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1. 发明授权

US07255874B1 Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto 失效
标题翻译：生物相容性聚合物和粘合剂：与其相关的组合物，制备和使用方法
公开(公告)号：US07255874B1
公开(公告)日：2007-08-14
申请号：US10024143
申请日：2001-12-21
申请人： John S. Bobo , Julian A. Quintero , Jerry Y. Jonn , Joe B. Barefoot , Jeffrey G. Clark , Upvan Narang , Scott Marc Cannizaro , J. Christopher Marmo
发明人： John S. Bobo , Julian A. Quintero , Jerry Y. Jonn , Joe B. Barefoot , Jeffrey G. Clark , Upvan Narang , Scott Marc Cannizaro , J. Christopher Marmo
IPC分类号： A61K9/127
CPC分类号： A61K9/5026 , A61L24/06 , A61L27/34 , C08L35/04
摘要： Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.
摘要翻译：生物相容的聚合物和粘合剂具有氰基丙烯酸核心和其它取代基，例如治疗剂，靶向部分，成像剂，氨基酸残基或其它有机部分。本发明组合物的示例性用途包括用作医疗用途的密封剂和粘合剂，以及用作生物相容性植入物和基质和药物递送的聚合物制剂。

2. 发明申请

US20080241249A1 Cyanoacrylate composite 审中-公开
标题翻译：氰基丙烯酸酯复合材料
公开(公告)号：US20080241249A1
公开(公告)日：2008-10-02
申请号：US11731839
申请日：2007-03-30
申请人： Julian A. Quintero , Jerry Y. Jonn
发明人： Julian A. Quintero , Jerry Y. Jonn
IPC分类号： A61K9/00 , A61K31/78 , A61P17/00
CPC分类号： A61K31/78 , A61L24/0089 , A61L24/06 , C08L35/04
摘要： An adhesive composite composition is provided including one or more polymerizable monomers and one or more metal stearates. The one or more polymerizable monomers may be a cyanoacrylate monomer. The adhesive composite composition may further comprise a plasticizer, an initiator, a rate modifier, a stabilizer, a colorant, a heat dissipating agent, or other additives. Methods for the application of the adhesive composite compositions to living tissue are also provided. The adhesive composite composition provides an adhesive composite material upon polymerization which is a polymer matrix entrapping the metal stearate. Polymerization of the adhesive composite composition at a site on living tissue provides an adhesive composite material which promotes microcirculation and tissue growth at the site of application of the adhesive composite composition.
摘要翻译：提供了包含一种或多种可聚合单体和一种或多种金属硬脂酸酯的粘合剂复合组合物。一种或多种可聚合单体可以是氰基丙烯酸酯单体。粘合剂复合组合物还可以包含增塑剂，引发剂，速率调节剂，稳定剂，着色剂，散热剂或其它添加剂。还提供了将粘合剂复合组合物应用于生物体组织的方法。粘合剂复合组合物在聚合时提供粘合剂复合材料，其是捕获金属硬脂酸酯的聚合物基质。粘合剂复合组合物在活组织部位的聚合提供粘合剂复合材料，其在粘合剂复合组合物的应用位置促进微循环和组织生长。

3. 发明授权

US08376642B2 Applicators, dispensers and methods for dispensing and applying adhesive material 有权
标题翻译：涂抹器，分配器以及分配和施加粘合剂材料的方法
公开(公告)号：US08376642B2
公开(公告)日：2013-02-19
申请号：US11928658
申请日：2007-10-30
申请人： Julian A. Quintero , Jerry Y. Jonn , Jack Goodman , Daniel L. Hedgpeth , William M. Cotter
发明人： Julian A. Quintero , Jerry Y. Jonn , Jack Goodman , Daniel L. Hedgpeth , William M. Cotter
IPC分类号： B43K5/14
CPC分类号： A61B17/0057 , A61B17/00491 , B05C17/002 , B05C17/00583 , B05C17/00586 , B05C17/0116
摘要： An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.
摘要翻译：一种用于分配和/或施加粘合剂材料的施加器/分配器组件包括：第一主体部分和第二主体部分，第一和第二主体部分中的至少一个可相对于第一和第二主体部分中的另一个运动; 在所述第一和第二主体部分中的至少一个中的空腔; 以及布置在所述第一和第二主体部分中的一个上的刺穿或断裂构件。第一和第二主体部分中的一个相对于第一和第二主体部分中的另一个的移动将穿孔或断裂部件移动到空腔中。当粘合剂材料的容器至少部分地设置在空腔内时，第一和第二主体部分之一相对于另一主体部分的运动移动穿孔或断裂部件以使容器破裂以分配和/或施加粘合剂材料。

4. 发明申请

US20080003196A1 Absorbable cyanoacrylate compositions 审中-公开
标题翻译：可吸收的氰基丙烯酸酯组合物
公开(公告)号：US20080003196A1
公开(公告)日：2008-01-03
申请号：US11479424
申请日：2006-06-30
申请人： Jerry Y. Jonn , Ibraheem T. Badejo , Julian A. Quintero , Teresa Warren , Melanie A. Vander Klok
发明人： Jerry Y. Jonn , Ibraheem T. Badejo , Julian A. Quintero , Teresa Warren , Melanie A. Vander Klok
IPC分类号： A61K31/74
CPC分类号： C09J4/00 , A61L24/06 , C08L33/00
摘要： An adhesive composition is provided including one or more polymerizable cyanoacrylate monomers and boron trifluoride as a stabilizer or complexing agent. The adhesive composition may also include or be used with a decomplexing agent, particularly one or more quaternary ammonium fluoride salts or one or more quaternary ammonium ether salts. A polymerization initiator or accelerator may also be used. The viscosity of the adhesive composition may be controlled by addition of a thickening agent which may be a polymer or copolymer catalyzed by a boron trifluoride complex or compound. Methods for the application of the adhesive compositions to living tissue are also provided.
摘要翻译：提供了包含一种或多种可聚合的氰基丙烯酸酯单体和三氟化硼作为稳定剂或络合剂的粘合剂组合物。粘合剂组合物还可以包括或与解络剂一起使用，特别是一种或多种季铵氟化物盐或一种或多种季铵醚盐。也可以使用聚合引发剂或促进剂。粘合剂组合物的粘度可以通过加入增稠剂来控制，增稠剂可以是由三氟化硼配合物或化合物催化的聚合物或共聚物。还提供了将粘合剂组合物施用于生物组织的方法。

5. 发明授权

US07306390B2 Applicators, dispensers and methods for dispensing and applying adhesive material 有权
标题翻译：涂抹器，分配器以及分配和施加粘合剂材料的方法
公开(公告)号：US07306390B2
公开(公告)日：2007-12-11
申请号：US10663909
申请日：2003-09-17
申请人： Julian A. Quintero , Jerry Y. Jonn , Jack Goodman , Daniel L. Hedgpeth , William M. Cotter
发明人： Julian A. Quintero , Jerry Y. Jonn , Jack Goodman , Daniel L. Hedgpeth , William M. Cotter
IPC分类号： B43K5/14
CPC分类号： B05C17/00583 , A61B17/00491 , B05C17/002 , B05C17/00586 , B05C17/0116
摘要： An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.
摘要翻译：一种用于分配和/或施加粘合剂材料的施加器/分配器组件包括：第一主体部分和第二主体部分，第一和第二主体部分中的至少一个可相对于第一和第二主体部分中的另一个运动; 在所述第一和第二主体部分中的至少一个中的空腔; 以及布置在所述第一和第二主体部分中的一个上的刺穿或断裂构件。第一和第二主体部分中的一个相对于第一和第二主体部分中的另一个的移动将穿孔或断裂部件移动到空腔中。当粘合剂材料的容器至少部分地设置在空腔内时，第一和第二主体部分之一相对于另一主体部分的运动移动穿孔或断裂部件以使容器破裂以分配和/或施加粘合剂材料。

6. 发明授权

US06607631B1 Adhesive compositions with reduced coefficient of friction 有权
标题翻译：具有降低的摩擦系数的粘合剂组合物
公开(公告)号：US06607631B1
公开(公告)日：2003-08-19
申请号：US09657912
申请日：2000-09-08
申请人： Ibraheem T. Badejo , Wendy Y. Su , Keith R. D'Alessio , Jerry Jonn , Julian A. Quintero , Michelle Knotts , Timothy P. Hickey , Lawrence H. Mainwaring , Upvan Narang
发明人： Ibraheem T. Badejo , Wendy Y. Su , Keith R. D'Alessio , Jerry Jonn , Julian A. Quintero , Michelle Knotts , Timothy P. Hickey , Lawrence H. Mainwaring , Upvan Narang
IPC分类号： C09J18304
CPC分类号： A61L24/06 , C09J4/00 , C08L35/04 , C08F222/32
摘要： A polymerizable monomer adhesive composition includes a 1,1-disubstituted ethylene monomer and at least one slip additive, where the slip additive causes a polymer film formed from the monomer to have a lower coefficient of friction than in an absence of the slip additive. The slip additive can be selected from, inter alia, fluorinated monomers or polymers, fluorinated additives, siloxane-containing monomers or polymers, siloxane-containing additives, fluorinated siloxanes, and long chain fatty acid esters. The slip additive can also form a second phase in a resultant polymer film, where the second phase is soluble in the monomer but is insoluble or substantially insoluble in the polymer.
摘要翻译：可聚合单体粘合剂组合物包括1,1-双取代的乙烯单体和至少一种滑爽添加剂，其中滑爽添加剂使得由单体形成的聚合物膜的摩擦系数低于不存在滑爽添加剂的摩擦系数。滑爽添加剂尤其可以选自氟化单体或聚合物，氟化添加剂，含硅氧烷的单体或聚合物，含硅氧烷的添加剂，氟化硅氧烷和长链脂肪酸酯。滑爽添加剂还可以在所得聚合物膜中形成第二相，其中第二相可溶于单体，但不溶或基本上不溶于聚合物。

7. 发明授权

US06705790B2 Adhesive applicators with improved applicator tips 有权
标题翻译：粘合剂涂抹器具有改进的涂抹器尖端
公开(公告)号：US06705790B2
公开(公告)日：2004-03-16
申请号：US10134603
申请日：2002-04-30
申请人： Julian A. Quintero , Keith R. D'Alessio , Daniel L. Hedgpeth , Roy Thompson
发明人： Julian A. Quintero , Keith R. D'Alessio , Daniel L. Hedgpeth , Roy Thompson
IPC分类号： B43M1100
CPC分类号： B65D81/32 , B65D83/00
摘要： An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.
摘要翻译：用于分配粘合剂材料的涂布器包括保持粘合剂材料的容器主体和构造成允许改进粘合剂的控制和经济性的施用器顶端。

8. 发明授权

US06547467B2 Microapplicators, delivery systems and methods for adhesives and sealants 有权
标题翻译：微型应用，交付系统和粘合剂和密封剂的方法
公开(公告)号：US06547467B2
公开(公告)日：2003-04-15
申请号：US09941217
申请日：2001-08-29
申请人： Julian A. Quintero
发明人： Julian A. Quintero
IPC分类号： A61L2400
CPC分类号： A61B17/00491 , A61M35/003 , B05C17/002 , Y10S206/813
摘要： A microapplicator for dispensing and applying an adhesive or sealant material comprises a handle portion, an applicator tip connected to the handle portion, and a microreservoir at the applicator tip arranged to hold a small amount, about 20 microliters or less, of an adhesive/sealant material until dispensing. In embodiments, the applicator tip has a width of about 1 mm. The microapplicator may include a second reservoir, containing the adhesive/sealant material, that is arranged to supply the adhesive/sealant material to the microreservoir at the applicator tip. The second reservoir may comprise a frangible ampoule disposed in the handle portion, a container, such as a syringe, connected to the handle portion, or the handle portion itself. The applicator tip may comprise one of a polymer loop, a spatula, a rolling ball, a grate, a porous material, such as a swab, a foam pad or a mesh, and a brush.
摘要翻译：用于分配和施加粘合剂或密封剂材料的微型施用器包括手柄部分，连接到手柄部分的施用器尖端和在施用器尖端处的微型储存器，其被布置成保持约20微升或更小的粘合剂/密封剂材料直到分配。在实施例中，施用器尖端具有约1mm的宽度。微型施用器可以包括容纳粘合剂/密封剂材料的第二储存器，其被布置成在施用器尖端处将粘合剂/密封剂材料供应到微储存器。第二储存器可以包括设置在手柄部分中的易碎安瓿，连接到手柄部分或手柄部分本身的容器，例如注射器。施用器尖端可以包括聚合物环，刮铲，滚球，格栅，多孔材料（例如棉签，泡沫垫或网）和刷子中的一种。

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