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1. 发明申请

US20060129054A1 Methods for non-invasivelyestimating pulmonary capillary blood flow or cardiac output 审中-公开
标题翻译：非侵入性地测量肺毛细血管血流量或心输出量的方法
公开(公告)号：US20060129054A1
公开(公告)日：2006-06-15
申请号：US11346913
申请日：2006-02-03
申请人： Joseph Orr , Michael Jaffe , Scott Kofoed , Dwayne Westenskow
发明人： Joseph Orr , Michael Jaffe , Scott Kofoed , Dwayne Westenskow
IPC分类号： A61B5/08 , G01N33/497 , F41A19/00
CPC分类号： A61B5/029 , A61B5/0836 , A61M16/0045 , A61M16/0833 , A61M2016/0036 , A61M2230/432 , G01N33/004 , Y02A50/243
摘要： Methods for non-invasively determining the cardiac output or pulmonary capillary blood flow of a subject include monitoring the subject's respiration during two ventilatory states. Such a method may include determining parameters of at least one of the ventilatory states based on one or more characteristics of the subject. Data obtained from monitoring the subject's respiration, such as an amount of gas present in exhaled gases and respiratiory flow, may be used to estimate respiratory or blood gas parameters, such as an amount of gas exchanged between blood and gases in the subject's lungs or an indicator of a content of the gas in the subject's blood.
摘要翻译：非侵入性地确定受试者的心输出量或肺毛细血管血流量的方法包括在两个通气状态期间监测受试者的呼吸。这种方法可以包括基于受试者的一个或多个特征确定至少一个通气状态的参数。通过监测受试者的呼吸获得的数据，例如呼出气体和呼吸气流中存在的气体的量可用于估计呼吸或血液气体参数，例如受试者的肺中血液和气体之间交换的气体量对象血液中气体含量的指标。

2. 发明申请

US20050203432A1 Apparatus and method for non-invasively measuring cardiac output 有权
标题翻译：非侵入性测量心输出量的装置和方法
公开(公告)号：US20050203432A1
公开(公告)日：2005-09-15
申请号：US11120103
申请日：2005-05-02
申请人： Joseph Orr , Scott Kofoed , Dwayne Westenskow , Michael Jaffe
发明人： Joseph Orr , Scott Kofoed , Dwayne Westenskow , Michael Jaffe
IPC分类号： A61B5/026 , A61B5/029 , A61B5/08 , A61B5/083 , A61B5/087 , A61B5/097 , A61B10/00 , A61M16/00 , G01N33/00 , G01N1/22 , B32B5/02
CPC分类号： A61B5/029 , A61B5/0836 , A61M16/0045 , A61M16/0833 , A61M2016/0036 , A61M2230/432 , G01N33/004 , Y02A50/243
摘要： Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO2 values rather than end-tidal CO2 values as previously practiced. A program for calculating cardiac output is also disclosed.
摘要翻译：公开了使用部分再呼吸技术非侵入性地确定心输出量的装置和方法，其中该装置构造有瞬时可调的死区，以适应各种患者的呼吸能力差异。该设备由便宜的元件构成，包括单个双向阀，其使得该设备使用起来非常简单且便宜，使得该单元可以容易地被一次性使用。本发明的方法提供了一种新颖的方法，用于估算基于肺泡CO 2值的心输出量而不是如先前所实施的潮汐末端CO 2 2值。还公开了一种用于计算心输出量的程序。

3. 发明申请

US20070225612A1 Metabolic measurements system including a multiple function airway adapter 审中-公开
标题翻译：代谢测量系统，包括多功能气道适配器
公开(公告)号：US20070225612A1
公开(公告)日：2007-09-27
申请号：US11701187
申请日：2007-02-01
申请人： Leslie Mace , Joseph Orr , David Rich , Michael Jaffe , Jason Alderete
发明人： Leslie Mace , Joseph Orr , David Rich , Michael Jaffe , Jason Alderete
IPC分类号： A61B5/083
CPC分类号： A61B5/083 , A61B5/087 , A61B5/097
摘要： A system for measuring a metabolic parameter. The system includes an integrated airway adapter capable of monitoring any combination of respiratory flow, O2 concentration, and concentrations of one or more of CO2, N2O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO2, N2O, and anesthetic agents.
摘要翻译：用于测量代谢参数的系统。该系统包括能够监测呼吸流量O 2浓度的任何组合以及CO 2 2 N 2 N 2的一种或多种的浓度的集成气道适配器， / SUB> O，麻醉剂实时呼吸。可以通过改进的传感器配置在不同入口条件下通过差压流量计监测呼吸流量，从而最小化气道内的相位滞后和死区。可以通过发光淬灭技术监测分子氧浓度。红外吸收技术可用于监测一种或多种CO 2，N 2 O和麻醉剂。

4. 发明申请

US20100256774A1 BONE/COLLAGEN COMPOSITES AND USES THEREOF 有权
标题翻译：骨/胶原蛋白复合物及其用途
公开(公告)号：US20100256774A1
公开(公告)日：2010-10-07
申请号：US12744810
申请日：2008-12-12
申请人： Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
发明人： Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
IPC分类号： A61F2/28
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/4644 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/46 , A61L2400/06 , A61L2430/02 , A61L2430/40 , C08L89/06
摘要： A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
摘要翻译：组合物包括骨和胶原，其中胶原蛋白已被酸处理，并通过脱水热处理或通过交联剂（例如柠檬酸衍生物）在至少约40MPa的压缩力下进行交联。

5. 发明申请

US20080009599A1 Thermoset epoxy polymers from renewable resources 有权
标题翻译：可再生资源的热固性环氧聚合物
公开(公告)号：US20080009599A1
公开(公告)日：2008-01-10
申请号：US11809034
申请日：2007-05-31
申请人： Anthony East , Michael Jaffe , Yi Zhang , Luiz Catalani
发明人： Anthony East , Michael Jaffe , Yi Zhang , Luiz Catalani
IPC分类号： C08G83/00
CPC分类号： C08G59/26 , C07D493/04 , C08G59/42 , C08G59/5046 , C08L63/00
摘要： Novel thermoset epoxy polymers using the bisglycidyl ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, are disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. The anhydrosugars are derived from renewable sources and the bisglycidyl ethers are not xenoestrogenic and the thermoset curing agents are likewise derived form renewable resources.
摘要翻译：公开了使用脱水糖的双缩水甘油醚的新型热固性环氧聚合物，例如异山梨醇，异烟肼和异氰酸酯。双缩水甘油醚在制备热固性环氧醚时可用作双酚A的替代物。脱水葡萄糖源自可再生来源，双缩水甘油醚不是异源雌激素，热固性固化剂同样衍生自可再生资源。

6. 发明申请

US20050033129A1 Method, apparatus and system for removing motion artifacts from measurements of bodily parameters 失效
标题翻译：用于从身体参数测量中去除运动伪影的方法，装置和系统
公开(公告)号：US20050033129A1
公开(公告)日：2005-02-10
申请号：US10873758
申请日：2004-06-22
申请人： Reuben Edgar , August Allo , Paul Gunneson , Jesus Martin , John DelFavero , Michael Jaffe
发明人： Reuben Edgar , August Allo , Paul Gunneson , Jesus Martin , John DelFavero , Michael Jaffe
IPC分类号： A61B5/00 , G06F17/00
CPC分类号： A61B5/14551 , A61B5/7207 , A61B5/7257 , A61B5/726
摘要： A method for removing motion artifacts from devices for sensing bodily parameters and apparatus and system for effecting same. The method includes analyzing segments of measured data representing bodily parameters and possibly noise from motion artifacts. Each segment of measured data may correspond to a single light signal transmitted and detected after transmission or reflection through bodily tissue. Each data segment is frequency analyzed to determine up to three candidate peaks for further analysis. Each of the up to three candidate frequencies may be filtered and various parameters associated with each of the up to three candidate frequencies are calculated. The best frequency, if one exists, is determined by arbitrating the candidate frequencies using the calculated parameters according to predefined criteria. If a best frequency is found, a pulse rate and SPO2 may be output. If a best frequency is not found, other, conventional techniques for calculating pulse rate and SpO2 may be used. The above method may be applied to red and infrared pulse oximetry signals prior to calculating pulse rate and/or pulsatile blood oxygen concentration. Apparatus and systems disclosed are configured to perform methods disclosed according to the invention.
摘要翻译：一种用于从用于感测身体参数的装置和用于实现其的设备和系统的装置中去除运动假象的方法。该方法包括分析表示身体参数和可能的运动伪影噪声的测量数据的段。测量数据的每一段可对应于通过身体组织透射或反射后传输和检测的单个光信号。对每个数据段进行频率分析，以确定最多三个候选峰进行进一步分析。可以对最多三个候选频率中的每一个进行滤波，并且计算与最多三个候选频率中的每一个相关联的各种参数。通过使用根据预定准则的计算参数来仲裁候选频率来确定最佳频率（如果存在）。如果找到最佳频率，则可能会输出脉搏率和SPO2。如果没有发现最佳频率，则可以使用用于计算脉率和SpO2的其它常规技术。在计算脉搏率和/或脉动血氧浓度之前，上述方法可以应用于红色和红外脉搏血氧饱和度信号。公开的设备和系统被配置为执行根据本发明公开的方法。

7. 发明授权

US4457962A Molded article comprised of a thermotropic liquid crystal line polymer with an inherently weak weld line incorporated therein 失效
标题翻译：由热熔液晶线聚合物组成的模制品，其中结合有固有的弱焊接线
公开(公告)号：US4457962A
公开(公告)日：1984-07-03
申请号：US413759
申请日：1982-09-01
申请人： Michael Jaffe , Zohar Ophir
发明人： Michael Jaffe , Zohar Ophir
IPC分类号： B29C45/00 , B29C67/24 , C08G63/60 , C09K19/38 , F16L9/16 , B29F3/04 , B65D65/28
CPC分类号： C09K19/3809 , B29C45/0001 , B29C67/24 , C08G63/605 , B29K2067/00 , B29K2105/0079 , Y10T428/139 , Y10T428/1397 , Y10T428/15 , Y10T428/252 , Y10T428/253 , Y10T428/254 , Y10T428/256 , Y10T428/257 , Y10T428/259 , Y10T428/31786
摘要： An article is provided comprised of a thermotropic liquid crystalline polymer having an inherently weak weld line incorporated therein which renders the article suitable for use as a breakaway part.
摘要翻译：提供了一种制品，其由其中结合有固有的弱焊接线的热致液晶聚合物构成，其使得该制品适合用作分离部分。

8. 发明授权

US09447230B2 Polyester ethers derived from asymmetrical monomers based upon bisanydrohexitols 有权
标题翻译：衍生自基于双羟基己酸的不对称单体的聚酯醚
公开(公告)号：US09447230B2
公开(公告)日：2016-09-20
申请号：US13050684
申请日：2011-03-17
申请人： Michael Jaffe , Willis Hammond , Xianhong Feng , Anthony East
发明人： Michael Jaffe , Willis Hammond , Xianhong Feng , Anthony East
IPC分类号： C07D493/00 , C08G63/664 , C07D493/04 , C07D519/00 , C08G63/66 , C08G63/58
CPC分类号： C07D493/04 , C07D519/00 , C08G63/66 , C08G63/664 , C08G63/672 , Y02P20/55
摘要： A process for producing a copolyester through the production of an AB monomer of isoidide - Isodide 2-(4-carbomethoxyphenyl) ether. In certain aspects, the AB monomer is produced by performing the steps of: protecting the 2-position of isosorbide with a protecting group; functionalizing the 5-position of isosorbide with a suitable leaving group to form a reactive ester; nucleophilicly displacing the leaving group in a reaction with an alkali metal alkoxide or phenoxide to give an isoidide ether through a stereochemical inversion of the 5-position; and removing the protective moiety to create the AB monomer. In certain embodiments, the copolyester is produced by melting the AB monomer and a polyester, optionally with a catalyst.
摘要翻译：通过生产异氰酸酯 - 异二氢-2-（4-甲酯基苯基）醚的AB单体制备共聚酯的方法。在某些方面，通过执行以下步骤制备AB单体：用保护基保护异山梨醇的2-位; 用合适的离去基官能化异山梨醇的5-位以形成反应性酯; 在与碱金属醇盐或酚盐的反应中亲核取代离去基团，通过5-位的立体化学反应得到异氰醚; 并除去保护部分以产生AB单体。在某些实施方案中，共聚多酯通过将AB单体和聚酯任选地与催化剂一起熔化来制备。

9. 发明申请

US20080021209A1 Ethers of bisanhydrohexitols 审中-公开
标题翻译：双氢己氮醚的醚
公开(公告)号：US20080021209A1
公开(公告)日：2008-01-24
申请号：US11809035
申请日：2007-05-31
申请人： Anthony East , Michael Jaffe , Yi Zhang , Luiz Catalani
发明人： Anthony East , Michael Jaffe , Yi Zhang , Luiz Catalani
IPC分类号： C07H1/00
CPC分类号： C07H1/00
摘要： A novel method for the synthesis of ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, is disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. Anhydrosugar ethers are derived from renewable sources and are not xenoestrogenic. Higher alkyl and aralkyl ethers are stable high-boiling oils that are good plasticizers for materials such as PVC.
摘要翻译：公开了一种用于合成诸如异山梨醇，异烟肼和异氰酸酯的脱水糖醚的新方法。双缩水甘油醚在制备热固性环氧醚时可用作双酚A的替代物。脱水糖醚源自可再生能源，不是异源雌激素。高级烷基和芳烷基醚是稳定的高沸点油，它们是用于诸如PVC的材料的良好的增塑剂。

10. 发明授权

US06187437B1 Process for making high denier multilobal filaments of thermotropic liquid crystalline polymers and compositions thereof 有权
标题翻译：用于制备热致液晶聚合物的高旦数多叶长丝的方法及其组合物
公开(公告)号：US06187437B1
公开(公告)日：2001-02-13
申请号：US09150921
申请日：1998-09-10
申请人： M. Ishaq Haider , John Anthony Flint , Michael Jaffe , Joseph J. DiBiase , John Edward Cornetta
发明人： M. Ishaq Haider , John Anthony Flint , Michael Jaffe , Joseph J. DiBiase , John Edward Cornetta
IPC分类号： B32B2734
CPC分类号： D01F6/82 , D01D5/253 , D01F6/62 , D01F6/84 , Y10T428/2969 , Y10T428/2973 , Y10T428/2975
摘要： The present invention discloses and claims a novel process for the formation of high denier as-spun and heat-treated multilobal filaments of a thermotropic liquid crystalline polymer. Preferred embodiments include process for the formation of as-spun and heat treated octalobal monofilaments of a few wholly aromatic polyesters and polyesteramides. The process involves (a) heating of a thermotropic liquid crystalline polymer to above its melting transition temperature; (b) passing said molten polymer through an extrusion chamber equipped with an extrusion capillary having a multilobal cross-section to form a multilobal filament; and (c) winding the filament at a suitable draw-down. The filaments so formed are of at least 50 denier per filament (dpf) and feature essentially uniform molecular orientation across their cross-section. In a final optional step, the filaments are heat treated in stages to form filaments exhibiting excellent tensile properties. Both as-spun and heat-treated filaments feature remarkably good tensile properties comparable to those of round filaments. Most importantly, the multilobal filaments of this invention feature much superior adhesion properties than the conventional round filaments.
摘要翻译：本发明公开并要求一种用于形成热致伸缩液晶聚合物的高旦旦纺丝和热处理多叶长丝的新方法。优选的实施方案包括形成几种完全芳族聚酯和聚酯酰胺的初纺和热处理的八面体单丝的方法。该方法包括（a）将热致液晶聚合物加热至其熔融转变温度以上; （b）使所述熔融聚合物通过装备有具有多叶横截面的挤出毛细管的挤出室以形成多叶长丝; 和（c）将丝缠绕在合适的拉伸下。如此形成的细丝具有至少50旦尼尔/丝（dpf），并且在其横截面上具有基本均匀的分子取向。在最后的任选步骤中，细丝被分阶段热处理以形成显示出优异拉伸性能的长丝。初纺和热处理的长丝具有与圆丝相当的非常好的拉伸性能。最重要的是，本发明的多叶长丝具有比常规圆丝更好的粘合性能。

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