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1. 发明授权

US06184265B2 Low temperature pressure stabilization of implant component 有权
标题翻译：植入物组件的低温压力稳定
公开(公告)号：US06184265B2
公开(公告)日：2001-02-06
申请号：US09362965
申请日：1999-07-29
申请人： John V. Hamilton , Mary Beth Schmidt , Keith Greer
发明人： John V. Hamilton , Mary Beth Schmidt , Keith Greer
IPC分类号： C08F246
CPC分类号： A61L2/081 , A61L2/082 , A61L2/087 , A61L27/16 , C08L23/06 , C08L2207/068 , C08L2312/06 , Y10S422/903 , Y10S522/911 , Y10S522/912
摘要： Wear resistance and oxidation resistance of polymer material or a polymer component for bioimplantation are improved by packaging a polymer object in a sealed gas impermeable package substantially free of oxygen, irradiating the package with penetrating radiation to an extent sufficient to effect a desired substantial level of cross-linking within the polymer, and warming the packaged object while maintaining an elevated hydrostatic pressure to cause gases released during irradiation to recombine, stabilizing the material against subsequent oxidative change. The pressure stabilization terminates active sites, substantially eliminating free radicals. When applied to finished parts, the process simultaneously hardens and sterilizes the parts without degrading mechanical properties or dimensions. When applied to bulk material or unfinished parts, the part may be subsequent machined or otherwise finished, and sterilized by any conventional means. The procedure achieves high levels of cross linking without increasing susceptibility to aging or chemical degradation.
摘要翻译：聚合物材料或用于生物植入的聚合物组分的耐磨性和抗氧化性通过将聚合物物体包装在基本上不含氧的密封气体不可渗透的包装中，通过将穿透辐射照射到足以实现期望的相当程度的交叉在聚合物内连接并加热包装物体，同时保持升高的静水压力以引起在照射期间释放的气体重组，使材料稳定化以防止随后的氧化变化。压力稳定终止活性位点，基本上消除自由基。当应用于成品时，该工艺同时硬化和消毒零件，而不会降低机械性能或尺寸。当应用于散装材料或未完成的部件时，可以随后机械加工或以其他方式完成该部件，并且通过任何常规方法进行灭菌。该程序实现高水平的交联，而不增加对老化或化学降解的易感性。

2. 发明申请

US20100094229A1 SPINAL FLUID INTRODUCTION 审中-公开
标题翻译：脊柱液介绍
公开(公告)号：US20100094229A1
公开(公告)日：2010-04-15
申请号：US12632038
申请日：2009-12-07
申请人： Nelson Scarborough , John V. Hamilton , Andy H. Uchida , Ralph I. McNall , Steven Lepke
发明人： Nelson Scarborough , John V. Hamilton , Andy H. Uchida , Ralph I. McNall , Steven Lepke
IPC分类号： A61M5/315
CPC分类号： A61M5/1456 , A61B17/3401 , A61B17/8822 , A61M5/16827 , A61M5/16854 , A61M2025/0007 , A61M2205/3331
摘要： A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer.
摘要翻译：流体引入系统包括导引器，其构造成在脊柱内产生至少69kPa的压力，以及操作器，其配置成致动导引器以根据预定流体导入曲线将流体引入脊柱。该系统可以包括具有用于接收指示流体引入参数的流体引入数据的代码的计算机可读介质，以及用于在与流体引入数据的时间相关的时间接收表示患者的响应的响应数据。用于引入流体的方法包括将第一导引器定位在脊柱的第一部分中，将第二导引器定位在脊柱的第二不同部分中，并且不移除第一和第二导引器，将流体引入脊柱的第一部分与第一导引器一起引入流体到第二引导器到脊柱的第二部分。

3. 发明授权

US07662133B2 Spinal fluid introduction 失效
标题翻译：脊柱液介绍
公开(公告)号：US07662133B2
公开(公告)日：2010-02-16
申请号：US10782900
申请日：2004-02-23
申请人： Nelson Scarborough , John V. Hamilton , Andy H. Uchida , Ralph I. McNall , Steven Lepke , Peter A. Weissman
发明人： Nelson Scarborough , John V. Hamilton , Andy H. Uchida , Ralph I. McNall , Steven Lepke , Peter A. Weissman
IPC分类号： A61M37/00 , A61B5/103 , A61B5/117
CPC分类号： A61M5/1456 , A61B17/3401 , A61B17/8822 , A61M5/16827 , A61M5/16854 , A61M2025/0007 , A61M2205/3331
摘要： A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer.
摘要翻译：流体引入系统包括导引器，其构造成在脊柱内产生至少69kPa的压力，以及操作器，其配置成致动导引器以根据预定流体导入曲线将流体引入脊柱。该系统可以包括具有用于接收指示流体引入参数的流体引入数据的代码的计算机可读介质，以及用于在与流体引入数据的时间相关的时间接收表示患者的响应的响应数据。用于引入流体的方法包括将第一导引器定位在脊柱的第一部分中，将第二导引器定位在脊柱的第二不同部分中，并且不移除第一和第二导引器，将流体引入脊柱的第一部分与第一导引器一起引入流体到第二引导器到脊柱的第二部分。

4. 发明申请

US20100114111A1 DELIVERY APPARATUS AND METHODS FOR VERTEBROSTENTING 有权
标题翻译：交付装置和方法用于VERTEBROSTENTING
公开(公告)号：US20100114111A1
公开(公告)日：2010-05-06
申请号：US12688437
申请日：2010-01-15
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Parrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Parrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61F11/00
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent.
摘要翻译：本发明涉及一种将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的方法。本发明还涉及可用于执行递送和展开支架的步骤的装置。

5. 发明授权

US5480449A Composite prosthesis and method of manufacture 失效
标题翻译：复合假体及其制造方法
公开(公告)号：US5480449A
公开(公告)日：1996-01-02
申请号：US10133
申请日：1993-01-28
申请人： John V. Hamilton , Salvatore Caldarise , Debra J. Treacy
发明人： John V. Hamilton , Salvatore Caldarise , Debra J. Treacy
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/36 , A61L27/44 , B29C35/02 , B29C70/86 , A61F2/02 , B23Q9/02
CPC分类号： B29C70/86 , A61F2/30907 , A61F2/30965 , A61L27/443 , B29C35/0272 , A61F2/3094 , A61F2/3662 , A61F2002/30004 , A61F2002/30009 , A61F2002/30014 , A61F2002/30065 , A61F2002/30357 , A61F2002/3038 , A61F2002/3625 , A61F2002/3631 , A61F2002/365 , A61F2002/3652 , A61F2210/0071 , A61F2220/0033 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2310/00023 , A61F2310/00029 , B29C2035/0211 , B29L2031/7532 , Y10S623/911 , Y10T29/49897
摘要： A process for making a composite stem for a prosthesis by providing a tapered metal core with a predetermined cross section and a composite shell having a tapered cavity having a cross sectional configuration to receive the metal core. Adhesive is applied to the metal core and the core is placed in the cavity and pressure is applied along the axis of the metal core toward the smaller end of the core to force the core against the composite shell and heat is applied with the pressure to bond the composite shell to the metal core.
摘要翻译：一种用于通过提供具有预定横截面的锥形金属芯制造用于假体的复合杆的方法，以及具有锥形腔体的复合壳体，所述锥形腔体具有用于容纳金属芯的横截面构造。将粘合剂施加到金属芯上，并且将芯放置在空腔中，并且沿着金属芯的轴线朝向芯的较小端施加压力，以迫使芯抵靠复合壳，并施加压力以粘合复合外壳到金属芯。

6. 发明授权

US5314492A Composite prosthesis 失效
标题翻译：复合假体
公开(公告)号：US5314492A
公开(公告)日：1994-05-24
申请号：US881105
申请日：1992-05-11
申请人： John V. Hamilton , Salvatore Caldarise , Debra J. Treacy
发明人： John V. Hamilton , Salvatore Caldarise , Debra J. Treacy
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/36 , A61L27/44 , B29C35/02 , B29C70/86 , A61F2/32
CPC分类号： B29C70/86 , A61F2/30907 , A61F2/30965 , A61L27/443 , B29C35/0272 , A61F2/3094 , A61F2/3662 , A61F2002/30004 , A61F2002/30009 , A61F2002/30014 , A61F2002/30065 , A61F2002/30357 , A61F2002/3038 , A61F2002/3625 , A61F2002/3631 , A61F2002/365 , A61F2002/3652 , A61F2210/0071 , A61F2220/0033 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2310/00023 , A61F2310/00029 , B29C2035/0211 , B29L2031/7532 , Y10S623/911 , Y10T29/49897
摘要： A composite stem for a prosthesis, particularly a hip prosthesis, including a metal core and a fiber reinforced composite shell surrounding the core to provide modulus values that are similar to bone. The composite shell is preferably composed of braided fibers and a thermoplastic resin. The stiffness of the prosthesis can be varied along the length of the stem. The metal core contributing between 5 and 25 percent of the total flexural stiffness of the stem.
摘要翻译：用于假体，特别是髋关节假体的复合杆，包括金属芯和围绕芯的纤维增强复合壳，以提供类似于骨的模数值。复合外壳优选由编织纤维和热塑性树脂组成。假体的刚度可以沿茎的长度变化。金属芯占杆的总弯曲刚度的5％至25％。

7. 发明申请

US20140121667A1 Delivery of Apparatus and Methods for Vertebrostenting 有权
标题翻译：交付装置和方法进行制版
公开(公告)号：US20140121667A1
公开(公告)日：2014-05-01
申请号：US14096951
申请日：2013-12-04
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher
IPC分类号： A61B17/88 , A61B17/16
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The present invention generally is directed toward a spinal fixation system whereby a coupling element allows the physician to selectively lock or unlock either the connection between the coupling element and a fastener, such as to allow for repositioning of the coupling element, or the connection between the coupling element and an elongate rod. The locking or unlocking of these connections may be made independently and as desired by the physician.
摘要翻译：本发明通常涉及一种脊柱固定系统，由此联接元件允许医师选择性地锁定或解锁联接元件和紧固件之间的连接，例如允许联接元件的重新定位，或者连接元件之间的连接联接元件和细长杆。这些连接的锁定或解锁可以独立地并且根据医师的要求进行。

8. 发明授权

US08623025B2 Delivery apparatus and methods for vertebrostenting 有权
标题翻译：输送装置和方法
公开(公告)号：US08623025B2
公开(公告)日：2014-01-07
申请号：US12688437
申请日：2010-01-15
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61B17/60 , A61F2/44
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a systems, devices and methods of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. In some instances, a system can include an elongate shaft for delivering a self-expanding, cement-directing stent. The elongate shaft can include at least one of an inner shaft, an outer shaft, a tubular sheath, a flexible guidewire, and an internal polymer extrusion. A rotational handle can be used to control movement of the elongate shaft. The rotational handle can incorporate one or more pins in slots associated with each of the components (e.g., inner shaft, outer shaft, and tubular sheath), such that upon rotation of the handle, the pins are forced to move in the direction of their respective slots.
摘要翻译：本发明涉及将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的系统，装置和方法。在一些情况下，系统可以包括用于输送自膨胀水泥定向支架的细长轴。细长轴可以包括内轴，外轴，管状护套，柔性导丝和内部聚合物挤压中的至少一个。旋转手柄可用于控制细长轴的运动。旋转手柄可以在与每个部件（例如，内轴，外轴和管状护套）相关联的狭槽中结合有一个或多个销，使得在手柄旋转时，销被迫沿其方向移动各个插槽。

9. 发明授权

US07909873B2 Delivery apparatus and methods for vertebrostenting 有权
标题翻译：输送装置和方法
公开(公告)号：US07909873B2
公开(公告)日：2011-03-22
申请号：US11957039
申请日：2007-12-14
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61F2/44 , A61F2/46 , A61B17/58
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent.
摘要翻译：本发明涉及一种将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的方法。本发明还涉及可用于执行递送和展开支架的步骤的装置。

10. 发明申请

US20080208320A1 Delivery Apparatus and Methods for Vertebrostenting 有权
标题翻译：输送装置和方法
公开(公告)号：US20080208320A1
公开(公告)日：2008-08-28
申请号：US11957039
申请日：2007-12-14
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61F2/06
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent.
摘要翻译：本发明涉及一种将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的方法。本发明还涉及可用于执行递送和展开支架的步骤的装置。

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