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1. 发明申请

US20120330328A1 TISSUE FIXATION DEVICES AND A TRANSORAL ENDOSCOPIC GASTROESOPHAGEAL FLAP VALVE RESTORATION DEVICE AND ASSEMBLY USING SAME 审中-公开
标题翻译：组织固定装置和转移性内镜胃气道瓣瓣恢复装置及其组装
公开(公告)号：US20120330328A1
公开(公告)日：2012-12-27
申请号：US13604276
申请日：2012-09-05
申请人： Steve G. BAKER , Brett J. Carter , Stefan J.M. Kraemer , Clifton A. Alferness , John M. Adams
发明人： Steve G. BAKER , Brett J. Carter , Stefan J.M. Kraemer , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.
摘要翻译：携带在组织穿刺部署线上的组织紧固件将哺乳动物身体的组织层紧固在一起。紧固件包括第一构件，第二构件和在第一构件和第二构件之间延伸的连接构件。第一和第二构件基本上彼此平行。紧固件可以在有限的空间和各种应用中部署，包括恢复胃食管瓣阀。

2. 发明申请

US20080097324A1 Disposable infusion device with linear peristaltic pump 有权
标题翻译：一次性输液装置，带有线性蠕动泵
公开(公告)号：US20080097324A1
公开(公告)日：2008-04-24
申请号：US11516456
申请日：2006-09-06
申请人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
发明人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
IPC分类号： A61M1/00
CPC分类号： A61M5/14248 , A61M5/152
摘要： A wearable infusion device delivers a liquid medicant, such as insulin, to a patient. The infusion device comprises a base that contacts a patient's skin and a reservoir arranged to contain a liquid medicant to be delivered beneath a patient's skin. The reservoir has an outlet through which the medicant flows. The infusion device further includes a flexible conduit communicating with the outlet of the reservoir and a pump that causes the medicant to flow down the conduit.
摘要翻译：可佩戴的输注装置将诸如胰岛素的液体药物递送给患者。输注装置包括接触患者皮肤的基部和布置成容纳要在患者皮肤下方递送的液体药物的储存器。储存器具有药物流过的出口。输液装置还包括与储存器的出口连通的柔性导管和使得药物沿管道流下的泵。

3. 发明授权

US07270676B2 Mitral valve therapy device, system and method 有权
标题翻译：二尖瓣治疗装置，系统及方法
公开(公告)号：US07270676B2
公开(公告)日：2007-09-18
申请号：US10925570
申请日：2004-08-24
申请人： Clifton A. Alferness , John M. Adams , John Melmoth Power
发明人： Clifton A. Alferness , John M. Adams , John Melmoth Power
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： An assembly and method for effecting the condition of a mitral valve annulus of a heart includes a guide wire configured to be fed into the coronary sinus of the heart, and a mitral valve annulus therapy device configured to be slidingly received on the guide wire and advanced into the coronary sinus of the heart on the guide wire. A guide tube may further be employed for guiding the device into the coronary sinus. An introducer which may be employed for pushing the device into or pulling device out of the heart has a mechanism for releasably locking to the device. This enables substitution of the device if needed. Also, the crossover point of the circumflex artery and coronary sinus may be determined and avoided when the device is deployed.
摘要翻译：用于实现心脏二尖瓣环的状态的组件和方法包括：构造成供给到心脏的冠状窦内的导线，以及构造成滑动地容纳在导丝上并提前的二尖瓣环空间治疗装置进入导丝的心脏冠状窦。还可以使用导管来将装置引导到冠状窦中。可以用于将装置推入或拉出装置离开心脏的导引器具有用于可释放地锁定到装置的机构。如果需要，这可以替代设备。此外，当部署装置时，可以确定并避免回旋动脉和冠状窦的交叉点。

4. 发明授权

US07179282B2 Device and method for modifying the shape of a body organ 有权
公开(公告)号：US07179282B2
公开(公告)日：2007-02-20
申请号：US10429171
申请日：2003-05-02
申请人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
发明人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
IPC分类号： A61F2/06 , A61B19/00 , A61M29/00
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

5. 发明授权

US5766224A Temporary, post-heart surgery cardioverting and pacing system and lead systems for use therein 失效
标题翻译：临床，心脏手术后心脏转复和起搏系统及其使用的引导系统
公开(公告)号：US5766224A
公开(公告)日：1998-06-16
申请号：US627688
申请日：1996-04-02
申请人： Clifton A. Alferness , John M. Adams , Gregory M. Ayers , Hugo X. Gonzalez
发明人： Clifton A. Alferness , John M. Adams , Gregory M. Ayers , Hugo X. Gonzalez
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/0587
摘要： A post-surgical atrial cardioverting, atrial pacing, and ventricular pacing system and lead system provides for cardioverting the atria, pacing the atria, and/or pacing the ventricles of the heart of a post-surgical heart patient. The system includes a first lead and a second lead providing a pair of atrial cardioverting electrodes, an atrial pacing electrode, and a ventricular pacing electrode. The electrodes are electrically isolated from each other. The system further includes at least one anchor releasably disposing the electrodes beneath the skin of the patient with each atrial cardioverting electrode electrically contacting a respective given one of the atria, the atrial pacing electrode electrically contacting one of the atria, and the ventricular pacing electrode electrically contacting a ventricle. The system further includes at least one of an external cardiovertor coupled to the cardioverting electrodes for cardioversion, an external atrial pacer coupled to the atrial pacing electrode and one of the atrial cardioverting electrodes for pacing the atria, and an external ventricular pacer coupled to the ventricular pacing electrode and one of the atrial cardioverting electrodes for pacing the ventricles.
摘要翻译：手术后心房心律转复，心房起搏和心室起搏系统和牵引系统提供心脏转移心房，起搏心房和/或起搏手术后心脏病人心脏的心室。该系统包括提供一对心房心脏转复电极，心房起搏电极和心室起搏电极的第一引线和第二引线。电极彼此电隔离。所述系统还包括至少一个锚定器，其可释放地将电极设置在患者皮肤下方，每个心房心脏转复电极与相应的心房起搏器电气接触，心房起搏电极与心房起搏器电气接触，接触心室。该系统还包括耦合到用于心脏复律的复律电极的外部心脏转换器中的至少一个，耦合到心房起搏电极的外部心房起搏器和用于起搏心房的心房心律转换电极之一和与心室联接的外部心室起搏器起搏电极和心房心律转复电极之一用于起搏心室。

6. 发明授权

US5279291A Method for atrial defibrillation 失效
标题翻译：心房除颤方法
公开(公告)号：US5279291A
公开(公告)日：1994-01-18
申请号：US924323
申请日：1992-08-03
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. An endocardial lead is also described which ensures that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了一种心内膜导联，其确保输送的心房除颤电能基本上限于心脏的心房。

7. 发明授权

US10064615B2 Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same 有权
公开(公告)号：US10064615B2
公开(公告)日：2018-09-04
申请号：US13604276
申请日：2012-09-05
申请人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams
发明人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/04 , A61B17/064 , A61B17/068 , A61B17/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.

8. 发明授权

US08956374B2 Shockwave balloon catheter system 有权
公开(公告)号：US08956374B2
公开(公告)日：2015-02-17
申请号：US13049199
申请日：2011-03-16
申请人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
发明人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/22 , A61B17/225 , A61B17/3207
CPC分类号： A61B17/22022 , A61B17/2202 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B2017/22001 , A61B2017/22021 , A61B2017/22024 , A61B2017/22025 , A61B2017/22038 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062
摘要： A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.

9. 发明授权

US08956371B2 Shockwave balloon catheter system 有权
标题翻译：冲击波球导管系统
公开(公告)号：US08956371B2
公开(公告)日：2015-02-17
申请号：US12482995
申请日：2009-06-11
申请人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
发明人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/22 , A61B17/225 , A61B17/3207
CPC分类号： A61B17/22022 , A61B17/2202 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B2017/22001 , A61B2017/22021 , A61B2017/22024 , A61B2017/22025 , A61B2017/22038 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062
摘要： A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.
摘要翻译：用于破坏体腔内的障碍物的系统包括导管，其包括细长的载体，围绕载体与其密封的关系的气囊，所述气囊被布置成在其中容纳使气囊膨胀的流体，以及包括至少一个电极的电弧发生器气球在气球内形成机械冲击波。该系统还包括向电弧发生器提供电能的电源。

10. 发明授权

US08162923B2 Disposable infusion device with automatic unlocking mechanism 有权
标题翻译：具有自动解锁机构的一次性输液装置
公开(公告)号：US08162923B2
公开(公告)日：2012-04-24
申请号：US11516812
申请日：2006-09-06
申请人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
发明人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
IPC分类号： A61K9/22
CPC分类号： A61M5/152 , A61M5/14248
摘要： A wearable infusion device delivers a liquid medicant to a patient. The infusion device comprises a base that contacts a patient's skin and a reservoir arranged to be filled with a liquid medicant to be delivered beneath a patient's skin. The reservoir has an outlet through which the medicant flows. The infusion device further comprises a flexible conduit communicating with the outlet of the reservoir, a pump that causes the medicant to flow down the conduit, an actuator that performs a function related to the operation of the device, and an enable mechanism that enables the actuator in response to the filling of the reservoir with the liquid medicant.
摘要翻译：可戴式输液装置将液体药剂递送给患者。输液装置包括接触患者皮肤的基部和布置成填充有待在患者皮肤下方递送的液体药物的储存器。储存器具有药物流过的出口。输液装置还包括与储存器的出口连通的柔性导管，使得药剂沿着管道流下的泵，执行与装置的操作有关的功能的致动器，以及启动机构，其使致动器响应于用液体药物填充储存器。

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