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1. 发明申请

US20160374810A1 TISSUE SHAPING DEVICE 审中-公开
公开(公告)号：US20160374810A1
公开(公告)日：2016-12-29
申请号：US15261628
申请日：2016-09-09
申请人： Mark L. MATHIS , Leonard KOWALSKY , David G. REUTER , Cruz BEESON
发明人： Mark L. MATHIS , Leonard KOWALSKY , David G. REUTER , Cruz BEESON
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/2466 , A61F2002/91591 , A61F2210/0014 , A61F2220/0091 , A61F2230/0023 , A61F2250/0004 , A61F2250/0008 , A61F2250/0012 , A61F2250/0086 , A61F2310/00017 , A61F2310/00023
摘要： An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.

2. 发明申请

US20120197389A1 Device and Method for Modifying the Shape of a Body Organ 审中-公开
标题翻译：修饰身体器官形状的装置和方法
公开(公告)号：US20120197389A1
公开(公告)日：2012-08-02
申请号：US13443709
申请日：2012-04-10
申请人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
发明人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
摘要翻译：血管内支持装置包括支撑件或再生线，近端锚和远端锚。支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。锚固件可以锁定到位以将支撑件固定在容器内。

3. 发明授权

US07837729B2 Percutaneous mitral valve annuloplasty delivery system 有权
标题翻译：经皮二尖瓣瓣环成形术输送系统
公开(公告)号：US07837729B2
公开(公告)日：2010-11-23
申请号：US10946332
申请日：2004-09-20
申请人： Lucas S. Gordon , Mark L. Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian J. Doll
发明人： Lucas S. Gordon , Mark L. Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian J. Doll
IPC分类号： A61F2/06
CPC分类号： A61B17/3468 , A61F2/2451 , A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.
摘要翻译：本发明是一种组织成形系统，包括具有可扩张锚和锁的组织成形装置; 输送导管; 输送机构，其适于经由输送导管将患者外部的组织成形装置输送到患者体内的内腔内的目标部位; 以及致动器，其适于将致动力传递到所述锁以将所述锚固件锁定在扩展构型中。本发明也是适于在患者的内腔内的目标部位经皮输送和部署组织整形装置的系统。该系统包括：手柄; 由手柄支撑并适于经由输送导管将组织成形装置从患者外部递送到治疗部位的递送机构; 以及致动器，其由所述手柄支撑并且适于递送致动力以将所述组织整形装置的锚固件以扩展构型锁定。

4. 发明申请

US20050187619A1 Body lumen device anchor, device and assembly 有权
标题翻译：身体流明装置锚，装置和装配
公开(公告)号：US20050187619A1
公开(公告)日：2005-08-25
申请号：US10994161
申请日：2004-11-19
申请人： Mark Mathis , Leonard Kowalsky , David Reuter , Cruz Beeson
发明人： Mark Mathis , Leonard Kowalsky , David Reuter , Cruz Beeson
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/2466 , A61F2002/91591 , A61F2210/0014 , A61F2220/0091 , A61F2230/0023 , A61F2250/0004 , A61F2250/0008 , A61F2250/0012 , A61F2250/0086 , A61F2310/00017 , A61F2310/00023
摘要： An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member. carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.
摘要翻译：锚定器将具有细长体的治疗装置锚定在体腔内。锚固件包括固定构件。承载在可从第一构造调节的装置上，该第一配置允许将装置放置在体腔中至第二配置，该装置将装置固定在体腔内。锚固件还包括将固定构件锁定在第二构造中的锁。固定构件可以锁定在第一构造和最大第二构造之间的多个中间点中的任何一个中。

5. 发明授权

US08182529B2 Percutaneous mitral valve annuloplasty device delivery method 有权
标题翻译：经皮二尖瓣瓣环成形术装置输送方法
公开(公告)号：US08182529B2
公开(公告)日：2012-05-22
申请号：US10945855
申请日：2004-09-20
申请人： Lucas S. Gordon , Mark L. Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian J. Doll
发明人： Lucas S. Gordon , Mark L. Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian J. Doll
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/95 , A61B17/3468 , A61B2017/1205 , A61F2002/9511
摘要： The invention is a method of delivering and deploying a tissue shaping device in a lumen within a patient, with the tissue shaping device including an anchor. In some embodiments the method includes the steps of: inserting a delivery catheter into the lumen; percutaneously delivering the device to a target site within the lumen through a delivery catheter; operating an actuator to expose an anchor; and operating the actuator to lock the anchor. In other, the method includes the steps of: inserting a delivery catheter into the lumen; moving the device from a cartridge into the delivery catheter; delivering the device to a target site within the lumen; operating an actuator to move the delivery catheter with respect to the anchor to expose the anchor; and expanding the anchor.
摘要翻译：本发明是一种在组织整形装置中包括锚固件的方式，将组织成形装置递送和展开在患者体内。在一些实施例中，该方法包括以下步骤：将输送导管插入内腔; 通过输送导管将装置经皮递送到内腔内的目标部位; 操作致动器以暴露锚; 并操作致动器以锁定锚。另外，该方法包括以下步骤：将输送导管插入内腔; 将装置从药筒移动到输送导管中; 将装置输送到管腔内的目标部位; 操作致动器以使输送导管相对于锚固件移动以暴露锚固件; 并扩大锚点。

6. 发明授权

US07828841B2 Device and method for modifying the shape of a body organ 有权
公开(公告)号：US07828841B2
公开(公告)日：2010-11-09
申请号：US11963417
申请日：2007-12-21
申请人： Mark L. Mathis , Leonard Kowalsky , David G. Reuter , Cruz Beeson
发明人： Mark L. Mathis , Leonard Kowalsky , David G. Reuter , Cruz Beeson
IPC分类号： A61F2/06
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

7. 发明授权

US06964683B2 System and method to effect the mitral valve annulus of a heart 有权
标题翻译：影响心脏二尖瓣环的系统和方法
公开(公告)号：US06964683B2
公开(公告)日：2005-11-15
申请号：US10798728
申请日：2004-03-10
申请人： Leonard Kowalsky , Gregory D. Nieminen , Ryan H. Braxtan , Mark L. Mathis
发明人： Leonard Kowalsky , Gregory D. Nieminen , Ryan H. Braxtan , Mark L. Mathis
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： An assembly for effecting the condition of a mitral valve annulus includes a mitral valve therapy device, a coupling structure carried by the device, a catheter, a second coupling structure, and a locking member. To implant the device, the device is first releasably locked to a pushing member by the coupling structures and the locking member. When the device is positioned within the coronary sinus adjacent the mitral valve annulus and deployed, the coupling structures may be released from each other by the release of the locking member.
摘要翻译：用于实现二尖瓣环的状态的组件包括二尖瓣治疗装置，由装置承载的联接结构，导管，第二联接结构和锁定构件。为了植入装置，装置首先通过联接结构和锁定构件可释放地锁定到推动构件。当装置定位在邻近二尖瓣环并展开的冠状窦内时，联接结构可以通过释放锁定构件而相互释放。

8. 发明申请

US20050149180A1 Body lumen device anchor, device and assembly 有权
公开(公告)号：US20050149180A1
公开(公告)日：2005-07-07
申请号：US10994169
申请日：2004-11-19
申请人： Mark Mathis , Leonard Kowalsky , David Reuter , Cruz Beeson
发明人： Mark Mathis , Leonard Kowalsky , David Reuter , Cruz Beeson
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/2466 , A61F2002/91591 , A61F2210/0014 , A61F2220/0091 , A61F2230/0023 , A61F2250/0004 , A61F2250/0008 , A61F2250/0012 , A61F2250/0086 , A61F2310/00017 , A61F2310/00023
摘要： An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.

9. 发明申请

US20050119673A1 Percutaneous mitral valve annuloplasty device delivery method 有权
标题翻译：经皮二尖瓣瓣环成形术装置输送方法
公开(公告)号：US20050119673A1
公开(公告)日：2005-06-02
申请号：US10945855
申请日：2004-09-20
申请人： Lucas Gordon , Mark Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian Doll
发明人： Lucas Gordon , Mark Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian Doll
IPC分类号： A61B17/12 , A61B17/34 , A61F2/06 , A61F2/84 , A61B17/00
CPC分类号： A61F2/95 , A61B17/3468 , A61B2017/1205 , A61F2002/9511
摘要： The invention is a method of delivering and deploying a tissue shaping device in a lumen within a patient, with the tissue shaping device including an anchor. In some embodiments the method includes the steps of: inserting a delivery catheter into the lumen; percutaneously delivering the device to a target site within the lumen through a delivery catheter; operating an actuator to expose an anchor; and operating the actuator to lock the anchor. In other, the method includes the steps of: inserting a delivery catheter into the lumen; moving the device from a cartridge into the delivery catheter; delivering the device to a target site within the lumen; operating an actuator to move the delivery catheter with respect to the anchor to expose the anchor; and expanding the anchor.
摘要翻译：本发明是一种在组织整形装置中包括锚固件的方式，将组织成形装置递送和展开在患者体内。在一些实施例中，该方法包括以下步骤：将输送导管插入内腔; 通过输送导管将装置经皮递送到内腔内的目标部位; 操作致动器以暴露锚; 并操作致动器以锁定锚。另外，该方法包括以下步骤：将输送导管插入内腔; 将装置从药筒移动到输送导管中; 将装置输送到管腔内的目标部位; 操作致动器以使输送导管相对于锚固件移动以暴露锚固件; 并扩大锚点。

10. 发明申请

US20050096666A1 Percutaneous mitral valve annuloplasty delivery system 有权
标题翻译：经皮二尖瓣瓣环成形术输送系统
公开(公告)号：US20050096666A1
公开(公告)日：2005-05-05
申请号：US10946332
申请日：2004-09-20
申请人： Lucas Gordon , Mark Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian Doll
发明人： Lucas Gordon , Mark Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian Doll
IPC分类号： A61B17/12 , A61B17/34 , A61F2/06 , A61F2/24 , A61F2/84 , A61F11/00
CPC分类号： A61B17/3468 , A61F2/2451 , A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.
摘要翻译：本发明是一种组织成形系统，包括具有可扩张锚和锁的组织成形装置; 输送导管; 输送机构，其适于经由输送导管将患者外部的组织成形装置输送到患者体内的内腔内的目标部位; 以及致动器，其适于将致动力传递到所述锁以将所述锚固件锁定在扩展构型中。本发明也是适于在患者的内腔内的目标部位经皮输送和部署组织整形装置的系统。该系统包括：手柄; 由手柄支撑并适于经由输送导管将组织成形装置从患者外部递送到治疗部位的递送机构; 以及致动器，其由所述手柄支撑并且适于递送致动力以将所述组织整形装置的锚固件以扩展构型锁定。

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