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    • 4. 发明申请
    • Composition and Treatment Methods for Coronary Artery Disease
    • 冠状动脉疾病的组成和治疗方法
    • US20080207503A1
    • 2008-08-28
    • US11722664
    • 2005-12-22
    • Byung-Hong ChungByung Hui Cho
    • Byung-Hong ChungByung Hui Cho
    • A61K38/12A61K31/685A61P9/10
    • A61K38/12A61K31/685
    • The present disclosure demonstrates that cholesterol-free discoidal reconstituted HDL (R-HDL), phosphatidyl-choline (PC) and PC liposomes effectively released cholesterol from ICP. Native HDL and its apolipoproteins were not able to release cholesterol from ICP. The release of ICP cholesterol by R-HDL was dose-dependent and accompanied by the transfer of >8× more PC in the reverse direction (i.e., from R-HDL to ICP), resulting in a marked enrichment of ICP with PC. The enrichment of ICP with PC resulted in the dissolution of cholesterol crystals on ICP and allowed the removal of ICP cholesterol by apo HDL and plasma. The present disclosure provides a method of treatment for removal of cholesterol from ICP in vivo and compositions for use in such method of treatment. Such methods may be used in the treatment and/or prevention of atherosclerosis, coronary artery disease, and related disease states and conditions.
    • 本公开内容表明,无胆固醇的盘状重组HDL(R-HDL),磷脂酰胆碱(PC)和PC脂质体有效地从ICP中释放胆固醇。 天然HDL及其载脂蛋白不能从ICP中释放胆固醇。 通过R-HDL释放ICP胆固醇是剂量依赖性的,并且伴随着相反方向(即,从R-HDL到ICP)转移> 8x个更多的PC,导致ICP与PC的显着浓缩。 ICP与PC的富集导致胆固醇晶体在ICP上的溶解,并允许通过载脂蛋白HDL和血浆去除ICP胆固醇。 本公开提供了一种用于从体内从ICP中除去胆固醇的方法和用于这种治疗方法的组合物。 这些方法可用于治疗和/或预防动脉粥样硬化,冠状动脉疾病和相关疾病状态和病症。
    • 7. 发明授权
    • Non-volatile memory device having a bit line contact pad and method for manufacturing the same
    • US06593190B2
    • 2003-07-15
    • US10072577
    • 2002-02-06
    • Seung-Min LeeByung-Hong Chung
    • Seung-Min LeeByung-Hong Chung
    • H01L21336
    • H01L21/76895H01L27/115H01L27/11521
    • A non-volatile memory device and a method for manufacturing the same are disclosed. A non-volatile memory device comprises a semiconductor substrate having active areas which extend in a first direction and are repeatedly arranged in a second direction orthogonal to the first direction, a plurality of word lines formed on the semiconductor substrate which extending in the second direction while being repeatedly arranged in the first direction, string select lines adjacent to a first word line and extending in the second direction, ground select lines adjacent to a last word line and extending in the second direction, a first insulating interlayer formed on the resultant structure and comprising a first opening exposing the active area between the ground select lines and a second opening exposing the active area between the string select lines, a bit line contact pad formed in the second opening. A sidewall of the contact pad comprises a negative slope in the first direction and a positive slope in the second direction. A hard mask layer pattern, having the same pattern size as the active area, is formed on the contact pad and the first insulating interlayer. A second insulating interlayer is formed on the hard mask layer pattern and the first insulating interlayer. The second insulating interlayer has a bit line contact hole on the contact pad and thus the process margin is sufficiently achieved.
    • 8. 发明申请
    • Method of manufacturing a semiconductor device
    • 制造半导体器件的方法
    • US20090004826A1
    • 2009-01-01
    • US12214019
    • 2008-06-16
    • Young-Hoo KimHyun ParkByung-Hong ChungJeong-Lim Nam
    • Young-Hoo KimHyun ParkByung-Hong ChungJeong-Lim Nam
    • H01L21/20
    • H01L27/11568H01L21/8221H01L27/0688H01L27/115H01L27/11521H01L27/11524H01L27/11551
    • In a method of manufacturing a semiconductor device, a first substrate and a second substrate, which include a plurality of memory cells and selection transistors, respectively, are provided. A first insulating interlayer and a second insulating interlayer are formed on the first substrate and the second substrate, respectively, to cover the memory cells and the selection transistors. A lower surface of the second substrate is partially removed to reduce a thickness of the second substrate. The lower surface of the second substrate is attached to the first insulating interlayer. Plugs are formed through the second insulating interlayer, the second substrate and the first insulating interlayer to electrically connect the selection transistors in the first substrate and the second substrate to the plugs. Thus, impurity ions in the first substrate will not diffuse during a thermal treatment process.
    • 在制造半导体器件的方法中,提供分别包括多个存储单元和选择晶体管的第一衬底和第二衬底。 分别在第一基板和第二基板上形成第一绝缘层和第二绝缘中间层,以覆盖存储单元和选择晶体管。 部分地去除第二基板的下表面以减小第二基板的厚度。 第二基板的下表面附接到第一绝缘中间层。 插塞通过第二绝缘中间层,第二基板和第一绝缘夹层形成,以将第一基板和第二基板中的选择晶体管电连接到插头。 因此,在热处理过程中,第一衬底中的杂质离子将不会扩散。
    • 9. 发明授权
    • Dual gate oxide structure in semiconductor device and method thereof
    • 半导体器件中的双栅极氧化物结构及其方法
    • US07250346B2
    • 2007-07-31
    • US10876277
    • 2004-06-23
    • Jong-Sik ChunHyun-Ho JoByung-Hong Chung
    • Jong-Sik ChunHyun-Ho JoByung-Hong Chung
    • H01L21/336
    • H01L21/823481H01L21/76229H01L21/823462
    • In the method of manufacturing a dual gate oxide layer of a semiconductor device, which has first and second active regions operating at mutually different voltages on a semiconductor substrate, the first and second active regions having a device isolation layer of STI (Shallow Trench Isolation) structure; the method of manufacturing the dual gate insulation layer includes, forming the device isolation layer so that an uppermost part thereof is positioned lower than an upper surface of the first and second active regions, before forming a gate insulation layer corresponding to each of the first and second active regions. Whereby, it is be effective till a portion of trench sidewall utilized as the active region, to increase a cell current of the active region and to prevent a stringer caused by a stepped coverage between the active region and a field region and a dent caused on a boundary face between the active region and the field region.
    • 在制造半导体器件的双栅氧化层的方法中,其具有在半导体衬底上以相互不同的电压工作的第一和第二有源区,所述第一和第二有源区具有STI(浅沟槽隔离)的器件隔离层, 结构体; 制造双栅极绝缘层的方法包括:在形成与第一和第二有源区的上表面相对应的栅绝缘层之前,形成器件隔离层,使其最上部位于第一和第二有源区的上表面下方, 第二活跃区域。 由此,直到用作有源区域的沟槽侧壁的一部分为止,增加有源区域的单元电流并且防止由有源区域和场区域之间的阶梯式覆盖引起的桁条以及由 活动区域和场区域之间的边界面。