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1. 发明授权

US06602984B1 Human elastase IV 失效
标题翻译：人弹性蛋白酶IV
公开(公告)号：US06602984B1
公开(公告)日：2003-08-05
申请号：US09613822
申请日：2000-07-11
申请人： John M. Greene , Mark D. Adams
发明人： John M. Greene , Mark D. Adams
IPC分类号： C07K14435
CPC分类号： C12N9/6424 , A61K38/00
摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：人弹性蛋白酶IV多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法，并且用于治疗目的，例如恢复动脉壁的弹性，改善血清脂质异常和改善血清脂蛋白公开了代谢。还公开了针对这种多肽的拮抗剂/抑制剂及其在治疗炎症，关节炎等中的用途。类风湿关节炎和骨关节炎，脓毒性休克，胰腺炎和限制溃疡组织损伤。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

2. 发明授权

US6107075A Human elastase IV 失效
公开(公告)号：US6107075A
公开(公告)日：2000-08-22
申请号：US199793
申请日：1998-11-25
申请人： John M. Greene , Mark D. Adams
发明人： John M. Greene , Mark D. Adams
IPC分类号： C12N15/09 , A61K38/00 , A61K38/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P31/04 , C07H21/04 , C07K16/40 , C12N1/21 , C12N9/64 , C12N9/66 , C12N9/99 , C12N15/12 , C12N15/57 , C12Q1/68 , C12R1/19 , C12Q1/37 , C12N15/63 , C12N15/85
CPC分类号： C12N9/6424 , A61K38/00
摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

3. 发明授权

US5710035A Human elastase IV 失效
标题翻译：人弹性蛋白酶IV
公开(公告)号：US5710035A
公开(公告)日：1998-01-20
申请号：US270584
申请日：1994-07-05
申请人： John M. Greene , Mark D. Adams
发明人： John M. Greene , Mark D. Adams
IPC分类号： C12N15/09 , A61K38/00 , A61K38/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P31/04 , C07H21/04 , C07K16/40 , C12N1/21 , C12N9/64 , C12N9/66 , C12N9/99 , C12N15/12 , C12N15/57 , C12Q1/68 , C12R1/19 , C12N1/18 , C12N1/20 , C12N5/10 , C12N15/63
CPC分类号： C12N9/6424 , A61K38/00
摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration.
摘要翻译：人弹性蛋白酶IV多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法，并且用于治疗目的，例如恢复动脉壁的弹性，改善血清脂质异常和改善血清脂蛋白公开了代谢。还公开了针对这种多肽的拮抗剂/抑制剂及其在治疗炎症，关节炎等中的用途。类风湿关节炎和骨关节炎，脓毒性休克，胰腺炎和限制溃疡组织损伤。

4. 发明授权

US06936688B2 Human chemokine beta-10 mutant polypeptides 失效
标题翻译：人趋化因子β-10突变体多肽
公开(公告)号：US06936688B2
公开(公告)日：2005-08-30
申请号：US10125451
申请日：2002-04-19
申请人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
发明人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
IPC分类号： A61K38/19 , C07H21/04 , C07K14/52 , C12N5/06 , C12N5/10 , C12N15/19 , C12N15/63 , C12P21/02
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/00
摘要： Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译：公开了人趋化因子β-10多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

5. 发明授权

US06790826B2 Human haemopoietic maturation factor 失效
标题翻译：人类造血成熟因子
公开(公告)号：US06790826B2
公开(公告)日：2004-09-14
申请号：US10004832
申请日：2001-12-07
申请人： Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
发明人： Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
IPC分类号： A61K3816
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed are human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and for using such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations are also disclosed. Diagnostic assays are also disclosed to detect both the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译：公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法，并且使用这些多肽来治疗白血病，自身免疫疾病和与血液相关的疾病。还公开了抗这些多肽的拮抗剂及其作为治疗剂用于预防T细胞群扩增的用途。还公开了诊断测定以检测造血成熟因子核酸序列中突变的存在和蛋白质的改变的水平。

6. 发明授权

US06518046B1 Human chemokine &bgr;-9 失效
标题翻译：人趋化因子β-9
公开(公告)号：US06518046B1
公开(公告)日：2003-02-11
申请号：US08793381
申请日：1997-05-19
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： C12N1500
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/523 , G01N33/564 , G01N33/57426 , G01N33/6863 , G01N2333/52
摘要： The present invention relates to Human Ck&bgr;-9 polypeptides and DNA (RNA) encoding such chemolcine polypeptides. Moreover, a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ck&bgr;-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune diseases, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic agent to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective disease, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ck&bgr;-9 coding sequence and over-expression of the Ck&bgr;-9 protein.
摘要翻译：本发明涉及人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）。此外，公开了通过重组技术生产这种多肽的方法。还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的用途。还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

7. 发明授权

US06383737B1 Human oxalyl-CoA Decarboxylase 有权
公开(公告)号：US06383737B1
公开(公告)日：2002-05-07
申请号：US09732020
申请日：2000-12-08
申请人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
发明人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
IPC分类号： C12Q1527
摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.

8. 发明授权

US06346246B1 Antibodies that bind human haemopoietic maturation factor 失效
标题翻译：结合人类造血成熟因子的抗体
公开(公告)号：US06346246B1
公开(公告)日：2002-02-12
申请号：US09333033
申请日：1999-06-15
申请人： Ewen F. Kirkness , Mark D. Adams , Henrik S. Olsen , Craig A. Rosen
发明人： Ewen F. Kirkness , Mark D. Adams , Henrik S. Olsen , Craig A. Rosen
IPC分类号： A61K39395
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译：公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。

9. 发明授权

US06255077B1 Human DNA topoisomerase I &agr; 有权
标题翻译：人类DNA拓扑异构酶Iα
公开(公告)号：US06255077B1
公开(公告)日：2001-07-03
申请号：US09325430
申请日：1999-06-04
申请人： Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann
发明人： Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann
IPC分类号： C12N1563
CPC分类号： C12N9/90 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y599/01002
摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

10. 发明授权

US06188279B1 Low cost miniature broadband linearizer 有权
标题翻译：低成本微型宽带线性化电路
公开(公告)号：US06188279B1
公开(公告)日：2001-02-13
申请号：US09433128
申请日：1999-11-03
申请人： Cindy H. C. Yuen , Mark D. Adams , James A. Fuchs , Kirk G. Laursen , Steve S. Yang
发明人： Cindy H. C. Yuen , Mark D. Adams , James A. Fuchs , Kirk G. Laursen , Steve S. Yang
IPC分类号： H03F126
CPC分类号： H03F1/3252 , H03F1/3276
摘要： A broadband linearizer for use with a power amplifier. The broadband linearizer includes a preamplifier, a postamplifier and a broadband linearizer bridge coupled between the preamplifier and postamplifier. The linearizer bridge comprises a power divider for coupling power to linear and nonlinear arms, and a power combiner for combining outputs of the linear and nonlinear arms. The linear arm includes a first equalizer and a delay line, and the nonlinear arm includes a distortion generator and an attenuator. A second equalizer is coupled between the power combiner and the postamplifier. A control circuit controls settings of the preamplifier, the broadband linearizer bridge, and the postamplifier. The control circuit outputs voltage bias and constant current signals to control operation of the broadband linearizer. The broadband linearizer provides for independent, flexible gain and phase control that can mate with different kinds of power amplifiers, such as travelling wave tube amplifiers and solid state power amplifiers having various gain and phase performance.
摘要翻译：用于功率放大器的宽带线性化电路。宽带线性化器包括前置放大器，后置放大器和耦合在前置放大器和后置放大器之间的宽带线性化电路桥。线性化电桥包括用于将功率耦合到线性和非线性臂的功率分配器和用于组合线性和非线性臂的输出的功率组合器。线性臂包括第一均衡器和延迟线，非线性臂包括失真发生器和衰减器。功率组合器和后置放大器之间耦合第二均衡器。控制电路控制前置放大器，宽带线性化电路桥和后置放大器的设置。控制电路输出电压偏置和恒流信号，以控制宽带线性化电路的工作。宽带线性化电路提供独立，灵活的增益和相位控制，可以与不同种类的功率放大器匹配，如行波管放大器和具有各种增益和相位性能的固态功率放大器。

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