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1. 发明申请

US20130273635A1 BACTERIOPHAGE KILLING PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：杀菌剂杀虫剂AERUGINOSA和STAPHYLOCOCCUS AUREUS
公开(公告)号：US20130273635A1
公开(公告)日：2013-10-17
申请号：US13445564
申请日：2012-04-12
申请人： Jung Min Kim , Shuk Ho Kim , Seongjun Yoon , Sooyoun Jun , Sanghyeon Kang
发明人： Jung Min Kim , Shuk Ho Kim , Seongjun Yoon , Sooyoun Jun , Sanghyeon Kang
IPC分类号： C12N7/00
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/10321 , C12N2795/10331 , C12N2795/10332 , Y02A50/475
摘要： The present invention relates to a bacteriophage PA1Φ belonging to family Siphoviridae, characterized that it is capable of killing one or more bacteria strains selected from a group comprising Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus homonis, Shigella sonnei, Listeria monocytogenes and Streptococcus pneumonia, and contains a full-length genome of SEQ ID NO: 1.According to the present invention, the bacteriophage PA1Φ can be used to kill said bacteria and reduce the same effectively. Also, it can be used to remove biofilms generated by said bacteria. Especially, this bacteriophage is applicable for medical industry, food industry, biotechnology and the like, because it is a sort of virus that kills host bacteria without any adverse effect on human, animals and so on. In addition, this bacteriophage can kill noxious bacteria on target sites or target supports without any problem related with resistance development of bacteria.
摘要翻译：本发明涉及属于家蚕科的噬菌体PA1Phi，其特征在于能够杀死一种或多种选自包括绿脓假单胞菌，金黄色葡萄球菌，表皮葡萄球菌，金黄色葡萄球菌，志贺氏菌，单核细胞增生利斯特氏菌和肺炎链球菌的细菌菌株，并含有SEQ ID NO：1的全长基因组。根据本发明，噬菌体PA1Phi可用于杀死所述细菌并有效地减少。此外，它可以用于去除由所述细菌产生的生物膜。特别是，这种噬菌体适用于医疗工业，食品工业，生物技术等，因为它是一种杀死宿主细菌而不对人类，动物等产生不利影响的病毒。此外，这种噬菌体可以在目标部位或靶支架上杀死有害细菌，而不会与细菌的抗性发展相关。

2. 发明授权

US10077468B2 PCR primer capable of reducing non-specific amplification and PCR method using the PCR primer 有权
公开(公告)号：US10077468B2
公开(公告)日：2018-09-18
申请号：US12228302
申请日：2008-08-12
申请人： Seongjun Yoon , Hyunyoung Lee , Jinseok Yu , Sooyoun Jun , Sanghyeon Kang
发明人： Seongjun Yoon , Hyunyoung Lee , Jinseok Yu , Sooyoun Jun , Sanghyeon Kang
IPC分类号： C12Q1/68 , C12Q1/686
CPC分类号： C12Q1/686 , C12Q2549/101 , C12Q2525/151
摘要： The present invention relates to a PCR primer facilitating hot-start PCR by suppressing non-specific amplification at room temperature and at the same time capable of reducing significantly non-specific amplification by dominating the amplification of the PCR product rather than the amplification of the original template from the third PCR cycle, more precisely a PCR primer prepared by additionally inserting the reverse-complementary sequence to a certain region starting from the 5′-start site of the 5′-terminus of the original primer which is composed of priming sequence to anneal to a PCR template into the 5′-terminus of the original primer and a PCR method using the same. The primer of the present invention has a original primer sequence composed of priming sequence to anneal to a PCR template and an additional reverse-complementary sequence, which inserted into the 5′-terminus of the original primer, to a certain region starting from the 5′-start site of the 5′-terminus of the original primer sequence, suggesting that a template-specific sequence and its reverse-complementary sequence are included in the same primer. The present invention can improve PCR specificity by reducing non-specific amplification.

3. 发明授权

US08043613B2 Podoviriedae bacteriophage having killing activity specific to Staphylococcus aureus 有权
标题翻译：波多病毒噬菌体具有对金黄色葡萄球菌特异性的杀伤活性
公开(公告)号：US08043613B2
公开(公告)日：2011-10-25
申请号：US12378457
申请日：2009-02-12
申请人： Seongjun Yoon , Yunjaie Choi , Seyung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
发明人： Seongjun Yoon , Yunjaie Choi , Seyung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
IPC分类号： A01N63/00
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/10232
摘要： The present invention relates to a novel bacteriophage, more precisely a Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious disease in human and animals, a pharmaceutical composition for the prevention and treatment of the disease caused by Staphylococcus aureus, an antibiotic and a disinfectant containing the bacteriophage as an active ingredient.
摘要翻译：本发明涉及一种新型噬菌体，更确切地说，具有针对人和动物感染性疾病引起的金黄色葡萄球菌特异性杀伤活性的波形病毒噬菌体，用于预防和治疗由金黄色葡萄球菌引起的疾病的药物组合物，含有噬菌体作为活性成分的抗生素和消毒剂。

4. 发明申请

US20100203180A1 Antimicrobial protein derived from podoviriedae bacteriophage specific to staphylococcus aureus 有权
标题翻译：源自金黄色葡萄球菌特异性的巨球菌噬菌体的抗菌蛋白质
公开(公告)号：US20100203180A1
公开(公告)日：2010-08-12
申请号：US12378365
申请日：2009-02-12
申请人： Seongjun Yoon , Yunjaie Choi , Seyung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
发明人： Seongjun Yoon , Yunjaie Choi , Seyung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
IPC分类号： A61K38/16 , C07K14/01 , C12N15/31 , C12N1/21 , A61P31/04
CPC分类号： C07K14/005 , A61K9/0017 , A61K38/00 , C12N9/503 , C12N2795/10222
摘要： The present invention relates to a novel antimicrobial protein derived from bacteriophage having killing activity specific to Staphylococcus aureus, more precisely an antimicrobial protein originated from Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious disease in human and animals, a pharmaceutical composition for the prevention and treatment of infectious disease caused by Staphylococcus aureus, an antibiotic and a disinfectant containing the bacteriophage-originated antimicrobial protein as an active ingredient.
摘要翻译：本发明涉及一种新型的抗菌药物，其具有对金黄色葡萄球菌特异性杀伤活性的噬菌体，更准确地说，是源于波氏病毒噬菌体的抗微生物蛋白质，其具有对人和动物感染性疾病引起的金黄色葡萄球菌特异性杀伤活性，用于预防和治疗由金黄色葡萄球菌引起的感染性疾病的药物组合物，抗生素和含有噬菌体起始的抗微生物蛋白作为活性成分的消毒剂。

5. 发明申请

US20130011369A1 Method for Prevention and Treatment of Salmonella Infection 审中-公开
标题翻译：预防和治疗沙门氏菌感染的方法
公开(公告)号：US20130011369A1
公开(公告)日：2013-01-10
申请号：US13176458
申请日：2011-07-05
申请人： Seongjun Yoon , Sooyoun Jun , Hyoungrok Paik , Gimo Jung , Yoonsik Shin , Sanghyeon Kang
发明人： Seongjun Yoon , Sooyoun Jun , Hyoungrok Paik , Gimo Jung , Yoonsik Shin , Sanghyeon Kang
IPC分类号： A61K35/76 , C12N7/00 , A61P31/04
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/00021 , C12N2795/00032 , Y02A50/471 , Y02A50/481
摘要： The present invention relates to a composition comprising bacteriophage SP-1, the bacteriophage capable of destroying Salmonella once being infected in Salmonella, as an active ingredient, and a method for prevention and treatment of Salmonella infection using the same. Bacteriophage SP-1, the active ingredient of the composition of the present invention, characteristically has the killing activity to Salmonella and has the genome represented by SEQ. ID. NO: 1.
摘要翻译：本发明涉及包含噬菌体SP-1，能够在沙门氏菌中被感染的沙门氏菌的噬菌体作为活性成分的组合物，以及使用该组合物的沙门氏菌感染的预防和治疗方法。噬菌体SP-1是本发明组合物的活性成分，其特征在于具有沙门氏菌的杀伤活性，并具有SEQ ID NO： ID。 NO：1。

6. 发明授权

US08066990B2 Lysin protein having broad antibacterial activity specific to bacteria 有权
标题翻译：赖氨酸蛋白具有对细菌特异性的广泛抗菌活性
公开(公告)号：US08066990B2
公开(公告)日：2011-11-29
申请号：US12423322
申请日：2009-04-14
申请人： Seongjun Yoon , Yunjaie Choi , Jeesoo Son , Sooyoun Jun , Hyoungrok Paik , Sanghyeon Kang
发明人： Seongjun Yoon , Yunjaie Choi , Jeesoo Son , Sooyoun Jun , Hyoungrok Paik , Sanghyeon Kang
IPC分类号： A61K38/46
CPC分类号： C12N9/503 , A61K38/00 , C12N2795/00011 , C12N2795/00022
摘要： The present invention relates to a lysin protein originated from bacteriophage, more precisely a lysin protein comprising the amino acid sequence represented by SEQ. ID. NO: 2 which has no harm to human and animals comprising eukaryotic cells owing to its specificity to bacteria and has broad antibacterial activity, and a pharmaceutical composition for the prevention and treatment of infectious disease caused by bacteria comprising the said lysin protein as an active ingredient.
摘要翻译：本发明涉及来自噬菌体的赖氨酸蛋白质，更确切地说，涉及包含SEQ ID NO：1所示氨基酸序列的赖氨酸蛋白质。 ID。 NO：2，由于其对细菌的特异性而对包含真核细胞的人类和动物无害，并且具有广泛的抗菌活性，以及用于预防和治疗由细菌引起的感染性疾病的药物组合物，所述细菌包含所述溶素蛋白作为活性成分。

7. 发明申请

US20100254950A1 Bacteriophage or lytic protein derived from the bacteriophage which effective for the treatment of staphylococcus aureus biofilm 有权
标题翻译：来自有效治疗金黄色葡萄球菌生物膜的噬菌体的噬菌体或溶解蛋白
公开(公告)号：US20100254950A1
公开(公告)日：2010-10-07
申请号：US12677990
申请日：2008-09-12
申请人： Seongjun Yoon , Yunjaie Choi , Se Yung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
发明人： Seongjun Yoon , Yunjaie Choi , Se Yung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
IPC分类号： A01N63/02 , A01N63/00 , A01P1/00 , A61K35/76 , A61K35/00 , A61P31/04
CPC分类号： A01N63/00 , A61K35/76 , A61K38/00 , C12N2795/00031 , C12N2795/00032
摘要： The present invention relates to compositions for removing a biofilm formed by Staphylococcus aureus, comprising a bacteriophage, such as Myoviridae family T4-like phage genus bacteriophage (Accession No: KCTC 11153BP, SAP-I) or Podoviridae family φ29-like virus genus bacteriophage (Accession No: KCTC11154BP, SAP-2), and lytic protein derived therefrom, that destroys the biofilm. Also disclosed are pharmaceutical compositions for the treatment of diseases caused by Staphylococcus aureus capable of forming biofilm.
摘要翻译：本发明涉及用于除去由金黄色葡萄球菌形成的生物膜的组合物，其包含噬菌体，例如Myoviridae家族T4样噬菌体噬菌体（登录号：KCTC 11153BP，SAP-1）或Podoviridae家族和类肿瘤病毒属噬菌体（登录号：KCTC11154BP，SAP-2）和从其衍生的裂解蛋白，破坏生物膜。还公开了用于治疗能够形成生物膜的由金黄色葡萄球菌引起的疾病的药物组合物。

8. 发明授权

US08329165B2 Composition for the treatment of ballast water containing bacteriophage as an effective component and biological method with the same for removing bacteria present in ballast water 有权
标题翻译：用于治疗含有噬菌体的压载水作为有效成分的组合物和用于除去压载水中存在的细菌的生物学方法
公开(公告)号：US08329165B2
公开(公告)日：2012-12-11
申请号：US12231691
申请日：2008-09-05
申请人： Seongjun Yoon , Sooyoun Jun , Sanghyeon Kang , Yunjaie Choi , Jeesoo Son
发明人： Seongjun Yoon , Sooyoun Jun , Sanghyeon Kang , Yunjaie Choi , Jeesoo Son
IPC分类号： A01N63/00 , C12N7/00 , C12N7/01
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/00032 , C12N2795/10132 , C12N2795/10232 , C12N2795/10332
摘要： The present invention relates to a composition for the treatment of ballast water containing bacteriophage capable of killing specific target bacteria as an active ingredient in order to eliminate or reduce bacteria including pathogenic bacteria present in ballast water, and a biological treatment method of ballast water.
摘要翻译：本发明涉及一种用于治疗含有噬菌体的压载水组合物，其能够杀死特定靶细菌作为活性成分，以消除或减少包含压载水中存在的病原菌的细菌，以及压载水的生物处理方法。

9. 发明申请

US20090258353A1 PCR primer capable of reducing non-specific amplification and PCR method using the PCR primer 审中-公开
标题翻译：使用PCR引物能够减少非特异性扩增和PCR方法的PCR引物
公开(公告)号：US20090258353A1
公开(公告)日：2009-10-15
申请号：US12228302
申请日：2008-08-12
申请人： Seongjun Yoon , Hyunyoung Lee , Jinseok Yu , Sooyoun Jun , Sanghyeon Kang
发明人： Seongjun Yoon , Hyunyoung Lee , Jinseok Yu , Sooyoun Jun , Sanghyeon Kang
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/686 , C12Q2549/101 , C12Q2525/151
摘要： The present invention relates to a PCR primer facilitating hot-start PCR by suppressing non-specific amplification at room temperature and at the same time capable of reducing significantly non-specific amplification by dominating the amplification of the PCR product rather than the amplification of the original template from the third PCR cycle, more precisely a PCR primer prepared by additionally inserting the reverse-complementary sequence to a certain region starting from the 5′-start site of the 5′-terminus of the original primer which is composed of priming sequence to anneal to a PCR template into the 5′-terminus of the original primer and a PCR method using the same. The primer of the present invention has a original primer sequence composed of priming sequence to anneal to a PCR template and an additional reverse-complementary sequence, which inserted into the 5′-terminus of the original primer, to a certain region starting from the 5′-start site of the 5′-terminus of the original primer sequence, suggesting that a template-specific sequence and its reverse-complementary sequence are included in the same primer. The present invention can improve PCR specificity by reducing non-specific amplification.
摘要翻译：本发明涉及通过在室温下抑制非特异性扩增而促进热启动PCR的PCR引物，并且同时能够通过主导PCR产物的扩增来显着降低非特异性扩增，而不是原始扩增来自第三PCR循环的模板，更确切地说，是通过将原始引物的5'末端的5'-起始位点开始的反向互补序列另外插入到由引发序列组成的特定区域而制备的PCR引物，与PCR模板退火到原始引物的5'末端，使用PCR法进行PCR扩增。本发明的引物具有由引物序列组成的原始引物序列，其与PCR模板退火，并将插入原始引物的5'末端的另外的反向互补序列从5 '起始引物序列的5'末端的位点，表明模板特异性序列及其反向互补序列被包含在相同的引物中。本发明可以通过减少非特异性扩增来提高PCR特异性。

10. 发明授权

US08377866B2 Antimicrobial protein derived from Podoviridae bacteriophage specific to Staphylococcus aureus 有权
标题翻译：来源于金黄色葡萄球菌特异性的波多病毒噬菌体的抗微生物蛋白质
公开(公告)号：US08377866B2
公开(公告)日：2013-02-19
申请号：US12378365
申请日：2009-02-12
申请人： Seongjun Yoon , Yunjaie Choi , Seyung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
发明人： Seongjun Yoon , Yunjaie Choi , Seyung Lee , Jeesoo Son , Sooyoun Jun , Sanghyeon Kang
IPC分类号： A61K38/16
CPC分类号： C07K14/005 , A61K9/0017 , A61K38/00 , C12N9/503 , C12N2795/10222
摘要： The present invention relates to a novel antimicrobial protein derived from bacteriophage having killing activity specific to Staphylococcus aureus, more precisely an antimicrobial protein originated from Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious disease in human and animals, a pharmaceutical composition for the prevention and treatment of infectious disease caused by Staphylococcus aureus, an antibiotic and a disinfectant containing the bacteriophage-originated antimicrobial protein as an active ingredient.
摘要翻译：本发明涉及一种新型的抗菌药物，其具有对金黄色葡萄球菌特异性杀伤活性的噬菌体，更准确地说，是源于波氏病毒噬菌体的抗微生物蛋白质，其具有对人和动物感染性疾病引起的金黄色葡萄球菌特异性的杀伤活性，用于预防和治疗由金黄色葡萄球菌引起的感染性疾病的药物组合物，抗生素和含有噬菌体起始的抗微生物蛋白作为活性成分的消毒剂。

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