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1. 发明申请

US20090246811A1 DRY ANALYTICAL ELEMENT FOR LIPASE MEASUREMENT 有权
标题翻译：用于脂肪测量的干燥分析元素
公开(公告)号：US20090246811A1
公开(公告)日：2009-10-01
申请号：US12410035
申请日：2009-03-24
申请人： Jun Arakawa , Nobuhito Masuda , Kentaro Nakamura , Shigeki Kageyama
发明人： Jun Arakawa , Nobuhito Masuda , Kentaro Nakamura , Shigeki Kageyama
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , G01N2333/92
摘要： The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, and comprises a water-impermeable support and at least one spreading or reagent layer, said method comprising the step of coating an emulsion/dispersion solution of triglyceride with an average particle size of 1 μm or less.
摘要翻译：本发明提供了含有含有碳原子数12〜22的长链烷基脂肪酸甘油三酯，单甘油酯脂肪酶，甘油测定试剂的体液中所含的胰脂肪酶的测定用干燥分析元件的制造方法，水不渗透性载体和至少一种扩散剂或试剂层，所述方法包括涂覆平均粒度为1μm以下的甘油三酯的乳液/分散液的步骤。

2. 发明授权

US08168406B2 Dry analytical element for lipase measurement 有权
标题翻译：用于脂肪酶测量的干燥分析元件
公开(公告)号：US08168406B2
公开(公告)日：2012-05-01
申请号：US12410035
申请日：2009-03-24
申请人： Jun Arakawa , Nobuhito Masuda , Kentaro Nakamura , Shigeki Kageyama
发明人： Jun Arakawa , Nobuhito Masuda , Kentaro Nakamura , Shigeki Kageyama
IPC分类号： C12Q1/44 , C12M1/36 , C12M1/34 , C12M1/00
CPC分类号： C12Q1/44 , G01N2333/92
摘要： The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, and comprises a water-impermeable support and at least one spreading or reagent layer, said method comprising the step of coating an emulsion/dispersion solution of triglyceride with an average particle size of 1 μm or less.
摘要翻译：本发明提供了含有含有碳原子数12〜22的长链烷基脂肪酸甘油三酯，单甘油酯脂肪酶，甘油测定试剂的体液中所含的胰脂肪酶的测定用干燥分析元件的制造方法，水不渗透性支持体和至少一种扩散剂或试剂层，所述方法包括涂布平均粒径为1μm以下的甘油三酯的乳液/分散液的步骤。

3. 发明授权

US08906641B2 Method for measuring animal α-amylase 有权
标题翻译：测定动物α-淀粉酶的方法
公开(公告)号：US08906641B2
公开(公告)日：2014-12-09
申请号：US12015151
申请日：2008-01-16
申请人： Shigeki Kageyama , Nobuhito Masuda , Kazuya Kawasaki , Satoru Toda
发明人： Shigeki Kageyama , Nobuhito Masuda , Kazuya Kawasaki , Satoru Toda
IPC分类号： C12Q1/40 , G01N33/52
CPC分类号： C12Q1/40 , G01N33/523 , G01N33/526
摘要： It is an object of the present invention to provide a method capable of measuring a high concentration (up to 2500 U/L) of animal sample without dilutions, which is further capable of specifically measuring α-amylase even in a sample comprising animal α-amylase (EC 3.2.1.1) and glucoamylase (EC 3.2.1.3). The present invention provides a method for specifically measuring α-amylase contained in a non-human animal sample comprising α-amylase and glucoamylase without diluting said sample, wherein measurement is carried out by using an oligosaccharide having a protected nonreducing terminus and a p-nitrophenyl group at the reducing terminus thereof, and pH of reaction is 6 or more, and less than 7.
摘要翻译：本发明的目的是提供一种能够测量高浓度（高达2500U / L）的动物样品而不稀释的方法，即使在包含动物α-淀粉样品的样品中也能够特异性地测量α-淀粉酶，淀粉酶（EC 3.2.1.1）和葡糖淀粉酶（EC 3.2.1.3）。本发明提供一种用于特异性测量包含α-淀粉酶和葡糖淀粉酶的非人动物样品中α-淀粉酶的方法，而不稀释所述样品，其中通过使用具有受保护的非还原末端的寡糖和对硝基苯在其还原末端，反应的pH为6以上且小于7。

4. 发明申请

US20080182285A1 METHOD FOR MEASURING ANIMAL alpha-AMYLASE 有权
标题翻译：用于测量动物α-淀粉酶的方法
公开(公告)号：US20080182285A1
公开(公告)日：2008-07-31
申请号：US12015151
申请日：2008-01-16
申请人： Shigeki Kageyama , Nobuhito Masuda , Kazuya Kawasaki , Satoru Toda
发明人： Shigeki Kageyama , Nobuhito Masuda , Kazuya Kawasaki , Satoru Toda
IPC分类号： C12Q1/40
CPC分类号： C12Q1/40 , G01N33/523 , G01N33/526
摘要： It is an object of the present invention to provide a method capable of measuring a high concentration (up to 2500 U/L) of animal sample without dilutions, which is further capable of specifically measuring α-amylase even in a sample comprising animal α-amylase (EC 3.2.1.1) and glucoamylase (EC 3.2.1.3). The present invention provides a method for specifically measuring α-amylase contained in a non-human animal sample comprising α-amylase and glucoamylase without diluting said sample, wherein measurement is carried out by using an oligosaccharide having a protected nonreducing terminus and a p-nitrophenyl group at the reducing terminus thereof, and pH of reaction is 6 or more, and less than 7.
摘要翻译：本发明的目的是提供一种能够测量没有稀释度的动物样品的高浓度（高达2500U / L）的方法，其甚至能够特异性地测量α-淀粉酶，即使在包含动物α-淀粉酶的样品中，淀粉酶（EC 3.2.1.1）和葡糖淀粉酶（EC 3.2.1.3）。本发明提供了一种用于特异性测量包含α-淀粉酶和葡糖淀粉酶的非人动物样品中α-淀粉酶的方法，而不稀释所述样品，其中通过使用具有受保护的非还原末端的寡糖和对硝基苯在其还原末端，反应的pH为6以上且小于7。

5. 发明授权

US08288117B2 Dry analytical element for lipase measurement 有权
标题翻译：用于脂肪酶测量的干燥分析元件
公开(公告)号：US08288117B2
公开(公告)日：2012-10-16
申请号：US12410046
申请日：2009-03-24
申请人： Kentaro Nakamura , Shigeki Kageyama
发明人： Kentaro Nakamura , Shigeki Kageyama
IPC分类号： C12Q1/44 , C12M1/36 , C12M1/34 , C12M1/00
CPC分类号： C12Q1/44 , G01N2333/92
摘要： It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that the dry analytical element is stable and is compatible with production. The present invention provides a dry analytical element for measuring pancreatic lipase contained in body fluid, which comprises triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerin measurement reagent, and which comprises a water-impermeable support and at least one spreading or reagent layer, wherein a hydrophilic polymer at a weight ratio of 1.8:1 or greater with respect to the triglyceride is contained.
摘要翻译：本发明的目的是提供：用于分析胰脂肪酶的干燥分析元件，其中甘油三酯不在载体上转录以污染运输滑移或其它分析元件，并且其中甘油三酯的添加剂溶液既不再聚集也不沉淀，使干燥分析元件稳定，与生产兼容。本发明提供一种用于测量体液中包含的胰脂肪酶的干燥分析元件，其包含具有12-22个碳原子的长链烷基脂肪酸甘油三酯，甘油单酯脂肪酶和甘油测量试剂，并且其包含不透水的载体和至少一个铺展剂或试剂层，其中含有相对于甘油三酯的1.8:1或更大重量比的亲水性聚合物。

6. 发明申请

US20090246812A1 DRY ANALYTICAL ELEMENT FOR LIPASE MEASUREMENT 有权
标题翻译：用于脂肪测量的干燥分析元素
公开(公告)号：US20090246812A1
公开(公告)日：2009-10-01
申请号：US12410046
申请日：2009-03-24
申请人： Kentaro Nakamura , Shigeki Kageyama
发明人： Kentaro Nakamura , Shigeki Kageyama
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , G01N2333/92
摘要： It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that the dry analytical element is stable and is compatible with production. The present invention provides a dry analytical element for measuring pancreatic lipase contained in body fluid, which comprises triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerin measurement reagent, and which comprises a water-impermeable support and at least one spreading or reagent layer, wherein a hydrophilic polymer at a weight ratio of 1.8:1 or greater with respect to the triglyceride is contained.
摘要翻译：本发明的目的是提供：用于分析胰脂肪酶的干燥分析元件，其中甘油三酯不在载体上转录以污染运输滑移或其它分析元件，并且其中甘油三酯的添加剂溶液既不再聚集也不沉淀，使干燥分析元件稳定，与生产兼容。本发明提供一种用于测量体液中包含的胰脂肪酶的干燥分析元件，其包含具有12-22个碳原子的长链烷基脂肪酸甘油三酯，甘油单酯脂肪酶和甘油测量试剂，并且其包含不透水的载体和至少一个铺展剂或试剂层，其中含有相对于甘油三酯的1.8:1或更大重量比的亲水性聚合物。

7. 依法登记的发明

USH791H Multilayer analytical element for quantitative analysis of bilirubin 失效
标题翻译： BILIRUBIN定量分析的多层分析元件
公开(公告)号：USH791H
公开(公告)日：1990-06-05
申请号：US106906
申请日：1987-10-08
申请人： Harumi Katsuyama , Shigeki Kageyama , Shigeru Nagatomo
发明人： Harumi Katsuyama , Shigeki Kageyama , Shigeru Nagatomo
IPC分类号： G01N33/72 , G01N21/78
CPC分类号： G01N33/728
摘要： A multilayer analytical element for quantitative analysis of bilirubin in a liquid sample by a diazo method, which comprises a laminated structure consisting essentially of:(1) a porous reagent layer containing an acidic binder and a diazonium salt being reactive to bilirubin to produce azobilirubin;(2) an absorbent layer capable of absorbing an excessive liquid portion; and(3) a liquid-impermeable light-transmissive support.

8. 发明申请

US20080279725A1 Multilayer Analytical Element 审中-公开
标题翻译：多层分析单元
公开(公告)号：US20080279725A1
公开(公告)日：2008-11-13
申请号：US11664284
申请日：2005-09-29
申请人： Mitsuharu Nirasawa , Shigeki Kageyama , Toshihisa Ito
发明人： Mitsuharu Nirasawa , Shigeki Kageyama , Toshihisa Ito
IPC分类号： G01N33/00 , B32B37/12
CPC分类号： G01N33/525 , B01L3/5023 , G01N31/22
摘要： The object of the invention is to provide a multilayer analytical element having a non-fibrous porous film with high film strength, which does not produce uneven coloration in the form of a white-out and which has high accuracy of analysis. The present invention provides a dry multilayer analytical element for the analysis of a liquid sample which comprises a water-non-transmitting planar support on one side of which at least one adhesion layer and a porous liquid-sample-developing layer are integrally layered in the mentioned order, wherein the porous liquid-sample-developing layer comprises a non-fibrous porous film whose bending fracture strength is 20 g weight or more and whose elongation ratio when pulled with a 50-g weight is 2% or less, and wherein a adhesion layer polymer binder is caused to become seeped up in the non-fibrous porous film to 2 to 50 μm.
摘要翻译：本发明的目的是提供一种具有高膜强度的非纤维多孔膜的多层分析元件，其不会产生白色形式的不均匀着色，并且分析精度高。本发明提供了一种用于分析液体样品的干燥多层分析元件，该液体样品在其一侧包括水不透过平面支撑体，其中至少一个粘附层和多孔液体样品显影层一体地层叠在其中多孔液体样品显影层包括弯曲断裂强度为20g或更大的非纤维多孔膜，其拉伸50g时的伸长率为2％以下，其中，使粘合层聚合物粘合剂在非纤维多孔膜中渗透至2〜50μm。

9. 发明授权

US5603898A Dry-type analytical element for immunoassay 失效
标题翻译：用于免疫测定的干式分析元件
公开(公告)号：US5603898A
公开(公告)日：1997-02-18
申请号：US993964
申请日：1992-12-17
申请人： Yoshihiro Ashihara , Yukio Sudo , Isao Nishizono , Toshikage Hiraoka , Tetsuji Tanimoto , Shigeki Kageyama
发明人： Yoshihiro Ashihara , Yukio Sudo , Isao Nishizono , Toshikage Hiraoka , Tetsuji Tanimoto , Shigeki Kageyama
IPC分类号： G01N33/543 , G01N33/58 , G01N21/00 , C07K16/00 , C12M1/14 , G01N33/53
CPC分类号： G01N33/581 , G01N33/54386
摘要： A dry-type analytical element for immunoassay having at least one water-permeable layer for measuring a ligand in a sample according to enzyme immunoassay, which comprises,(A) a water-soluble macromolecular substrate, and(B) an enzyme conjugated with antibody reacting with the ligand in the sample capable to act on the above water-soluble macromolecular substrate. The above analytical element further comprises,(C) a macromolecular antigen which is a conjugate of the ligand or its derivative with a macromolecular compound in the above water-permeable layer of the above dry-type analytical element.The invention can conduct highly sensitive and simple enzyme immunoassay.
摘要翻译：一种用于免疫测定的干式分析元件，其具有至少一个用于根据酶免疫测定法测量样品中的配体的透水层，其包含（A）水溶性大分子底物和（B）与抗体结合的酶与能够作用于上述水溶性大分子底物的样品中的配体反应。上述分析元素还包含（C）在上述干式分析元件的上述透水层中作为配体或其衍生物与高分子化合物的共轭物的高分子抗原。本发明可以进行高灵敏度和简单的酶免疫测定。

10. 发明授权

US5161167A Semiconductor laser producing visible light 失效
标题翻译：半导体激光生产可见光
公开(公告)号：US5161167A
公开(公告)日：1992-11-03
申请号：US717046
申请日：1991-06-18
申请人： Takashi Murakami , Shigeki Kageyama , Kazuo Mizuguchi
发明人： Takashi Murakami , Shigeki Kageyama , Kazuo Mizuguchi
IPC分类号： H01S5/22 , H01S5/223 , H01S5/323
CPC分类号： H01S5/32325 , H01S5/2231 , H01S5/2206 , H01S5/2207 , H01S5/2209 , H01S5/221 , H01S5/2219
摘要： A semiconductor laser producing visible light includes a first conductivity type GaAs substrate, a first conductivity type (Al.sub.w Ga.sub.1-w).sub.0.5 In.sub.0.5 P cladding layer disposed on the substrate, a (Al.sub.z Ga.sub.1-z).sub.0.5 In.sub.0.5 P active layer disposed on the first conductivity type cladding layer wherein 0.ltoreq.z

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