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1. 发明授权

US5932446A HMVAB41 失效
公开(公告)号：US5932446A
公开(公告)日：1999-08-03
申请号：US979095
申请日：1997-11-26
申请人： Kathleen Theresa Gallagher , Mark R Hurle , Kristine Kay Kikly
发明人： Kathleen Theresa Gallagher , Mark R Hurle , Kristine Kay Kikly
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C12N5/10 , C07H21/00 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00
摘要： HMVAB41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMVAB41 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammation, autoimmunity, allergy, asthma, rheumatoid arthritis, CNS inflammation, cerebellar degeneration, Alzheimer's disease, Parkison's disease, multiple sclerosis, amylotrophic lateral sclerosis, head injury damage, and other neurological abnormalities, septic shock, sepsis, stroke, osteoporosis, osteoarthritis, ischemia reperfusion injury, cardiovascular disease, kidney disease, liver disease, ischemic injury, myocardial infarction, hypotension, hypertension, AIDS, myelodysplastic syndromes and other hematologic abnormalities, aplastic anemia, male pattern bladness, and bacterial, fungal, protozoan and viral infections, among others, and diagnostic assays for such conditions.
摘要翻译：公开HMVAB41多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗癌症，炎症，自身免疫，过敏，哮喘，类风湿性关节炎，CNS炎症，小脑变性，阿尔茨海默氏病，帕金森氏病，多发性硬化，肌营养不良性侧索硬化症的方案的设计中使用HMVAB41多肽和多核苷酸的方法，头部损伤损伤等神经系统异常，败血性休克，败血症，中风，骨质疏松症，骨关节炎，缺血再灌注损伤，心血管疾病，肾脏疾病，肝脏疾病，缺血性损伤，心肌梗死，低血压，高血压，艾滋病，骨髓增生异常综合征等血液异常，再生障碍性贫血，男性模式勃起，以及细菌，真菌，原生动物和病毒感染等，以及这些病症的诊断测定。

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