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1. 发明公开

EP3185921A1 METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXSOMES 有权
标题翻译：处理用于隔离微泡，纳米材料或外来物的工具和工具的方法
公开(公告)号：EP3185921A1
公开(公告)日：2017-07-05
申请号：EP15767421.9
申请日：2015-08-25
申请人： Jozef Stefan Institute , Univerza v Ljubljani
发明人： JUNKAR, Ita , MOZETIC, Miran , ZAPLOTNIK, Rok , KRALJ-IGLIC, Veronika , TUKELJ, Roman
IPC分类号： A61L29/14 , A61L33/00 , A61M1/02 , A61M5/14 , B05D3/14
CPC分类号： A61L29/14 , A61L33/0094 , A61L2400/18
摘要： According to the present invention a method which prevents excessive adsorption of microvesicles on the surfaces of tools used for sampling, storing and handling body flu- ids containing microvesicles is provided. The method comprises the steps of: selecting said a tool from the a list plurality of tools including but not limited to needles, blood tubing, blood bags, catheters, Eppendorf tubes, pipettes or the like, providing said tool from said plurality of tools, providing a source of positively and negatively charged particles of high density, selecting a source assuring for formation of positively and negatively charged particles of high density and treating a surface of said tool by applying short pulses of said source of particles next to or on the said surface of said tool to assure surface modification of said surface by reacting said positively and negatively charged particles of high density on said surface. The method according to the present invention ensures contacting of tools with short pulses of highly ionized gas comprising both positively and negatively charged particles, the pulses being essentially short enough to avoid excessive heating of materials used for collecting, sampling, storage, transport and isolation of micro vesicles and the density of both positively and negatively charged particles which is essentially high enough to cause roughening of said tools on sub-micrometer or nanometer scale. Especially tools treated according to the present inventive method prevents excessive adsorption of microvesicles on the surfaces of said tools used for collecting, sampling, storing, transporting and isolating of microvesicles or the like. The method according to the present invention enables higher yields and lower frag- mentation of microvesicles for instance by preventing adsorption of this valuable diag- nostic material on the surface of different tools used for isolation and detection. Accordingly, the present invention also provides increasing the roughness of a material by the method according to the present invention. In particular the material which is used to produce diagnostic or medical tools or devices. (Fig. 1)
摘要翻译：根据本发明，提供了防止微囊过度吸附在用于取样，储存和处理含有微泡的体液的工具表面上的方法。该方法包括以下步骤：从列表中选择所述工具，所述工具包括但不限于针，血液管，血袋，导管，Eppendorf管，移液管等，提供来自所述多个工具的所述工具，提供具有高密度的带正电和带负电粒子的来源，选择确保形成高密度带正电荷和负带电粒子的源，并通过在所述场的旁边或上面施加所述粒子源的短脉冲来处理所述工具的表面所述工具的表面以通过使所述表面上的所述高密度正电荷和负电荷颗粒反应来确保所述表面的表面改性。根据本发明的方法确保工具与包含带正电和带负电的颗粒的高度电离气体的短脉冲的接触，脉冲本质上足够短以避免用于收集，取样，储存，运输和隔离的材料的过度加热微囊泡以及带正电和带负电粒子的密度，其基本上足够高以致在亚微米或纳米尺度上使所述工具粗糙化。特别是根据本发明方法处理的工具防止微囊过度吸附在用于收集，取样，储存，运输和分离微泡等的所述工具的表面上。根据本发明的方法例如通过防止这种有价值的诊断材料在用于分离和检测的不同工具的表面上的吸附而实现更高的收率和更低的微泡破碎。因此，本发明还通过根据本发明的方法提供增加材料的粗糙度。特别是用于生产诊断或医疗工具或设备的材料。（图。1）

2. 发明公开

EP4049690A1 METHOD FOR TREATMENT OF MEDICAL METALS AND THEIR ALLOYS 有权
公开(公告)号：EP4049690A1
公开(公告)日：2022-08-31
申请号：EP21159240.7
申请日：2021-02-25
申请人： Jozef Stefan Institute
发明人： JUNKAR, Ita , BENCINA, Metka , ZAPLOTNIK, Rok , MOZETIC, Miran , SODIN-SEMRL, SNEZNA , LAKOTA, Katja , IGLIC, Ales
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14
摘要： The method for treatment metals and metal alloys used for implants, especially vascular stents, is provided. The method comprises of three combined steps, including the first plasma-treatment step, the hydrothermal treatment and the second plasma-treatment step. The first plasma-treatment step assures for a contaminant-free surface with high surface energy, which in turn enables nucleation sites of appropriate properties for depositing a nano-structured film of titanium oxide. The next step is the deposition of a titanium oxide film. The second step is preferably performed within 10 to 1000 s after the first plasma treatment to minimise the risk of spontaneous hydrophobic recovery. The as-deposited materials are further treated by the second plasma treatment, which assures for appropriate surface finish and crystallinity of the thin nano-structured titanium oxide film. The methods of invention enable the formation of the titanium oxide layer on the surface of metals or alloys with improved biocompatibility/hemocompatibility against state of the art.

3. 发明公开

EP4129351A1 METHOD FOR PRODUCTION OF NANOSTRUCTURED SURFACES ON STENTS FOR IMPROVED BIOCOMPATIBILITY 无效
公开(公告)号：EP4129351A1
公开(公告)日：2023-02-08
申请号：EP21190007.1
申请日：2021-08-05
申请人： Jozef Stefan Institute , Ürgen, Mustafa Kamil
发明人： ÜRGEN, Mustafa Kamil , JUNKAR, Ita , KOVAC, Janez , RECEK, Nina , MOZETIC, Miran , YELKARASI, Çagatay , KAZMANLI, Muhammet Kürsat , KARAMAN, Berke
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14
摘要： The present invention relates to methods for suppressing unwanted effects upon installing a bare metallic stent into the human body, such as restenosis and thrombosis. A bare metallic stent made from a metal or an alloy of appropriate mechanical properties is subjected to a six-step procedure which includes selecting the appropriate metal or alloy, treatment with Ar ions, depositing a uniform film of titanium, anodization until a fraction of said titanium film is oxidized, removal of the said oxide film and activation of the product with atomic oxygen. The present invention also relates to a metallic stent made from a material of appropriate mechanical properties coated with a thin film of titanium with nanostructured surface and surface energy above 50 mN/m in accordance with the method of the present invention.

4. 发明授权

EP3185921B1 METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXOSOMES 有权
公开(公告)号：EP3185921B1
公开(公告)日：2019-09-04
申请号：EP15767421.9
申请日：2015-08-25
申请人： Jozef Stefan Institute , Univerza v Ljubljani
发明人： JUNKAR, Ita , MOZETIC, Miran , ZAPLOTNIK, Rok , KRALJ-IGLIC, Veronika , STUKELJ, Roman
IPC分类号： A61L29/14 , A61L33/00 , A61M1/02 , A61M5/14 , B05D3/14

5. 发明公开

EP3496776A1 METHOD FOR COATING A MEDICAL DEVICE, ESPECIALLY A VASCULAR STENT 审中-公开
公开(公告)号：EP3496776A1
公开(公告)日：2019-06-19
申请号：EP17758070.1
申请日：2017-08-08
申请人： Jozef Stefan Institute , Univerza v Ljubljani
发明人： KULKARNI, Mukta , JUNKAR, Ita , IGLIC, Ales , KOVAC, Janez , MOZETIC, Miran
IPC分类号： A61L31/08

6. 发明公开

EP3636294A1 METHOD FOR TREATMENT MEDICAL DEVICES MADE FROM NICKEL - TITANIUM (NITI) ALLOYS 有权
公开(公告)号：EP3636294A1
公开(公告)日：2020-04-15
申请号：EP18199209.0
申请日：2018-10-08
申请人： Jozef Stefan Institute
发明人： JUNKAR, Ita , ZAPLOTNIK, Rok , BENCINA, Metka , MOZETIC, Miran
IPC分类号： A61L31/02 , A61L31/08 , A61L33/02
摘要： The present invention improves the surface modification of NiTi alloys used for instance in medical devices through treatment with hydrogen particles in a suitable gaseous discharge and with oxygen atoms. The technique according to the present invention provides the formation of biocompatible solely titanium oxide layer thus preventing nickel to be present in the top surface layer. Furthermore this enables nanostructuring of the surface which depends on the treatment conditions. Devices made from NiTi alloys treated with the method according to the present invention have improved biocompatibility; platelets do not readily attach and activate on such surfaces and the thrombus formation rate is reduced in comparison with extensively used untreated NiTi alloys.

7. 发明申请

WO2016030358A1 METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXSOMES 审中-公开
标题翻译：用于分离用于分离微胶囊，纳米颗粒或异物的工具和工具的方法
公开(公告)号：WO2016030358A1
公开(公告)日：2016-03-03
申请号：PCT/EP2015/069420
申请日：2015-08-25
申请人： JOZEF STEFAN INSTITUTE , UNIVERZA V LJUBLJANI
发明人： JUNKAR, Ita , MOZETIC, Miran , ZAPLOTNIK, Rok , KRALJ-IGLIC, Veronika , ŠTUKELJ, Roman
IPC分类号： A61L29/14 , A61L33/00 , A61M1/02 , A61M5/14 , B05D3/14
CPC分类号： A61L29/14 , A61L33/0094 , A61L2400/18
摘要： According to the present invention a method which prevents excessive adsorption of microvesicles on the surfaces of tools used for sampling, storing and handling body flu- ids containing microvesicles is provided. The method comprises the steps of: selecting said a tool from the a list plurality of tools including but not limited to needles, blood tubing, blood bags, catheters, Eppendorf tubes, pipettes or the like, providing said tool from said plurality of tools, providing a source of positively and negatively charged particles of high density, selecting a source assuring for formation of positively and negatively charged particles of high density and treating a surface of said tool by applying short pulses of said source of particles next to or on the said surface of said tool to assure surface modification of said surface by reacting said positively and negatively charged particles of high density on said surface. The method according to the present invention ensures contacting of tools with short pulses of highly ionized gas comprising both positively and negatively charged particles, the pulses being essentially short enough to avoid excessive heating of materials used for collecting, sampling, storage, transport and isolation of micro vesicles and the density of both positively and negatively charged particles which is essentially high enough to cause roughening of said tools on sub-micrometer or nanometer scale. Especially tools treated according to the present inventive method prevents excessive adsorption of microvesicles on the surfaces of said tools used for collecting, sampling, storing, transporting and isolating of microvesicles or the like. The method according to the present invention enables higher yields and lower frag- mentation of microvesicles for instance by preventing adsorption of this valuable diag- nostic material on the surface of different tools used for isolation and detection. Accordingly, the present invention also provides increasing the roughness of a material by the method according to the present invention. In particular the material which is used to produce diagnostic or medical tools or devices. (Fig. 1)
摘要翻译：根据本发明，提供了防止微泡在用于取样，储存和处理含有微泡的体液的工具的表面上过度吸附的方法。该方法包括以下步骤：从列表中选择多个工具的工具，包括但不限于针，血管，血袋，导管，Eppendorf管，移液管等，从所述多个工具提供所述工具，提供具有高密度的正带负电粒子源，选择源确保形成具有高密度的带正电荷和带负电荷的颗粒并通过施加所述工具的表面的所述短脉冲来施加所述工具的表面的所述短脉冲，所述工具的表面以通过在所述表面上反应所述带正电荷和带负电荷的高密度颗粒来确保所述表面的表面改性。根据本发明的方法确保工具与包括正带电荷和带负电粒子的短电离气体的短脉冲接触，所述脉冲基本足够短以避免过度加热用于收集，取样，储存，运输和分离的材料微泡和正和负带电粒子的密度，其基本上足够高以在亚微米或纳米级上引起所述工具的粗糙化。特别是根据本发明方法处理的工具防止微囊在用于收集，取样，储存，运输和分离微泡等的所述工具的表面上过度吸附。根据本发明的方法，通过防止这种有价值的诊断材料在用于分离和检测的不同工具的表面上的吸附，能够实现更高的产率和更低的微泡分解。因此，本发明还通过根据本发明的方法提高材料的粗糙度。特别是用于生产诊断或医疗工具或设备的材料。（图。1）

8. 发明申请

WO2016059024A1 METHOD OF GROWING CARBON NANOWALLS ON A SUBSTRATE 审中-公开
标题翻译：在基材上生长碳纳米管的方法
公开(公告)号：WO2016059024A1
公开(公告)日：2016-04-21
申请号：PCT/EP2015/073630
申请日：2015-10-13
申请人： JOZEF STEFAN INSTITUTE , NATIONAL INSTITUTE FOR LASER, PLASMA AND RADIATION PHYSICS , UNIVERSITY OF MARIBOR
发明人： JUNKAR, Ita , MODIC, Martina , VESEL, Alenka , MOZETIC, Miran , DINESCU, Gheorghe , VIZIREANU, Sorin Ionut , STOICA, Silviu-Daniel , KLEINSCHEK, Karin Stana
IPC分类号： A61L27/30 , A61L27/50 , A61L31/08 , A61L33/02
CPC分类号： A61L27/303 , A61L27/50 , A61L31/084 , A61L33/025 , A61L2400/12 , A61L2420/02 , A61L2430/20
摘要： A method for growing carbon nanowalls on a substrate of an implantable medical device by means of a processing chamber is provided, said method comprising: providing said substrate in said processing chamber, evacuating said processing chamber to a processing pressure, entering a gas mixture inside the processing chamber, providing radicals inside said chamber and adsorbing said radicals on said substrate leading to growing of carbon nanowalls on said substrate.
摘要翻译：提供了一种通过处理室在可植入医疗装置的衬底上生长碳纳米壁的方法，所述方法包括：在所述处理室中提供所述衬底，将所述处理室抽空至加工压力，在其内进入气体混合物在所述室内提供自由基，并在所述衬底上吸附所述自由基，导致在所述衬底上生长碳纳米壁。

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