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1. 发明授权

US07253281B2 Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles 失效
标题翻译：抗肥胖症1,2,3,4,10,10a-六氢吡嗪并[1,2-a]吲哚
公开(公告)号：US07253281B2
公开(公告)日：2007-08-07
申请号：US11169079
申请日：2005-06-28
申请人： Jonathan Mark Bentley , Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
发明人： Jonathan Mark Bentley , Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04
摘要： The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
摘要翻译：本发明涉及1,2,3,4,10,10a，六氢吡嗪并[1,2-a]吲哚衍生物及其药学上可接受的盐，溶剂合物和酯，其中R 1〜具有权利要求1给出的含义以药物制剂的形式用于治疗或预防中枢神经系统病症，对中枢神经系统的损害，心血管疾病，胃肠道疾病，尿崩症，肥胖和睡眠呼吸暂停。

2. 发明授权

US06844345B2 Piperazine derivatives 失效
标题翻译：哌嗪衍生物
公开(公告)号：US06844345B2
公开(公告)日：2005-01-18
申请号：US10092751
申请日：2002-03-07
申请人： Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
发明人： Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
IPC分类号： A61K31/337 , A61K31/4985 , A61P3/00 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides piperazine derivatives in accordance with formula (I) as well as salts, hydrates and esters thereof. The substituent designations are as provided in the specification. The compounds of the present invention can be used in the treatment of type II diabetes or obesity.
摘要翻译：本发明提供根据式（I）的哌嗪衍生物及其盐，水合物和酯。取代基名称如本说明书中所提供。本发明的化合物可用于治疗II型糖尿病或肥胖症。

3. 发明申请

US20050239789A1 Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a] indoles 失效
标题翻译：抗肥胖症1,2,3,4,10,10a-六氢吡嗪并[1,2-a]吲哚
公开(公告)号：US20050239789A1
公开(公告)日：2005-10-27
申请号：US11169079
申请日：2005-06-28
申请人： Jonathan Bentley , Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
发明人： Jonathan Bentley , Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
IPC分类号： A61K31/337 , A61K31/4985 , A61K45/00 , A61P1/00 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/00 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , C07D487/04 , A61K31/498
CPC分类号： C07D487/04
摘要： The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
摘要翻译：本发明涉及1,2,3,4,10,10a，六氢吡嗪并[1,2-a]吲哚衍生物及其药学上可接受的盐，溶剂合物和酯，其中R 1〜具有权利要求1给出的含义以药物制剂的形式用于治疗或预防中枢神经系统病症，对中枢神经系统的损害，心血管疾病，胃肠道疾病，尿崩症，肥胖和睡眠呼吸暂停。

4. 发明申请

US20070106076A1 Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino [1,2-a] indoles 审中-公开
标题翻译：抗肥胖症1,2,3,4,10,10a-六氢吡嗪并[1,2-a]吲哚
公开(公告)号：US20070106076A1
公开(公告)日：2007-05-10
申请号：US11649132
申请日：2007-01-03
申请人： Jonathan Bentley , Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
发明人： Jonathan Bentley , Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
IPC分类号： C07D487/04 , A61K31/498
CPC分类号： C07D487/04
摘要： The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a] indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
摘要翻译：本发明涉及1,2,3,4,10,10a，六氢吡嗪并[1,2-a]吲哚衍生物及其药学上可接受的盐，溶剂合物和酯，其中R 1〜具有权利要求1给出的含义以药物制剂的形式用于治疗或预防中枢神经系统病症，对中枢神经系统的损害，心血管疾病，胃肠道疾病，尿崩症，肥胖和睡眠呼吸暂停。

5. 发明授权

US06933387B2 Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles 失效
标题翻译：抗肥胖症1,2,3,4,10,10a-六氢吡嗪并[1,2-a]吲哚
公开(公告)号：US06933387B2
公开(公告)日：2005-08-23
申请号：US10396242
申请日：2003-03-25
申请人： Jonathan Mark Bentley , Paul Hebeisen , Marc Muller , Hans Richter , Stephan Roever
发明人： Jonathan Mark Bentley , Paul Hebeisen , Marc Muller , Hans Richter , Stephan Roever
IPC分类号： A61K31/337 , A61K31/4985 , A61K45/00 , A61P1/00 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/00 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is directed to 1,2,3,4,10,10a-hexahydropyrazino [1,2-a]indole derivatives of formula (I): as well as pharmaceutically acceptable salts, hydrates and esters thereof, wherein the substituents have the meanings provided in the specification. Compounds of the present invention may be used in the treatment or prevention of obesity or Type II diabetes.
摘要翻译：本发明涉及式（I）的1,2,3,4,10,10a-六氢吡嗪并[1,2-a]吲哚衍生物：及其药学上可接受的盐，水合物和酯，其中取代基具有说明书中提供的含义。本发明的化合物可用于治疗或预防肥胖或II型糖尿病。

6. 发明授权

US06357034B1 Data communication method and the use of the method in a system for remotely reading meters 有权
标题翻译：数据通信方式和使用方法在系统中远程读取仪表
公开(公告)号：US06357034B1
公开(公告)日：2002-03-12
申请号：US09232576
申请日：1999-01-16
申请人： Marc Muller , Patrick Moreau , Philippe Godlewski
发明人： Marc Muller , Patrick Moreau , Philippe Godlewski
IPC分类号： H03M1300
CPC分类号： G08C15/00 , G08C17/02 , H03M13/15
摘要： A method of communicating data in a system having a plurality of transmitters each adapted to transmit a radio signal, and a receiver situated at a distance from the transmitters to receive and process the signals transmitted by the transmitters, information for transmission being subdivided into N-bit symbols, the method consisting in: giving a numerical value to each symbol; and compressing the data using a CHIP encoding technique in which the values of the symbols are transposed to an encoded value having x digits in a base B, each digit subsequently being represented in the form of n chips, the base B, the number n of chips, and the number x of digits for an encoded value satisfying the following conditions: B≦2&ngr; and 2N≦B&xgr; so that the total number of chips x.n representing the coded value is less than 2.N.
摘要翻译：一种在具有多个发射机的系统中传送数据的方法，每个发射机各自适于传送无线电信号;以及接收机，位于离发射机一定距离处，以接收和处理由发射机发射的信号，用于传输的信息被细分为N- 位符号，该方法包括：给每个符号的数值; 并且使用其中将符号的值转置到在基数B中具有x位数的编码值的CHIP编码技术来压缩数据，随后以n个码片的形式表示每个数字，基数B，码片数n 以及满足以下条件的编码值的数字数x：使得表示编码值的码片xn的总数小于2.N。

7. 发明授权

US06043385A Vitamin D derivatives 有权
标题翻译：维生素D衍生物
公开(公告)号：US06043385A
公开(公告)日：2000-03-28
申请号：US203088
申请日：1998-12-01
申请人： Pierre Barbier , Franz Bauer , Peter Mohr , Marc Muller , Wolfgang Pirson
发明人： Pierre Barbier , Franz Bauer , Peter Mohr , Marc Muller , Wolfgang Pirson
IPC分类号： C07C401/00 , A61N45/00
CPC分类号： C07C401/00
摘要： The present invention relates to vitamin D derivatives of the formula I ##STR1## wherein X is C.dbd.CH.sub.2 or CH.sub.2 ;Y is hydrogen, fluorine or hydroxyZ is hydroxyn is 1 or 2R.sup.1 is lower alkyl,R.sup.2 is a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents, or is a phenyl group which is unsubstituted or substituted with a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents;and the dotted carbon-carbon bond in ring D is --C--C-- or --C.dbd.C--; or a pharmaceutically usable salt thereof.
摘要翻译：本发明涉及式I的维生素D衍生物，其中X为C = CH 2或CH 2; Y是氢，氟或羟基，Z是羟基，n是1或2，R 1是低级烷基，R 2是未取代或被一个或多个卤素或OH取代基取代的具有3-8个碳原子的支链烷基，或是苯基其未取代或被未取代或被一个或多个卤素或OH取代基取代的具有3-8个碳原子的支链烷基取代; 环D中的点状碳 - 碳键为-C-C-或-C = C-; 或其药学上可用的盐。

8. 发明授权

US5387873A Method of synchronizing two signals 失效
标题翻译：两个信号同步的方法
公开(公告)号：US5387873A
公开(公告)日：1995-02-07
申请号：US957134
申请日：1992-10-07
申请人： Marc Muller , Philippe Sarquiz
发明人： Marc Muller , Philippe Sarquiz
IPC分类号： H04B1/707 , H04J13/00 , H03K5/26
CPC分类号： H04B1/7075 , H04B1/70753 , H04J13/0022
摘要： This method which enables two periodic signals having the same waveform and the same theoretical period to be synchronized is of the type in which the second signal is synthesized iteratively at a phase that is adjusted as a function of a measure of the correlation between the first and second signals. Synchronization is obtained by progressively shifting the phase of the second signal until a correlation maximum is detected, after which said signal is locked onto the correlation peak by phase skips on either side thereof.
摘要翻译：使具有相同波形和相同理论周期的两个周期信号同步的方法是这样的类型，其中第二信号在被调整为根据第一和第第二信号。通过逐渐移位第二信号的相位直到检测到相关最大值来获得同步，之后通过其两侧的相位跳跃将所述信号锁定在相关峰上。

9. 发明授权

US5226674A Cycle rear suspension system 失效
标题翻译：循环后悬挂系统
公开(公告)号：US5226674A
公开(公告)日：1993-07-13
申请号：US763460
申请日：1991-09-20
申请人： Erik F. Buell , Marc Muller
发明人： Erik F. Buell , Marc Muller
IPC分类号： B62K25/04 , B62K25/28
CPC分类号： B62K25/286 , B62K25/04
摘要： A rear suspension system for a two wheel cycle such as a bicycle or motorcycle having a main frame which includes a rearwardly or downwardly inclined down tube. A vertically pivotable rear frame assembly includes a pair of swing arms which extend rearwardly from pivotal connections on the main frame. Rear wheel fitments are carried by the swing arms. A pair of elongated tubelike or rodlike chain stays extend forwardly from the rear fitments at a fixed angle relative to the swing arms. A tubular shock absorber assembly is supported on the down tube and has a spring urging a coupler portion thereof in a forward and upward direction. A double-pivoted link is pivotally connected between the forward ends of the chain stays and a bell crank assembly which is pivotally connected to the underside of the frame, and in turn, connects the double-pivoted link to the coupler portion of the shock absorber assembly. Upward impacts on the rear wheel are reacted on the main frame as a downward and rearward force with a largely downward force component so pitching motion at the rear end of the main frame is minimized when moving over ground or highway irregularities or rough terrain encountered in off road riding. In one embodiment, the shock absorber assembly is supported on the forward side of the down tube; in another embodiment, the shock absorber assembly is inside an open-rear-ended down tube.
摘要翻译：一种用于两轮循环的后悬架系统，例如具有主框架的自行车或摩托车，该主框架包括向后或向下倾斜的下管。可垂直枢转的后框架组件包括从主框架上的枢转连接向后延伸的一对摆臂。后轮配件由摆臂承载。一对细长的管状或棒状链条支架相对于摆臂以固定的角度从后部配件向前延伸。管状减震器组件支撑在下管上，并且具有向前和向上方向推动其联接器部分的弹簧。双重枢转连杆被枢转地连接在链条的前端和可枢转地连接到框架的下侧的钟形曲柄组件之间，并且将双重枢转连杆连接到减震器的联接器部分部件。对后轮的向上冲击作为向下和向后的力在主框架上反作用，具有大的向下的力分量，因此当在主体框架的后端移动时，当在地面或高速公路不规则或崎岖的地形遇到偏移时，俯仰运动被最小化骑马。在一个实施例中，减震器组件支撑在下管的前侧; 在另一个实施例中，减震器组件在开放后端下管中。

10. 发明授权

US08450477B2 Process for the manufacture of bridged monobactam intermediates 失效
标题翻译：桥联单体中间体的制备方法
公开(公告)号：US08450477B2
公开(公告)日：2013-05-28
申请号：US12676580
申请日：2008-09-15
申请人： Marc Muller , Xiaoping Wu , Lin Xu
发明人： Marc Muller , Xiaoping Wu , Lin Xu
IPC分类号： C07D487/04 , C07C271/22 , C07C269/04
CPC分类号： C07C271/54 , C07C271/22 , C07D487/04
摘要： A process for manufacturing a compound of Formula (I) which has cis-conformation and wherein R1 represents a 1-phenyl-C1-C4alkyl or 1-naphthyl-C1-C4alkyl group, wherein the phenyl or naphthyl moiety of R1 is unsubstituted or substituted with one or more C1-C4alkoxy groups and the carbon atoms in 2-, 3-, and/or 4-position of the alkyl part of R1 are, independently of the phenyl or naphthyl moiety of R1 and independently of one another, unsubstituted or substituted with C1-C4alkoxy and/or silyloxy or, preferably, are unsubstituted or substituted with one C1-C4alkoxy group and/or silyloxy group per carbon atom, and R2 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, in which process a compound of Formula (II) wherein R3 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, and R1 and R2 have the same meaning as in formula (I); is treated with a base at a temperature of 0° C. or less in a liquid aprotic solvent for a time period sufficient to obtain the compound of formula (I).
摘要翻译：制备具有顺式构型的式（I）化合物的方法，其中R 1表示1-苯基-C 1 -C 4烷基或1-萘基-C 1 -C 4烷基，其中R 1的苯基或萘基部分是未取代或取代的与一个或多个C 1 -C 4烷氧基和R 1的烷基部分的2-，3-和/或4-位上的碳原子独立地为R 1的苯基或萘基部分且彼此独立地是未取代的或未取代的被C1-C4烷氧基和/或甲硅烷氧基取代，或优选未被取代或被每个碳原子一个C 1 -C 4烷氧基和/或甲硅烷氧基取代，并且R 2表示C 1 -C 6烷基或未取代或取代的苄基，其中处理其中R 3表示C 1 -C 6烷基或未取代或取代的苄基的式（II）化合物，并且R 1和R 2具有与式（I）中相同的含义。在液体非质子溶剂中在0℃或更低的温度下用碱处理足以获得式（I）化合物的时间段。

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