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1. 发明申请

US20050119176A1 Methods and compositions for derepression of IAP-inhibited caspase 审中-公开
标题翻译：用于抑制IAP抑制半胱天冬酶的方法和组合物
公开(公告)号：US20050119176A1
公开(公告)日：2005-06-02
申请号：US10748128
申请日：2003-12-24
申请人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： A61K38/00 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K5/117 , C07K7/06 , C12N9/99 , A61K38/52
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K5/1027 , C07K7/06
摘要： The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24, a core structure selected from the group of TPI 759, TPI 882, TPI 914 or TPI 927; and a core structure from a library selected from TPI 1391, TPI 1349, TPI 1396, TPI 1509, TPI 1540, TPI 1400, TPI 792 and TPI 1332, wherein the agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase.
摘要翻译：本发明提供了具有选自核心肽5至39和42至55的核心肽的分离的试剂，其中所述试剂减阻IAP抑制的半胱天冬酶。还提供了一种隔离剂，其具有选自图中的任何一种结构的核心结构。 5,9，10,114和21-24，选自TPI 759，TPI 882，TPI 914或TPI 927的核心结构; 以及来自选自TPI1391，TPI1349，TPI1396，TPI1509，TPI1540，TPI1400，TPI792和TPI1332的文库的核心结构，其中所述试剂去抑制IAP抑制的半胱天冬酶。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。

2. 发明申请

US20060258581A1 Methods and composition for derepressions of IAP-inhibited caspase 审中-公开
标题翻译：抑制IAP抑制半胱天冬酶的方法和组成
公开(公告)号：US20060258581A1
公开(公告)日：2006-11-16
申请号：US11251617
申请日：2005-10-14
申请人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： A61K38/54
CPC分类号： A61K31/337 , A61K31/17 , A61K31/704 , A61K31/7048 , A61K38/1761 , A61K45/06 , G01N33/573 , G01N2333/95 , G01N2500/02 , G01N2510/00 , A61K2300/00
摘要： The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, 21-24 and 48, a core structure selected from the group of TPI 759, TPI 882, TPI 914 or TPI 927; and a core structure from a library selected from TPI 1391, TPI 1349, TPI 1396, TPI 1509, TPI 1540, TPI 1400, TPI 792, TPI 1332, TPI 1567, TPI 1576 and TPI 1577, wherein the agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase.
摘要翻译：本发明提供了具有选自核心肽5至39和42至55的核心肽的分离的试剂，其中所述试剂减阻IAP抑制的半胱天冬酶。还提供了一种隔离剂，其具有选自图1和图2所示的任何结构的芯结构。 5,9,10,14B，21-24和48，选自TPI 759，TPI 882，TPI 914或TPI 927的核心结构; 和来自选自TPI1391，TPI1349，TPI1396，TPI1509，TPI1540，TPI1400，TPI792，TPI1332，TPI1567，TPI1576和TPI1577的文库的核心结构，其中所述试剂去抑制IAP抑制半胱天冬酶本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。

3. 发明申请

US20070003535A1 Methods and compositions for derepression of IAP-inhibited caspase 审中-公开
公开(公告)号：US20070003535A1
公开(公告)日：2007-01-04
申请号：US11084714
申请日：2005-03-17
申请人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： A61K38/54 , G01N33/574 , C07H21/04 , C12N9/99 , C07K16/40
CPC分类号： C07D207/09 , A61K38/00
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.

4. 发明申请

US20060211627A1 Methods and compositions for derepression of IAP-inhibited caspase 失效
公开(公告)号：US20060211627A1
公开(公告)日：2006-09-21
申请号：US11186629
申请日：2005-07-19
申请人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： A61K38/08 , A61K38/06
CPC分类号： C07D207/09 , A61K38/00
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.

5. 发明申请

US20050159359A1 Methods and compositions for derepression of IAP-inhibited caspase 审中-公开
标题翻译：用于抑制IAP抑制半胱天冬酶的方法和组合物
公开(公告)号：US20050159359A1
公开(公告)日：2005-07-21
申请号：US11021517
申请日：2004-12-23
申请人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John Reed , Richard Houghten , Adel Nefzi , John Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： C12Q1/02 , A61K38/00 , A61P1/04 , A61P3/10 , A61P5/16 , A61P9/10 , A61P17/06 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K5/117 , C07K7/04 , C07K7/06 , C12Q1/37 , A61K38/52 , C07K14/47
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K5/1027
摘要： The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882, TPI914 or TPI927. The methods of the invention also can be used for promoting apoptosis in a cell and for reducing the severity of a pathology characterized by reduced levels of apoptosis. Methods for identifying agents that derepress an IAP-inhibited caspase are also provided.
摘要翻译：本发明提供了具有选自核心肽5至39和42至55的核心肽的分离的试剂，其中所述试剂减阻IAP抑制的半胱天冬酶。还提供了一种隔离剂，其具有选自图1和图2所示的任何结构的芯结构。 5,9,10,14B和21-24，其中所述药物抑制IAP抑制的半胱天冬酶。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。该方法包括使IAP抑制的半胱天冬酶与有效量的试剂接触以对抑制IAP-抑制的半胱天冬酶进行脱保护，该试剂具有选自核心肽的核心基序，所述核心基序具有核心肽 4至39和42至55，以及选自TPI759，TPI882，TPI914或TPI927的核心结构。本发明的方法还可用于促进细胞凋亡和降低以凋亡水平降低为特征的病理学的严重性。还提供了用于鉴定抑制IAP抑制的半胱天冬酶的药剂的方法。

6. 发明授权

US11172653B1 Squirrel repelling bird feeder 有权
公开(公告)号：US11172653B1
公开(公告)日：2021-11-16
申请号：US16747605
申请日：2020-01-21
申请人： John Reed , Undrella Reed
发明人： John Reed , Undrella Reed
IPC分类号： A01K39/00
摘要： The squirrel repelling bird feeder comprises a first pole section, a second pole section, a cable, a baffle, and a bird feeder. The squirrel repelling bird feeder may be adapted to feed birds from the bird feeder. The bird feeder may be suspended above the ground via the first pole section and the second pole section. The baffle may prevent squirrels from accessing bird seed in the bird feeder. The bird feeder may be lowered via the cable for refilling. The feeder may be retained in an elevated position by securing an end of the cable to an anchor located on the second pole.

7. 发明申请

US20080172708A1 Point-to-multipoint high definition multimedia transmitter and receiver 失效
标题翻译：点对多点高清多媒体发射机和接收机
公开(公告)号：US20080172708A1
公开(公告)日：2008-07-17
申请号：US11896970
申请日：2007-09-07
申请人： Jedd Perry , James Pursel , Lawrence Lo , Phil Kent , Bob Seifert , Luis Reyes , Jeff Fore , Wes Wirth , Doug Collins , John Hoskyn , Edwin Wong , Mike Straub , John Reed , Keith Schuettpelz , Karl Mills
发明人： Jedd Perry , James Pursel , Lawrence Lo , Phil Kent , Bob Seifert , Luis Reyes , Jeff Fore , Wes Wirth , Doug Collins , John Hoskyn , Edwin Wong , Mike Straub , John Reed , Keith Schuettpelz , Karl Mills
IPC分类号： H04N7/173
CPC分类号： H04W72/005 , H04W84/20
摘要： A high definition video transmitter and receiver are disclosed. The transmitter provides high definition video to a one-point receiver or to multipoint receivers. The transmission network is asynchronous and the receiver re-synchronizes the video. The transmission can be wired or wireless.
摘要翻译：公开了一种高分辨率视频发射机和接收机。发射机向单点接收机或多点接收机提供高清晰度视频。传输网络是异步的，接收机重新同步视频。传输可以是有线或无线。

8. 发明申请

US20070230412A1 Scheduling in wireless communication systems 有权
标题翻译：无线通信系统中的调度
公开(公告)号：US20070230412A1
公开(公告)日：2007-10-04
申请号：US11392077
申请日：2006-03-29
申请人： Sean McBeath , Hao Bi , Danny Pinckley , John Reed , Jack Smith
发明人： Sean McBeath , Hao Bi , Danny Pinckley , John Reed , Jack Smith
IPC分类号： H04Q7/24 , H04Q7/00
CPC分类号： H04W72/1289 , H04W72/121
摘要： A wireless communication infrastructure entity assigns a plurality of schedulable wireless communication entities to a group wherein each entity is assigned a location within the group. The infrastructure entity indicates which of the plurality of schedulable wireless communication entities assigned to the group have been assigned a radio resource, for example in a first bitmap (510), and indicates radio resource allocation policy information (520) and indicates a weighting for each assigned wireless communication entity, for example, in a second bitmap (530), to the schedulable wireless communication entities that have been assigned a radio resource.
摘要翻译：无线通信基础设施实体将多个可调度无线通信实体分配给组，其中每个实体被分配在组内的位置。基础设施实体指示分配给组的多个可调度无线通信实体中的哪一个已经被分配了无线电资源，例如在第一位图（510）中，并且指示无线电资源分配策略信息（520），并且指示每个分配的无线通信实体，例如，在第二位图（530）中，被分配给无线电资源的可调度的无线通信实体。

9. 发明申请

US20070211657A1 Apparatus and Method for Assigning Time Domain Resources to a Receiver 审中-公开
标题翻译：将时域资源分配给接收器的装置和方法
公开(公告)号：US20070211657A1
公开(公告)日：2007-09-13
申请号：US11276656
申请日：2006-03-09
申请人： Sean McBeath , Hao Bi , Danny Pinckley , John Reed , Jack Smith
发明人： Sean McBeath , Hao Bi , Danny Pinckley , John Reed , Jack Smith
IPC分类号： H04Q7/00
CPC分类号： H04W72/0446
摘要： In order to address the above-mentioned need, a method and apparatus for assigning time-domain resources to a wireless receiver is provided herein. During operation a resource assigned to a particular node will comprise a particular-length subframe having a unique combination of a number of contiguous slots and a slot start time. The subframe will repeat after a predetermined number of slots to form a subframe pattern. For a given frequency resource (group of subchannels), each node to which the base station is transmitting a packet will have a unique subframe length, starting slot, and repetition time period. Because each node will be assigned a subframe pattern having a particular length, and because each node's transmissions will begin at varying slots, the resources may be assigned to multiple nodes without having any transmissions overlap.
摘要翻译：为了解决上述需要，本文提供了一种用于向无线接收机分配时域资源的方法和装置。在操作期间，分配给特定节点的资源将包括具有多个连续时隙和时隙开始时间的唯一组合的特定长度子帧。子帧将在预定数量的时隙之后重复以形成子帧模式。对于给定的频率资源（子信道组），基站发送分组的每个节点将具有唯一的子帧长度，起始时隙和重复时间段。因为每个节点将被分配具有特定长度的子帧模式，并且因为每个节点的传输将以不同的时隙开始，所以可以将资源分配给多个节点而不会有任何传输重叠。

10. 发明申请

US20070194976A1 Radar apparatus and processing method for detecting human carried explosive devices 有权
公开(公告)号：US20070194976A1
公开(公告)日：2007-08-23
申请号：US11356997
申请日：2006-02-17
申请人： John Reed , John Gorman
发明人： John Reed , John Gorman
IPC分类号： G01S13/04
CPC分类号： G01S13/04 , G01S7/024 , G01S7/411 , G01S13/34 , G01S13/887
摘要： A linear FM pulse radar with Doppler processing of co-polarized and cross-polarized radar return signals isolates the target echo signal content associated with a moving pedestrian to provide high quality target echo data for standoff HCE detection based on polarimetric signature analysis. Baseband co-polarized and cross-polarized radar return signals are repeatedly and coherently integrated across numerous successive radar return pulses to create co-polarized and cross-polarized range vs. velocity (Doppler) data maps. The co-polarized data map is used to identify a moving pedestrian, and co-polarized and cross-polarized data subsets corresponding to the identified pedestrian are extracted and subjected to polarization signature analysis to determine if the pedestrian is bearing explosive devices. Low pass filtering of the of the baseband co-polarized and cross-polarized radar return signals prior to integration provides range aliasing to reject signal content associated with objects beyond the unambiguous range of the radar apparatus.

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