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1. 发明申请

US20050256542A1 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US20050256542A1
公开(公告)日：2005-11-17
申请号：US11184325
申请日：2005-07-19
申请人： Joseph Pastore , Steven Girouard , Bruce KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph Pastore , Steven Girouard , Bruce KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

2. 发明申请

US20080021508A1 METHOD AND APPARATUS FOR DETECTING OSCILLATIONS IN CARDIAC RHYTHM WITH ELECTROGRAM SIGNALS 失效
标题翻译：用电子信号检测心脏红细胞振荡的方法和装置
公开(公告)号：US20080021508A1
公开(公告)日：2008-01-24
申请号：US11832552
申请日：2007-08-01
申请人： Joseph Pastore , Steven Girouard , Bruce KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph Pastore , Steven Girouard , Bruce KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

3. 发明申请

US20050137633A1 Pacing method and device for preserving native conduction system 失效
标题翻译：起搏方法和保存天然传导系统的装置
公开(公告)号：US20050137633A1
公开(公告)日：2005-06-23
申请号：US10744952
申请日：2003-12-22
申请人： Rodney Salo , Bruce KenKnight , Joseph Pastore , Steven Girouard
发明人： Rodney Salo , Bruce KenKnight , Joseph Pastore , Steven Girouard
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译：用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。

4. 发明申请

US20050070967A1 Method and system for automatic anti-tachycardia pacing 有权
标题翻译：自动抗心动过速起搏方法与系统
公开(公告)号：US20050070967A1
公开(公告)日：2005-03-31
申请号：US10914495
申请日：2004-08-09
申请人： Qingsheng Zhu , Stephen Hahn , Steven Girouard
发明人： Qingsheng Zhu , Stephen Hahn , Steven Girouard
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3622 , A61N1/3712
摘要： A method and system for delivering anti-tachycardia pacing is disclosed. A cardiac rhythm management device, such as an implantable pacemaker having anti-tachycardia pacing capability, delivers anti-tachycardia pacing therapy in accordance with an anti-tachycardia pacing protocol upon detection of a terminable arrhythmia. The anti-tachycardia pacing is delivered as a burst of one or more pacing pulses at a specified coupling interval after a sensed ventricular polarization. By sensing if an evoked potential occurs, the device can determine whether or not the anti-tachycardia pacing burst has captured the ventricle and can adjust the coupling interval and/or other parameters accordingly.
摘要翻译：公开了用于递送抗心动过速起搏的方法和系统。具有抗心动过速起搏能力的心脏节律管理装置，例如具有抗心动过速起搏能力的可植入起搏器，在检测到可终止的心律失常时，根据抗心动过速起搏方案提供抗心动过速起搏治疗。抗心动过速起搏在感测到的心室极化之后以指定的耦合间隔作为一个或多个起搏脉冲的脉冲串发送。通过感测是否发生诱发电位，该装置可以确定抗心动过速起搏脉冲是否已经捕获到心室，并且可以相应地调整耦合间隔和/或其他参数。

5. 发明申请

US20080021507A1 SENSING WITH COMPENSATION FOR NEURAL STIMULATOR 审中-公开
标题翻译：感觉神经刺激器补偿
公开(公告)号：US20080021507A1
公开(公告)日：2008-01-24
申请号：US11621194
申请日：2007-01-09
申请人： Imad Libbus , Qingsheng Zhu , Steven Girouard
发明人： Imad Libbus , Qingsheng Zhu , Steven Girouard
IPC分类号： A61N1/365
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/36564
摘要： An aspect relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy.
摘要翻译：一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心脏事件检测器和通信电路。刺激器包括脉冲发生器以应用压力反射刺激疗法。检测器包括用于检测指示心脏事件的电信号的传感器，以及连接到传感器的控制器，以使用事件检测程序从电信号确定心脏事件的发生。通信电路在压力反射刺激器和心脏事件检测器之间进行通信，以解决所施加的压力反射刺激治疗，并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。

6. 发明申请

US20060247686A1 IMPLANTABLE DEVICE FOR DELIVERING CARDIAC DRUG THERAPY 失效
标题翻译：用于输送心脏药物治疗的可植入装置
公开(公告)号：US20060247686A1
公开(公告)日：2006-11-02
申请号：US11425263
申请日：2006-06-20
申请人： Steven Girouard , Qingsheng Zhu
发明人： Steven Girouard , Qingsheng Zhu
IPC分类号： A61N1/362
CPC分类号： A61N1/36592 , A61B5/0452 , A61M5/14276 , A61M5/1723 , A61M2230/04 , A61N1/3622 , A61N1/36507 , A61N1/36585
摘要： An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.
摘要翻译：记录和分析电描记图以便检测指示心脏缺血的变化的可植入医疗装置。可以通过从装置的感测通道记录电描记图并将记录的电描记图与参考电描记图进行比较来检测心脏缺血。如果检测到心脏缺血，则输送心脏药物如溶栓剂。

7. 发明申请

US20050149133A1 Sensing with compensation for neural stimulator 审中-公开
标题翻译：感应神经刺激器补偿
公开(公告)号：US20050149133A1
公开(公告)日：2005-07-07
申请号：US10746847
申请日：2003-12-24
申请人： Imad Libbus , Qingsheng Zhu , Steven Girouard
发明人： Imad Libbus , Qingsheng Zhu , Steven Girouard
IPC分类号： A61N1/36 , A61N1/365 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/36564
摘要： An aspect of the present subject matter relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心脏事件检测器和通信电路。刺激器包括脉冲发生器以应用压力反射刺激疗法。检测器包括用于检测指示心脏事件的电信号的传感器，以及连接到传感器的控制器，以使用事件检测程序从电信号确定心脏事件的发生。通信电路在压力反射刺激器和心脏事件检测器之间进行通信，以解决所施加的压力反射刺激治疗，并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。本文提供了其他方面。

8. 发明申请

US20090053180A1 Tandem cardiac pacemaker system 审中-公开
标题翻译：串联心脏起搏器系统
公开(公告)号：US20090053180A1
公开(公告)日：2009-02-26
申请号：US11490997
申请日：2006-07-21
申请人： Michael R. Rosen , Peter R. Brink , Richard B. Robinson , Ira S. Cohen , Steven Girouard , Bruce Kenknight
发明人： Michael R. Rosen , Peter R. Brink , Richard B. Robinson , Ira S. Cohen , Steven Girouard , Bruce Kenknight
IPC分类号： A61K35/12 , A61N1/362 , A61P9/00
CPC分类号： A61N1/372 , C12N5/0657 , C12N2502/1329 , C12N2502/1358 , C12N2510/00
摘要： This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.
摘要翻译：本发明提供了起搏器系统，其包括（1）电子起搏器和（2）生物起搏器，其中生物起搏器包括功能性地表达嵌合超极化激活的环核苷酸门控（HCN）离子通道的细胞，其水平有效在细胞中诱导起搏器电流。本发明还提供了相关的生物起搏器，房室桥梁，其制造方法以及治疗患有心律失常的受试者的方法。

9. 发明申请

US20050283195A1 Methods and apparatuses for localizing myocardial infarction during catheterization 失效
标题翻译：导管期局部心肌梗塞的方法和装置
公开(公告)号：US20050283195A1
公开(公告)日：2005-12-22
申请号：US10871865
申请日：2004-06-18
申请人： Joseph Pastore , Steven Girouard
发明人： Joseph Pastore , Steven Girouard
IPC分类号： A61B5/00 , A61B5/0265 , A61B5/11 , A61B8/12 , A61N1/362 , A61N1/37
CPC分类号： A61B5/4839 , A61B5/0071 , A61B5/0084 , A61B5/0265 , A61B5/1107 , A61B5/6869 , A61B8/12 , A61B2562/0219 , A61N1/3702
摘要： A catheter with a tissue property sensor provides for localization of myocardial infarction (MI) by utilizing one or more differences between properties of infarcted myocardial tissue and properties of normal myocardial tissue. The tissue property sensor is to be placed on endocardial wall or epicardial wall during catheterization to sense at least one tissue property allowing for detection of MI. Examples of the tissue property sensor include, but are not limited to, an optical sensor, an acoustic sensor, a contractility sensor, a temperature sensor, and a drug response sensor. In one embodiment, the tissue property sensor senses a tissue property in various locations on endocardial wall or epicardial wall and detects substantial changes in the tissue property that indicate a boundary between infarcted tissue and normal tissue.
摘要翻译：具有组织属性传感器的导管通过利用梗死心肌组织的性质与正常心肌组织的性质之间的一个或多个差异来提供心肌梗死（MI）的定位。在导管插入期间，将组织性质传感器放置在心内膜壁或心外膜上以感测至少一个允许检测MI的组织特性。组织性质传感器的实例包括但不限于光学传感器，声学传感器，收缩性传感器，温度传感器和药物响应传感器。在一个实施例中，组织性质传感器检测心内膜壁或心外壁上各种位置的组织特性，并且检测指示梗塞组织与正常组织之间的边界的组织性质的实质性变化。

10. 发明申请

US20070233216A1 HIS BUNDLE MAPPING, PACING, AND INJECTION LEAD 有权
标题翻译：他的包装映射，打印和注入引导
公开(公告)号：US20070233216A1
公开(公告)日：2007-10-04
申请号：US11760294
申请日：2007-06-08
申请人： Lili Liu , Randy Westlund , Steven Girouard
发明人： Lili Liu , Randy Westlund , Steven Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0568
摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.
摘要翻译：心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。可导向的管心针允许心内区域的电生理作图。中空针允许将化学，生物化学和/或生物物质递送至心内区域。

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