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1. 发明授权

US06770452B1 Methods for the identification of inhibitors of serine acetyltransferase activity in plants 失效
标题翻译：鉴定植物中丝氨酸乙酰转移酶活性抑制剂的方法
公开(公告)号：US06770452B1
公开(公告)日：2004-08-03
申请号：US10402818
申请日：2003-03-28
申请人： John W Rice , Lining Guo , Keith Davis , Adel Zayed , Robert Ascenzi , Joseph Cameron Mitchell , Daniel N Riggsbee , Douglas Boyes , Rao Mulpuri , Neil Hoffman , Susanne Kjemtrup , Carol Hamilton , Jeffrey Woessner , Jorn Gorlach
发明人： John W Rice , Lining Guo , Keith Davis , Adel Zayed , Robert Ascenzi , Joseph Cameron Mitchell , Daniel N Riggsbee , Douglas Boyes , Rao Mulpuri , Neil Hoffman , Susanne Kjemtrup , Carol Hamilton , Jeffrey Woessner , Jorn Gorlach
IPC分类号： C12Q148
CPC分类号： C12N9/1029 , C12N15/8261 , C12N15/8274 , C12Q1/48 , G01N2333/91057 , G01N2500/02 , Y02A40/146
摘要： The present inventors have discovered that serine acetyltransferase (SAT) is essential for plant growth. Specifically, the inhibition of SAT gene expression in plant seedlings results in reduced growth and altered pigmentation. Thus, SAT is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of an SAT in the presence and absence of a compound, wherein an alteration of SAT activity in the presence of the compound indicates the compound as a candidate for a herbicide.
摘要翻译：本发明人发现丝氨酸乙酰转移酶（SAT）对于植物生长是必需的。具体地说，在植物幼苗中抑制SAT基因表达导致生长减少和色素沉着改变。因此，SAT可用作鉴定除草剂的靶标。因此，本发明提供了通过在化合物存在和不存在下测量SAT的活性来鉴定除草剂的方法，其中在化合物存在下SAT活性的改变表示作为除草剂候选物的化合物。

2. 发明申请

US20050112715A1 Methods for the identification of inhibitors of pectin esterase expression or activity in plants 审中-公开
标题翻译：用于鉴定植物中果胶酯酶表达或活性抑制剂的方法
公开(公告)号：US20050112715A1
公开(公告)日：2005-05-26
申请号：US10717879
申请日：2003-11-20
申请人： Adel Zayed , Robert Ascenzi , Douglas Boyes , Rao Mulpuri , Neil Hoffman , Keith Davis , Jorn Gorlach , Jeffrey Woessner , Carol Hamilton , Kenneth Phillips
发明人： Adel Zayed , Robert Ascenzi , Douglas Boyes , Rao Mulpuri , Neil Hoffman , Keith Davis , Jorn Gorlach , Jeffrey Woessner , Carol Hamilton , Kenneth Phillips
IPC分类号： C12Q1/44 , A01N25/00
CPC分类号： C12Q1/44 , G01N2500/00
摘要： The present inventors have discovered that pectin esterase is essential for plant growth. Specifically, the inhibition of pectin esterase gene expression resulted in seedlings that were damaged, short, and stunted at a very early growth stage. Thus, pectin esterase can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit pectin esterase expression or activity, comprising: contacting a compound with a pectin esterase and detecting the presence and/or absence of binding between said compound and said pectin esterase, or detecting a decrease in pectin esterase expression or activity. The methods of the invention are useful for the identification of herbicides.
摘要翻译：本发明人发现，果胶酯酶对植物生长至关重要。具体来说，果胶酯酶基因表达的抑制导致幼苗在非常早期的生长阶段受损，短缺和发育迟缓。因此，果胶酯酶可以用作鉴定除草剂的靶标。因此，本发明提供了鉴定抑制果胶酯酶表达或活性的化合物的方法，包括：使化合物与果胶酯酶接触并检测所述化合物与所述果胶酯酶之间的结合的存在和/或不存在，或检测果胶酯酶表达或活性降低。本发明的方法可用于鉴定除草剂。

3. 发明申请

US20050100879A1 Methods for the identification of inhibitors of flavanone 3-hydroxylase expression or activity in plants 审中-公开
标题翻译：鉴定黄烷酮3-羟化酶抑制剂在植物中的表达或活性的方法
公开(公告)号：US20050100879A1
公开(公告)日：2005-05-12
申请号：US10702306
申请日：2003-11-06
申请人： Keith Davis , Adel Zayed , Robert Ascenzi , Douglas Boyes , Neil Hoffman , Jorn Gorlach , Jeffrey Woessner , Carol Hamilton , Kenneth Phillips
发明人： Keith Davis , Adel Zayed , Robert Ascenzi , Douglas Boyes , Neil Hoffman , Jorn Gorlach , Jeffrey Woessner , Carol Hamilton , Kenneth Phillips
IPC分类号： A01N25/00 , C12Q1/00 , C12Q1/26 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/5097 , C12Q1/26 , G01N2430/20 , G01N2500/00
摘要： The present inventors have discovered that Flavanone 3-hydroxylase (“FHT”) is essential for plant growth. Specifically, the inhibition of FHT gene expression in plant seedlings results in small and chlorotic seedlings. Thus, FHT can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit FHT expression or activity. The present invention can be used to identify compounds having herbicide activity by contacting a compound with FHT and detecting the presence and/or absence of binding between the compound and the FHT, or alternatively, detecting a decrease in FHT expression or activity.
摘要翻译：本发明人已经发现，黄酮酮3-羟化酶（“FHT”）对于植物生长是必需的。具体来说，植物幼苗中FHT基因表达的抑制作用会导致幼苗和幼苗的生长。因此，FHT可用作鉴定除草剂的靶标。因此，本发明提供了鉴定抑制FHT表达或活性的化合物的方法。本发明可用于通过使化合物与FHT接触并检测化合物与FHT之间的结合的存在和/或不存在，或者检测FHT表达或活性的降低来鉴定具有除草剂活性的化合物。

4. 发明申请

US20050101485A1 Methods for the identification of inhibitors of biotin synthase expression or activity in plants 审中-公开
标题翻译：用于鉴定植物中生物素合酶表达抑制剂或活性的方法
公开(公告)号：US20050101485A1
公开(公告)日：2005-05-12
申请号：US10702364
申请日：2003-11-06
申请人： Neil Hoffman , Jorn Gorlach , Douglas Boyes , Adel Zayed , Jeffrey Woessner , Carol Hamilton , Keith Davis , Robert Ascenzi
发明人： Neil Hoffman , Jorn Gorlach , Douglas Boyes , Adel Zayed , Jeffrey Woessner , Carol Hamilton , Keith Davis , Robert Ascenzi
IPC分类号： A01N61/00 , C12Q1/48 , G01N33/50 , G01N33/573 , A01N25/00 , C12Q1/37
CPC分类号： G01N33/5097 , A01N61/00 , C12Q1/48 , G01N33/573 , G01N2500/02 , G01N2500/04
摘要： The present inventors have discovered that Biotin synthase (BS) is essential for plant growth. Specifically, inhibition of BS gene expression in plant seedlings results in severe chlorosis and reduced growth. Thus, BS can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit BS expression or activity, and as such, the methods of the invention are useful for the identification of herbicides.
摘要翻译：本发明人已经发现，生物素合酶（BS）对于植物生长是必需的。具体来说，植物幼苗中BS基因表达的抑制导致严重的萎黄症和生长减少。因此，BS可以用作鉴定除草剂的目标。因此，本发明提供了鉴定抑制BS表达或活性的化合物的方法，因此，本发明的方法可用于鉴定除草剂。

5. 发明申请

US20100254924A1 METHODS AND KITS FOR MAINTAINING THE CONDITION OF COLORED HAIR 有权
标题翻译：用于维护有色头发的条件的方法和工具
公开(公告)号：US20100254924A1
公开(公告)日：2010-10-07
申请号：US12679572
申请日：2008-10-27
申请人： Carol Hamilton , François Cottard , Caroline Goget
发明人： Carol Hamilton , François Cottard , Caroline Goget
IPC分类号： A61K8/72 , A61Q5/08 , A61Q5/10
CPC分类号： A61Q5/10 , A61K8/342 , A61K8/345 , A61K8/39 , A61K8/42 , A61K8/64 , A61K8/68 , A61K8/891 , A61K8/893 , A61K8/898 , A61K2800/594 , A61K2800/88 , A61K2800/884 , A61Q5/004 , A61Q5/12
摘要： The present invention provides for kits and methods of treating hair in order to inhibit color fading and/or impart both shine- and condition-enhancing properties to colored hair, comprising a pre-treatment composition, a color-altering composition, a developer composition, a shampoo composition, a conditioner composition, and a post-treatment composition, wherein the post-treatment composition contains at least about 5% by weight of at least one oily component, based on the total weight of the post-treatment composition.
摘要翻译：本发明提供了治疗毛发的试剂盒和方法，以便抑制颜色褪色和/或赋予着色头发光泽和条件增强性能，包括预处理组合物，变色组合物，显影剂组合物，洗发剂组合物，调理剂组合物和后处理组合物，其中所述后处理组合物基于所述后处理组合物的总重量含有至少约5重量％的至少一种油性组分。

6. 发明申请

US20070062956A1 Products, packagings, displays, and methods relating to hair coloring 审中-公开
标题翻译：产品，包装，显示器和与染发有关的方法
公开(公告)号：US20070062956A1
公开(公告)日：2007-03-22
申请号：US11231984
申请日：2005-09-22
申请人： Kathy Roher , Carol Hamilton , Celine Brucker , Laura Azaria , Victoria Lerner
发明人： Kathy Roher , Carol Hamilton , Celine Brucker , Laura Azaria , Victoria Lerner
IPC分类号： B65D1/24
CPC分类号： A45D44/005 , A45D2200/25 , B65D5/02 , B65D2201/00 , B65D2203/00
摘要： Products, packagings, display, and methods relating to hair coloring are disclosed. In some examples, a packaging for a hair coloring product includes a reflective portion configured to provide a reflection of a subject's hair color so as to permit the subject to compare the reflection of the subject's hair color to at least one representation of hair color. Certain examples may include multiple representations of hair after treatment with differing hair coloring products.
摘要翻译：公开了与染发有关的产品，包装，显示和方法。在一些实例中，用于头发着色产品的包装包括被配置为提供被检者的头发颜色的反射以使得受试者将被检者的头发颜色的反射与头发颜色的至少一个表示进行比较的反射部。某些实例可以包括用不同的头发着色产品处理后头发的多重表示。

7. 发明授权

US06660519B2 High throughput method, apparatus and kit for plating microorganisms and cell cultures 失效
公开(公告)号：US06660519B2
公开(公告)日：2003-12-09
申请号：US10076712
申请日：2002-02-15
申请人： Carol Hamilton
发明人： Carol Hamilton
IPC分类号： C12M126
CPC分类号： B01L3/5085 , B01L2300/0618 , B01L2300/069 , B01L2300/0809 , C12M23/04 , C12M23/34 , C12M23/38 , C12M33/06 , C12N1/18
摘要： The present invention relates to a highly effective method, apparatus and kit for growing and plating out cultures of microorganisms or cell culture, especially derived from culture blocks containing multiple wells, such as a 96-well or 384-well plate or block.

8. 发明授权

US07972388B2 Methods and kits for maintaining the condition of colored hair 有权
标题翻译：维持彩色头发状况的方法和试剂盒
公开(公告)号：US07972388B2
公开(公告)日：2011-07-05
申请号：US12679572
申请日：2008-10-27
申请人： Carol Hamilton , Francois Cottard , Caroline Goget
发明人： Carol Hamilton , Francois Cottard , Caroline Goget
IPC分类号： A61Q5/10 , A61K8/00
CPC分类号： A61Q5/10 , A61K8/342 , A61K8/345 , A61K8/39 , A61K8/42 , A61K8/64 , A61K8/68 , A61K8/891 , A61K8/893 , A61K8/898 , A61K2800/594 , A61K2800/88 , A61K2800/884 , A61Q5/004 , A61Q5/12
摘要： The present invention provides for kits and methods of treating hair in order to inhibit color fading and/or impart both shine- and condition-enhancing properties to colored hair, comprising a pre-treatment composition, a color-altering composition, a developer composition, a shampoo composition, a conditioner composition, and a post-treatment composition, wherein the post-treatment composition contains at least about 5% by weight of at least one oily component, based on the total weight of the post-treatment composition.
摘要翻译：本发明提供了治疗毛发的试剂盒和方法，以便抑制颜色褪色和/或赋予着色头发光泽和条件增强性能，包括预处理组合物，变色组合物，显影剂组合物，洗发剂组合物，调理剂组合物和后处理组合物，其中所述后处理组合物基于所述后处理组合物的总重量含有至少约5重量％的至少一种油性组分。

9. 发明申请

US20070137669A1 Hair coloring system including an applicator tip 审中-公开
标题翻译：头发着色系统，包括涂抹头
公开(公告)号：US20070137669A1
公开(公告)日：2007-06-21
申请号：US11543073
申请日：2006-10-05
申请人： Carol Hamilton , Kathy Roher , Celine Brucker-Doessant
发明人： Carol Hamilton , Kathy Roher , Celine Brucker-Doessant
IPC分类号： A61K8/18
CPC分类号： A45D19/02 , A45D2019/0066
摘要： A hair coloring system includes at least one component of a hair coloring product and a container configured to contain the hair coloring product. The container may include a neck having a connecting portion and a top neck end. The system may further include an applicator tip for applying the hair coloring product to hair. The applicator tip may include a base portion configured to connect the applicator tip releasably to the connecting portion of the neck of the container and a nozzle portion extending from the base portion to a top end of the tip. The applicator tip and the container may be configured such that when the applicator tip is fully connected to the connecting portion of the neck of the container, an axial length from the top neck end to the top end of the tip is greater than about 1.9 inches. In some examples, the applicator tip and the container may be configured such that a ratio of the axial length to an outer diameter of a portion of the neck including the top neck end is greater than about 1.8.
摘要翻译：毛发着色系统包括至少一种毛发着色产品的成分和容纳毛发着色产品的容器。容器可以包括具有连接部分和顶部颈部端部的颈部。该系统还可以包括用于将头发着色产品施加到头发上的施用器尖端。施用器末端可以包括基部，该基部构造成将施用器末端可释放地连接到容器的颈部的连接部分以及从基部延伸到尖端的顶端的喷嘴部分。施用器尖端和容器可以构造成使得当施用器尖端完全连接到容器的颈部的连接部分时，从尖端的顶部颈端到顶端的轴向长度大于约1.9英寸。在一些示例中，施用器尖端和容器可以被配置为使得包括顶部颈部的颈部的一部分的轴向长度与外径之比大于约1.8。

10. 发明申请

US20050076313A1 Display of biological data to maximize human perception and apprehension 审中-公开
标题翻译：显示生物数据，最大限度地提高人的感知和忧虑
公开(公告)号：US20050076313A1
公开(公告)日：2005-04-07
申请号：US10678661
申请日：2003-10-03
申请人： David Pegram , Carol Hamilton , Matthew Lawrence
发明人： David Pegram , Carol Hamilton , Matthew Lawrence
IPC分类号： G06F20060101 , G06F3/00 , G06F19/00
CPC分类号： G16B45/00
摘要： The present invention provides methods and systems for presenting complex biological data in a display format that facilitates perception and apprehension by an operator. The invention presented herein leverages the bandwidth of the human perceptual system to enable operators of the invention to quickly recognize and identify trends and relationships within the data. The invention is useful in multiple applications, including applications in the agricultural, pharmaceutical, forensic, biotechnology and nutriceutical industries.
摘要翻译：本发明提供用于以显示格式呈现复杂的生物数据的方法和系统，其便于操作者的感知和理解。本文提出的本发明利用人类感知系统的带宽使本发明的操作者能够快速识别和识别数据内的趋势和关系。本发明在多种应用中有用，包括农业，制药，法医，生物技术和营养行业的应用。

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