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1. 发明授权

US08197811B2 Methods of use of sialoadhesin factor-2 antibodies 有权
标题翻译：唾液酸蛋白因子-2抗体的使用方法
公开(公告)号：US08197811B2
公开(公告)日：2012-06-12
申请号：US13007450
申请日：2011-01-14
申请人： Julie A. Abrahamson , Connie L. Erickson-Miller , Kristine Kay Kikly , Bruce Scott Bochner , Robert Schleimer , T. Esra Nutku
发明人： Julie A. Abrahamson , Connie L. Erickson-Miller , Kristine Kay Kikly , Bruce Scott Bochner , Robert Schleimer , T. Esra Nutku
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/56 , C07K2317/73
摘要： Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
摘要翻译：已经产生了结合人唾液酸粘附因子-2的单克隆抗体。这些抗体可用作诊断和治疗试剂。

2. 发明授权

US6146845A Polynucleotides encoding a sialoadhesin family member-2 (SAF-2) 失效
标题翻译：编码唾液酸粘蛋白家族成员-2（SAF-2）的多核苷酸
公开(公告)号：US6146845A
公开(公告)日：2000-11-14
申请号：US38832
申请日：1998-03-12
申请人： Kristine Kay Kikly , Connie Lynn Erickson-Miller , Bruce Bochner , Robert Schleimer
发明人： Kristine Kay Kikly , Connie Lynn Erickson-Miller , Bruce Bochner , Robert Schleimer
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K48/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/08 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , C12P19/34 , C12N1/20 , C12N15/67
CPC分类号： C07K14/705 , A61K38/00
摘要： SAF-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了通过重组技术产生这种多肽的SAF-2多肽和多核苷酸和方法。还公开了在治疗中使用SAF-2多肽和多核苷酸的方法，以及用于其的诊断测定法。

3. 发明授权

US6060277A Human AFC1 失效
标题翻译：人类AFC1
公开(公告)号：US6060277A
公开(公告)日：2000-05-09
申请号：US22699
申请日：1998-02-12
申请人： Kristine Kay Kikly , Anne M Knab , Christopher Donald Southan
发明人： Kristine Kay Kikly , Anne M Knab , Christopher Donald Southan
IPC分类号： C12N9/64 , C12N15/09 , C12N15/00 , C12N15/11 , C12N15/63 , C12N15/85
CPC分类号： C12N9/6489
摘要： The hAFC1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hAFC1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了通过重组技术产生这种多肽的hAFC1多肽和多核苷酸和方法。还公开了在治疗中利用hAFC1多肽和多核苷酸的方法，以及用于其的诊断测定法。

4. 发明授权

US5932446A HMVAB41 失效
公开(公告)号：US5932446A
公开(公告)日：1999-08-03
申请号：US979095
申请日：1997-11-26
申请人： Kathleen Theresa Gallagher , Mark R Hurle , Kristine Kay Kikly
发明人： Kathleen Theresa Gallagher , Mark R Hurle , Kristine Kay Kikly
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C12N5/10 , C07H21/00 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00
摘要： HMVAB41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMVAB41 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammation, autoimmunity, allergy, asthma, rheumatoid arthritis, CNS inflammation, cerebellar degeneration, Alzheimer's disease, Parkison's disease, multiple sclerosis, amylotrophic lateral sclerosis, head injury damage, and other neurological abnormalities, septic shock, sepsis, stroke, osteoporosis, osteoarthritis, ischemia reperfusion injury, cardiovascular disease, kidney disease, liver disease, ischemic injury, myocardial infarction, hypotension, hypertension, AIDS, myelodysplastic syndromes and other hematologic abnormalities, aplastic anemia, male pattern bladness, and bacterial, fungal, protozoan and viral infections, among others, and diagnostic assays for such conditions.
摘要翻译：公开HMVAB41多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗癌症，炎症，自身免疫，过敏，哮喘，类风湿性关节炎，CNS炎症，小脑变性，阿尔茨海默氏病，帕金森氏病，多发性硬化，肌营养不良性侧索硬化症的方案的设计中使用HMVAB41多肽和多核苷酸的方法，头部损伤损伤等神经系统异常，败血性休克，败血症，中风，骨质疏松症，骨关节炎，缺血再灌注损伤，心血管疾病，肾脏疾病，肝脏疾病，缺血性损伤，心肌梗死，低血压，高血压，艾滋病，骨髓增生异常综合征等血液异常，再生障碍性贫血，男性模式勃起，以及细菌，真菌，原生动物和病毒感染等，以及这些病症的诊断测定。

5. 发明授权

US07872102B2 Anti-IL-23 antibodies 有权
标题翻译：抗IL-23抗体
公开(公告)号：US07872102B2
公开(公告)日：2011-01-18
申请号：US11997597
申请日：2006-08-23
申请人： Catherine Brautigam Beidler , Stuart Willis Bright , Craig Duane Dickinson , Kristine Kay Kikly , David Matthew Marquis , Alain Philippe Vasserot
发明人： Catherine Brautigam Beidler , Stuart Willis Bright , Craig Duane Dickinson , Kristine Kay Kikly , David Matthew Marquis , Alain Philippe Vasserot
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind to the p19 subunit of IL-23. These antibodies, or antigen-binding portions thereof, are high affinity, neutralizing antibodies useful for the treatment of autoimmune disease.
摘要翻译：本发明包括与IL-23的p19亚基特异性结合的分离的抗体或其抗原结合部分。这些抗体或其抗原结合部分是可用于治疗自身免疫疾病的高亲和力中和抗体。

6. 发明申请

US20090240036A1 Anti-IL-23 Antibodies 有权
标题翻译：抗IL-23抗体
公开(公告)号：US20090240036A1
公开(公告)日：2009-09-24
申请号：US11997597
申请日：2006-08-23
申请人： Catherine Brautigam Beidler , Stuart Willis Bright , Craig Duane Dickinson , Kristine Kay Kikly , David Matthew Marquis , Alain Philippe Vasserot
发明人： Catherine Brautigam Beidler , Stuart Willis Bright , Craig Duane Dickinson , Kristine Kay Kikly , David Matthew Marquis , Alain Philippe Vasserot
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind to the p19 subunit of IL-23. These antibodies, or antigen-binding portions thereof, are high affinity, neutralizing antibodies useful for the treatment of autoimmune disease.
摘要翻译：本发明包括与IL-23的p19亚基特异性结合的分离的抗体或其抗原结合部分。这些抗体或其抗原结合部分是可用于治疗自身免疫疾病的高亲和力中和抗体。

7. 发明授权

US6121018A Interleukin-1.beta. converting enzyme like apoptosis protease-10 失效
标题翻译：白细胞介素-1β转换酶如凋亡蛋白酶-10
公开(公告)号：US6121018A
公开(公告)日：2000-09-19
申请号：US23023
申请日：1998-02-12
申请人： Kristine Kay Kikly
发明人： Kristine Kay Kikly
IPC分类号： G01N33/50 , A61K35/74 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P7/00 , A61P9/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/09 , C12N15/12 , C12N15/57 , C12P21/00 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/68 , C07H21/00 , C12N15/63
CPC分类号： C12N9/6475 , A61K2039/51 , A61K38/00
摘要： ICE-LAP-10 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ICE-LAP-10 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了ICE-LAP-10多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在治疗中利用ICE-LAP-10多肽和多核苷酸的方法，以及用于其的诊断测定法。

8. 发明授权

US6090582A Sialoadhesin Family Member-3 失效
标题翻译： Sialoadhesin家庭成员-3
公开(公告)号：US6090582A
公开(公告)日：2000-07-18
申请号：US46736
申请日：1998-03-24
申请人： Kristine Kay Kikly , Connie Lynn Erickson-Miller
发明人： Kristine Kay Kikly , Connie Lynn Erickson-Miller
IPC分类号： C07K14/705 , C12P21/06
CPC分类号： C07K14/705
摘要： SAF-3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了SAF-3多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在治疗中使用SAF-3多肽和多核苷酸的方法，以及用于其的诊断测定法。

9. 发明授权

US07317089B2 Antagonistic anti-hTNFSF13b human antibodies 有权
标题翻译：拮抗性抗hTNFSF13b人抗体
公开(公告)号：US07317089B2
公开(公告)日：2008-01-08
申请号：US10484790
申请日：2002-08-15
申请人： Kristine Kay Kikly
发明人： Kristine Kay Kikly
IPC分类号： C07K16/24
CPC分类号： C07K16/2875 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/53 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b(e.g., KD=10−8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
摘要翻译：公开了特异性结合TNFSF13b多肽的人单克隆抗体。这些抗体对hTNFSF13b具有高亲和力（例如，K N D = 10 -8 M或更小），TNFSF13b解离的缓慢速率（例如，K off 或更低），并在体外和体内中和TNFSF13b活性。本发明的抗体在一个实施方案中可用于在患有hTNFSF13b活性有害的病症的人类受试者中抑制TNFSF13b活性。编码本发明抗体的核酸以及用于表达本发明抗体的载体和宿主细胞也包括在本发明中。

10. 发明授权

US06207803B1 Human requiem 失效
标题翻译：人类要求
公开(公告)号：US06207803B1
公开(公告)日：2001-03-27
申请号：US09233342
申请日：1999-01-19
申请人： Mitchell S Gross , Mark Robert Hurle , Kristine Kay Kikly
发明人： Mitchell S Gross , Mark Robert Hurle , Kristine Kay Kikly
IPC分类号： C07K14435
CPC分类号： C07K14/4747 , A61K48/00 , C12N2799/026 , G01N33/564 , G01N33/6863 , G01N33/74 , G01N2500/00 , G01N2510/00
摘要： Human REQUIEM polypeptides and DNA (RNA) encoding such REQUIEM and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such REQUIEM for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control of embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such REQUIEM and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding REQUIEM polypeptide and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类REQUIEM多肽和编码这种REQUIEM的DNA（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这种REQUIEM来治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态的疾病和缺陷的方法，并且上述核酸序列可以用于确定这种敏感性的测定。对抗这些REQUIEM的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，CNS炎症，骨质疏松症，缺血再灌注损伤，与心血管疾病相关的细胞死亡，多囊肾病，凋亡还公开了心血管疾病，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗塞，AIDS，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤损伤的内皮细胞。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码REQUIEM多肽的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

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