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1. 发明授权

US5899856A Dermal patch detecting long-term alcohol consumption and method of use 失效
标题翻译：皮肤贴剂检测长期饮酒及使用方法
公开(公告)号：US5899856A
公开(公告)日：1999-05-04
申请号：US747304
申请日：1996-11-12
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N33/50 , A61B5/00 , A61B10/00 , B01L3/00 , G01N33/483 , G01N33/497
CPC分类号： A61B5/4266 , A61B10/0035 , A61B10/0064 , B01L3/505 , A61B2010/0009 , G01N33/4972
摘要： A non-occlusive dermal patch for collecting vapor phase perspiration from a subject's skin and retaining an analyte such as ethanol in the perspiration is disclosed. A method of collecting vapor phase perspiration containing an analyte such as ethanol over a period up to several days and detecting the analyte to determine the wearer's consumption of the analyte during the period when the patch was worn is disclosed.
摘要翻译：公开了一种用于从受试者的皮肤收集气相汗液并将分析物（例如乙醇）保留在出汗中的非闭塞皮肤贴剂。公开了一种在多达几天的时间内收集含有分析物（例如乙醇）的气相汗液的方法，并且检测分析物以确定佩戴者在穿着贴片期间的分析物消耗量。

2. 发明授权

US5403272A Apparatus and methods for generating leukocyte free platelet concentrate 失效
标题翻译：用于产生无白血球的血小板浓缩物的装置和方法
公开(公告)号：US5403272A
公开(公告)日：1995-04-04
申请号：US890980
申请日：1992-05-29
申请人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
发明人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
IPC分类号： A61M1/02 , A61K35/14 , A61M1/26 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置从白细胞污染的血液分数中分离白细胞的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置以及可用于与自动取样仪器相关联的管线束/部件系统（图2a，2b，2c）。

3. 发明授权

US4957108A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US4957108A
公开(公告)日：1990-09-18
申请号：US241707
申请日：1988-09-08
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N31/22 , A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/50 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B10/0064 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。

4. 发明授权

US5649903A Apparatus and methods for generating leukocyte free platelet concentrate 失效
标题翻译：用于产生无白血球的血小板浓缩物的装置和方法
公开(公告)号：US5649903A
公开(公告)日：1997-07-22
申请号：US373359
申请日：1995-01-17
申请人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
发明人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
IPC分类号： A61M1/02 , A61K35/14 , A61M1/26 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置从白细胞污染的血液分数中分离白细胞的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置以及可用于与自动取样仪器相关联的管线束/部件系统（图2a，2b，2c）。

5. 发明授权

US5445147A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5445147A
公开(公告)日：1995-08-29
申请号：US344407
申请日：1994-11-23
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。补片可以包括用于筛选多个分析物的多个测试区。还公开了另外的正负控制区。补片可以包括检测篡改贴片以产生假阴性结果的特征，特别是当用于滥用药物的屏幕时。除了作为滥用药物屏幕有用之外，该补丁可用于诊断目的。

6. 发明授权

US5203327A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5203327A
公开(公告)日：1993-04-20
申请号：US569007
申请日：1990-08-15
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： G01N33/50 , A61B5/00 , A61B10/00 , A61F13/00 , A61F13/15 , B01L3/00 , G01N33/15 , G01N33/483 , G01N33/487 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B10/0064 , A61B5/14521 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4266 , A61B5/6833 , A61M35/006 , B01L3/505 , A61B10/0051 , A61B2010/0009 , A61B5/14532 , A61F2013/00195 , A61F2013/00434 , A61F2013/00608 , A61F2013/00642 , A61F2013/00646 , A61F2013/00655 , A61F2013/00731 , A61F2013/00863 , A61F2013/00902 , A61F2013/8411 , A61F2013/842 , A61F2013/8473 , A61F2013/8491
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。补片可以包括用于筛选多个分析物的多个测试区。还公开了另外的正负控制区。补片可以包括检测篡改贴片以产生假阴性结果的特征，特别是当用于滥用药物的屏幕时。除了作为滥用药物屏幕有用之外，该补丁可用于诊断目的。

7. 发明授权

US5076273A Method and apparatus for determination of chemical species in body fluid 失效
标题翻译：用于测定体液中化学物质的方法和装置
公开(公告)号：US5076273A
公开(公告)日：1991-12-31
申请号：US611460
申请日：1990-11-13
申请人： Donald W. Schoendorfer , William R. Miller
发明人： Donald W. Schoendorfer , William R. Miller
IPC分类号： A61B5/00 , A61B10/00 , A61F13/00 , B01L3/00 , G01N33/543
CPC分类号： G01N33/54386 , A61B10/0035 , A61B5/14521 , A61B5/415 , A61B5/418 , A61B5/4266 , B01L3/505 , A61B10/0051 , A61B10/0064 , A61B2010/0009 , A61F2013/00608 , A61F2013/00646
摘要： Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed.
摘要翻译：公开了一种用于非侵入式确定通过皮肤表达的体液中的一种或多种预选分析物的方法和装置。将液体收集在皮肤浓度贴片中，并通过在身体热量的影响下驱除掉一部分实质的水分而浓缩。分析物与固定化的特异性结合配偶体最佳复合，并且目视表达分析物存在的标记。

8. 发明授权

US07623985B2 Method and apparatus for a web based punch clock/time clock 失效
标题翻译：用于基于网络的打孔时钟/时钟的方法和装置
公开(公告)号：US07623985B2
公开(公告)日：2009-11-24
申请号：US11477102
申请日：2006-06-27
申请人： Curtis L. Finch, II , William Leake , William R. Miller , Chris V. Anderson
发明人： Curtis L. Finch, II , William Leake , William R. Miller , Chris V. Anderson
IPC分类号： G04F3/00 , G06F15/14 , H04M15/00
CPC分类号： G06Q10/109 , G06Q10/06311 , G06Q10/063114 , G06Q10/1091 , G06Q40/123
摘要： A system and method for building GUI screen screens for a time keeping and expense tracking system includes a time keeping and expense tracking (TKET) server that includes computer instructions that define logic for building GUI screen screens according to user definitions, communication channel throughput capacity, and terminal capacity. In one embodiment of the present invention, the TKET server is operable to receive communication signals transmitted by way of a wireless communication channel and to generate corresponding display screens that are responsive to the user terminal type. The TKET server is also operable to act as a remote time clock. Accordingly, the TKET server is formed to receive and interpret signals that define the user ID, an account code, and whether a start or stop timekeeping event has been selected. The TKET server also is operable to prompt an IVR to interact with the user.
摘要翻译：用于构建用于时间和费用跟踪系统的GUI屏幕的系统和方法包括：时间维持和费用跟踪（TKET）服务器，其包括根据用户定义，通信信道吞吐量容量定义用于构建GUI屏幕屏幕的逻辑的计算机指令，和终端容量。在本发明的一个实施例中，TKET服务器可操作以接收通过无线通信信道发送的通信信号并产生响应于用户终端类型的相应显示屏幕。 TKET服务器还可以用作远程时钟。因此，TKET服务器被形成为接收和解释定义用户ID，帐户代码以及是否已经选择了开始或停止计时事件的信号。 TKET服务器还可以提示IVR与用户交互。

9. 发明授权

US6126013A Embossed plastic sheet and method of manufacture 失效
标题翻译：压花塑料片及其制造方法
公开(公告)号：US6126013A
公开(公告)日：2000-10-03
申请号：US209144
申请日：1998-12-10
申请人： William R. Miller
发明人： William R. Miller
IPC分类号： B65D81/03
CPC分类号： B65D81/03 , Y10T428/1334
摘要： An embossed plastic sheet material is molded to have a relief image with a peripheral edge that is formed by a partial shearing of the material of the plastic sheet near or at the peripheral edge so that the image lasts longer and does not relax or deteriorate naturally or with repeated and prolonged use. Also disclosed is a protective container made from the embossed plastic sheet material that can be used in a carrying case and an album to safely store and transport valuable and collectible items including coins, bottle tops, pogs, optical disks, magnetic disks, audio and video disks and tapes, stamps, photographs, match books, and other similar items. An embossing roller assembly is also described that can be used to fabricate the embossed plastic sheet material.
摘要翻译：压花塑料片材被模制成具有外周边缘的浮雕图像，周边边缘是通过在周边边缘处或周边边缘部分地剪切塑料薄片材料形成的，使得图像持续更长时间，并且不会自然地松弛或变质反复和长期使用。还公开了一种由压花塑料片材制成的保护容器，其可用于手提箱和相册中以安全地存储和运输有价值和可收集的物品，包括硬币，瓶盖，插头，光盘，磁盘，音频和视频磁盘和磁带，邮票，照片，匹配书籍和其他类似物品。还描述了可用于制造压花塑料片材的压花辊组件。

10. 发明授权

US5595797A Protective holders for disks 失效
标题翻译：磁盘保护夹
公开(公告)号：US5595797A
公开(公告)日：1997-01-21
申请号：US145253
申请日：1993-10-29
申请人： William R. Miller
发明人： William R. Miller
IPC分类号： B31B23/00 , B31B41/00 , B65D85/57 , G11B33/04 , B65D73/00
CPC分类号： B31B41/00 , B31B23/00 , B65D85/548 , G11B33/0444 , G11B33/0472 , B31B2237/10 , B31B2237/50 , B31B2241/007 , Y10S428/90 , Y10T428/1334 , Y10T428/161 , Y10T428/239 , Y10T428/24777 , Y10T428/24843
摘要： A device for protectively storing collectible disks, in particular a plastic album leaf for protectively storing and displaying collectible disks such as milk caps or coins. The device comprises two flexible plastic panels in superposed relation, and securing means securing the panels in such relation with a first opening between the panels, the securing means including an arcuate seam sealing the superposed panels together along a circular arc for containing at least one-half but not the entirety of the disk between the panels within the arc of the seam, the arc of the seam exceeding 180.degree. and terminating at a second opening between the superposed panels of sufficient width for permitting passage therethrough and into the arc of at least one-half of the disk when the disk is received by the first opening for containing the entirety of the disk between the panels.
摘要翻译：一种用于保护性地存储收集盘的装置，特别是用于保护性地存储和显示诸如牛奶帽或硬币的收集盘的塑料册页。该装置包括两个重叠关系的柔性塑料面板，以及固定装置，将面板与面板之间的第一开口固定在一起，固定装置包括弧形接缝，该弧形接缝沿着圆弧将该叠置的面板一起密封在一起，一半但不是在接缝弧内的板之间的整个盘，接缝的弧线超过180度，并且在足够宽度的叠置板之间的第二开口处终止，以允许至少通过其中并进入至少弧当磁盘被第一开口接收以容纳盘之间的整个盘时，盘的一半。

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