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1. 发明授权

US08623025B2 Delivery apparatus and methods for vertebrostenting 有权
标题翻译：输送装置和方法
公开(公告)号：US08623025B2
公开(公告)日：2014-01-07
申请号：US12688437
申请日：2010-01-15
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61B17/60 , A61F2/44
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a systems, devices and methods of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. In some instances, a system can include an elongate shaft for delivering a self-expanding, cement-directing stent. The elongate shaft can include at least one of an inner shaft, an outer shaft, a tubular sheath, a flexible guidewire, and an internal polymer extrusion. A rotational handle can be used to control movement of the elongate shaft. The rotational handle can incorporate one or more pins in slots associated with each of the components (e.g., inner shaft, outer shaft, and tubular sheath), such that upon rotation of the handle, the pins are forced to move in the direction of their respective slots.
摘要翻译：本发明涉及将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的系统，装置和方法。在一些情况下，系统可以包括用于输送自膨胀水泥定向支架的细长轴。细长轴可以包括内轴，外轴，管状护套，柔性导丝和内部聚合物挤压中的至少一个。旋转手柄可用于控制细长轴的运动。旋转手柄可以在与每个部件（例如，内轴，外轴和管状护套）相关联的狭槽中结合有一个或多个销，使得在手柄旋转时，销被迫沿其方向移动各个插槽。

2. 发明授权

US07909873B2 Delivery apparatus and methods for vertebrostenting 有权
标题翻译：输送装置和方法
公开(公告)号：US07909873B2
公开(公告)日：2011-03-22
申请号：US11957039
申请日：2007-12-14
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61F2/44 , A61F2/46 , A61B17/58
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent.
摘要翻译：本发明涉及一种将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的方法。本发明还涉及可用于执行递送和展开支架的步骤的装置。

3. 发明申请

US20080208320A1 Delivery Apparatus and Methods for Vertebrostenting 有权
标题翻译：输送装置和方法
公开(公告)号：US20080208320A1
公开(公告)日：2008-08-28
申请号：US11957039
申请日：2007-12-14
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61F2/06
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent.
摘要翻译：本发明涉及一种将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的方法。本发明还涉及可用于执行递送和展开支架的步骤的装置。

4. 发明申请

US20140121667A1 Delivery of Apparatus and Methods for Vertebrostenting 有权
标题翻译：交付装置和方法进行制版
公开(公告)号：US20140121667A1
公开(公告)日：2014-05-01
申请号：US14096951
申请日：2013-12-04
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Farrissey , John Mugan , Martin Bruggemann , Dion Gallagher
IPC分类号： A61B17/88 , A61B17/16
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The present invention generally is directed toward a spinal fixation system whereby a coupling element allows the physician to selectively lock or unlock either the connection between the coupling element and a fastener, such as to allow for repositioning of the coupling element, or the connection between the coupling element and an elongate rod. The locking or unlocking of these connections may be made independently and as desired by the physician.
摘要翻译：本发明通常涉及一种脊柱固定系统，由此联接元件允许医师选择性地锁定或解锁联接元件和紧固件之间的连接，例如允许联接元件的重新定位，或者连接元件之间的连接联接元件和细长杆。这些连接的锁定或解锁可以独立地并且根据医师的要求进行。

5. 发明申请

US20100114111A1 DELIVERY APPARATUS AND METHODS FOR VERTEBROSTENTING 有权
标题翻译：交付装置和方法用于VERTEBROSTENTING
公开(公告)号：US20100114111A1
公开(公告)日：2010-05-06
申请号：US12688437
申请日：2010-01-15
申请人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Parrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
发明人： Francisca Tan-Malecki , John V. Hamilton , Andrew R. Sennett , Ronald Sahatjian , James Coyle , James Cannon , Liam Parrissey , John Mugan , Martin Bruggemann , Dion Gallagher , Damien Ryan
IPC分类号： A61F11/00
CPC分类号： A61B17/1637 , A61B17/16 , A61B17/1617 , A61B17/1642 , A61B17/1671 , A61B17/88 , A61B17/8805 , A61B17/8808 , A61B17/8816 , A61B17/8822 , A61B17/885 , A61B17/8858
摘要： The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent.
摘要翻译：本发明涉及一种将支架递送和展开到椎体或其他骨骼或身体结构内的曲线腔中的方法。本发明还涉及可用于执行递送和展开支架的步骤的装置。

6. 发明授权

US09126023B1 Balloon expandable cement director and related methods 有权
标题翻译：气球膨胀水泥总监及相关方法
公开(公告)号：US09126023B1
公开(公告)日：2015-09-08
申请号：US13035423
申请日：2011-02-25
申请人： Ronald Sahatjian , Andrew R. Sennett
发明人： Ronald Sahatjian , Andrew R. Sennett
IPC分类号： A61F2/44 , A61M25/10 , A61B17/88 , A61F2/46
CPC分类号： A61B17/8811 , A61B17/7098 , A61B17/8802 , A61B17/8819 , A61B17/8855 , A61B2017/00867 , A61F2/4601 , A61M25/10 , A61M25/1002 , A61M25/1018 , A61M25/10181 , A61M2025/1075 , A61M2025/1084
摘要： The invention relates to a cement director for insertion within a vertebral body or other body structure, and related methods of use. An example method includes creating a cavity in a vertebral body, inserting a collapsible mesh structure into the cavity in a collapsed state, wherein the collapsible mesh structure comprises regions of different permeability to a bone cement, inflating a balloon within the collapsible mesh structure to expand the mesh structure, and injecting a bone cement into the mesh structure, wherein the bone cement flows preferentially out of the mesh structure through at least one region of greater permeability.
摘要翻译：本发明涉及一种用于插入椎体或其他身体结构内的水泥导管，以及相关的使用方法。一种示例性方法包括在椎体中产生空腔，将折叠的网状结构以折叠状态插入空腔中，其中可收缩的网状结构包括对骨粘固剂渗透性不同的区域，使可收缩网状结构内的气囊膨胀所述网状结构，并且将骨水泥注入所述网状结构中，其中所述骨粘固剂优选地流过所述网状结构通过至少一个较大渗透性的区域。

7. 发明授权

US5304121A Drug delivery system making use of a hydrogel polymer coating 失效
标题翻译：使用水凝胶聚合物涂层的药物递送系统
公开(公告)号：US5304121A
公开(公告)日：1994-04-19
申请号：US795976
申请日：1991-11-22
申请人： Ronald Sahatjian
发明人： Ronald Sahatjian
IPC分类号： A61M25/00 , A61F2/00 , A61F2/90 , A61K9/00 , A61K38/49 , A61K48/00 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61M16/04 , A61M29/02 , A61M31/00
CPC分类号： A61K9/0024 , A61F2/90 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61M16/0481 , A61M25/104 , A61F2230/0013 , A61F2250/0067 , A61L2300/416 , A61L2300/42 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266
摘要： The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.
摘要翻译：本发明的特征在于导管和用于将药物递送到体腔壁的所需位置处的组织的方法。导管被构造成用于插入体腔，并且具有导管轴和安装在导管轴上的可扩张部分。可膨胀部分可膨胀至受控的压力以填充体腔的横截面并压靠身体腔的壁。在一个实施例中，可膨胀部分的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层限定。掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液。选择水凝胶聚合物和药物，以便当可膨胀部分膨胀时，水凝胶聚合物涂层在水凝胶聚合物涂层压靠内腔壁时，从水凝胶聚合物涂层快速释放所需剂量的药物。在其它实施方案中，聚合物响应于压力从可膨胀部分释放，以涂覆体腔的壁。

8. 发明授权

US5238004A High elongation linear elastic guidewire 失效
标题翻译：高伸长线性弹性导丝
公开(公告)号：US5238004A
公开(公告)日：1993-08-24
申请号：US954469
申请日：1992-09-30
申请人： Ronald Sahatjian , Fernando Alvarez de Toledo
发明人： Ronald Sahatjian , Fernando Alvarez de Toledo
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M25/0015 , A61F2002/9665 , A61M2025/09175 , A61M25/0009
摘要： A guidewire and a method for its manufacture, wherein at least the distal portion of the guidewire comprises an element made of a precursor of a superelastic alloy such as a Ni--Ti linear elastic alloy. The element exhibits a stress strain curve with a linear stress-strain relationship and a yield point. At room temperature to body temperature the precursor is in the martensitic phase. The distal portion of the guidewire is deformable beyond the yield point by the physician in the field to a desired set shape and exhibits resistance to kinking during insertion into the body as a result of its elasticity.
摘要翻译：导丝及其制造方法，其中至少导丝的远端部分包括由诸如Ni-Ti线弹性合金的超弹性合金的前体制成的元件。该元素呈现出具有线性应力 - 应变关系和屈服点的应力应变曲线。在室温至体温下，前体处于马氏体相。导丝的远端部分可以由外科医生在现场的屈服点之外变形到期望的固定形状，并且由于其弹性而在插入身体期间表现出抗扭结作用。

9. 发明授权

US5191883A Device for heating tissue in a patient's body 失效
标题翻译：用于加热患者身体中的组织的装置
公开(公告)号：US5191883A
公开(公告)日：1993-03-09
申请号：US527047
申请日：1990-05-22
申请人： Charles D. Lennox , Richard A. Noddin , Ronald Sahatjian
发明人： Charles D. Lennox , Richard A. Noddin , Ronald Sahatjian
IPC分类号： A61B17/00 , A61B17/22 , A61B18/04 , A61B18/08
CPC分类号： A61B18/08 , A61B18/082 , A61B17/22 , A61B2017/00084 , A61B2017/00088 , A61B2017/00132 , A61B2017/00274 , A61B2017/22062 , A61B2018/0022 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/00791 , A61B2018/044
摘要： Device and method for heating tissue, the device having a catheter shaft for insertion into a patient's body, a chamber formed by a collapsible balloon mounted on the catheter shaft and filled with an electrically conductive fluid, two or more electrical contacts enclosed within the chamber, a power supply for applying an electrical potential to the contacts, and a two or more conductors for connecting each of the contacts to the power supply. The fluid is heated on the basis of I.sup.2 R losses by a radio frequency electric current flowing between the electrodes, and the fluid in turn heats the surrounding tissue by heat transfer through the wall of the chamber. According to the method, the apparatus is inserted into the patient's body, the chamber is filled with an electrically conductive fluid, and an electrical potential is applied to the contacts. The apparatus functions as a temperature source. A thermister sensor in the balloon or in contact with tissue responds to the heating effect to control the application of the current. Advantageously, by periodic sensing of temperature, and application of controlled rf power, a preset constant temperature is maintained at the selected sensing point, either at the internal body site or the liquid within the balloon. In this way carefully controlled therapy can be conducted at constant temperature.
摘要翻译：用于加热组织的装置和方法，所述装置具有用于插入患者体内的导管轴，由可安装在导管轴上并填充有导电流体的可折叠气囊形成的腔室，封闭在腔室内的两个或更多个电触点，用于向触点施加电势的电源，以及用于将每个触点连接到电源的两个或更多个导体。基于I2R损耗，通过在电极之间流动的射频电流来加热流体，并且流体又通过腔室壁的热传递来加热周围组织。根据该方法，将该装置插入到患者体内，对该腔室填充有导电性流体，并向触点施加电位。该装置用作温度源。气囊中的热敏传感器或与组织接触的热敏电阻传感器响应加热效应以控制电流的施加。有利地，通过周期性地检测温度和施加受控射频功率，在所选择的感测点处，在内部身体部位或球囊内的液体中保持预设的恒定温度。以这种方式，可以在恒温下进行精心控制的治疗。

10. 发明授权

US08394059B2 Immobilizing objects in the body 有权
公开(公告)号：US08394059B2
公开(公告)日：2013-03-12
申请号：US13242961
申请日：2011-09-23
申请人： Ronald Sahatjian , Arthur Madenjian , Bill Little
发明人： Ronald Sahatjian , Arthur Madenjian , Bill Little
IPC分类号： A61F7/12
CPC分类号： A61B17/221 , A61B17/00491 , A61B17/22 , A61B17/22004 , A61B17/22012 , A61B17/3478 , A61B2017/2253 , A61B2090/0815 , A61L26/008 , A61L27/52 , A61L31/145 , A61M5/178 , A61M5/20 , A61M5/32 , A61M25/00
摘要： Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.

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