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1. 发明申请

US20050019778A1 Sequential generation of multiple chemiluminescent signals on solid supports 审中-公开
标题翻译：在固体支持物上顺序生成多种化学发光信号
公开(公告)号：US20050019778A1
公开(公告)日：2005-01-27
申请号：US10620332
申请日：2003-07-17
申请人： John Voyta , Robert Smith , Gary Schroth , Alison Sparks , Brooks Edwards , Carolyn Gonzalez
发明人： John Voyta , Robert Smith , Gary Schroth , Alison Sparks , Brooks Edwards , Carolyn Gonzalez
IPC分类号： C12Q20060101 , C12Q1/68 , G01N33/53 , G01N33/535 , G01N33/537 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/58
CPC分类号： G01N33/543 , C12Q1/6837 , G01N33/58 , C12Q2565/102 , C12Q2563/103 , C12Q2537/149
摘要： Chemiluminescent assays to determine the presence and/or amount of one or more labeled analytes in a sample are described wherein a solid support is contacted sequentially with first and second chemiluminescent substrates each of which are capable of being activated by an enzyme and the resulting chemiluminescent signals are detected. A plurality of probes are disposed on a surface layer of the solid support in a plurality of discrete areas. Some of the probes are bound to a conjugate of the first enzyme and some of the probes are bound to a conjugate of the second enzyme. The assay can be used to compare biological samples (e.g., mRNA populations from different cells) on the same support surface. Alternatively, one of the chemiluminescent signals generated can be used as a control signal for normalizing the chemiluminescent assay data.
摘要翻译：描述了用于确定样品中一种或多种标记的分析物的存在和/或量的化学发光测定法，其中固体支持物依次与第一和第二化学发光底物接触，每个化学发光底物能够被酶活化，并且得到的化学发光信号被检测到。多个探针设置在多个离散区域中的固体支持体的表面层上。一些探针与第一酶的缀合物结合，一些探针与第二酶的缀合物结合。该测定法可用于比较同一支持物表面上的生物学样品（例如来自不同细胞的mRNA群体）。或者，所生成的化学发光信号之一可以用作控制信号，用于归一化化学发光测定数据。

2. 发明申请

US20050026151A1 Simultaneous generation of multiple chemiluminescent signals on solid supports 审中-公开
标题翻译：在固体支持物上同时产生多种化学发光信号
公开(公告)号：US20050026151A1
公开(公告)日：2005-02-03
申请号：US10620333
申请日：2003-07-17
申请人： John Voyta , Robert Smith , Gary Schroth , Alison Sparks , Brooks Edwards
发明人： John Voyta , Robert Smith , Gary Schroth , Alison Sparks , Brooks Edwards
IPC分类号： G01N33/58 , C12Q1/68
CPC分类号： G01N33/581
摘要： A chemiluminescent assay to determine the presence and/or amount of one or more labeled target molecules in a sample is described in which the surface layer of a solid support is contacted with a composition comprising first and second chemiluminescent substrates capable of being activated by first and second enzymes, respectively. A plurality of probes are disposed on the surface layer in discrete areas. At least some of the probes are bound to a first enzyme conjugate comprising the first enzyme and at least some of the probes are bound to a second enzyme conjugate comprising the second enzyme. The resulting chemiluminescent signals are then detected. The method can be used to compare two biological samples (e.g., mRNA populations from different cells) on the same support surface or to provide a chemiluminescent control signal for normalizing chemiluminescent assay data from a biological sample.
摘要翻译：描述了用于确定样品中一种或多种标记的靶分子的存在和/或量的化学发光测定法，其中固体支持物的表面层与包含能够被第一和第二化学发光底物活化的第一和第二化学发光底物的组合物接触，第二种酶。多个探针设置在离散区域的表面层上。至少一些探针与包含第一酶的第一酶结合物结合，并且至少一些探针与包含第二酶的第二酶缀合物结合。然后检测所得到的化学发光信号。该方法可用于比较两个生物样品（例如，来自不同细胞的mRNA群体）在相同的支持物表面上，或提供化学发光控制信号，用于从生物样品中归一化化学发光测定数据。

3. 发明申请

US20070190598A1 METHOD OF REDUCING LEACHATE FROM PROTEIN A AFFINITY MEDIA 审中-公开
标题翻译：降低蛋白质亲和介质中浸出液的方法
公开(公告)号：US20070190598A1
公开(公告)日：2007-08-16
申请号：US11696653
申请日：2007-04-04
申请人： Thomas Leete , Theresa Creasey , Robert Smith , James Coull , Darryl Pappin , Brooks Edwards , Mark McCoy
发明人： Thomas Leete , Theresa Creasey , Robert Smith , James Coull , Darryl Pappin , Brooks Edwards , Mark McCoy
IPC分类号： C12P21/06 , C07K16/18
CPC分类号： C07K16/065
摘要： Disclosed are methods and compositions that may be used for purifying antibodies.
摘要翻译：公开了可用于纯化抗体的方法和组合物。

4. 发明申请

US20050165222A1 Method of reducing leachate from protein a affinity media 审中-公开
标题翻译：从蛋白质亲和介质中还原渗滤液的方法
公开(公告)号：US20050165222A1
公开(公告)日：2005-07-28
申请号：US10966188
申请日：2004-10-15
申请人： Thomas Leete , Theresa Creasey , Robert Smith , James Coull , Darryl Pappin , Brooks Edwards , Mark McCoy
发明人： Thomas Leete , Theresa Creasey , Robert Smith , James Coull , Darryl Pappin , Brooks Edwards , Mark McCoy
IPC分类号： C07K1/22 , C07K16/06 , C07K16/18 , C12N9/99
CPC分类号： C07K16/065
摘要： Disclosed are methods and compositions that may be used for purifying antibodies.
摘要翻译：公开了可用于纯化抗体的方法和组合物。

5. 发明授权

US11405717B2 Pressure equalizing earphone 有权
公开(公告)号：US11405717B2
公开(公告)日：2022-08-02
申请号：US17125603
申请日：2020-12-17
申请人： Robert Smith , Casey Ng
发明人： Robert Smith , Casey Ng
IPC分类号： H04R1/10
摘要： An earphone has a body housing a transducer that is capable of generating an acoustic signal and directing the acoustic signal to an outlet in the body, the body being positionable in, on, or near an ear of user so that the acoustic signal can be directed into the ear canal of the user. The earphone also has an ear coupling mechanism comprising a sealing mechanism with a sealing member that is adapted to contact a portion of the ear of the user to at least partially create a seal between the ear canal and the external environment and a venting mechanism capable of venting air between the ear canal and the external environment, the venting mechanism comprising an air conduit that is adapted to communicate on one end with the ear canal and at another end with the external environment so that air can flow through the conduit to equalize a pressure differential across the sealing mechanism. The air conduit is sized and shaped so as to provide an improved audio performance over an earphone without the air conduit.

6. 外观设计

USD906911S1 Handlebar 有权
公开(公告)号：USD906911S1
公开(公告)日：2021-01-05
申请号：US29666409
申请日：2018-10-12
申请人： Robert Smith
设计人： Robert Smith

7. 外观设计

USD728052S1 Limbo device 有权
标题翻译： Limbo设备
公开(公告)号：USD728052S1
公开(公告)日：2015-04-28
申请号：US29480950
申请日：2014-01-30
申请人： Robert Smith , Tyler Livesay
设计人： Robert Smith , Tyler Livesay

8. 发明授权

US08919861B1 Portable temporary extension enclosure for folding trailers 有权
标题翻译：便携式折叠式拖车的临时扩展机柜
公开(公告)号：US08919861B1
公开(公告)日：2014-12-30
申请号：US14107571
申请日：2013-12-16
申请人： Robert Smith
发明人： Robert Smith
IPC分类号： B60P3/00 , B60P3/36
CPC分类号： B60P3/36
摘要： A flexible extension storage enclosure for folding travel trailers that is selectively secured to the underside of a folding trailer extension after it has been deployed from the main body of the travel trailer. The storage extension enclosure provides additional usable weather tight storage area beneath the extension by using a combination of track insertable support rails and a plurality of wall surface mounted snaps to define selectively accessible integrated storage compartment there beneath with a selective access closure.
摘要翻译：用于折叠行走拖车的灵活的扩展存储箱，其在从行驶拖车的主体部署之后被选择性地固定到折叠拖车延伸部的下侧。存储延伸机架通过使用可轨道插入的支撑轨道和多个壁表面安装的卡扣的组合，在延伸部下方提供额外的可用的天气紧密的存储区域，以在其下方具有选择性的存取闭合件来限定可选择地可访问的集成的存储隔间。

9. 发明授权

US08636140B2 Chain tension sensor 有权
标题翻译：链式张力传感器
公开(公告)号：US08636140B2
公开(公告)日：2014-01-28
申请号：US13553487
申请日：2012-07-19
申请人： John Tout , Gordon Powell , Robert Smith
发明人： John Tout , Gordon Powell , Robert Smith
IPC分类号： B65G23/44
CPC分类号： B65G43/00 , B65G19/10 , B65G19/18 , B65G23/44 , B65G43/02 , B65G43/06 , G01L5/04
摘要： A chain tension sensor for a chain conveyor, the conveyor including a frame and a chain having a plurality of flights. The tension sensor includes a reaction arm and a load sensing pin. The reaction arm includes a first end, a second end opposite the first end, and a load pad. The first end is pivotably coupled to the frame by a pivot pin defining a pivot axis. The load pad is adjacent the conveyor chain and positioned to contact flights passing the load pad. The flights contacting the load pad exert a force on the reaction in a direction that is perpendicular to the pivot axis. The load sensing pin is coupled to the reaction arm such that the load sensing pin senses the force that is exerted by the flights.
摘要翻译：用于链式输送机的链式张力传感器，该输送机包括具有多个飞行的框架和链条。张力传感器包括反作用臂和负载传感销。反作用臂包括第一端，与第一端相对的第二端和负载垫。第一端通过限定枢转轴线的枢轴枢转地联接到框架。负载垫与输送链相邻并且定位成与经过负载垫的接触点接触。与负载垫接触的飞行器在垂直于枢转轴线的方向上对反作用力施加力。负载感测销耦合到反作用臂，使得负载感测销感测到由翼片施加的力。

10. 发明申请

US20130222139A1 HUMAN SAFETY INDICATOR 有权
标题翻译：人类安全指标
公开(公告)号：US20130222139A1
公开(公告)日：2013-08-29
申请号：US13594300
申请日：2012-08-24
申请人： Charles Mack Gouge , Kenneth Armstrong , Terrance Ransbury , Robert Smith , Darrel Self
发明人： Charles Mack Gouge , Kenneth Armstrong , Terrance Ransbury , Robert Smith , Darrel Self
IPC分类号： G08B21/02
CPC分类号： G08B21/02 , A61B5/01 , A61B5/02055 , A61B5/1118 , A61B5/6801 , A61B5/6803 , A61B5/681 , A61B5/7405 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61B2560/0431 , G01K13/002
摘要： A human safety system includes a circuit including a microcontroller and at least one power source; a probe in communication with the circuit; at least one use detector in communication with the circuit; and at least one alert indicator in communication with the circuit. A method of using a human safety device, the method includes initiating operation of the human safety device; arranging the human safety device in communication with skin; and monitoring the human safety device for alert indicators. A method of monitoring a user includes waking from sleep state; sensing at least one condition of the user; determining if the sensed condition is in a human condition; continuously monitoring the condition of the user; and, returning to sleep state when the user condition is outside of the human condition for an amount of time.
摘要翻译：人体安全系统包括包括微控制器和至少一个电源的电路; 与电路通信的探头; 至少一个使用检测器与电路通信; 以及与电路通信的至少一个警报指示器。一种使用人体安全装置的方法，所述方法包括启动人体安全装置的操作; 安排人体安全装置与皮肤通信; 并监控人体安全装置的警报指示。监视用户的方法包括从睡眠状态唤醒; 感测用户的至少一个条件; 确定感测到的状况是否处于人的状况; 持续监控用户的状况; 并且当用户状态超出人类状况一段时间时返回睡眠状态。

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