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1. 发明授权

US5649903A Apparatus and methods for generating leukocyte free platelet concentrate 失效
标题翻译：用于产生无白血球的血小板浓缩物的装置和方法
公开(公告)号：US5649903A
公开(公告)日：1997-07-22
申请号：US373359
申请日：1995-01-17
申请人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
发明人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
IPC分类号： A61M1/02 , A61K35/14 , A61M1/26 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置从白细胞污染的血液分数中分离白细胞的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置以及可用于与自动取样仪器相关联的管线束/部件系统（图2a，2b，2c）。

2. 发明授权

US5403272A Apparatus and methods for generating leukocyte free platelet concentrate 失效
标题翻译：用于产生无白血球的血小板浓缩物的装置和方法
公开(公告)号：US5403272A
公开(公告)日：1995-04-04
申请号：US890980
申请日：1992-05-29
申请人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
发明人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
IPC分类号： A61M1/02 , A61K35/14 , A61M1/26 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置从白细胞污染的血液分数中分离白细胞的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置以及可用于与自动取样仪器相关联的管线束/部件系统（图2a，2b，2c）。

3. 发明授权

US5899856A Dermal patch detecting long-term alcohol consumption and method of use 失效
标题翻译：皮肤贴剂检测长期饮酒及使用方法
公开(公告)号：US5899856A
公开(公告)日：1999-05-04
申请号：US747304
申请日：1996-11-12
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N33/50 , A61B5/00 , A61B10/00 , B01L3/00 , G01N33/483 , G01N33/497
CPC分类号： A61B5/4266 , A61B10/0035 , A61B10/0064 , B01L3/505 , A61B2010/0009 , G01N33/4972
摘要： A non-occlusive dermal patch for collecting vapor phase perspiration from a subject's skin and retaining an analyte such as ethanol in the perspiration is disclosed. A method of collecting vapor phase perspiration containing an analyte such as ethanol over a period up to several days and detecting the analyte to determine the wearer's consumption of the analyte during the period when the patch was worn is disclosed.
摘要翻译：公开了一种用于从受试者的皮肤收集气相汗液并将分析物（例如乙醇）保留在出汗中的非闭塞皮肤贴剂。公开了一种在多达几天的时间内收集含有分析物（例如乙醇）的气相汗液的方法，并且检测分析物以确定佩戴者在穿着贴片期间的分析物消耗量。

4. 发明授权

US4957108A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US4957108A
公开(公告)日：1990-09-18
申请号：US241707
申请日：1988-09-08
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N31/22 , A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/50 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B10/0064 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。

5. 发明授权

US5445147A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5445147A
公开(公告)日：1995-08-29
申请号：US344407
申请日：1994-11-23
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。补片可以包括用于筛选多个分析物的多个测试区。还公开了另外的正负控制区。补片可以包括检测篡改贴片以产生假阴性结果的特征，特别是当用于滥用药物的屏幕时。除了作为滥用药物屏幕有用之外，该补丁可用于诊断目的。

6. 发明授权

US5203327A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5203327A
公开(公告)日：1993-04-20
申请号：US569007
申请日：1990-08-15
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N33/50 , A61B5/00 , A61B10/00 , A61F13/00 , A61F13/15 , B01L3/00 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/14521 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , A61B5/6833 , A61M35/006 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61B5/14532 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。补片可以包括用于筛选多个分析物的多个测试区。还公开了另外的正负控制区。补片可以包括检测篡改贴片以产生假阴性结果的特征，特别是当用于滥用药物的屏幕时。除了作为滥用药物屏幕有用之外，该补丁可用于诊断目的。

7. 发明授权

US5076273A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5076273A
公开(公告)日：1991-12-31
申请号：US611460
申请日：1990-11-13
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B5/14521 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B10/0064 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。

8. 发明授权

US5817011A Method and apparatus for determination of chemical species in perspiration 失效
公开(公告)号：US5817011A
公开(公告)日：1998-10-06
申请号：US794284
申请日：1997-02-03
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61B5/00 , A61B10/00 , A61F13/00 , A61F13/15 , B01L3/00 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/14521 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , A61B5/6833 , A61M35/006 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61B5/14532 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491
摘要： A dermal patch to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection.

9. 发明授权

US5676144A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5676144A
公开(公告)日：1997-10-14
申请号：US483504
申请日：1995-06-07
申请人： Donald W. Schoendorfer
发明人： Donald W. Schoendorfer
IPC分类号： A61B5/00 , A61B10/00 , A61F7/03 , A61F13/00 , A61F13/15 , B01L3/00 , G01N1/10 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491 , A61F7/032
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。补片可以包括用于筛选多个分析物的多个测试区。还公开了另外的正负控制区。补片可以包括检测篡改贴片以产生假阴性结果的特征，特别是当用于滥用药物的屏幕时。除了作为滥用药物屏幕有用之外，该补丁可用于诊断目的。

10. 发明授权

US4944883A Continuous centrifugation system and method for directly deriving intermediate density material from a suspension 失效
标题翻译：连续离心系统和从悬浮液中直接得到中密度材料的方法
公开(公告)号：US4944883A
公开(公告)日：1990-07-31
申请号：US256234
申请日：1988-10-11
申请人： Donald W. Schoendorfer , Claude E. Berthe
发明人： Donald W. Schoendorfer , Claude E. Berthe
IPC分类号： A61M1/26 , A61M1/30 , A61M1/36 , B04B5/04
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3696 , B04B5/0442 , B04B2005/0464
摘要： A system for continuously separating lighter and intermediate density matter, such as plasma rich in platelets from whole blood moves blood through a diverging centrifugation gap between inner and outer walls of a rotor rotating about a central axis within an outer housing. The centrifugation action creates layered flow along an intermediate section. However by crating trailing wakes in the gap between the rotor and housing, localized remixing patterns tending to move in the opposite direction are induced in the layered matter. Platelet rich plasm may then be extracted through adjacent platelet concentrate ports on the inner wall of the rotor. An interior passageway system passes the platelet rich plasma to a platelet concentrate reservoir. Recirculation of blood in the rotor-housing gap between the output and input, and pumping action provided by the diverging centrifugation gap, aid in enhancing throughput and concentration levels. Prior to the centrifugation gap an initial narrow gap section is employed to limit backward propagation of the induced circulatory patterns.
摘要翻译：用于连续分离较轻和中等密度物质的系统，例如来自全血的富含血小板的血浆，使血液通过在外壳内围绕中心轴旋转的转子的内壁和外壁之间的发散的离心间隙移动。离心作用沿着中间部分产生分层流。然而，通过在转子和壳体之间的间隙中装配尾部的擦拭物，在分层物质中引起倾向于在相反方向移动的局部再混合模式。然后可以通过转子内壁上的相邻血小板浓缩物端口提取富血小板血浆。内部通道系统将富含血小板的血浆传递到血小板浓缩物储存器。在输出和输入之间的转子 - 壳体间隙中的血液再循环以及由分散离心间隙提供的泵送作用有助于提高产量和浓度水平。在离心间隙之前，采用初始窄间隙部分来限制诱导循环图案的反向传播。

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