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1. 发明授权

US06316666B1 Method for producing purified phenylenedioxydiacetic acids 失效
标题翻译：纯化苯二氧基二乙酸生产方法
公开(公告)号：US06316666B1
公开(公告)日：2001-11-13
申请号：US09495951
申请日：2000-02-02
申请人： Junji Morimoto , Takashi Kamikawa , Hiroshi Ueda
发明人： Junji Morimoto , Takashi Kamikawa , Hiroshi Ueda
IPC分类号： C07C5948
CPC分类号： C07C51/367 , C07C51/43 , C07C59/70
摘要： A method for producing phenylenedioxydiacetic acids of high purity at high yield from crude phenylenedioxydiacetic acids which mainly contains phenylenedioxydiacetic acids represented by the following general formula (I): wherein, R represents a hologen, carboxyl group or hydrocarbon group having 1-4 carbon atoms, and n represents an integer from 0 to 3, wherein an alkaline aqueous solution of the crude phenylenedioxydiacetic acids is mixed with a mineral acid to precipitate the phenylenedioxydiacetic acids, wherein at least 10% by weight of the alkaline aqueous solution is mixed with a mineral acid at 0 to 50° C.; and, after completion of the mixing, the temperature of the mixture is kept at 80 to 110° C.
摘要翻译：由以下通式（I）表示的主要含有亚苯基二氧二乙酸的粗亚苯基二氧基二乙酸生产高纯度亚苄二氧基二乙酸的方法：其中，R表示氢原子，羧基或具有1-4个碳原子的烃基， n表示0〜3的整数，将亚苯基二氧二乙酸粗碱的碱性水溶液与无机酸混合，使亚苯二氧基二乙酸沉淀，其中将至少10重量％的碱性水溶液与无机酸在0至50℃。混合完成后，将混合物的温度保持在80〜110℃。

2. 发明授权

US09023835B2 Agent for ameliorating blood-brain barrier disorders 有权
标题翻译：改善血脑屏障障碍的药剂
公开(公告)号：US09023835B2
公开(公告)日：2015-05-05
申请号：US13390058
申请日：2010-08-09
申请人： Hiroshi Ueda
发明人： Hiroshi Ueda
IPC分类号： A61K38/22 , A61K45/06
CPC分类号： A61K38/2292 , A61K45/06 , A61K2300/00
摘要： The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin α, or a protein or polypeptide possessing the same function as the prothymosin α. The invention also provides polypeptides useful in the context of the aforesaid methods.
摘要翻译：本发明提供一种改善血脑屏障障碍的方法，以及治疗伴有血脑屏障障碍的疾病的方法和治疗脑缺血疾病的方法，通过施用孕激素α或蛋白质或具有与胸腺素α相同功能的多肽。本发明还提供了在上述方法的上下文中有用的多肽。

3. 发明申请

US20130203738A1 USE OF COMPOUND BINDING TO MSIN3B THAT SPECIFICALLY BINDS TO NEURON RESTRICTIVE SILENCER FACTOR (NRSF) 有权
标题翻译：使用化合物结合到MSIN3B，特异性结合到神经元限制性沉默因子（NRSF）
公开(公告)号：US20130203738A1
公开(公告)日：2013-08-08
申请号：US13578230
申请日：2011-02-09
申请人： Yoshifumi Nishimura , Aritaka Nagadoi , Yuuka Hirao , Yoshio Goshima , Naoya Yamashita , Naoki Miyata , Takayoshi Suzuki , Ryuta Hiraishi , Hiroshi Ueda
发明人： Yoshifumi Nishimura , Aritaka Nagadoi , Yuuka Hirao , Yoshio Goshima , Naoya Yamashita , Naoki Miyata , Takayoshi Suzuki , Ryuta Hiraishi , Hiroshi Ueda
IPC分类号： C07D211/16 , C07D211/10 , C07D265/30 , C07D207/06 , C07D223/04 , C07D225/02 , C07D211/14 , C07C233/65
CPC分类号： C07D211/16 , A61K31/445 , C07C233/65 , C07C233/66 , C07C2601/14 , C07D207/06 , C07D211/10 , C07D211/14 , C07D211/96 , C07D223/04 , C07D225/02 , C07D265/30 , C07D295/192
摘要： The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain.The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (I), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.
摘要翻译：本发明鉴定了与特异性结合神经限制性沉默因子NRSF的mSin3B的PAH1结构域结合的化合物，并且将该化合物用作与神经限制性消音因子NRSF / REST的异常表达相关的疾病的预防和/或治疗或NRSF / REST靶向的基因异常表达，如亨廷顿氏病，成神经管细胞瘤和神经性疼痛。本发明提供一种药物组合物，其包含能够结合mSin3B的PAH1结构域的物质，例如下式（I）表示的化合物，其药理学上可接受的盐或其药理学上可接受的酯：其中n表示0 或1; R1，R2，R3，R4和R5各自独立地表示氢原子，烃基或官能团; Y表示单键，羰基，-CONH-，-NHCO-或磺酰基; Z表示可以具有取代基的含氮杂环基，可以具有烃基或芳香族烃基的氨基或可以具有取代基的含氮和含氧杂环基。

4. 发明授权

US08411196B2 Digital camera with movable mirror for AF in live view mode and optical viewfinder mode 有权
标题翻译：带实时取景模式和光学取景器模式的AF的可移动镜头的数码相机
公开(公告)号：US08411196B2
公开(公告)日：2013-04-02
申请号：US12095818
申请日：2006-11-30
申请人： Hiroshi Ueda , Kenichi Honjo , Naoto Yumiki , Toshio Makabe , Kenji Maeda , Kaoru Mokunaka , Kazuhiko Ishimaru
发明人： Hiroshi Ueda , Kenichi Honjo , Naoto Yumiki , Toshio Makabe , Kenji Maeda , Kaoru Mokunaka , Kazuhiko Ishimaru
IPC分类号： H04N5/232
CPC分类号： H04N5/23203 , G03B19/00 , G03B19/12 , H04N5/2254 , H04N5/23212 , H04N5/23245 , H04N5/23293 , H04N5/238
摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 130 or image data obtained by subjecting the image data generated by the CMOS sensor 130 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein when a release button 141 receives an instruction regarding start of an autofocus operation in a live view mode, the microcomputer 110 controls a movable mirror to enter an optical path to measure by an AF sensor 132, and thereafter, allow the movable mirror to retract from the optical path to return the digital camera to the live view mode. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.
摘要翻译：本发明的数码相机包括具有实时取景模式控制的微型计算机110，使得由CMOS传感器130生成的图像数据或通过对由CMOS传感器130生成的图像数据进行预定处理而获得的图像数据显示在液体晶体监视器150作为运动图像实时地实现，其中当释放按钮141接收到关于在实时取景模式中的自动对焦操作的开始的指令时，微型计算机110控制可移动反射镜进入光学路径以由AF传感器 132，然后允许可移动镜从光路缩回以将数字照相机返回到实时取景模式。由于这种结构，在包括可移动镜并且能够通过电子取景器在实时取景中显示被摄体图像的数码相机中，可以提高其可操作性。

5. 发明申请

US20120270338A1 FLUOROIMMUNOASSAY METHOD 审中-公开
标题翻译：荧光分光法
公开(公告)号：US20120270338A1
公开(公告)日：2012-10-25
申请号：US13510105
申请日：2010-11-19
申请人： Hiroshi Ueda , Ryoji Abe , Masaki Ihara , Hiroaki Takagi
发明人： Hiroshi Ueda , Ryoji Abe , Masaki Ihara , Hiroaki Takagi
IPC分类号： G01N21/76 , C07K17/02
CPC分类号： G01N33/582 , A61K49/0058 , C07K16/18 , C07K16/44 , C07K2317/56 , C07K2317/622 , C07K2317/92 , G01N21/6428 , G01N33/6857 , G01N2021/6439
摘要： An object is to provide an immunoassay method requiring neither a solid-phase immobilization step nor a washing step, enabling quick and simple quantitative measurement of a target substance in a liquid phase and capable of visualizing an antigen. Such an object is attained by measuring the concentration of a target antigen present in a test substance by sequentially performing a step (a) of bringing an antibody light-chain variable region polypeptide and an antibody heavy-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; or bringing an antibody heavy-chain variable region polypeptide and an antibody light-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; a step (b) of measuring the fluorescence intensity of the fluorescent dye; and a step (c) of computationally obtaining the level of the antigen contained in the test substance with reference to a positive correlation between the concentration of the antigen in a liquid phase and the fluorescence intensity of the fluorescent dye.
摘要翻译：本发明的目的是提供一种不需要固相固定步骤和洗涤步骤的免疫测定方法，能够快速和简单地定量测定液相中的目标物质并能够使抗原呈现。通过依次进行使荧光染料标记的抗体轻链可变区多肽和抗体重链可变区多肽的步骤（a），测定待测物质中存在的靶抗原的浓度，与液相中测试物质中的抗原接触; 或使用荧光染料标记的抗体重链可变区多肽和抗体轻链可变区多肽与液相中的测试物质中的抗原接触; 测量荧光染料的荧光强度的步骤（b）; 和（c）参考在液相中的抗原浓度与荧光染料的荧光强度之间的正相关性来计算获得测试物质中含有的抗原水平的步骤（c）。

6. 发明授权

US08223263B2 Digital camera 有权
公开(公告)号：US08223263B2
公开(公告)日：2012-07-17
申请号：US12831001
申请日：2010-07-06
申请人： Hiroshi Ueda , Kenichi Honjo , Naoto Yumiki , Toshio Makabe , Kenji Maeda , Kaoru Mokunaka , Kazuhiko Ishimaru
发明人： Hiroshi Ueda , Kenichi Honjo , Naoto Yumiki , Toshio Makabe , Kenji Maeda , Kaoru Mokunaka , Kazuhiko Ishimaru
IPC分类号： H04N5/225
CPC分类号： H04N5/23203 , G03B19/00 , G03B19/12 , H04N5/2254 , H04N5/23212 , H04N5/23245 , H04N5/23293 , H04N5/238
摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 133 or image data obtained by subjecting the image data generated by the CMOS sensor 133 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein the microcomputer 110 controls so that, when the live view mode is set, the digital camera comes out of the live view mode, and setting information on the digital camera is displayed on the liquid crystal monitor 150, in accordance with the manipulation of the manipulation portion 140. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.

7. 发明授权

US08077560B2 Additionally recordable information recording medium, information recording method, information reproducing method, information recording apparatus and information reproducing apparatus 有权
标题翻译：信息记录介质，信息记录方法，信息再现方法，信息记录装置和信息再现装置
公开(公告)号：US08077560B2
公开(公告)日：2011-12-13
申请号：US12608173
申请日：2009-10-29
申请人： Hiroshi Ueda , Motoshi Ito
发明人： Hiroshi Ueda , Motoshi Ito
IPC分类号： G11B7/00
CPC分类号： G11B27/105 , G11B7/00736 , G11B20/1217 , G11B27/329 , G11B2220/218 , G11B2220/2562
摘要： An additionally recordable information recording medium has a complicated management structure for managing an unrecorded area. Therefore, there are problems that it takes a long time for a disk to startup and it is difficult to build a recording/reproducing system. The additionally recordable information recording medium according to the present invention includes a simple data structure for managing a location information for a recorded area located at the rearmost location in a user data area. An additionally recordable apparatus according to the present invention also includes means for updating the location information of the recorded area so that the recorded area located at the rearmost location in the user data area is always managed.
摘要翻译：另外可记录的信息记录介质具有用于管理未记录区域的复杂管理结构。因此，存在磁盘启动需要很长时间并且难以构建记录/再现系统的问题。根据本发明的另外可记录的信息记录介质包括用于管理位于用户数据区域中最后位置的记录区域的位置信息的简单数据结构。根据本发明的另外可记录的装置还包括用于更新记录区域的位置信息的装置，使得位于用户数据区域中的最后位置的记录区域总是被管理。

8. 发明授权

US08004945B2 Recording medium access device 有权
标题翻译：记录介质访问设备
公开(公告)号：US08004945B2
公开(公告)日：2011-08-23
申请号：US12282439
申请日：2007-03-13
申请人： Harumitsu Miyashita , Kohei Nakata , Hiroshi Ueda , Youichi Ogura
发明人： Harumitsu Miyashita , Kohei Nakata , Hiroshi Ueda , Youichi Ogura
IPC分类号： G11B7/00
CPC分类号： G11B20/10009 , G11B7/0053 , G11B7/08523 , G11B2220/2537
摘要： An information reproduction device according to the present invention is a device for accessing a recording medium having first address information and second address information recorded thereon. The first address information is represented by a shape formed on the recording medium in advance; and the second address information is recorded on the recording medium together with data. The information reproduction device includes a head section for accessing the recording medium to generate a reproduction signal; a first detection section for detecting the first address information from the reproduction signal; a second detection section for detecting the second address information from the reproduction signal; and a control section for, based on a detection result of either the first detection section or the second detection section which detected the address information first, controlling an access after the detection to the recording medium.
摘要翻译：根据本发明的信息再现装置是用于访问其上记录有第一地址信息和第二地址信息的记录介质的装置。第一地址信息由形成在记录介质上的形状预先表示; 并且第二地址信息与数据一起被记录在记录介质上。信息再现装置包括用于访问记录介质以产生再现信号的头部分; 第一检测部分，用于从再现信号中检测第一地址信息; 第二检测部分，用于从再现信号中检测第二地址信息; 以及控制部分，用于基于首先检测到地址信息的第一检测部分或第二检测部分的检测结果，控制检测到记录介质之后的访问。

9. 再颁专利

USRE42585E1 Information recording medium, recording apparatus, reproduction apparatus, recording method, reproduction method and defect management method 有权
标题翻译：信息记录介质，记录装置，再现装置，记录方法，再现方法和缺陷管理方法
公开(公告)号：USRE42585E1
公开(公告)日：2011-08-02
申请号：US12819785
申请日：2010-06-21
申请人： Yoshikazu Yamamoto , Motoshi Ito , Hiroshi Ueda
发明人： Yoshikazu Yamamoto , Motoshi Ito , Hiroshi Ueda
IPC分类号： G11B5/09
CPC分类号： G11B20/1217 , G11B20/1883 , G11B2020/1893 , G11B2220/20 , G11B2220/2537
摘要： Information recording media 101 and 102 usable for either a first recording density D1 or a second recording density D2 each include a user data area 106 in which user data is to be recorded, a first defect management information area 108 in which first defect management information for managing a defect area in the user data area is to be recorded, and a second defect management information area 109 in which second defect management information having an identical content to that of the first defect management information is to be recorded. The first and second defect management information areas 108 and 109 are located such that angles θ1 and θ2 made by start blocks thereof fulfill the relationships of 150°≦θ1≦210° and 150°≦θ2≦210° (θ1: in the case of the first recording density, and θ2: in the case of the second recording density).
摘要翻译：可用于第一记录密度D1或第二记录密度D2的信息记录介质101和102分别包括要记录用户数据的用户数据区域106，第一缺陷管理信息区域108，其中第一缺陷管理信息用于要记录用户数据区域中的缺陷区域的管理，以及要记录与第一缺陷管理信息的内容相同的第二缺陷管理信息的第二缺陷管理信息区域109。第一和第二缺陷管理信息区域108和109被定位成使得由其起始块制成的角度和角度1和θ2与第一和第二缺陷管理信息区域108和109之间的关系满足150°＆nlE;＆amp; thetas; 1＆nlE; 210°和150°＆nlE;＆thetas; 2＆nlE ; 210°（＆amp; thetas; 1：在第一记录密度的情况下，和＆amp;; 2：在第二记录密度的情况下）。

10. 发明授权

US07983131B2 Information recording apparatus, information recording method and integrated circuit 有权
标题翻译：信息记录装置，信息记录方法和集成电路
公开(公告)号：US07983131B2
公开(公告)日：2011-07-19
申请号：US12714705
申请日：2010-03-01
申请人： Hisae Kato , Hiroshi Ueda , Motoshi Ito
发明人： Hisae Kato , Hiroshi Ueda , Motoshi Ito
IPC分类号： G11B7/00
CPC分类号： G11B20/1883 , G11B20/1217 , G11B20/1879 , G11B2020/10916 , G11B2020/1221 , G11B2020/1232 , G11B2020/1267 , G11B2020/1277 , G11B2020/1297 , G11B2220/20 , G11B2220/2541 , G11B2220/2562
摘要： An information recording apparatus is provided with a recording controller for recording data on an information recording medium, a verification controller for verifying whether or not the recorded data can be correctly reproduced, a continuous recording controller for providing a gap region of a specified interval between a verification region and a recording region and successively performing a verify processing and a record processing with rotation waiting in between, an error region discriminator for discriminating an error region in the event of an error in the process of performing the verify processing and the record processing, and an error processor for performing an error processing according to the error region. The error processor performs an error processing different from the one performed when an error occurred in either one of the verification region and the recording region if an error is discriminated to have occurred in the gap region. By this construction, a recording time is shortened and it is prevented that data cannot be recorded on the information recording medium.
摘要翻译：信息记录装置设置有用于在信息记录介质上记录数据的记录控制器，用于验证记录数据是否可以被正确再现的验证控制器，用于提供记录数据之间的间隔区域的连续记录控制器验证区域和记录区域，并且在循环等待中继续执行验证处理和记录处理，用于在执行验证处理的处理和记录处理的过程中识别错误区域的错误区域鉴别器，以及用于根据误差区域执行错误处理的错误处理器。错误处理器执行与当在差异区域中出现错误时，在验证区域和记录区域中的任一个中发生错误时执行的错误处理。通过这种结构，缩短了记录时间，并且防止了数据不能被记录在信息记录介质上。

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