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1. 发明授权

US08110386B2 Lipase powder, methods for producing the same and use thereof 有权
标题翻译：脂肪酶粉末，其制造方法及其用途
公开(公告)号：US08110386B2
公开(公告)日：2012-02-07
申请号：US12314473
申请日：2008-12-11
申请人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai
发明人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai
IPC分类号： C12N9/96
CPC分类号： C12P7/6454 , C12N9/20 , C12N9/96 , C12N9/98
摘要： A lipase powder which is a granulated substance containing a lipase and a solid content of animal milk, a lipase composition wherein said lipase powder is immersed or impregnated in fatty oil, and a method for producing the lipase powder which comprises the step of adding animal milk or cream derived from the animal milk to an aqueous solution containing a lipase, and the step of spray-drying, freeze-drying or solvent-precipitating the mixture thereof are provided. According to the present invention, a lipase powder of which lipase activity and stability are improved can be provided.
摘要翻译：一种脂肪酶粉末，其是含有脂肪酶和动物乳固体含量的粒状物质，其中所述脂肪酶粉末浸渍或浸渍在脂肪油中的脂肪酶组合物，以及包含添加动物乳的步骤的方法或来自动物乳的乳膏至含有脂肪酶的水溶液，并且提供其喷雾干燥，冷冻干燥或溶剂沉淀其混合物的步骤。根据本发明，可以提供脂肪酶活性和稳定性提高的脂肪酶粉末。

2. 发明申请

US20060105438A1 1,3-Specific lipase powder, methods for producing the same and use thereof 审中-公开
标题翻译： 1,3-特异性脂肪酶粉末，其制造方法及其用途
公开(公告)号：US20060105438A1
公开(公告)日：2006-05-18
申请号：US11320760
申请日：2005-12-30
申请人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai , Tadashiro Hirose , Hidetaka Uehara , Shin Arimoto , Tomomi Suganuma
发明人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai , Tadashiro Hirose , Hidetaka Uehara , Shin Arimoto , Tomomi Suganuma
IPC分类号： C12P7/64
CPC分类号： C12P7/6454 , C12N9/20
摘要： A method for producing a lipase powder, which comprises the step of spray drying an aqueous solution containing a lipase adjusted to pH 6 to 7.5; the lipase powder which is a 1,3-specific lipase derived from Rhizomucor miehei, spherical, and contains not more than 10% by weight of moisture; and a lipase composition wherein the lipase powder is immersed or impregnated in fatty oil. According to the present invention, a lipase powder of which 1,3-selectivity is improved can be provided.
摘要翻译：一种生产脂肪酶粉末的方法，其包括将含有调节至pH6-7.5的脂肪酶的水溶液喷雾干燥的步骤; 所述脂肪酶粉末是来自根毛霉（Rhizomucor miehei）的1,3-特异性脂肪酶，为球形，并且含有不超过10重量％的水分; 脂肪酶组合物，其中将脂肪酶粉末浸渍或浸渍在脂肪油中。根据本发明，可以提供改善1,3-选择性的脂肪酶粉末。

3. 发明申请

US20090104680A1 Lipase powder, methods for producing the same and use thereof 有权
标题翻译：脂肪酶粉末，其制造方法及其用途
公开(公告)号：US20090104680A1
公开(公告)日：2009-04-23
申请号：US12314473
申请日：2008-12-11
申请人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai
发明人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai
IPC分类号： C12N9/20
CPC分类号： C12P7/6454 , C12N9/20 , C12N9/96 , C12N9/98
摘要： A lipase powder which is a granulated substance containing a lipase and a solid content of animal milk, a lipase composition wherein said lipase powder is immersed or impregnated in fatty oil, and a method for producing the lipase powder which comprises the step of adding animal milk or cream derived from the animal milk to an aqueous solution containing a lipase, and the step of spray-drying, freeze-drying or solvent-precipitating the mixture thereof are provided. According to the present invention, a lipase powder of which lipase activity and stability are improved can be provided.
摘要翻译：一种脂肪酶粉末，其是含有脂肪酶和动物乳固体含量的粒状物质，其中所述脂肪酶粉末浸渍或浸渍在脂肪油中的脂肪酶组合物，以及包含添加动物乳的步骤的方法或来自动物乳的乳膏至含有脂肪酶的水溶液，并且提供其喷雾干燥，冷冻干燥或溶剂沉淀其混合物的步骤。根据本发明，可以提供脂肪酶活性和稳定性提高的脂肪酶粉末。

4. 发明申请

US20070264695A1 Method for producing a purified lipase 审中-公开
标题翻译：纯化脂肪酶的制备方法
公开(公告)号：US20070264695A1
公开(公告)日：2007-11-15
申请号：US11826459
申请日：2007-07-16
申请人： Satoshi Negishi , Junko Suzuki , Chika Sakurai , Shin Arimoto , Hidetaka Uehara , Tadashiro Hirose , Yoshie Yamauchi , Yuri Arai , Tomomi Suganuma
发明人： Satoshi Negishi , Junko Suzuki , Chika Sakurai , Shin Arimoto , Hidetaka Uehara , Tadashiro Hirose , Yoshie Yamauchi , Yuri Arai , Tomomi Suganuma
IPC分类号： C12P7/64 , C12N9/20
CPC分类号： C12N9/18
摘要： The present invention provides a method for producing a purified lipase which comprises steps of: (a) bringing a long chain fatty acid triglyceride and a medium-chain triglyceride into contact with a lipase to purify the lipase; and (b) collecting the purified lipase. According to this production method, the purified lipase can be obtained wherein content of impurity such as silicon is decreased.
摘要翻译：本发明提供了一种纯化脂肪酶的制备方法，其特征在于，包括以下步骤：（a）使长链脂肪酸甘油三酯和中链甘油三酯与脂肪酶接触以纯化脂肪酶; 和（b）收集纯化的脂肪酶。根据该制造方法，可以得到其中杂质如硅的含量降低的纯化的脂肪酶。

5. 发明申请

US20060105935A1 Lipase powder, methods for producing the same and use thereof 审中-公开
公开(公告)号：US20060105935A1
公开(公告)日：2006-05-18
申请号：US11320756
申请日：2005-12-30
申请人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai
发明人： Junko Suzuki , Satoshi Negishi , Yuri Arai , Chika Sakurai
IPC分类号： C11D17/00
CPC分类号： C12P7/6454 , C12N9/20 , C12N9/96 , C12N9/98
摘要： A lipase powder which is a granulated substance containing a lipase and a solid content of animal milk, a lipase composition wherein said lipase powder is immersed or impregnated in fatty oil, and a method for producing the lipase powder which comprises the step of adding animal milk or cream derived from the animal milk to an aqueous solution containing a lipase, and the step of spray-drying, freeze-drying or solvent-precipitating the mixture thereof are provided. According to the present invention, a lipase powder of which lipase activity and stability are improved can be provided.

6. 发明授权

US09550961B2 Lipase powder compositions 有权
标题翻译：脂肪酶粉末组合物
公开(公告)号：US09550961B2
公开(公告)日：2017-01-24
申请号：US12000032
申请日：2007-12-07
申请人： Satoshi Negishi , Junko Suzuki , Isamu Takahashi , Hans Christian Holm
发明人： Satoshi Negishi , Junko Suzuki , Isamu Takahashi , Hans Christian Holm
IPC分类号： C12N11/12 , C11C3/10 , C12N9/20 , C12N11/14 , C12P7/64
CPC分类号： C11C3/10 , C12N9/20 , C12N11/14 , C12P7/6436 , C12P7/6454 , Y02P20/52
摘要： The present invention provides a lipase powder composition which comprises a filter aid(s) and a product obtained by pulverizing a Thermomyces sp.-derived lipase immobilized to a silica carrier(s) into the average particle diameter of 1 μm or more and less than 300 μm. This lipase powder composition improves the lipase activity and operability and, therefore, can be suitably used in the methods for exchanging esters of fats and oils and for esterification.
摘要翻译：本发明提供一种脂肪酶粉末组合物，其包含助滤剂和通过将固定于二氧化硅载体上的嗜热链球菌来源的脂肪酶粉碎成平均粒径为1μm以上且小于 300μm。这种脂肪酶粉末组合物改善了脂肪酶活性和可操作性，因此可以适用于脂肪和油的酯交换方法和酯化反应。

7. 发明授权

US08921081B2 Powdery lipase preparation, method for producing the same and use thereof 有权
标题翻译：粉末脂肪酶制剂及其制备方法及其用途
公开(公告)号：US08921081B2
公开(公告)日：2014-12-30
申请号：US12531327
申请日：2008-03-12
申请人： Junko Suzuki , Yoshie Yamauchi , Tamami Manabe , Satoshi Negishi
发明人： Junko Suzuki , Yoshie Yamauchi , Tamami Manabe , Satoshi Negishi
IPC分类号： C12P7/64 , C12N9/20 , C12P7/62
CPC分类号： C12N9/96 , C12N9/20 , C12P7/62 , C12P7/6445
摘要： The present invention discloses a powdery lipase preparation which is a granulated material comprising a lipase derived from Rhizopus oryzae and/or a lipase derived from Rhizopus delemar and a soybean powder having a fat content of 5 mass % or more. A lipase activity is improved by using this powdery lipase preparation.
摘要翻译：本发明公开了一种粉状脂肪酶制剂，其是包含源自米曲霉的脂肪酶和/或来自根霉属的脂肪酶和脂肪含量为5质量％以上的大豆粉末的造粒物质。通过使用该粉末状脂肪酶制剂，脂肪酶活性得到改善。

8. 发明授权

US5696299A Optical resolution for producing optically active alcohol 失效
标题翻译：用于制造光学活性醇的光学分辨率
公开(公告)号：US5696299A
公开(公告)日：1997-12-09
申请号：US529059
申请日：1995-09-15
申请人： Satoshi Negishi , Seiichi Shirasawa , Junko Suzuki , Yukie Masuda
发明人： Satoshi Negishi , Seiichi Shirasawa , Junko Suzuki , Yukie Masuda
IPC分类号： C12P7/62 , C12P41/00 , C07C33/18 , C07C33/46
CPC分类号： C12P7/62 , C12P41/004
摘要： A process for producing an optically active alcohol comprising carrying out interesterification between a racemic alcohol and an ester selected from the group consisting of (a) a diester between a lower monohydric alcohol and a saturated dicarboxylic acid having 14 or more carbon atoms, (b) a triglyceride of a saturated fatty acid having 16 or more carbon atoms, and (c) a monoester between a lower monohydric alcohol and a saturated fatty acid having 18 or more carbon atoms in the presence of lipase, preferably heat-resistant lipase, and in the presence or absence of a solvent, preferably in the absence of a solvent, under a substantially water-free condition, separating an optically active alcohol rich in either one of R- and S-forms from the reaction mixture, and adding an optically inactive non-racemic alcohol to the residue of the previous step to carry out interesterification under the same conditions as in the previous reaction to separate the other enantiomer. According to the present invention a racemic alcohol can easily be resolved into each enantiomer with high purity in good yield.
摘要翻译：一种光学活性醇的制造方法，其包括在外消旋醇与选自（a）低级一元醇和具有14个或更多个碳原子的饱和二羧酸之间的二酯的酯中进行酯交换，（b）具有16个或更多个碳原子的饱和脂肪酸的甘油三酯，和（c）在脂肪酶，优选耐热脂肪酶存在下，具有18个或更多个碳原子的低级一元醇和饱和脂肪酸之间的单酯，以及在基本无水条件下，优选在不存在溶剂的情况下存在或不存在溶剂，从反应混合物中分离富含R-和S-形式的任何一种的光学活性醇，并加入光学惰性将非外消旋醇与前述步骤的残余物进行酯交换，在与之前反应相同的条件下进行酯交换以分离另一种对映异构体。根据本发明，外消旋醇可以容易地以良好的产率分离成高纯度的每种对映异构体。

9. 发明授权

US5480787A Transesterification method using lipase powder with a particle diameter of 20-50 microns 失效
标题翻译：使用粒径为20-50微米的脂肪酶粉末的酯交换方法
公开(公告)号：US5480787A
公开(公告)日：1996-01-02
申请号：US296921
申请日：1994-08-31
申请人： Satoshi Negishi , Seiichi Shirasawa , Junko Suzuki , Tateo Murui
发明人： Satoshi Negishi , Seiichi Shirasawa , Junko Suzuki , Tateo Murui
IPC分类号： C12N9/20 , C12N11/14 , C12P7/62 , C12P7/64 , C12R1/05
CPC分类号： C12P7/6454 , C12N11/14
摘要： The transesterification method is conducted with a powdery lipase wherein the powdery lipase is dispersed in ester-containing starting materials in the presence or absence of an inert organic solvent, and the diameter of at least 90% of the dispersed lipase particles is kept in the range of 1 to 100 .mu.m in the course of the trans-esterification reaction. A reactivity higher than that realized by the conventional transesterification method with a powdery lipase is obtained and the lipase can be easily recovered and reused, without causing a loss of the lipase activity, lowering of the conversion due to the residence of the substrate on the immobilizing carrier and side reactions caused by water introduced into the reaction system by the immobilizing carrier.
摘要翻译：酯交换方法用粉状脂肪酶进行，其中在存在或不存在惰性有机溶剂的情况下将粉状脂肪酶分散在含酯原料中，并且至少90％的分散的脂肪酶颗粒的直径保持在在反式酯化反应过程中为1〜100微米。获得比通过常规酯交换法用粉末脂肪酶实现的更高的反应性，并且可以容易地回收和再利用脂肪酶，而不会引起脂肪酶活性的丧失，由于底物停留在固定化上的转化率降低由固定载体引入反应体系的水引起的载体和副反应。

10. 发明申请

US20090075349A1 METHOD OF RECOVERING LIPASE ACTIVITY 有权
标题翻译：回收脂肪酶活性的方法
公开(公告)号：US20090075349A1
公开(公告)日：2009-03-19
申请号：US12266617
申请日：2008-11-07
申请人： Satoshi NEGISHI , Junko Suzuki , Yoshie Yamauchi
发明人： Satoshi NEGISHI , Junko Suzuki , Yoshie Yamauchi
IPC分类号： C12P7/64 , C12N9/98 , C12N11/14
CPC分类号： C12N9/20 , C11C3/02 , C11C3/10 , C12N11/14 , C12P7/62 , C12P7/6454
摘要： The present invention discloses a method of recovering lipase activity which comprises the steps of using a lipase derived from Thermomyces sp. and immobilized on a carrier, or a lipase powder composition which comprises a filter aid and the lipase derived from Thermomyces sp. and immobilized on a carrier which is crushed into the average particle size of 1 μm or larger and smaller than 300 μm in an esterification or transesterification reaction; and washing said lipase or lipase powder composition with triacylglycerol. According to this method, the decreased lipase activity can be effectively recovered.
摘要翻译：本发明公开了一种回收脂肪酶活性的方法，该方法包括以下步骤：使用源自Thermomyces sp。并固定在载体上，或包含助滤剂和源自Thermomyces sp。的脂肪酶的脂肪酶粉末组合物。并固化在酯化或酯交换反应中被粉碎成平均粒径为1μm以上且小于300μm的载体; 并用三酰基甘油洗涤所述脂肪酶或脂肪酶粉末组合物。根据该方法，可以有效地回收脂肪酶活性降低。

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