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1. 发明授权

US08725228B2 Steerable catheter having intermediate stiffness transition zone 有权
标题翻译：具有中等刚度过渡带的导向导管
公开(公告)号：US08725228B2
公开(公告)日：2014-05-13
申请号：US12708114
申请日：2010-02-18
申请人： Josef V. Koblish , Mark Forrest , Zaya Tun
发明人： Josef V. Koblish , Mark Forrest , Zaya Tun
IPC分类号： A61B5/042 , A61B18/24
CPC分类号： A61M25/0141 , A61M25/0144 , A61M25/0147
摘要： A flexible, steerable intravascular catheter includes an elongate flexible shaft having a heterogeneous or multi-zone stiffness profile or structure. A first or distal portion of the catheter shaft may have a substantially constant or distinct stiffness or flexibility, a second, intermediate or transition section is proximal relative to, and less flexible than, the first section, and a third section is proximal relative to, and also less more flexible than, the first section. The third section also includes a substantially constant or distinct stiffness or flexibility. The flexibility or stiffness of the second section varies along its length, e.g., in a substantially linear, step-like or ramp-like manner to provide a smooth or gradual transition between the stiffness of the first or distal section and the flexibility or stiffness of the third or proximal section.
摘要翻译：柔韧的，可操纵的血管内导管包括具有异质或多区域刚度分布或结构的细长柔性轴。导管轴的第一或远端部分可以具有基本上恒定或不同的刚度或柔性，第二中间或过渡部分相对于第一部分近端并且比第一部分更柔性，并且第三部分相对于第二部分近端，并且也比第一部分更不灵活。第三部分还包括基本上恒定或不同的刚度或柔性。第二部分的柔韧性或刚度沿其长度变化，例如以基本线性的阶梯状或斜坡状方式变化，以提供第一或远端部分的刚度之间的平滑或逐渐过渡，以及柔性或刚度第三或近端部分。

2. 发明申请

US20100217184A1 STEERABLE CATHETER HAVING INTERMEDIATE STIFFNESS TRANSITION ZONE 有权
标题翻译：具有中间强度转换区的可转向导管
公开(公告)号：US20100217184A1
公开(公告)日：2010-08-26
申请号：US12708114
申请日：2010-02-18
申请人： Josef V. Koblish , Mark Forrest , Zaya Tun
发明人： Josef V. Koblish , Mark Forrest , Zaya Tun
IPC分类号： A61M25/08 , A61M25/092
CPC分类号： A61M25/0141 , A61M25/0144 , A61M25/0147
摘要： A flexible, steerable intravascular catheter includes an elongate flexible shaft having a heterogeneous or multi-zone stiffness profile or structure. A first or distal portion of the catheter shaft may have a substantially constant or distinct stiffness or flexibility, a second, intermediate or transition section is proximal relative to, and less flexible than, the first section, and a third section is proximal relative to, and also less more flexible than, the first section. The third section also includes a substantially constant or distinct stiffness or flexibility. The flexibility or stiffness of the second section varies along its length, e.g., in a substantially linear, step-like or ramp-like manner to provide a smooth or gradual transition between the stiffness of the first or distal section and the flexibility or stiffness of the third or proximal section.
摘要翻译：柔韧的，可操纵的血管内导管包括具有异质或多区域刚度分布或结构的细长柔性轴。导管轴的第一或远端部分可以具有基本上恒定或不同的刚度或柔性，第二中间或过渡部分相对于第一部分近端并且比第一部分更柔性，并且第三部分相对于第二部分近端，并且也比第一部分更不灵活。第三部分还包括基本上恒定或不同的刚度或柔性。第二部分的柔韧性或刚度沿其长度变化，例如以基本线性的阶梯状或斜坡状方式变化，以提供第一或远端部分的刚度之间的平滑或逐渐过渡，以及柔性或刚度第三或近端部分。

3. 发明申请

US20130066312A1 ABLATION DEVICE WITH MULTIPLE ABLATION MODES 有权
公开(公告)号：US20130066312A1
公开(公告)日：2013-03-14
申请号：US13613931
申请日：2012-09-13
申请人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
发明人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00065 , A61B2018/00232 , A61B2018/00238 , A61B2018/00345 , A61B2018/00351 , A61B2018/00577 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839
摘要： Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon is configured to transmit the RF energy in a direction distally towards a leading end of the ablation device. Multiple ablation electrodes on the device can be used for providing lesions of different size or shape.

4. 发明授权

US09125668B2 Ablation device with multiple ablation modes 有权
标题翻译：消融装置具有多种消融模式
公开(公告)号：US09125668B2
公开(公告)日：2015-09-08
申请号：US13613931
申请日：2012-09-13
申请人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
发明人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
IPC分类号： A61B18/18 , A61B17/20 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00065 , A61B2018/00232 , A61B2018/00238 , A61B2018/00345 , A61B2018/00351 , A61B2018/00577 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839
摘要： Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon is configured to transmit the RF energy in a direction distally towards a leading end of the ablation device. Multiple ablation electrodes on the device can be used for providing lesions of different size or shape.
摘要翻译：公开了用于对身体组织进行消融治疗的装置，系统和方法。用于治疗身体组织的示例性消融装置包括离子导电球囊和将RF能量递送到气囊的远端部分的射频电极。气囊被配置为在远离消融装置的前端的方向上传送RF能量。器件上的多个消融电极可用于提供不同大小或形状的病灶。

5. 发明申请

US20130066315A1 ABLATION DEVICE WITH IONICALLY CONDUCTIVE BALLOON 有权
标题翻译：具有导电性气泡的吸引装置
公开(公告)号：US20130066315A1
公开(公告)日：2013-03-14
申请号：US13616161
申请日：2012-09-14
申请人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
发明人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
IPC分类号： A61B18/14 , B44C1/22
CPC分类号： A61B18/1492 , A61B2018/00077 , A61B2018/0022 , A61B2018/00238
摘要： Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon can have a composite structure with a non-conductive section and a conductive section. A method for fabricating a semi-permeable ablation balloon using ionizing radiation and an etching process is also disclosed.
摘要翻译：公开了用于对身体组织进行消融治疗的装置，系统和方法。用于治疗身体组织的示例性消融装置包括离子导电球囊和将RF能量递送到气囊的远端部分的射频电极。球囊可以具有非导电部分和导电部分的复合结构。还公开了一种使用电离辐射和蚀刻工艺制造半透光消融球的方法。

6. 发明授权

US09603659B2 Ablation device with ionically conductive balloon 有权
公开(公告)号：US09603659B2
公开(公告)日：2017-03-28
申请号：US13616161
申请日：2012-09-14
申请人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
发明人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
IPC分类号： A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/00077 , A61B2018/0022 , A61B2018/00238
摘要： Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon can have a composite structure with a non-conductive section and a conductive section. A method for fabricating a semi-permeable ablation balloon using ionizing radiation and an etching process is also disclosed.

7. 发明授权

US09320564B2 Steerable catheter and method for performing medical procedure adjacent pulmonary vein ostia 有权
公开(公告)号：US09320564B2
公开(公告)日：2016-04-26
申请号：US11418757
申请日：2006-05-05
申请人： Boaz Avitall , Josef V. Koblish
发明人： Boaz Avitall , Josef V. Koblish
IPC分类号： A61B18/14 , A61M25/01 , A61B6/06 , A61B17/00 , A61B18/00 , A61B19/00
CPC分类号： A61B18/1492 , A61B6/06 , A61B2017/003 , A61B2018/00375 , A61B2034/2051 , A61M25/0144 , A61M25/0147 , A61M25/0152 , A61M2025/0161
摘要： Catheters, systems, and methods are provided for performing medical procedures, such as tissue ablation, adjacent the ostia of anatomical vessels, such as pulmonary veins. The catheter comprises an elongated flexible catheter body including a proximal shaft portion and a distal shaft portion, which has a proximal section pre-shaped to form a curve having an apex sized to be inserted into an anatomical vessel, such as a pulmonary vein, and a distal section configured to contact an ostium of the vessel when the curve apex is inserted within the vessel ostium. The catheter further comprises a steering mechanism configured for decreasing a radius of curvature of the curve.

8. 发明申请

US20090287202A1 APPARATUS AND METHODS FOR CRYOGENICALLY ABLATING TISSUE AND ADJUSTING CRYOGENIC ABLATION REGIONS 有权
标题翻译：冷冻组织和调节低温消退区的装置和方法
公开(公告)号：US20090287202A1
公开(公告)日：2009-11-19
申请号：US12432538
申请日：2009-04-29
申请人： Frank W. Ingle , Robert F. Bencini , Josef V. Koblish , Jonathan A. Wohlgemuth , Paul Roche
发明人： Frank W. Ingle , Robert F. Bencini , Josef V. Koblish , Jonathan A. Wohlgemuth , Paul Roche
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2017/22054 , A61B2018/00196 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011
摘要： Apparatus and methods for performing cryogenic ablation of tissue and adjusting the size and/or location of a cryogenic cooling region. A cooling assembly may include tubes for dispensing and exhausting a coolant or refrigerant. One or both of the tubes may be moved, e.g., slidably adjusted, in order to adjust the location or size of a cryogenic ablation region. The cooling assembly may be integrated into cryogenic ablation devices including a cryogenic balloon device that includes an inner inflatable balloon and another balloon that is at least partially wrapped around the inner balloon and carries refrigerant for performing cryo-ablation. Electrodes permit electrical mapping of tissue before or after cryo-ablation to verify success of the procedure.
摘要翻译：用于对组织进行低温消融并调节低温冷却区域的尺寸和/或位置的装置和方法。冷却组件可以包括用于分配和排出冷却剂或制冷剂的管。一个或两个管可以被移动，例如可滑动地调节，以便调节低温消融区域的位置或尺寸。冷却组件可以集成到低温消融装置中，包括低温球囊装置，其包括内部可充气球囊和至少部分地缠绕在内球囊周围并承载用于进行低温消融的制冷剂的另一球囊。电极允许在低温消融之前或之后对组织进行电气测绘，以验证该程序的成功。

9. 发明授权

US07435248B2 Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel 有权
标题翻译：用于创建和诊断血管口内或周围周围损伤的医用探针
公开(公告)号：US07435248B2
公开(公告)日：2008-10-14
申请号：US10672457
申请日：2003-09-26
申请人： Miriam H. Taimisto , Josef V. Koblish
发明人： Miriam H. Taimisto , Josef V. Koblish
IPC分类号： A61B18/14 , A61B5/042
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2018/00214 , A61B2018/0022 , A61B2018/00375 , A61B2018/00839 , A61B2018/1435
摘要： The present inventions provide assemblies, probes, and methods for creating circumferential lesions in tissue, e.g., the tissue within or around the ostium of a vessel. An ablation probe with an ablative structure can be placed in contact within or around the ostium of the vessel. A diagnostic probe can be introduced through a lumen within the ablation probe and inserted into the vessel. The energy can be provided to the ablative structure to create a circumferential lesion within or around the ostium of the vessel, and the diagnostic structure can be used to diagnose the tissue to determine whether the circumferential lesion can be properly created.
摘要翻译：本发明提供用于在组织中产生周向损伤的组件，探针和方法，例如在血管的口内或周围的组织。具有烧蚀结构的消融探针可以在容器的口中或周围接触放置。诊断探针可以通过消融探针中的内腔引入并插入血管。可以将能量提供给烧蚀结构以在容器的口内或周围形成周缘损伤，并且诊断结构可用于诊断组织以确定是否可以适当地产生周缘损伤。

10. 发明授权

US06837885B2 Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors 失效
标题翻译：用于支撑可膨胀的治疗装置的手术探针，其与身体孔内或肿瘤周围的组织接触
公开(公告)号：US06837885B2
公开(公告)日：2005-01-04
申请号：US09737176
申请日：2000-12-13
申请人： Josef V. Koblish , Anat V. Hegde , David K. Swanson
发明人： Josef V. Koblish , Anat V. Hegde , David K. Swanson
IPC分类号： A61B17/34 , A61B5/042 , A61B18/04 , A61B18/14 , A61F2/958 , A61B18/18
CPC分类号： A61B18/1492 , A61B5/0422 , A61B2018/00065 , A61B2018/00083 , A61B2018/00095 , A61B2018/00214 , A61B2018/0022 , A61B2018/00238 , A61B2018/00577 , A61B2018/00839 , A61B2090/065 , A61B2218/002
摘要： A probe that facilitates the creation of lesions in bodily tissue. The probe includes a relatively short shaft and an inflatable therapeutic element.

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