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1. 发明申请

US20060178655A1 Implantable, tissue conforming drug delivery device 失效
标题翻译：可植入，组织贴合药物输送装置
公开(公告)号：US20060178655A1
公开(公告)日：2006-08-10
申请号：US11291973
申请日：2005-12-01
申请人： John Santini , Michael Cima , Norman Sheppard , Stephen Herman
发明人： John Santini , Michael Cima , Norman Sheppard , Stephen Herman
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A drug delivery device for implantation into a patient is provided that includes at least one device element which comprises a substrate having a plurality of discrete reservoirs disposed therein, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.
摘要翻译：提供了一种用于植入患者的药物递送装置，其包括至少一个装置元件，其包括具有设置在其中的多个离散储存器的基底，所述储存器包含药物分子和控制体内释放药物分子的可降解基质材料其中所述药物递送装置适于符合弯曲的骨组织表面。在一个实施例中，基底是柔性的并且符合骨组织表面。在另一个实施例中，该装置具有两个或更多个装置元件，其连接到柔性支撑层或与柔性支撑层成一体。

2. 发明申请

US20080071252A1 METHOD OF ACTUATING IMPLANTED MEDICAL DEVICE 有权
标题翻译：实施植入式医疗装置的方法
公开(公告)号：US20080071252A1
公开(公告)日：2008-03-20
申请号：US11925507
申请日：2007-10-26
申请人： John Santini , Michael Cima , Robert Langer , Dennis Ausiello , Norman Sheppard
发明人： John Santini , Michael Cima , Robert Langer , Dennis Ausiello , Norman Sheppard
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located in the reservoir, and (iii) control circuitry and a power source for disintegrating or permeabilizing the reservoir cap, and (iv) an external interface to receive incident light energy; and directing focused light to the external interface of the implanted device to actuate disintegration or permeabilization of the reservoir cap to release the drug or expose the sensor. The device may implanted onto or into the sclera or other tissue surface of the eye of the patient. The focused light may be laser light which may be used to transmit power or data to the device.
摘要翻译：提供了用于治疗或诊断患者的方法。该方法包括向患者植入一种装置，该装置包括：（i）至少一个储存器定位并被第一储存器盖覆盖的基底，（ii）位于储存器中的药物或传感器，以及（iii）控制电路以及用于使储存器盖分解或渗透的电源，以及（iv）外部接口以接收入射光能; 并将聚焦的光引导到植入装置的外部界面以致驱动贮存器盖的分解或透化以释放药物或暴露传感器。该装置可植入患者眼睛的巩膜或其他组织表面上或其中。聚焦光可以是可以用于将功率或数据传输到设备的激光。

3. 发明申请

US20050143715A1 Device for controlled reservoir opening with reinforced reservoir caps 审中-公开
标题翻译：受控储层开启装置，加强储层盖
公开(公告)号：US20050143715A1
公开(公告)日：2005-06-30
申请号：US10937616
申请日：2004-09-09
申请人： Michael Cima , John Santini , Stephen Herman
发明人： Michael Cima , John Santini , Stephen Herman
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61K9/0097 , A61K9/0009 , Y10T137/8242
摘要： Device are provided for the controlled release or exposure of molecules or secondary devices comprising a substrate; a plurality of reservoirs located in the substrate; reservoir contents comprising molecules, a secondary device, or both, isolated inside the reservoirs; reservoir caps positioned on the reservoirs over the reservoir contents, wherein the reservoir caps (which can comprise a metal film) are mechanically reinforced with a second material deposited and patterned on the surface of the metal film inside the reservoir or on the surface of the metal film outside the reservoir or on both of said surfaces; and control circuitry and a power source for disintegrating the reservoir caps to initiate exposure or release of the reservoir contents in selected reservoirs.
摘要翻译：提供了用于受控释放或暴露包括基底的分子或二次装置的装置; 位于所述基板中的多个储存器; 储存器内容物包含分离在储存器内部的分子，次要装置或二者; 储存器盖位于储存器上方的储存器内容物上，其中储存器盖（其可以包括金属膜）用沉积和图案化的第二材料机械地增强，该金属膜在储存器内部或金属表面上的金属膜的表面上在所述储存器外部或所述两个所述表面上的膜; 以及控制电路和用于分解储存器盖的电源，以开始在所选择的储存器中储存器内容物的曝光或释放。

4. 发明申请

US20080015494A1 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或输送物质的多储层泵装置
公开(公告)号：US20080015494A1
公开(公告)日：2008-01-17
申请号：US11776351
申请日：2007-07-11
申请人： John Santini , Michael Cima , Jonathan Coppeta , James Prescott , Zouhair Sbiaa , Mark Staples
发明人： John Santini , Michael Cima , Jonathan Coppeta , James Prescott , Zouhair Sbiaa , Mark Staples
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供泵补丁装置用于药物递送。该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。

5. 发明申请

US20060189963A1 MULTI-RESERVOIR DEVICE FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物递送的多储存装置
公开(公告)号：US20060189963A1
公开(公告)日：2006-08-24
申请号：US11379017
申请日：2006-04-17
申请人： Amy Richards , John Santini , Michael Cima , Robert Langer
发明人： Amy Richards , John Santini , Michael Cima , Robert Langer
IPC分类号： A61K9/22
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , Y10T436/25
摘要： An implantable device for the controlled release of drug or diagnostic molecules in vivo which includes a substrate formed of a metal or a polyethylene, a plurality of discrete reservoirs provided in spaced positions in the substrate, and a release system disposed in the at least two reservoirs, wherein the release system comprises drug or diagnostic molecules combined with a release-controlling polymer matrix, wherein the kinetics of release of the drug or diagnostic molecules is controlled by disintegration of the polymeric matrix. The substrate and reservoirs therein may be made by a manufacturing technique which comprises compression molding, thermoforming, casting, laser cutting, etching, or a combination thereof.
摘要翻译：一种用于体内药物或诊断分子的受控释放的可植入装置，其包括由金属或聚乙烯形成的基底，在所述基底中以间隔开的位置设置的多个离散储存器以及设置在所述至少两个储存器中的释放系统其中所述释放系统包含与释放控制聚合物基质结合的药物或诊断分子，其中所述药物或诊断分子的释放动力学通过所述聚合物基质的分解来控制。其中的基材和储器可以通过包括压塑，热成型，铸造，激光切割，蚀刻或其组合的制造技术制成。

6. 发明申请

US20060093646A1 Orthopedic and dental implant devices providing controlled drug delivery 审中-公开
标题翻译：提供控制药物输送的矫形和牙种植体装置
公开(公告)号：US20060093646A1
公开(公告)日：2006-05-04
申请号：US11262413
申请日：2005-10-28
申请人： Michael Cima , John Santini , Mark Staples , Charles Hutchinson
发明人： Michael Cima , John Santini , Mark Staples , Charles Hutchinson
IPC分类号： A61F2/28 , A61F2/02
CPC分类号： A61F2/30771 , A61B17/0642 , A61B17/80 , A61B17/86 , A61B17/8625 , A61B2017/0648 , A61C8/0012 , A61C8/0016 , A61C19/063 , A61F2/30744 , A61F2/30767 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4425 , A61F2/446 , A61F2002/2817 , A61F2002/30013 , A61F2002/30032 , A61F2002/30036 , A61F2002/30062 , A61F2002/30064 , A61F2002/30075 , A61F2002/30224 , A61F2002/30324 , A61F2002/30326 , A61F2002/30677 , A61F2002/3068 , A61F2002/30787 , A61F2002/30808 , A61F2002/3081 , A61F2002/30838 , A61F2002/30878 , A61F2002/30929 , A61F2002/30971 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/4631 , A61F2210/0004 , A61F2210/0061 , A61F2230/0069 , A61F2250/0024 , A61F2250/003 , A61F2250/0035 , A61F2250/0036 , A61F2250/0037 , A61F2250/0068 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61N1/30
摘要： Implantable prosthetic devices are provided for controlled drug delivery, for orthopedic and dental applications. The device may include a prosthetic device body having at least one outer surface area; two or more discrete reservoirs located in spaced apart positions across at least a portion of the outer surface area, the reservoirs formed with an opening at the surface of the device body and extending into the device body; and a release system disposed in the reservoirs which comprises at least one therapeutic or prophylactic agent, wherein following implantation into a patient the therapeutic or prophylactic agent is released in a controlled manner from the reservoirs. The prosthetic device body preferably is a joint prosthesis or part thereof, such as a hip prosthesis, a knee prosthesis, a vertebral or spinal disc prosthesis, or part thereof. Optional reservoir caps may further control release kinetics.
摘要翻译：提供可植入的假体装置用于受控的药物递送，用于矫形和牙科应用。该装置可以包括具有至少一个外表面区域的假体装置主体; 两个或更多个离散的储存器位于跨过外表面区域的至少一部分的间隔位置，储存器在装置主体的表面处形成并延伸到装置主体中的开口; 以及设置在储存器中的释放系统，其包括至少一种治疗或预防剂，其中在植入患者体内后，以受控的方式从所述储存器释放所述治疗剂或预防剂。修复装置本体优选地是关节假体或其部分，例如髋关节假体，膝假体，椎骨或脊椎椎间盘假体或其一部分。可选的储存瓶盖可进一步控制释放动力学。

7. 发明申请

US20080047926A1 Method for Making Microchip Reservoir Device 审中-公开
标题翻译：制作Microchip储存器件的方法
公开(公告)号：US20080047926A1
公开(公告)日：2008-02-28
申请号：US11930328
申请日：2007-10-31
申请人： John Santini , Michael Cima , Robert Langer
发明人： John Santini , Michael Cima , Robert Langer
IPC分类号： C25F7/00 , A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Methods are provide for fabricating a microchip device having containment reservoirs. In one embodiment, the method includes providing a substrate; forming a plurality of reservoirs in the substrate, each reservoir having an opening in a surface of the substrate; fabricating a plurality of metal reservoir caps, each of which closes off one of said openings; and sealing each of said reservoirs. The method may further include loading chemical molecules, such a drug, into each of said reservoirs before said sealing of the reservoirs.
摘要翻译：提供制造具有容纳储存器的微芯片装置的方法。在一个实施例中，该方法包括提供基板; 在所述基板中形成多个储存器，每个储存器在所述基板的表面中具有开口; 制造多个金属容器盖，每个金属容器盖封闭所述开口中的一个; 并密封每个所述储存器。该方法还可以包括在储存器的所述密封之前将化学分子（例如药物）加载到每个所述储存器中。

8. 发明申请

US20070088442A1 PASSIVE WEAR-INDICATING SENSOR FOR IMPLANTABLE PROSTHETIC DEVICE 审中-公开
标题翻译：无源磨损传感器，用于可植入的前置设备
公开(公告)号：US20070088442A1
公开(公告)日：2007-04-19
申请号：US11549831
申请日：2006-10-16
申请人： Michael Cima , John Santini , Kurt Shelton , James Prescott , Mark Staples , Jonathan Coppeta
发明人： Michael Cima , John Santini , Kurt Shelton , James Prescott , Mark Staples , Jonathan Coppeta
IPC分类号： A61F2/30 , A61F2/28 , A61B6/12
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/037 , A61B6/481 , A61B8/481 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4425 , A61F2/4657 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30075 , A61F2002/30113 , A61F2002/30154 , A61F2002/30156 , A61F2002/30326 , A61F2002/30673 , A61F2002/30677 , A61F2002/30682 , A61F2002/30733 , A61F2002/30787 , A61F2002/3081 , A61F2002/30838 , A61F2002/30878 , A61F2002/30884 , A61F2002/30904 , A61F2002/30971 , A61F2002/3401 , A61F2002/3456 , A61F2002/3469 , A61F2002/3495 , A61F2002/3611 , A61F2002/3625 , A61F2002/4662 , A61F2002/488 , A61F2210/0004 , A61F2210/0061 , A61F2230/0006 , A61F2230/0021 , A61F2230/0023 , A61F2250/0014 , A61F2250/0037 , A61F2310/00011 , A61F2310/00179 , A61L27/50
摘要： A method is provided for non-invasively detecting mechanical wear of a prosthetic device implanted in a patient, the method comprises using a non-invasive imaging technique to image the prosthetic device that includes a wear indicating composition; and detecting whether the wear indicating composition has been released from the prosthetic device, and, if so, the location, type, and/or amount thereof. The implant device includes a prosthetic device body having at least one outer surface area; at least one reservoir (e.g., a plurality of discretely spaced micro-reservoirs) in the device body; a wear indicator composition disposed in said at least one reservoir, wherein mechanical wear of the at least one outer surface area of the device body in vivo causes release of at least part of the wear indicator composition. The prosthetic device body may be one for replacement of a hip, a knee, a shoulder, an elbow, or a vertebra.
摘要翻译：提供了一种用于非侵入性地检测植入患者体内的假体装置的机械磨损的方法，所述方法包括使用非侵入性成像技术对包括磨损指示组合物的假体装置进行成像; 以及检测磨损指示组合物是否已经从假体装置释放，以及如果是，则其位置，类型和/或数量。植入装置包括具有至少一个外表面区域的假体装置主体; 设备主体中的至少一个储存器（例如，多个离散间隔的微储器）; 布置在所述至少一个储存器中的磨损指示剂组合物，其中所述装置主体的所述至少一个外表面区域的体内机械磨损导致所述磨损指示剂组合物的至少一部分的释放。假体装置主体可以是用于替换髋部，膝盖，肩部，肘部或椎骨的人造体。

9. 发明申请

US20050149000A1 Medical device with controlled reservoir opening 有权
标题翻译：具有受控储存器开口的医疗装置
公开(公告)号：US20050149000A1
公开(公告)日：2005-07-07
申请号：US11041161
申请日：2005-01-21
申请人： John Santini , Michael Cima , Robert Langer , Achim Gopferich
发明人： John Santini , Michael Cima , Robert Langer , Achim Gopferich
IPC分类号： A61K9/00 , A61M37/00 , A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Reservoir-based medical devices are provided. In one embodiment, the medical device comprises a substrate; at least two discrete, microfabricated reservoirs provided in spaced positions across at least one surface of the substrate; discrete reservoir caps covering the at least two reservoirs; and control circuitry for selectively disintegrating the reservoir caps to open the reservoirs. The reservoirs of the device can include a diagnostic reagent or other molecules useful in medical diagnostics. In one embodiment, the reservoir cap comprises an anode and the control circuitry comprises a cathode and a power source for creating an electric potential between the cathode and the anode. Application of the electric potential causes the reservoir cap to disintegrate, thereby opening the reservoir.
摘要翻译：提供了基于水库的医疗设备。在一个实施例中，医疗装置包括基底; 至少两个离散的，微制造的储存器，跨过衬底的至少一个表面设置在间隔位置; 覆盖至少两个储存器的分立贮存器盖; 以及用于选择性地分解储存器盖以打开储存器的控制电路。装置的储存器可以包括诊断试剂或用于医学诊断的其它分子。在一个实施例中，储存器盖包括阳极，并且控制电路包括用于在阴极和阳极之间产生电位的阴极和电源。施加电势会导致储存器盖分解，从而打开储存器。

10. 发明申请

US20080051766A1 Method for Operating Microchip Reservoir Device 有权
标题翻译： Microchip储存器件的工作方法
公开(公告)号：US20080051766A1
公开(公告)日：2008-02-28
申请号：US11930406
申请日：2007-10-31
申请人： John Santini , Michael Cima , Robert Langer
发明人： John Santini , Michael Cima , Robert Langer
IPC分类号： A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： A method is provided for operating a device for the containment and controlled release or exposure of a chemical substance. The method includes (i) providing a device which includes a substrate having a plurality of reservoirs, at least one chemical substance stored in the reservoirs, a plurality of metal reservoir caps, each of which closes an opening of one of said reservoir caps, and power and electrode means for disintegrating each of said reservoir caps; and (ii) disintegrating at least one of said reservoir caps, using said power and electrode means, to expose or release the chemical substance, wherein said disintegration comprises using potentiostatic or galvanostatic control to a voltage potential at said at least one reservoir cap.
摘要翻译：提供了一种用于操作用于化学物质的容纳和控制释放或暴露的装置的方法。该方法包括（i）提供一种装置，其包括具有多个储存器的基板，存储在储存器中的至少一种化学物质，多个金属储存器盖，每个金属储存器盖封闭其中一个储存器盖的开口，以及功率和电极装置，用于分解每个所述储存器盖; 以及（ii）使用所述功率和电极装置分解至少一个所述储存器盖以暴露或释放所述化学物质，其中所述分解包括对所述至少一个储存器盖的电压电位进行恒电位或恒电流控制。

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