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1. 发明申请

US20080027093A1 Cyclohexylalanine Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权
标题翻译：环己基丙氨酸衍生物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
公开(公告)号：US20080027093A1
公开(公告)日：2008-01-31
申请号：US11579265
申请日：2005-05-13
申请人： Joseph Duffy , David Kaelin , Ann Weber , Brian Kirk
发明人： Joseph Duffy , David Kaelin , Ann Weber , Brian Kirk
IPC分类号： A61K31/4025 , A61K31/4015 , A61K31/437 , A61K31/4439 , A61P3/10 , C07D207/16 , C07D401/02 , C07D403/02 , C07D471/04
CPC分类号： C07D207/27 , C07D207/10 , C07D211/38 , C07D401/08 , C07D401/12 , C07D413/08 , C07D471/04
摘要： The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新型环己基丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如作为糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

2. 发明申请

US20060052382A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 审中-公开
公开(公告)号：US20060052382A1
公开(公告)日：2006-03-09
申请号：US10540283
申请日：2003-12-16
申请人： Joseph Duffy , Scott Edmondson , Dooseop Kim , Brian Kirk , Liping Wang , Ann Weber
发明人： Joseph Duffy , Scott Edmondson , Dooseop Kim , Brian Kirk , Liping Wang , Ann Weber
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

3. 发明授权

US10211577B2 High performance cable connector 有权
公开(公告)号：US10211577B2
公开(公告)日：2019-02-19
申请号：US13671096
申请日：2012-11-07
申请人： Donald W. Milbrand, Jr. , Prescott B. Atkinson , Brian Kirk
发明人： Donald W. Milbrand, Jr. , Prescott B. Atkinson , Brian Kirk
IPC分类号： H01R13/64 , H01R24/28 , H01R13/6599 , H01R13/6585 , H01R12/50 , H01R12/70 , H01R12/72 , H01R13/6583 , H01R13/6587 , H01R43/20 , H01R43/26 , H01R13/514 , H01R13/6461 , H01R13/6473 , H01R24/60
摘要： A cable connector with improved performance and ease of use. The connector has staggered ports to reduce crosstalk and to prevent incorrect insertion of a plug into a receptacle. The plug may be constructed with subassemblies, each of which has a lossy central portion. Conductive members embedded within an insulative housing of the subassemblies may be used to electrically connect ground conductors within the subassemblies. Further, the connector may have a quick connect locking screw that can be engaged by pressing on the screw, but requires rotation of the screw to remove. Additionally, a ferrule may be used in making a mechanical connection between a cable bundle and a plug and making an electrical connection between a braid of the cable bundle and a conductive shell of the plug. The ferrule may be in multiple pieces for easy attachment while precluding deformation of the cable, which disrupts electrical performance.

4. 发明授权

US08864521B2 High frequency electrical connector 有权
标题翻译：高频电连接器
公开(公告)号：US08864521B2
公开(公告)日：2014-10-21
申请号：US13029052
申请日：2011-02-16
申请人： Prescott B. Atkinson , Brian Kirk , Mark W. Gailus , David Manter , Thomas S. Cohen
发明人： Prescott B. Atkinson , Brian Kirk , Mark W. Gailus , David Manter , Thomas S. Cohen
IPC分类号： H01R13/648 , H01R12/73 , H01R13/6585 , H01R13/6477 , H01R13/514 , H01R13/504 , H01R12/72 , H01R13/6587
CPC分类号： H01R13/6461 , H01R12/585 , H01R12/724 , H01R12/735 , H01R13/504 , H01R13/514 , H01R13/6471 , H01R13/6477 , H01R13/658 , H01R13/6585 , H01R13/6587 , H01R13/6598 , H01R24/62 , H01R24/68
摘要： An improved broadside coupled, open pin field connector. The connector incorporates lossy material to selectively dampen resonance within pairs of conductive members connected to ground when the connector is mounted to a printed circuit board. The material may also decrease crosstalk and mode conversion. The lossy material is selectively positioned to substantially dampen resonances along pairs that may be connected to ground without unacceptably attenuating signals carried by other pairs. The lossy material may be selectively positioned near mating contact portions of the conductive members. Multiple techniques are described for selectively positioning the lossy material, including molding, inserting lossy members into a housing or coating surfaces of the connector housing. The lossy material alternatively may be positioned between broad sides of conductive members of a pair.
摘要翻译：一个改进的宽边耦合，开放引脚现场连接器。当连接器安装到印刷电路板上时，连接器包含有损耗材料以选择性地抑制连接到地面的成对的导电构件内的谐振。该材料还可以减少串扰和模式转换。选择性地定位有损耗材料以基本上抑制可能连接到地面的成对的谐振，而不会有不可接受地衰减由其他对承载的信号。有损材料可以选择性地定位在导电构件的匹配接触部分附近。描述了用于选择性地定位有损材料的多种技术，包括模制，将有损构件插入到连接器壳体的壳体或涂层表面中。有损耗材料可替代地位于一对导电构件的宽侧之间。

5. 发明授权

US08657627B2 Mezzanine connector 有权
标题翻译：夹层连接器
公开(公告)号：US08657627B2
公开(公告)日：2014-02-25
申请号：US13365203
申请日：2012-02-02
申请人： David M. McNamara , Brian Kirk
发明人： David M. McNamara , Brian Kirk
IPC分类号： H01R13/648
CPC分类号： H01R13/516 , H01R12/714 , H01R12/73 , H01R13/6461 , H01R13/6587
摘要： A two-piece mezzanine connector for high speed, high density signals. The connector is assembled from wafers that may be formed of identical wafer halves. The halves may have interior portions that form a channel in which a lossy member may be captured for selectively configuring the connector for high frequency performance. The lossy member may be serpentine, to both provide different spacing relative to signal and ground conductors and to provide compliance to press against ground conductors when captured between wafer halves. Instead of, or in addition to, the lossy member captured between two wafer halves, the wafer halves may each have lossy material overmolded on at least one side, so that an assembled wafer may have lossy material disposed on the outside. The wafers may have dovetail projections that are secured within dovetail channels, forming structural members of the connector.
摘要翻译：两片夹层连接器，用于高速，高密度信号。连接器由可由相同晶片半部形成的晶片组装。半部可以具有形成通道的内部部分，在该通道中可以捕获有损耗部件以有选择地配置用于高频性能的连接器。有损构件可以是蛇形的，以便相对于信号和接地导体提供不同的间隔，并且当捕获在晶片半部之间时，提供对接地导体的压制的顺应性。代替或补充在两个晶片半部之间捕获的有损构件，晶片半部可以各自具有在至少一侧上包覆成型的有损耗材料，使得组装的晶片可以具有设置在外部的有损耗材料。晶片可以具有固定在燕尾槽通道内的燕尾突起，形成连接器的结构构件。

6. 发明授权

US08460032B2 Differential electrical connector with improved skew control 有权
标题翻译：差分电连接器具有改进的扭曲控制
公开(公告)号：US08460032B2
公开(公告)日：2013-06-11
申请号：US13444593
申请日：2012-04-11
申请人： Brian Kirk
发明人： Brian Kirk
IPC分类号： H01R13/648
CPC分类号： H01R13/6473 , H01R12/727 , H01R13/6471 , H01R13/6585
摘要： An electrical interconnection system with high speed, differential electrical connectors. The connector is assembled from wafers each containing a column of conductive elements, some of which form differential pairs. Skew control is provided for at least some of the pairs by providing a profile on an edge of the shorter signal conductor of the pair. The profile may contain multiple curved segments that effectively lengthen the signal conductor without significantly impacting its impedance. For connectors in which ground conductors are included between adjacent pairs of signal conductors, patterned segments of varying parameters may be included on edges of the signal conductors and ground conductors to equalize electrical lengths of all edges in a set of edges for which there is common mode or differential mode coupling as a signal propagates along each pair.
摘要翻译：具有高速差动电连接器的电气互连系统。连接器由每个包含一列导电元件的晶片组装，其中一些形成差分对。通过在该对的较短信号导体的边缘上提供轮廓来为至少一些对提供倾斜控制。轮廓可以包含多个弯曲段，其有效地延长信号导体，而不会显着影响其阻抗。对于在相邻的信号导体对之间包括接地导体的连接器，可以在信号导体和接地导体的边缘上包括不同参数的图案化部分，以均衡具有共模的一组边缘中的所有边缘的电长度或者作为信号的差模耦合作为每一对传播。

7. 发明授权

US08357693B2 Pharmacokinetically improved compounds 有权
标题翻译：药代动力学改进的化合物
公开(公告)号：US08357693B2
公开(公告)日：2013-01-22
申请号：US11887218
申请日：2006-03-27
申请人： Alessandra Bartolozzi , Stewart Campbell , Hope Foudoulakis , Brian Kirk , Siya Ram , Paul Sweetnam
发明人： Alessandra Bartolozzi , Stewart Campbell , Hope Foudoulakis , Brian Kirk , Siya Ram , Paul Sweetnam
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D413/14 , B82Y30/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.
摘要翻译：本发明涉及ROCK1和ROCK2的抑制剂和调节这些化合物的药代动力学和/或药效学性质的方法。还提供抑制可用于治疗疾病的ROCK1和/或ROCK2的方法。

8. 发明申请

US20120311893A1 Plow Blade Wing 审中-公开
标题翻译：犁刀翼
公开(公告)号：US20120311893A1
公开(公告)日：2012-12-13
申请号：US13483489
申请日：2012-05-30
申请人： Charles O. Knott , Brian Kirk
发明人： Charles O. Knott , Brian Kirk
IPC分类号： E02F3/815 , E01H5/06
CPC分类号： E01H5/062 , E01H5/065 , E01H5/066
摘要： A wing extension for a plow blade is disclosed which comprises an extension plow blade having a plow surface for plowing a desired material; and mounting means for pivotally mounting the extension plow blade to an existing plow blade. The extension plow blade is pivotable from a first use position in alignment with the existing plow blade to a second rearwardly deflected position on contact with an immovable object. A biasing member, such as a torsion spring, is provided for biasing the extension plow blade in the first use position.
摘要翻译：公开了一种用于犁刀的机翼延伸部，其包括具有用于犁所需材料的犁面的延伸犁刀; 以及用于将延伸犁刀可枢转地安装到现有犁刀的安装装置。延伸犁刀可以从与现有犁刀对准的第一使用位置枢转到与不可移动物体接触的第二后向偏转位置。提供偏置构件，例如扭转弹簧，用于在第一使用位置偏置延伸犁刀。

9. 发明申请

US20120202386A1 MEZZANINE CONNECTOR 有权
标题翻译： MEZZANINE连接器
公开(公告)号：US20120202386A1
公开(公告)日：2012-08-09
申请号：US13365197
申请日：2012-02-02
申请人： David M. McNamara , Brian Kirk
发明人： David M. McNamara , Brian Kirk
IPC分类号： H01R12/73
CPC分类号： H01R13/516 , H01R12/714 , H01R12/73 , H01R13/6461 , H01R13/6587
摘要： A two-piece mezzanine connector for high speed, high density signals. One piece of the connector may have conductive elements with beam-shaped mating contacts. The beams may include openings to control mechanical properties while allowing edge to edge spacing between adjacent beams to be selected to provide desired electrical properties. The openings may be teardrop shaped, with a larger width at a distal end of the beams. Beams associated with signal conductors may have openings that are shaped differently from openings of beams associated with ground conductors. For a first connector piece, mating contact regions of signal conductors may be wider than mating contact regions of ground conductors. For a second connector piece adapted to mate with the first connector piece, mating contact regions of signal conductors may be narrower than mating contact regions of ground conductors. These contact shapes may provide float while maintaining a high contact density.
摘要翻译：两片夹层连接器，用于高速，高密度信号。一个连接器可以具有带有梁形配合触头的导电元件。梁可以包括用于控制机械特性的开口，同时允许相邻梁之间的边缘到边缘间隔被选择以提供期望的电特性。开口可以是泪珠状，在梁的远端具有较大的宽度。与信号导体相关联的梁可以具有不同于与接地导体相关联的梁的开口的开口。对于第一连接器部件，信号导体的配合接触区域可以比接地导体的配合接触区域宽。对于适于与第一连接器部件配合的第二连接器件，信号导体的配合接触区域可能比接地导体的配合接触区域窄。这些接触形状可以提供浮动，同时保持高的接触密度。

10. 发明申请

US20120202363A1 MEZZANINE CONNECTOR 有权
标题翻译： MEZZANINE连接器
公开(公告)号：US20120202363A1
公开(公告)日：2012-08-09
申请号：US13365203
申请日：2012-02-02
申请人： David M. McNamara , Brian Kirk
发明人： David M. McNamara , Brian Kirk
IPC分类号： H01R12/72 , H01R43/16
CPC分类号： H01R13/516 , H01R12/714 , H01R12/73 , H01R13/6461 , H01R13/6587
摘要： A two-piece mezzanine connector for high speed, high density signals. The connector is assembled from wafers that may be formed of identical wafer halves. The halves may have interior portions that form a channel in which a lossy member may be captured for selectively configuring the connector for high frequency performance. The lossy member may be serpentine, to both provide different spacing relative to signal and ground conductors and to provide compliance to press against ground conductors when captured between wafer halves. Instead of, or in addition to, the lossy member captured between two wafer halves, the wafer halves may each have lossy material overmolded on at least one side, so that an assembled wafer may have lossy material disposed on the outside. The wafers may have dovetail projections that are secured within dovetail channels, forming structural members of the connector.
摘要翻译：两片夹层连接器，用于高速，高密度信号。连接器由可由相同晶片半部形成的晶片组装。半部可以具有形成通道的内部部分，在该通道中可以捕获有损耗部件以有选择地配置用于高频性能的连接器。有损构件可以是蛇形的，以便相对于信号和接地导体提供不同的间隔，并且当捕获在晶片半部之间时，提供对接地导体的压制的顺应性。代替或补充在两个晶片半部之间捕获的有损构件，晶片半部可以各自具有在至少一侧上包覆成型的有损耗材料，使得组装的晶片可以具有设置在外部的有损耗材料。晶片可以具有固定在燕尾槽通道内的燕尾突起，形成连接器的结构构件。

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