测部分所承载的主捕获体或目标物质由被检测部分承载的主要捕获体捕获的捕获体被由磁性标签承载的次级捕获体俘获。

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