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1. 发明申请

US20080085559A1 Micro-pixelated active-matrix fluid-assay performance 有权
标题翻译：微像素化活性基质流体分析性能
公开(公告)号：US20080085559A1
公开(公告)日：2008-04-10
申请号：US11888491
申请日：2007-07-31
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele , Andrei Gindilis
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele , Andrei Gindilis
IPC分类号： B01J19/12 , G01N33/00 , G21G5/00
CPC分类号： C12Q1/6813 , Y10S436/805
摘要： A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment.
摘要翻译：使用包括至少一个具有传感器的活性像素的装置进行流体材料测定的方法，所述传感器具有用于所选流体测定材料功能化的测定位点。该方法包括将像素的传感器测定位点暴露于这种材料，并结合这样的曝光，并采用像素的主动特性，从像素的传感器测定位点远程请求测定结果输出报告。该方法还包括关于采用步骤，相对于至少一个像素中的传感器的测定位置产生预定的像素特定的电磁场环境。

2. 发明授权

US08232109B2 Micro-pixelated active-matrix fluid-assay performance 有权
标题翻译：微像素化活性基质流体分析性能
公开(公告)号：US08232109B2
公开(公告)日：2012-07-31
申请号：US11888491
申请日：2007-07-31
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele , Andrei Gindilis
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele , Andrei Gindilis
IPC分类号： G01N21/00
CPC分类号： C12Q1/6813 , Y10S436/805
摘要： A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment.
摘要翻译：使用包括至少一个具有传感器的活性像素的装置进行流体材料测定的方法，所述传感器具有用于所选流体测定材料功能化的测定位点。该方法包括将像素的传感器测定位点暴露于这种材料，并结合这样的曝光，并采用像素的主动特性，从像素的传感器测定位点远程请求测定结果输出报告。该方法还包括关于采用步骤，相对于至少一个像素中的传感器的测定位置产生预定的像素特定的电磁场环境。

3. 发明申请

US20120245049A1 System and Method for Pixelated Fluid Assay 审中-公开
标题翻译：像素流体测定的系统和方法
公开(公告)号：US20120245049A1
公开(公告)日：2012-09-27
申请号：US13488501
申请日：2012-06-05
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele , Andrei Gindilis
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele , Andrei Gindilis
IPC分类号： C40B40/06 , C40B30/04 , C40B50/18
CPC分类号： C12Q1/6813 , Y10S436/805
摘要： A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment.
摘要翻译：使用包括至少一个具有传感器的活性像素的装置进行流体材料测定的方法，所述传感器具有用于所选流体测定材料功能化的测定位点。该方法包括将像素的传感器测定位点暴露于这种材料，并结合这样的曝光，并采用像素的主动特性，从像素的传感器测定位点远程请求测定结果输出报告。该方法还包括关于采用步骤，相对于至少一个像素中的传感器的测定位置产生预定的像素特定的电磁场环境。

4. 发明申请

US20080079663A1 Micro-pixelated fluid-assay precursor structure 审中-公开
标题翻译：微像素化流体测定前体结构
公开(公告)号：US20080079663A1
公开(公告)日：2008-04-03
申请号：US11821148
申请日：2007-06-22
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G09G3/20
CPC分类号： G06Q10/08 , G06Q40/04
摘要： A pixel-by-pixel, digitally-addressable, pixelated, precursor, fluid-assay, active-matrix micro-structure including plural pixels formed on a substrate, wherein each pixel includes (a) at least one non-functionalized, digitally-addressable assay sensor, and (b), disposed operatively adjacent this sensor, digitally-addressable and energizable electromagnetic field-creating structure which is selectively energizable to create, in the vicinity of the at least one assay sensor, an ambient electromagnetic field environment which is structured to assist in functionalizing, as a possession on said at least one assay sensor, at least one digitally-addressable assay site which will display an affinity for a selected fluid-assay material.
摘要翻译：逐像素，可数字寻址，像素化，前体，流体测定，包括形成在衬底上的多个像素的有源矩阵微结构，其中每个像素包括（a）至少一个非功能化的，可数字寻址的和（b），其可操作地邻近该传感器设置，可数字寻址和激励的电磁场产生结构，其被选择性地激励以在所述至少一个测定传感器附近产生环境电磁场环境，所述环境电磁场环境被构造在所述至少一个测定传感器上辅助功能化至少一个可显示对所选择的流体测定材料的亲和性的可数字寻址的测定位点。

5. 发明授权

US08236571B2 Method of making micro-pixelated fluid-assay precursor structure 有权
标题翻译：制备微像素化流体测定前体结构的方法
公开(公告)号：US08236571B2
公开(公告)日：2012-08-07
申请号：US11827175
申请日：2007-07-10
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G01N21/00
CPC分类号： B81C1/00246 , B81B2201/0214 , B81C2203/075 , Y10S436/805
摘要： A method of producing a precursor, active-matrix, fluid-assay micro-structure including the steps of (1) utilizing low-temperature TFT and Si technology, establishing preferably on a glass or plastic substrate a matrix array of non-functionalized pixels, and (2) preparing at least one of these pixels for individual, digitally-addressed (a) functionalization, and (b) reading out, ultimately, of completed assay results.
摘要翻译：一种制备前体，活性基质，流体测定微结构的方法，包括以下步骤：（1）利用低温TFT和Si技术，优选在玻璃或塑料基材上建立非官能化像素的矩阵阵列，和（2）准备用于个体，数字寻址（a）功能化的这些像素中的至少一个，以及（b）最终读出完成的测定结果。

6. 发明申请

US20080084372A1 Micro-pixelated fluid-assay structure 有权
标题翻译：微像素化流体测定结构
公开(公告)号：US20080084372A1
公开(公告)日：2008-04-10
申请号：US11827174
申请日：2007-07-10
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G09G3/36
CPC分类号： B01L3/5027 , B01L3/502707 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827
摘要： A pixel-by-pixel digitally-addressable, pixelated, fluid-assay, active-matrix micro-structure including plural pixels formed preferably on a glass or plastic substrate, wherein each pixel, formed utilizing low-temperature TFT and Si technology, includes (a) at least one functionalized, digitally-addressable assay sensor including at least one functionalized, digitally-addressable assay site which has been affinity-functionalized to respond to a selected, specific fluid-assay material, and (b) disposed operatively adjacent that sensor and its associated assay site, digitally-addressable and energizable electromagnetic field-creating structure which is selectively energizable to create, in the vicinity of the sensor and its associated assay site, a selected, ambient, electromagnetic field environment which is structured to assist, selectively and optionally only, in the reading-out of an assay-result response from the assay sensor and assay site.
摘要翻译：逐像素可数字寻址，像素化，流体测定，包括优选地形成在玻璃或塑料基板上的多个像素的有源矩阵微结构，其中利用低温TFT和Si技术形成的每个像素包括（ a）至少一个功能化的，可数字寻址的测定传感器，其包括至少一个官能化的，可数字寻址的测定位点，其已经被亲和功能化以响应所选择的特定流体测定材料，和（b）可操作地邻近该传感器以及其相关联的测定位点，可数字寻址和可激励的电磁场创建结构，其可选择性地激励以在传感器及其相关联的测定位点附近产生所选择的环境电磁场环境，其被构造为有选择地辅助并且可选地仅在从测定传感器和测定位点读出测定结果响应中。

7. 发明授权

US08232108B2 Method of making micro-pixelated fluid-assay structure 有权
标题翻译：制作微像素化流体测定结构的方法
公开(公告)号：US08232108B2
公开(公告)日：2012-07-31
申请号：US11827176
申请日：2007-07-10
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G01N21/00
CPC分类号： B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00626 , B01J2219/00653 , B01J2219/00659 , B01J2219/00695 , B01J2219/00711 , B01J2219/00713 , B01J2219/00716 , B82Y30/00 , Y10S436/805
摘要： A method for producing an active-matrix, fluid-assay micro-structure including, utilizing low-temperature TFT and Si technology, establishing preferably on a glass or plastic substrate a matrix array of digitally-addressable, assay-material-specific-functionalizable pixels, and employing pixel-specific digital addressing for selected, array-established pixels, individually functionalizing these pixels.
摘要翻译：一种用于生产活性基质流体测定微结构的方法，包括利用低温TFT和Si技术，优选在玻璃或塑料基材上建立可数字寻址的测定材料特异性可官能化像素的矩阵阵列并且针对所选择的阵列建立的像素采用像素特定的数字寻址，分别对这些像素进行功能化。

8. 发明申请

US20080084363A1 Method of making micro-pixelated fluid-assay precursor structure 有权
标题翻译：制备微像素化流体测定前体结构的方法
公开(公告)号：US20080084363A1
公开(公告)日：2008-04-10
申请号：US11827175
申请日：2007-07-10
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G09G3/20
CPC分类号： B81C1/00246 , B81B2201/0214 , B81C2203/075 , Y10S436/805
摘要： A method of producing a precursor, active-matrix, fluid-assay micro-structure including the steps of (1) utilizing low-temperature TFT and Si technology, establishing preferably on a glass or plastic substrate a matrix array of non-functionalized pixels, and (2) preparing at least one of these pixels for individual, digitally-addressed (a) functionalization, and (b) reading out, ultimately, of completed assay results.
摘要翻译：一种制备前体，活性基质，流体测定微结构的方法，包括以下步骤：（1）利用低温TFT和Si技术，优选在玻璃或塑料基材上建立非官能化像素的矩阵阵列，和（2）准备用于个体，数字寻址（a）功能化的这些像素中的至少一个，以及（b）最终读出完成的测定结果。

9. 发明授权

US08236244B2 Micro-pixelated fluid-assay structure with on-board addressable, pixel-specific functionalization 有权
标题翻译：微像素化流体测定结构，具有可寻址的像素特征功能
公开(公告)号：US08236244B2
公开(公告)日：2012-08-07
申请号：US11827173
申请日：2007-07-10
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G01J3/00
CPC分类号： B01J19/0046 , B01J2219/0061 , B01J2219/00614 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B50/14 , C40B60/08 , G01N21/645 , G01N2021/6482 , Y10T29/49 , Y10T436/143333
摘要： A digitally-addressable, pixelated, DNA fluid-assay, active-matrix micro-structure formed, utilizing low-temperature TFT and Si technology, on a substrate preferably made of glass or plastic, and including at least one pixel which is defined by (a) an addressable pixel site, (b) a sensor home structure disposed within that site for receiving and hosting a functionalized assay site possessing a DNA oligonucleotide probe, and (c) an addressable, pixel-site-specific, energy-field-producing functionalizer (preferably optical) operable to functionalize such a probe on the assay site. Each pixel may also include a pixel-integrated optical detector. Further disclosed are related methodology facets involving (1) the making of such a micro-structure (a) in a precursor form (without a functionalized probe), and thereafter (b) in a finalized/functionalized form (with such a probe), and (2) the ultimate use of a completed micro-structure in the performance of a DNA assay.
摘要翻译：在优选由玻璃或塑料制成的衬底上，利用低温TFT和Si技术形成的可数字寻址，像素化，DNA流体测定，有源矩阵微结构，并且包括至少一个由（ a）可寻址像素位点，（b）设置在所述位置内的用于接收和承载具有DNA寡核苷酸探针的官能化测定位点的传感器家庭结构，和（c）可寻址的像素位点特异性能量场产生功能化剂（优选光学）可操作以在测定位点官能化这种探针。每个像素还可以包括像素集成的光学检测器。进一步公开的是相关的方法学方面，其涉及（1）以前体形式（无官能化探针）制备这种微结构（a），此后（b）以最终/功能化形式（具有这种探针），和（2）在DNA测定的表现中最终使用完整的微结构。

10. 发明授权

US08236245B2 Micro-pixelated fluid-assay precursor structure 有权
标题翻译：微像素化流体测定前体结构
公开(公告)号：US08236245B2
公开(公告)日：2012-08-07
申请号：US11827335
申请日：2007-07-10
申请人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
发明人： John W. Hartzell , Pooran Chandra Joshi , Paul J. Schuele
IPC分类号： G01N3/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , G01N2035/00158
摘要： A pixel-by-pixel, digitally-addressable, pixelated, precursor, fluid-assay, active-matrix micro-structure including plural pixels formed preferably on a glass or plastic substrate, wherein each pixel, formed utilizing low-temperature TFT and Si technology, includes (a) at least one non-functionalized, digitally-addressable assay sensor, and (b), disposed operatively adjacent this sensor, digitally-addressable and energizable electromagnetic field-creating structure which is selectively energizable to create, in the vicinity of the at least one assay sensor, an ambient electromagnetic field environment which is structured to assist in functionalizing, as a possession on said at least one assay sensor, at least one digitally-addressable assay site which will display an affinity for a selected fluid-assay material.
摘要翻译：逐像素，可数字寻址，像素化，前体，流体测定，包括优选在玻璃或塑料衬底上形成的多个像素的有源矩阵微结构，其中每个像素利用低温TFT和Si技术形成包括（a）至少一个非功能化的，可数字寻址的测定传感器，和（b）可操作地邻近该传感器设置数字寻址和激励的电磁场产生结构，其可选择性地激励以产生在所述至少一个测定传感器，环境电磁场环境，其被构造为协助在所述至少一个测定传感器上占有功能化至少一个可显示对所选流体测定法的亲和性的可数字寻址的测定位点材料。

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