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    • 4. 发明申请
    • Devices and methods for correlated analysis of multiple protein or peptide samples
    • 多种蛋白质或肽样品相关分析的装置和方法
    • US20060019399A1
    • 2006-01-26
    • US11171427
    • 2005-07-01
    • Brian BalgleyJonathan CooperCheng LeeDonald DeVoe
    • Brian BalgleyJonathan CooperCheng LeeDonald DeVoe
    • G01N33/00
    • C07K1/16G01N30/466G01N35/1095G01N2030/8813H01J49/009H01J49/0431
    • Disclosed is a system for performing multiple analyses of protein and/or peptide samples and correlating the results of the analyses. The system comprises a sample inlet, a splitter means, at least two sample delivery capillaries, at least two sample deposition tools, and at least two sample collectors, wherein said splitter means is in fluid communication with the sample inlet and the sample delivery capillaries, and wherein liquid flow entering the splitter means is split into a number of sub-flows equal to the number of sample delivery capillaries. In one preferred embodiment, at least one microenzyme reactor is interfaced to a first sample delivery capillary in order to digest a protein sample within the capillary, while a second sample delivery capillary does not contain a microenzyme reactor, thereby enabling correlated analysis of the same protein sample in digested and undigested form. Methods for performing two or more analyses of protein and/or peptide samples and correlating the results of the analyses are also disclosed.
    • 公开了一种用于进行蛋白质和/或肽样品的多次分析并将分析结果相关联的系统。 该系统包括样品入口,分离装置,至少两个样品输送毛细管,至少两个样品沉积工具和至少两个样品收集器,其中所述分离装置与样品入口和样品输送毛细管流体连通, 并且其中进入分离装置的液体流被分成等于样品递送毛细管数量的多个子流。 在一个优选的实施方案中,至少一个微酶反应器与第一样品递送毛细管连接,以便消化毛细管内的蛋白质样品,而第二样品递送毛细管不含有微酶反应器,从而能够进行相同蛋白质的相关分析 采样消化和未消化形式。 还公开了对蛋白质和/或肽样品进行两次或多次分析并关联分析结果的方法。
    • 7. 发明授权
    • System and method for provisioning a vehicle interface module
    • 用于配置车辆接口模块的系统和方法
    • US07970496B2
    • 2011-06-28
    • US12852047
    • 2010-08-06
    • Gerhard KoepfRobert YandrofskiRoy G. PerryJonathan Cooper
    • Gerhard KoepfRobert YandrofskiRoy G. PerryJonathan Cooper
    • G06F7/00G01M17/00
    • G06F11/25G06F11/273G07C5/008
    • The present invention provides systems and methods for provisioning a vehicle interface module comprising receiving a VIM from a VIM manufacturer and entering appropriate VIM data into a dealer inventory, activating a SIM card for the VIM and installing the VIM in a predetermined vehicle, selecting a wireless activated VIM from the dealer inventory and connecting the VIM to an OBD-II port of the vehicle, connecting a configuration PC to the VIM and downloading a modem configuration, selecting and downloading a vehicle-specific configuration file, accessing a telematics services provider's web portal, entering appropriate vehicle data, and associating the vehicle with the VIM, installing the VIM in the predetermined vehicle, and conducting an installation verification test.
    • 本发明提供用于提供车辆接口模块的系统和方法,包括从VIM制造商接收VIM并将合适的VIM数据输入经销商库存,激活用于VIM的SIM卡并将VIM安装在预定车辆中,选择无线 从经销商库存中激活VIM,并将VIM连接到车辆的OBD-II端口,将配置PC连接到VIM并下载调制解调器配置,选择和下载特定于车辆的配置文件,访问远程信息处理服务提供商的门户网站 ,输入适当的车辆数据,并将车辆与VIM相关联,将VIM安装在预定车辆中,并进行安装验证测试。
    • 8. 发明授权
    • Sign support system
    • 签署支持系统
    • US06393748B1
    • 2002-05-28
    • US09571375
    • 2000-05-15
    • Jonathan Cooper
    • Jonathan Cooper
    • G09F718
    • G09F15/0056G09F7/18
    • The system includes a plurality of parallel vertically disposed end support structures. Each support structure comprises two vertically disposed support legs. The upper and lower ends of the support legs are connected respectively to each other by upper and lower connecting members that can be extended or collapsed. When the connecting members are both extended the support structure forms a frame support structure and when collapsed, the support legs are in close proximity and parallel to each other, suitable for storage and/or transport. Channel members are removably mounted to the upper and lower ends of the support legs to connect the end support structures to each other when the connecting members of the support legs are extended. A sign panel is mounted between the upper and lower channel members. Optionally, the sign support system has vertically disposed parallel end support members removably mounted to the upper ends of the vertically disposed support legs. A top channel member is provided connecting and removably mounted to the upper ends of the support members. An upper sign panel is removably mounted between the top channel and the opposing upper channel member.
    • 该系统包括多个平行的垂直设置的端部支撑结构。 每个支撑结构包括两个垂直设置的支撑腿。 支撑腿的上端和下端分别通过能够延伸或折叠的上部和下部连接构件相互连接。 当连接构件都延伸时,支撑结构形成框架支撑结构,并且当折叠时,支撑腿彼此靠近并且彼此平行,适于储存和/或运输。 通道构件可拆卸地安装到支撑腿的上端和下端,以在支撑腿的连接构件延伸时将端部支撑结构彼此连接。 标记面板安装在上部和下部通道构件之间。 可选地,标志支撑系统具有可拆卸地安装到垂直设置的支撑腿的上端的垂直设置的平行端部支撑构件。 提供连接并可移除地安装到支撑构件的上端的顶部通道构件。 上标志板可拆卸地安装在顶部通道和相对的上部通道构件之间。
    • 10. 发明授权
    • Methods and systems for mass spectrometry
    • 质谱方法和系统
    • US08415619B2
    • 2013-04-09
    • US13296793
    • 2011-11-15
    • David R. GoodlettScott R. HeronJonathan Cooper
    • David R. GoodlettScott R. HeronJonathan Cooper
    • H01J49/26G01N23/00
    • H01J49/0454H01J49/0031
    • The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.
    • 本发明一般涉及质谱法。 本发明更具体地涉及用于各种分析物(包括高分子量物质如蛋白质)的质谱鉴定中的方法和系统。 本发明的一个实施方案是分析分析物的方法。 该方法包括将分析物在溶剂中的悬浮液与表面声波换能器雾化; 并对雾化悬浮液进行质谱分析。 例如,表面声波换能器可以用于将大气压下的非挥发性肽和蛋白质(以及其它分析物,例如寡核苷酸和聚合物)转移到气相中。 使用表面声波的雾化可以以不连续或脉冲模式进行,类似于在MALDI中使用的模式,或者以连续模式进行,如在ESI中。