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1. 发明授权

US06875182B2 Electrosurgical specimen-collection system 失效
标题翻译：电外科标本采集系统
公开(公告)号：US06875182B2
公开(公告)日：2005-04-05
申请号：US10136700
申请日：2002-04-30
申请人： John L. Wardle , Fred H. Burbank , Paul Lubock
发明人： John L. Wardle , Fred H. Burbank , Paul Lubock
IPC分类号： A61B20060101 , A61B10/00 , A61B10/02 , A61B10/04 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0233 , A61B10/02 , A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2010/0225 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： Devices, methods and systems for obtaining biopsy tissue samples are provided. Flexible hollow tubes with a rail and a tip cutting element advance within a shaft with an aperture and a bore having a ramp, so that the cutting element emerges from the aperture and cuts tissue as it moves over the ramp. Either or both shaft and bore may have guides, which may engage each other to guide the tube along a tissue cutting pathway. A tube may have a rail and the bore a channel which engages the rail and guides the tube. Cut tissue may be acquired and transported proximally within the tube by suction to a tissue collection chamber. Multiple tissue samples may be obtained from a single insertion point by rotation and/or translation of the shaft between biopsies.
摘要翻译：提供了用于获得活检组织样本的装置，方法和系统。具有导轨和尖端切割元件的柔性中空管在具有孔的轴内延伸并且具有斜坡的孔，使得切割元件从孔中露出并且在组织移动通过斜坡时切割组织。轴和孔中的一个或两个可以具有引导件，其可以彼此接合以沿着组织切割路径引导管。管可以具有轨道并且孔具有与轨道接合并引导管的通道。可以通过抽吸将组织收集并在管内向近端运送到组织收集室。可以通过在活组织检查之间的轴的旋转和/或平移从单个插入点获得多个组织样本。

2. 发明授权

US6017316A Vacuum control system and method for automated biopsy device 失效
标题翻译：真空控制系统及自动活检装置的方法
公开(公告)号：US6017316A
公开(公告)日：2000-01-25
申请号：US878468
申请日：1997-06-18
申请人： Mark A. Ritchart , Fred H. Burbank , Seth A. Foerster , John L. Wardle
发明人： Mark A. Ritchart , Fred H. Burbank , Seth A. Foerster , John L. Wardle
IPC分类号： A61B10/02 , A61B1/00 , A61B10/00 , A61B17/00 , A61B19/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B2010/0208 , A61B2017/00017 , A61B2090/0811
摘要： An automatic control system for a vacuum-assisted automatic core biopsy device (10) is provided, wherein the automatic core biopsy device (10) comprises a housing (12), out of which extends a needle assembly (14) including a hollow outer piercing needle (16), an inner cutter (18) having a lumen (20), a probe housing (22), and a tissue receiving notch (24). The automatic control system (92) is computerized to move the hollow outer piercing needle (16) automatically to the target tissue lesion, as was true in the prior art, but also is programmed to automatically control the rotational orientation of the piercing needle (16), and its associated tissue receiving notch (24), as well as the axial positioning and rotation of the cutting cannula (18). Consequently, a clinician user need only mark the desired locations within the target location from which tissue samples are desired and the automatic control system will operate the device to retrieve samples from the marked locations.
摘要翻译：提供了一种用于真空辅助自动核心活检装置（10）的自动控制系统，其中所述自动核心活检装置（10）包括壳体（12），所述壳体（12）从所述壳体（12）延伸出针组件（14），所述针组件包括中空外穿孔针（16），具有内腔（20）的内切割器（18），探针外壳（22）和组织接收凹口（24）。自动控制系统（92）被计算机化以将空心外穿刺针（16）自动移动到目标组织损伤，如现有技术中所述，但也被编程为自动控制穿刺针（16）的旋转取向）和其相关联的组织接收凹口（24）以及切割套管（18）的轴向定位和旋转。因此，临床医师用户仅需要在目标位置标记期望的位置，从该组织样本期望的位置，自动控制系统将操作该装置以从标记的位置检索样本。

3. 发明授权

US07890186B2 Retrieval devices for anchored cardiovascular sensors 有权
标题翻译：锚固心血管传感器检索装置
公开(公告)号：US07890186B2
公开(公告)日：2011-02-15
申请号：US11633819
申请日：2006-12-05
申请人： John L. Wardle , Neal L. Eigler
发明人： John L. Wardle , Neal L. Eigler
IPC分类号： A61N1/05
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/145 , A61B5/6882 , A61B17/064 , A61B2017/00243 , A61N1/057
摘要： An anchoring device and a delivery method thereof can effectively provide a means for securing an implant to a wall of an internal organ within a patient in a variety of clinical applications. In one embodiment, an anchoring device used to retain a cardiac pressure measurement device is provided. The device is implanted in the body by deforming it to a small cross section profile, sliding it through a low profile delivery device and ejecting from the delivery device at a targeted site. The anchoring mechanism, when ejected from the delivery device, reverts back to pre-formed configuration and engages opposite sides of an organ wall, thereby anchoring the implant in the organ wall.
摘要翻译：锚定装置及其递送方法可以有效地提供用于在多种临床应用中将植入物固定到患者内部器官的壁的装置。在一个实施例中，提供了用于保持心脏压力测量装置的锚定装置。通过将其变形成小的横截面轮廓将装置植入体内，将其通过低轮廓输送装置滑动并从目标部位的输送装置排出。当从输送装置弹出时，锚定机构回复到预先形成的构型并且接合器官壁的相对侧，从而将植入物固定在器官壁中。

4. 发明授权

US06488030B1 Articulating guide arm for medical applications 有权
标题翻译：用于医疗应用的铰接导向臂
公开(公告)号：US06488030B1
公开(公告)日：2002-12-03
申请号：US09496518
申请日：2000-02-02
申请人： John L. Wardle , Mark A. Ritchart
发明人： John L. Wardle , Mark A. Ritchart
IPC分类号： A61G1500
CPC分类号： A61B17/3403 , A61B10/0275 , A61B90/50 , A61B2090/5025
摘要： A device is provided for stabilizing and positioning an otherwise hand-held medical instrument, such as a biopsy power driver and probe, to ensure the ability to accurately place the probe into the breast and maintain position relative to a particular tissue site from any desired entry point. The device comprises a main arm having a generally vertical portion and a generally horizontal portion. A clamping assembly permits attachment of the apparatus to a stationary object, which is preferably an examination table, and includes a locking clamp having a gripping mode and a releasing mode for alternately gripping and releasing the main arm, and a lever assembly for actuating the locking clamp between the gripping mode and the releasing mode. A horizontal clamp, attached to the generally horizontal portion of the main arm, provides support for an articulating arm assembly having a first arm portion, or upper arm, and a second arm portion, or forearm, wherein the upper arm and forearm are attached together by an elbow joint, so that they may be articulated relative to one another about a common axis disposed through the elbow. A mounting bracket for securing the biopsy power driver and probe is attached to a distal end of the forearm. The elbow joint attaching the upper arm and forearm of the articulating arm assembly comprises a spring loaded counterbalance mechanism which functions to support the weight of the medical instrument, thereby giving the instrument a weightless feel during the positioning process, which prevents fatigue on the part of a user and therefore permits more delicate and precise movements of the instrument.
摘要翻译：提供了一种用于稳定和定位另外的手持医疗器械（例如活检动力驱动器和探针）的装置，以确保将探针准确地放置在乳房中并且能够相对于特定组织部位保持位置与任何期望的进入点。该装置包括具有大致垂直部分和大致水平部分的主臂。夹持组件允许将装置连接到静止物体上，该固定物体优选为检查台，并且包括具有用于交替地夹紧和释放主臂的夹持模式和释放模式的锁定夹具，以及用于致动锁定的杆组件在夹紧模式和释放模式之间夹紧。附接到主臂的大致水平部分的水平夹具为具有第一臂部分或上臂以及第二臂部分或前臂的关节臂组件提供支撑，其中上臂和前臂附接在一起通过肘关节，使得它们可以围绕穿过肘部设置的公共轴线相对于彼此铰接。用于固定活检动力驱动器和探针的安装支架附接到前臂的远端。连接关节臂组件的上臂和前臂的肘关节包括弹簧加载的平衡机构，其用于支撑医疗器械的重量，从而在定位过程期间给予仪器失重的感觉，其防止部分因此允许使用者更精细和精确地移动仪器。

5. 发明授权

US06432039B1 Methods and apparatus for reinforcement of the heart ventricles 失效
标题翻译：用于加强心室的方法和装置
公开(公告)号：US06432039B1
公开(公告)日：2002-08-13
申请号：US09346643
申请日：1999-07-01
申请人： John L. Wardle
发明人： John L. Wardle
IPC分类号： A61F1300
CPC分类号： A61F2/2481 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12 , A61M2039/0211
摘要： A device for treating heart disorders, and particularly cardiomyopathy. The device is comprised of a compliant containment structure shaped in a configuration such that it surrounds and encases the heart. Within this containment structure are housed two or more inflation pockets that are fabricated from a non-elastic compliant material. These pockets are disposed on the interior surface of the containment structure and are configured to oppose and support the external wall of at least one of the ventricles of the heart. In the preferred embodiment, there are a plurality of relatively small, spaced inflation pockets disposed to act against each ventricle which is to be contained.
摘要翻译：用于治疗心脏病的装置，特别是心肌病。该装置包括形状为配置的顺应性容纳结构，使得其围绕并包住心脏。在该容纳结构内容纳有两个或更多个由非弹性柔顺材料制成的充气袋。这些口袋设置在容纳结构的内表面上，并且构造成抵抗并支撑心脏的至少一个心室的外壁。在优选实施例中，存在多个相对较小的间隔开的充气袋，其设置成抵抗要包含的每个心室。

6. 发明授权

US4748969A Multi-lumen core deflecting endoscope 失效
标题翻译：多腔内芯偏转内窥镜
公开(公告)号：US4748969A
公开(公告)日：1988-06-07
申请号：US47687
申请日：1987-05-07
申请人： John L. Wardle
发明人： John L. Wardle
IPC分类号： G02B23/24 , A61B1/00 , A61B1/005 , A61B1/307 , A61B1/31
CPC分类号： A61B1/307 , A61B1/0051 , A61B1/31
摘要： An endoscope having a control head, an objective head and a flexible shaft therebetween. The shaft has a flexible core with a conduit means therewith. A deflection means is provided with the shaft having a tension member and a distal end compression member for controllably returning the distal end to an undeflected position.
摘要翻译：一种具有控制头，目标头和其间的柔性轴的内窥镜。轴具有带有导管装置的柔性芯。偏转装置设置有具有张紧构件的轴和用于可控制地将远端返回到未偏转位置的远端压缩构件。

7. 发明申请

US20130006201A1 ELUTING COILS AND METHODS OF DEPLOYING AND RETRIEVING 有权
标题翻译：校准线圈和方法的分配和检索
公开(公告)号：US20130006201A1
公开(公告)日：2013-01-03
申请号：US13610733
申请日：2012-09-11
申请人： John L. Wardle
发明人： John L. Wardle
IPC分类号： A61M5/00
CPC分类号： A61M31/002 , A61F2250/0068
摘要： Embodiments are directed to eluting coils having a relaxed coiled state and a straightened state that may be deployed at a fixed location within a patient's body and may accurately dispense and distribute fluids and or dissolvable substances at site specific locations of the body. Some embodiments of eluting elements are configured to be subsequently retrieved from a delivery site.
摘要翻译：实施方案涉及具有松弛的卷曲状态和矫直状态的洗脱线圈，其可以部署在患者体内的固定位置，并且可以在身体的特定位置准确地分配和分布流体和/或可溶解物质。洗脱元件的一些实施方案被配置为随后从递送部位检索。

8. 发明申请

US20110022057A1 APPARATUS AND METHODS FOR TRANSFERRING AN IMPLANTED ELONGATE BODY TO A REMOTE SITE 审中-公开
标题翻译：用于将一个植入的延伸体转移到远程站点的装置和方法
公开(公告)号：US20110022057A1
公开(公告)日：2011-01-27
申请号：US12842917
申请日：2010-07-23
申请人： Neal L. Eigler , James S. Whiting , John L. Wardle , Werner Hafelfinger , Apratim Dixit
发明人： Neal L. Eigler , James S. Whiting , John L. Wardle , Werner Hafelfinger , Apratim Dixit
IPC分类号： A61B19/00
CPC分类号： A61B17/3468 , A61B2017/00243 , A61M25/01 , A61M25/09 , A61M2025/0681 , A61N1/056
摘要： A transfer guidewire assembly configured to manipulate an implanted elongate body includes a flexible elongate portion, such as a guidewire, and coupler. The flexible elongate body has a proximal end and a distal end attached to the coupler. The coupler can include a catheter and/or a handle. The handle can include a screw. The coupler is configured to be removably attached to the end of an implanted elongate body, for example, by forming an interference fit with the outside diameter of the implanted body. A method for transferring an end of an implanted medical component from first site to a second site within a patient, such as a pacemaker, defibrillator, and/or sensor lead, etc., includes inserting a guidewire into the body at the first site and externalizing the guidewire at the second site. A proximal portion of the implanted component near the first site and is attached to the guidewire. The proximal portion of the implanted component is pulled through the patient's body and out the second site with the transfer guidewire assembly.
摘要翻译：构造成操纵植入的细长主体的传送导丝组件包括柔性细长部分，例如导丝和耦合器。柔性细长体具有附接到联接器的近端和远端。联接器可以包括导管和/或手柄。把手可以包括一个螺丝。耦合器被配置为可移除地附接到植入的细长体的端部，例如通过与植入体的外径形成过盈配合。用于将植入的医疗部件的端部从第一部位转移到患者（例如起搏器，除颤器和/或传感器引线等）内的第二部位的方法包括将引导线插入到第一部位的身体中，以及在第二站点外部化导丝。植入部件的近端部分靠近第一部位并附接到导丝。植入部件的近端部分通过患者的身体被拉出并且与传递导丝组件一起移出第二部位。

9. 发明授权

US5415653A Optical catheter with stranded fibers 失效
标题翻译：具有绞合纤维的光学导管
公开(公告)号：US5415653A
公开(公告)日：1995-05-16
申请号：US124383
申请日：1993-09-20
申请人： John L. Wardle , Tsvi Goldenberg
发明人： John L. Wardle , Tsvi Goldenberg
IPC分类号： A61B18/22 , A61B18/24 , G02B23/26 , A61B17/36
CPC分类号： G02B23/26 , A61B18/24 , A61B2018/2216 , A61B2018/2244 , A61M2025/0183
摘要： A catheter having an axis extending between a proximal end and an opposing distal end includes a plurality of optical fibers arranged to spiral in a first direction to form a circumferential layer around the axis. Rotation of the catheter in the first direction tends to expand the layer while rotation of the catheter in a second opposite direction tends to contract the circumferential layer. An outer jacket limits the expansion of the circumferential layer while an inner core limits the contraction of the circumferential layer to increase torquability of the catheter. The stranded fibers equalize bending stresses to maintain a circular cross-sectional configuration, increase flexibility and a reduced diameter for the catheter.
摘要翻译：具有在近端和相对的远端之间延伸的轴线的导管包括布置成在第一方向上螺旋形以围绕轴线形成周向层的多根光纤。导管在第一方向的旋转倾向于使层膨胀，同时导管在第二相反方向上的旋转倾向于收缩周向层。外套限制了周向层的膨胀，而内芯限制了周向层的收缩以增加导管的扭力。绞合纤维使弯曲应力相等，以保持圆形横截面形状，增加导管的柔性和减小的直径。

10. 发明授权

US4686963A Torsion resistant vertebrated probe of simple construction 失效
标题翻译：抗扭抗脊椎动物探头简单施工
公开(公告)号：US4686963A
公开(公告)日：1987-08-18
申请号：US836434
申请日：1986-03-05
申请人： Jack Cohen , John L. Wardle
发明人： Jack Cohen , John L. Wardle
IPC分类号： A61B1/00 , A61B1/005 , A61M25/01 , G02B23/24
CPC分类号： G02B23/2476 , A61B1/0055 , A61B2017/00314 , A61B2017/00327 , A61M25/0144 , A61M25/0147
摘要： An inspection instrument has an elongated flexible body which extends between a control assembly at a proximal end and an objective head at a distal end. Fiber optic bundles disposed within the instrument permit the illumination and the imaging of the interior regions of a structure being inspected. An articulating vertebrae assembly and a transitional coupler are disposed proximally of the objective head whereby the objective head is caused to move in an arc when tension is applied to interiorly disposed cables connecting the objective head to the control assembly. The vertebrae assembly is comprised of individual hollow vertebrae which are disposed along and axially aligned by a resilient stiffening member which is fixed at a distal end within the objective head and at a proximal end within the coupler. The member provides flexibility to the vertebrae assembly and, because it has a rectangular cross-sectional area, resists a torsion about its longitudinal axis, thus making the distal end of the instrument torque stable.
摘要翻译：检查仪器具有细长的柔性体，其在近端的控制组件和远端的物镜头之间延伸。设置在仪器内的光纤束允许被检查结构的内部区域的照明和成像。铰接的椎骨组件和过渡连接器设置在物镜头的近侧，由此当张力被施加到将目标头连接到控制组件的内部布置的电缆时，使目标头在电弧中移动。椎骨组件由单独的中空椎骨构成，其通过弹性加强构件设置并且由弹性加强构件沿轴向对齐，弹性加强构件固定在物镜头内的远端处，并且固定在联接器内的近端处。该构件为椎骨组件提供灵活性，并且由于其具有矩形横截面积，抵抗围绕其纵向轴线的扭转，从而使得仪器的远端扭矩稳定。

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