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1. 发明授权

US09061131B2 Disposable acoustic coupling medium container 有权
标题翻译：一次性声耦合介质容器
公开(公告)号：US09061131B2
公开(公告)日：2015-06-23
申请号：US12858242
申请日：2010-08-17
申请人： Russell C. Jahnke , James A. Bertolina , William W. Roberts , Charles A. Cain , Dejan Teofilovic , Thomas W. Davison
发明人： Russell C. Jahnke , James A. Bertolina , William W. Roberts , Charles A. Cain , Dejan Teofilovic , Thomas W. Davison
IPC分类号： A61B8/00 , A61N7/00 , A61B8/12 , A61B17/225 , A61B17/00 , A61B18/00 , A61B19/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是它可以将超声治疗换能器声学耦合到患者。在一些实施例中，医学成像和治疗装置被配置为符合患者的会阴区域的解剖结构，以便将超声治疗换能器声学耦合到患者以治疗BPH。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

2. 发明申请

US20140073995A1 HISTOTRIPSY THERAPY SYSTEM 审中-公开
标题翻译：病理治疗系统
公开(公告)号：US20140073995A1
公开(公告)日：2014-03-13
申请号：US14024394
申请日：2013-09-11
申请人： Dejan Teofilovic , Timothy L. Hall , Charles A. Cain
发明人： Dejan Teofilovic , Timothy L. Hall , Charles A. Cain
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B17/22004 , A61B2017/22008 , A61N7/02 , A61N2007/0039 , A61N2007/0078
摘要： A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes at least one signal switching amplifier electrically coupled to a high voltage power supply, a pulse generator electrically coupled to signal switching amplifier(s), at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element, each transducer element of the ultrasound transducer being coupled to the at least one matching network. In some embodiments, each transducer element has an input impedance that is higher, sometimes more than 2 times higher, than an output impedance of its corresponding signal switching amplifier. Methods of use are also described.
摘要翻译：提供组织切除术治疗系统，其可以包括任何数量的特征。在一些实施例中，系统包括电耦合到高电压电源的至少一个信号切换放大器，电耦合到信号切换放大器的至少一个匹配网络，电耦合到信号切换放大器，以及具有至少一个换能器元件的超声换能器，所述超声换能器的每个换能器元件耦合到所述至少一个匹配网络。在一些实施例中，每个换能器元件具有比其对应的信号开关放大器的输出阻抗高的输入阻抗，有时高于其2倍以上。还描述了使用方法。

3. 发明申请

US20110054315A1 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 有权
标题翻译：用于治疗和成像超声波传感器的微机控制器
公开(公告)号：US20110054315A1
公开(公告)日：2011-03-03
申请号：US12868768
申请日：2010-08-26
申请人： WILLIAM W. ROBERTS , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, JR. , Dejan Teofilovic
发明人： WILLIAM W. ROBERTS , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, JR. , Dejan Teofilovic
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是可以对目标组织体积进行成像，并将超声能量应用于目标组织体积。在一些实施例中，医疗成像和治疗装置被配置为可控制地将超声能量施加到前列腺中，通过维持由成像系统产生的前列腺图像内的超声治疗系统产生的空泡气泡云。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

4. 发明授权

US09943708B2 Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time 有权
公开(公告)号：US09943708B2
公开(公告)日：2018-04-17
申请号：US12868768
申请日：2010-08-26
申请人： William W. Roberts , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, Jr. , Dejan Teofilovic
发明人： William W. Roberts , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, Jr. , Dejan Teofilovic
IPC分类号： A61B8/00 , A61N7/00 , A61N7/02 , A61B8/12 , A61B34/00 , A61B17/22 , A61B90/50 , A61B90/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

5. 发明申请

US20110040190A1 Disposable Acoustic Coupling Medium Container 有权
标题翻译：一次性耦合介质容器
公开(公告)号：US20110040190A1
公开(公告)日：2011-02-17
申请号：US12858242
申请日：2010-08-17
申请人： Russell C. Jahnke , James A. Bertolina , William W. Roberts , Charles A. Cain , Dejan Teofilovic , Thomas W. Davison
发明人： Russell C. Jahnke , James A. Bertolina , William W. Roberts , Charles A. Cain , Dejan Teofilovic , Thomas W. Davison
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是它可以将超声治疗换能器声学耦合到患者。在一些实施例中，医学成像和治疗装置被配置为符合患者的会阴区域的解剖结构，以便将超声治疗换能器声学耦合到患者以治疗BPH。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

6. 发明授权

US09049783B2 Systems and methods for obtaining large creepage isolation on printed circuit boards 有权
标题翻译：在印刷电路板上获得大的爬电隔离的系统和方法
公开(公告)号：US09049783B2
公开(公告)日：2015-06-02
申请号：US13446783
申请日：2012-04-13
申请人： Dejan Teofilovic
发明人： Dejan Teofilovic
IPC分类号： G02B6/26 , G02B6/42 , H05K1/02
CPC分类号： H05K1/0256 , H05K1/0227 , H05K2201/0761 , H05K2201/09781 , H05K2201/09972 , H05K2201/10121
摘要： An electrical circuit with large creepage isolation distances is provided. In some embodiments, the electrical circuit is capable of increasing creepage isolation distances by many multiples over traditional electrical circuits. In one embodiment, an electrical circuit comprises a ground circuit optically coupled to a floating circuit, and an isolated circuit optically coupled to the floating circuit. The circuits can be optically coupled with opto-isolators, for example. The isolated circuit can have a creepage isolation distance at least twice as large as a traditional circuit. In some embodiments, “n” number of floating circuits can be optically coupled between the ground circuit and the isolated circuit to increase the total creepage isolation distance by a factor of “n”. Methods of use are also described.
摘要翻译：提供了具有大爬电隔离距离的电路。在一些实施例中，电路能够在传统电路上增加多个倍数的爬电隔离距离。在一个实施例中，电路包括光耦合到浮置电路的接地电路和与浮动电路光耦合的隔离电路。例如，电路可以与光隔离器光学耦合。隔离电路的爬电隔离距离至少为传统电路的两倍。在一些实施例中，“n”个浮动电路可以在接地电路和隔离电路之间光学耦合，以将总爬电隔离距离提高因子“n”。还描述了使用方法。

7. 发明申请

US20100172477A1 ELECTRICAL WHEEL LOCK SYSTEM AND METHOD 审中-公开
标题翻译：电动车轮锁系统及方法
公开(公告)号：US20100172477A1
公开(公告)日：2010-07-08
申请号：US12349884
申请日：2009-01-07
申请人： Michael Kusner , Dejan Teofilovic , William van Kampen
发明人： Michael Kusner , Dejan Teofilovic , William van Kampen
IPC分类号： H05G1/02
CPC分类号： A61B6/032 , A61B6/4405 , Y10T16/195
摘要： A system for performing medical imaging in a mobile environment. The system includes a sensing array, a controller, and a mobile frame. The sensing array is configured to image a subject. The controller is in communication with the sensing array to control and process the acquisition performed by the sensing array. The sensing array is attached to the mobile frame, and the mobile frame includes wheels to facilitate movement of the system. At least one of the wheels of the base interacts with a wheel lock, such that the wheel lock prevents motion of the wheel when activated by the controller.
摘要翻译：一种用于在移动环境中执行医学成像的系统。该系统包括感测阵列，控制器和移动框架。感测阵列被配置成对被摄体进行成像。控制器与感测阵列通信，以控制和处理由感测阵列执行的采集。感测阵列附接到移动框架，并且移动框架包括轮子以便于系统的移动。基座的至少一个轮与车轮锁相互作用，使得车轮锁防止当由控制器激活时车轮的运动。

8. 发明申请

US20080192885A1 CT SCANNER INCLUDING A SENSOR WHICH IS ACTIVATED TO ALLOW MANUAL ROTATION OF GANTRY 审中-公开
标题翻译： CT扫描仪包括一个传感器，它被激活以允许手动旋转GANTRY
公开(公告)号：US20080192885A1
公开(公告)日：2008-08-14
申请号：US12030341
申请日：2008-02-13
申请人： Dejan Teofilovic , Miodrag Rakic , Joseph Webster Stayman
发明人： Dejan Teofilovic , Miodrag Rakic , Joseph Webster Stayman
IPC分类号： G01N21/00
CPC分类号： G01N23/046 , A61B6/035 , A61B6/10 , A61B6/4405 , A61B6/467 , G01N2223/419 , G03B42/026
摘要： A CT scanner includes a gantry, a handle, and a sensor located on or connected to the handle. During operation of the CT scanner, a control provides a signal to a motor to rotate the gantry about an axis of rotation. When the CT scanner is not taking a CT scan, a locking mechanism locks the gantry to prevent rotation of the gantry. When the sensor detects an operator, the control provides a signal to disengage the locking mechanism, allowing the gantry to freely rotate about the axis of rotation. When the sensor no longer detects the operator, the control sends a signal to lock the locking mechanism and lock the gantry in the current position.
摘要翻译： CT扫描器包括位于或连接到手柄的龙门架，手柄和传感器。在CT扫描器的操作期间，控制器向马达提供信号以围绕旋转轴线旋转机架。当CT扫描仪不进行CT扫描时，锁定机构锁定机架以防止机架旋转。当传感器检测到操作者时，控制器提供信号以使锁定机构脱离，允许机架围绕旋转轴线自由旋转。当传感器不再检测到操作者时，控制器发出一个信号锁定锁定机构，并将龙门架锁定在当前位置。

9. 发明申请

US20150290477A1 DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 有权
标题翻译：可配置的声学耦合中间容器
公开(公告)号：US20150290477A1
公开(公告)日：2015-10-15
申请号：US14746692
申请日：2015-06-22
申请人： Russell C. JAHNKE , James A. BERTOLINA , William W. ROBERTS , Charles A. CAIN , Dejan TEOFILOVIC , Thomas W. DAVISON
发明人： Russell C. JAHNKE , James A. BERTOLINA , William W. ROBERTS , Charles A. CAIN , Dejan TEOFILOVIC , Thomas W. DAVISON
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是它可以将超声治疗换能器声学耦合到患者。在一些实施例中，医学成像和治疗装置被配置为符合患者的会阴区域的解剖结构，以便将超声治疗换能器声学耦合到患者以治疗BPH。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

10. 发明申请

US20150011916A1 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 审中-公开
标题翻译：使用震动散射优化的气泡形成的特征激发序列
公开(公告)号：US20150011916A1
公开(公告)日：2015-01-08
申请号：US14323693
申请日：2014-07-03
申请人： Jonathan M. CANNATA , Timothy L. HALL , Adam D. MAXWELL , Dejan TEOFILOVIC
发明人： Jonathan M. CANNATA , Timothy L. HALL , Adam D. MAXWELL , Dejan TEOFILOVIC
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B17/22004 , A61B17/225 , A61B2017/00176 , A61B2017/22008 , A61B2017/22028 , A61N2007/0039 , A61N2007/0078
摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.
摘要翻译：提供了用于在组织中产生空化的方法和装置。在一个实施例中，组织破坏治疗的休克散射方法包括将起始压力波形从超声治疗换能器输送到组织中，起始压力波形被配置为在组织中产生至少一个气泡，从超声治疗中输送散射压力波形换能器进入所述至少一个气泡的生命周期内的所述至少一个气泡，并且用所述散射压力波形在所述至少一个气泡附近产生气蚀核。散射压力波形可在至少一个气泡的生命周期内传送。在一些实施例中，散射压力波形在初始压力波形的5μs至1s内传送。还讨论了用于进行休克散射的系统组织切除术治疗。

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